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이민수,남종원,강성민,연병길,오병훈,이철,정인과,채정민,백인호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6
연구목적 : 주요우울증 환자에서 벤라팍신의 치료 효과와 안정성을 조사하기 위해 다기관 개방연구를 시행하였다. 방 법 : DSM-IV 진단 기준에 의거하여 주요우울증으로 진단된 환자중 벤라팍신 투여에 동의한 환자를 대상으로 하였다. 선택된 환자에서 다른 항우울제를 복용하고 있는 경우 14일 이상의 약물 배설기간을 가진후 벤라팍신을 6주간 투여하였으며, 기준점, 1주, 2주, 4주, 6주 후에 HAM-D, MADRS, 그리고 CGI등을 사용하여 평가하였다. 본 연구기간중 발생된 모든 부작용은 부작용의 발생 및 소설 시기, 심한 정도, 발생 빈도, 벤라팍신과의 관련성, 관련 조치 및 결과에 대하여 증례기록서에 기록하도록 하였다. 결 과 : 총 141명을 대상으로 하였으며, 이중 94명(66.7%)이 6주간의 연구를 완결하였고, 47명(33.3%)이 중도탈락하였다. HAM-D총점수는 벤라팍신 투여 1주후부터 유의한 감소를 나타내었으며, 2주,4주, 6주후에도 지속적인 감소를 보였다. MADRS의 총점수도벤라팍신 투여 1주 후부터 유의한 호전을 나타내었으며, 2주, 4주, 6주 후에도 지속적인 감소를 보였다. CGI에서도 기준점, 1주, 2주, 4주, 6주 후 각각의 시점 사이에 유의한 호전이 보였다. 활력징후, 일반 혈액학, 생화학, 심전도 검사 등에서 유의한 변화는 없었다. 벤라팍신과 관련된 부작용으로 흔히 보고한 증상은 오심(10.6%), 소화불량(9.5%), 변비(8.5%), 현기증(8.5%)등 이었다. 결 론 : 다기관 개방연구를 통해 주요우울증 환자에 대한 벤라팍신의 투여는 우울증상의 호전에 효과적이었으며 안전하였다. Objective : A Multicenter open-label study was conducted to evaluate the clinical efficacy and safety of venlafaxine for the tretment in patients with major depression. Method : The study was done in patients with major depression diagnosed by DSM-IV who accepted venlafaxine medication. In cases of the patients taking other antidepressants, 6 weeks of venlafaxine medication was carried out after 14 days of drug excretion period and evaluation using HAM-D, MADRS, and CGI was done at baseline, and after 1, 2, 4, and 6 weeks. Regarding all side effects that had occurred during the period of our study such as their developed/disappeared time, severities, incidences, relationship with venlafaxine, managements and results have been putted into the records. Results : A total of 141 patients were enrolled. Among 94 of them finished the 6 weeks of research and 41 of them did not make it through the research. Total HAM-D scores showed significant decrease after 1 week of venlafzxine medication and continous decrease through the study period. Total scores of MADRS also showed significant improvement after 1 week and continuous decrease through the study period. Similarly, CGI showed significant improvement between baseline, 1, 2, 4, and 6 weeks. There were no significant changes in vital sign, CBC, chemistry, and EKG. The commonly reported side effects of venlafaxine were nausea(10.6%), indigestion(9.5%), constipation(8.5%), and dizziness(8.5%). Conclusion : According to the results, venlafaxine was effective and safe in the treatment of patients with major depression.
저강도 펄스형 초음파를 이용한 개의 슬개골 탈구 치료 효과
조성진,김남수,김화영,김선균,이성호,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
The effect of low-intensity ultrasonography on dislocation of the patella and fracture healing is controversial, and current management of that does not generally involve the use of ultrasound therapy. Nine patients with dislocation of the patella were treated with low-intensity ultrasonography(l5 mW/㎠, 1∼3.3 MHz) per 10-15 min/days, with an interval of 3 days during the last 3 weeks, at Family Animal Hospital(in Kunsan city). Ultrasound therapy may be beneficial to dislocation of the patella and healing. This finding is of considerable importance in that treatment with a low-intensity pulsed ultrasound signal may reduce healing time and could yield substantial cost savings and decreases in disability associated with delayed healing of dislocation of the patella.
