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Anti-obesity Effect of Fermented Whey Beverage using Lactic Acid Bacteria in Diet-induced Obese Rats
Sung Moon Hong,Eui Chun Chung,Cheol Hyun Kim 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.5
High-protein fermented whey beverage (FWB) was manufactured using whey protein concentrate (WPC) and Lactobacillus plantarum DK211 isolated from kimchi. This study was designed to evaluate the anti-obesity activity of FWB in male rats fed a high-fat diet. Male Sprague-Dawley rats were randomly assigned to three groups (n=8 per group). The three groups differed in their diet; one group received a normal diet (ND), another, a high-fat diet (HD), and the third, a HD plus fermented whey beverage (HDFWB), for 4 wk. Supplementation with FWB (the HDFWB group) prevented weight gain and body fat accumulation. The food intake in the HDWFB group was significantly lower (p<0.05) than that of the HD group. The HDWFB group also showed a significant decrease in organ weights (p<0.05), except for the weight of the testis. There was a significant decrease in total cholesterol, LDL-cholesterol, and triglycerides in the HDFWB group compared with the HD group (p<0.05), but there was no significant difference in serum HDL-cholesterol levels among the experimental groups. Rats ingesting FWB (the HDFWB group) also showed a significant decrease in blood glucose levels, and plasma levels of insulin, leptin, and ghrelin compared to HD group (p<0.05). These results indicate that FWB has beneficial effects on dietary control, weight control, and reduction in fat composition and serum lipid level; consequently, it may provide antiobesity and hypolipidemic activity against high fat diet-induced obesity in rats.
Eui Ryong Chung,Sung Chul Shin,Jae Pil Heo 한국축산식품학회 2011 한국축산식품학회지 Vol.31 No.4
It is well established that uncoupling protein 3 (UCP3) is expressed largely in skeletal muscle, white adipose tissue and brown adipose tissue and has been suggested to play important roles in regulating energy expenditure, body weight, thermoregulation as well as fatty acid metabolism and obesity. Therefore, the UCP3 gene was selected as a candidate gene for carcass and meat quality traits in Korean cattle. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the UCP3 gene and to evaluate the association of UCP3 SNP markers with carcass and meat quality traits in Korean cattle. The five exons in the UCP3 gene were sequenced, and ten SNPs were identified. The PCR-SSCP method was then developed to genotype the individuals examined. The g.3076A>G genotype was significantly associated with marbling score (MS) of Korean cattle. Animals with the AA genotype had a higher MS than those with the AG and GG genotypes. No significant associations of the SNP g.3076A>G were observed for any traits. In conclusion, although SNP g.3076A>G, which showed an association with MS, does not cause amino acid changes, this SNP may be used as a DNA marker to select animals that have higher intramuscular fat content.