촉매로서 금속 착화합물이 실리카가 충전된 에폭시-산무수물 복합체의 경화 거동 및 물성에 미치는 영향
서병호 ( Byeong Ho Seo ),이동훈 ( Dong Hoon Lee ),이누리 ( Noo Ri Lee ),도기원 ( Ki Won Do ),마경남 ( Kyung Nam Ma ),김원호 ( Won Ho Kim ) 한국고무학회 2014 엘라스토머 및 콤포지트 Vol.49 No.1
본 연구에서는, 71℃/40 시간의 경화 조건에서 에폭시/산무수물로 구성된 몰딩 컴파운드를 경화시키기 위하여 촉매로서 코발트 (II) 아세틸아세토네이트, 칼륨 아세틸아세토네이트, 철 (III) 아세틸아세토네이트 및 크롬 (III)옥토에이트와 같은 다양한 금속 착화합물들을 각각 적용하였고, 몰딩 컴파운드의 기계적 강도를 향상시키기 위하여 에폭시 부/경화제 부의 무게비를 조절하였다. 실험 결과에 따라 크롬 (III) 옥토에이트 촉매는 71℃/40 시간의 경화조건에서 몰딩 컴파운드의 경화 반응을 완료시킬 뿐만 아니라 크롬 (III) 옥토에이트 촉매가 적용된 컴파운드는 상온에서 적절한 가공성을 나타내었다. 경화된 몰딩 컴파운드의 기계적 특성에서는 에폭시 부/경화제 부의 무게비가 0.9/1에서 0.5/1 사이에서 제조된 컴파운드가 가장 높은 굴곡강도를 나타내었고, 경화제 부의 함량이 증가함에 따라 더 높은 압축 강도를 나타내었다. In this study, in order to complete curing reaction of the molding compound comprising an epoxy/anhydride at 71℃ for 40 hours, metal coordination complexes such as cobalt (II) acetylacetonate, potassium acetylacetonate, iron (III) acetylacetonate and chromium (III) octoate as a catalyst were applied to the epoxy/anhydride compounds respectively. The weight ratio of an epoxy part/an anhydride part was adjusted to improve the mechanical properties of the molding compound. According to the experimental results, an epoxy/anhydride compound containing chromium (III) octoate showed a high conversion at 71℃ for 40 hours as well as a proper processability at room temperature among the several metal coordination complexes. For the mechanical properties of the cured epoxy/anhydride compound, the compounds containing weight ratio from 0.9/1 to 0.5/1 of the epoxy part/anhydride part with chromium (III) octoate showed the high flexural strength, and higher compressive strength was shown with increasing of the hardener part.
우리나라 長壽者의 生活 및 意識調査에 관한 硏究 Ⅳ. 長壽者의 過去 家族狀況과 夫婦生活
최진호(Jin-Ho Choi),변재형(Jae-Hyeung Pyeun),임채환(Chae-Hwan Rhim),양종순(Jong-Soon Yang),김수현(Soo-Hyun Kim),김정한(Jeung-Han Kim),이병호(Byeong-Ho Lee),우순임(Soon-Im Woo),최선남(Sun-Nam Choe),변대석(Dae-Seok Byun),김무남(Mu-Nam 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.1 No.-
The present study was conducted as a part of the research on the investigation on daily life and consciousness of the longevous people in Korea. Surveys were carried out on their familial organization and the marriage life of longevous people in order to achieve the purpose of the regearch. The materials for 121 males and 258 females aged more than 80 were collected and analyzed from June to November 1985. The results are summarized as follows: 1. As for parents' mortality age of longevous people, 48.5% of them showed "both above 70%"(20.3%) and/or "either father or mother above 70"(28.2%). Consequently, a significant difference was found between the life span and inherent factor. 2. By the birth order of longevous people, "1st" had the highest figure of 41.2%. and decreased in the order of "2nd"(25.1%) and "3rd"(l3.7%). It was observed that the more the birth order of longevous people preceded, the more life span of the aged increased. 3. Three to five persons in the number of brothers and sisters comprised 57.6% of total longevous people surveyed, while 63.9% of them were revealed to have three to six in the number of offsprings.