Run-Time Adaptive Workload Estimation for Dynamic Voltage Scaling
Sung-Yong Bang,Kwanhu Bang,Sungroh Yoon,Eui-Young Chung IEEE 2009 IEEE transactions on computer-aided design of inte Vol.28 No.9
<P>Dynamic voltage scaling (DVS) is a popular energy-saving technique for real-time tasks. The effectiveness of DVS critically depends on the accuracy of workload estimation, since DVS exploits the slack or the difference between the deadline and execution time. Many existing DVS techniques are profile based and simply utilize the worst-case or average execution time without estimation. Several recent approaches recognize the importance of workload estimation and adopt statistical estimation techniques. However, these approaches still require extensive profiling to extract reliable workload statistics and furthermore cannot effectively handle time-varying workloads. Feedback-control-based adaptive algorithms have been proposed to handle such nonstationary workloads, but their results are often too sensitive to parameter selection. To overcome these limitations of existing approaches, we propose a novel workload estimation technique for DVS. This technique is based on the Kalman filter and can estimate the processing time of workloads in a robust and accurate manner by adaptively calibrating estimation error by feedback. We tested the proposed method with workloads of various characteristics extracted from eight MPEG video clips. To thoroughly evaluate the performance of our approach, we used both a cycle-accurate simulator and an XScale-based test board. Our simulation result demonstrates that the proposed technique outperforms the compared alternatives with respect to the ability to meet given timing and Quality of Service constraints. Furthermore, we found that the accuracy of our approach is almost comparable to the oracle accuracy achievable only by offline analysis. Experimental results indicate that using our approach can reduce energy consumption by 57.5% on average, only with negligible deadline miss ratio (DMR) around 6.1%. Moreover, the average of computational overheads for the proposed technique is just 0.3%, which is the minimum value compared to other methods. More importantly, the DMR of our method is bounded by 11.7% in the worst case, while those of other methods are twice or more than ours.</P>
Chung, Eui-Ryong,Shin, Sung-Chul,Heo, Jae-Pil Korean Society for Food Science of Animal Resource 2011 한국축산식품학회지 Vol.31 No.4
Biological or physiological genes that regulate metabolism and energy partitioning have the potential to influence economically important traits such as carcass and meat quality traits in beef cattle. The neuropeptide Y (NPY) functions as a central appetite stimulator and plays a major role in feed intake and energy-balance control. Therefore, the NPY gene is an excellent biological and physiological candidate gene for body weight, feeding, fatness or growth related traits in beef cattle. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the NPY gene and to evaluate the association of NPY SNP markers with carcass and meat quality traits in Korean cattle. The genomic region (711 bp) including intron 2 of NPY gene was amplified and sequenced, and five SNPs, g.4389 Del(C), g.4371Del(C), g.4271T>C, g.1899A>G and g.1517A>C, were identified. The PCR-RFLP method was then developed to genotype the individuals examined. The g.4271T>C SNP was significantly associated with M. Longissimus dori area (LDA) value (p<0.027). Animals with the TT ($78.144{\pm}0.950\;cm^2$) genotype had higher LDA than those with the CC ($72.266{\pm}2.039\;cm^2$), and animals with TC genotype showed intermediate value. This SNP genotype also showed a highly significant additive genetic effect for the LDA (p<0.01). No significant associations, however, was detected between any of the SNP genotype and other carcass traits measured in this study. In conclusion, SNP genotype of the NPY gene may be used as DNA markers to select animals that have a higher meat yield.
( Sung Eic Hong ),( Jin Koo Kim ),( Jeong Nam Yu ),( Keun Yong Kim ),( Chung Il Lee ),( Kwan Eui Hong ),( Kie Young Park ),( Moongeun Yoon ) 한국수산과학회(구 한국수산학회) 2012 Fisheries and Aquatic Sciences Vol.15 No.1
Genetic variation in the Asian shore crab Hemigrapsus sanguineus was determined from partial mitochondrial DNA (mtDNA) sequences of the cytochrome b (Cytb) gene. Samples included 143 crabs from six localities along three coastlines in South Korea. A nucleotide sequence analysis revealed 38 variable sites in a 470-bp sequence, which defined 37 haplotypes. The haplotypes were not associated geographically and had a shallow genealogy. Pairwise FST tests and a two-dimensional scaling analysis revealed no significant genetic differentiation among most of the populations. The low pairwise comparison values, but significant genetic differentiation of a northeastern population from all other populations, might have been influenced by a restriction in gene flow caused by hydrographic conditions such as ocean boundaries. The high haplotype diversity, low nucleotide diversity, and time since H. sanguineus expansion in Korean coastal waters indicate rapid population growth and a recent, sudden expansion in the Late Pleistocene.
Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness
Sung, Pil Soo,Cheon, HyeonJoo,Cho, Chung Hwan,Hong, Seon-Hui,Park, Do Youn,Seo, Hyung-Il,Park, Su-Hyung,Yoon, Seung Kew,Stark, George R.,Shin, Eui-Cheol Proceedings of the National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.33