우리나라 長壽者의 生活 및 意識調査에 관한 硏究 Ⅲ. 長壽者의 過去 食生活 特性
최진호(Jin-Ho Choi),변재형(Jae-Hyeung Pyeun),임채환(Chae-Hwan Rhim),양종순(Jong-Soon Yang),김수현(Soo-Hyun Kim),김정한(Jeung-Han Kim),이병호(Byeong-Ho Lee),우순임(Soon-Im Woo),최선남(Sun-Nam Choe),변대석(Dae-Seok Byun),김무남(Mu-Nam 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.1 No.-
This study was designed to be link in the chain of the investigation on dally life and consciousness of longevol.ls people in Korea. and to jnvestigate the dietary life and its habit of longevous people in the past. The dietary Hie and its habit were surveyed on 319 subjects (male 121. female 258) of the aged who were above 80 years of age, from June to November in 1985. 1. Of the taste on staple food of longevous peoples in the past(between 40 and 60 years). ""meal mixed with barley"" had the highest figure of 49.9%, followed by ""boiled rice""(47.0%). But it is showed that male preferred ""meal mixed with barley""(56.2%) to ""boiled rice""(41.3%), whereas female slightly preferred ""boiled rice""(49.6%) to ""meal mixed with barley""(46.9%). 2. Of the experience of the food taste of these aged in the past, ""not salted"" and ""light"" had the highest figures of all 40.6%. It is showed that longevous peoples preferred ""not salted""(40.6%) and ""light""(40.6%) to ""saIty""(24.5%) and ""oily""(9.8%), respectively. 3. By comparison of the intake state of animal protein(meat and fish) of these aged in the past, ""occasionally"" was the highest of 55.4%, and decreased in the order of ""almost daily"" (31.9%) and ""scarcely""(I2.7%). Therefore, it is believed that 87.5% of longevous peoples has taken animal protein ""occasionally"" and ""almost daily"". 4. The intakes of major foods above 4~6 times a week of these aged in the past and present showed 50.4% and 67.5% for meat, fish, egg and soybean products, 26.6% and 51.5% for milk and its products, 89.9% and 81.0% for vegetables, 58.9% and 64.0% for oiled food, and 57.0% and 62.9% for seaweeds, respectively.
우리나라 長壽者의 生活 및 意識調査에 관한 硏究 - Ⅴ. 過去의 健康疾病 및 苦痛에 대한 態度 -
최진호(Jin-Ho Choi),변재형(Jae-Hyeung Pyeun),임채환(Chae-Hwan Rhim),양종순(Jong-Soon Yang),김수현(Soo-Hyun Kim),김정한(Jeung-Han Kim),이병호(Byeong-Ho Lee),우순임(Soon-Im Woo),최선남(Sun-Nam Choe),변대석(Dae-Seok Byun),김무남(Mu-Nam 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.1 No.-
The present study was designed to be link a part of the research on the investigation on daily life and consciousness of the longevous people in Korea, and to investigate the health conditions, and the attitude on disease and suffering of longevous people in the past. 1. By the health conditions of longevous people between 40 and 60 years, ""very good"" showed the highest figure of 71.0%, followed by ""ordinary"" (21.6%). Consequently it is found that 92.6% of total longevous people surveyed maintained the good health conditions above ordinary. 2. Of the experiences of disease and/or injury after 60 years of longevous people, ""never"" showed the highest figure of 74.7%, while ""had"" showed the only 22.6% of total longevous people surveyed. 3. Of the details of disease and/or injury after 60 years of longevous people. ""digestive disease"" showed the highest figure of 32.6%. followed by ""apoplexia cerebri & hypertensions""(14.0%) and ""heart disease""(14.0%), and followed by ""respiratory disease""(12.3%). 4. Of the experiences of suffering between 40 and 60 years of longevous people, ""never"" showed 53.7% of total longevous people surveyed, while the frequency of suffering decreased in the order of ""once""(22.7%), ""2 times""(15.8%) and ""3 times""(4.7%). By the details of suffering between 40 and 60 years of longevous people. ""family life"" showed the highest figure of 85.1%, followed by ""business""(10.1%). 5. By the attitude on suffering of longevous people, ""tried to forget soon"" showed the highest figure of 54.2%, followed by ""continuous worried""(23.3%), and followed by ""not worried""(7.2%).
우리나라 長壽者의 生活 및 意識調査에 관한 硏究 - Ⅳ. 長壽者의 過去 家族狀況과 夫婦生活
최진호(Jin-Ho Choi),변재형(Jae-Hyeung Pyeun),임채환(Chae-Hwan Rhim),양종순(Jong-Soon Yang),김수현(Soo-Hyun Kim),김정한(Jeung-Han Kim),이병호(Byeong-Ho Lee),우순임(Soon-Im Woo),최선남(Sun-Nam Choe),변대석(Dae-Seok Byun),김무남(Mu-Nam 한국식품영양과학회 1986 한국식품영양과학회지 Vol.15 No.4
우리나라 長壽者의 生活 및 意識調査硏究의 一環으로, 우리나라 長壽者의 過去 家族狀況과 夫婦生活에대해서 調査ㆍ比較한 結果는 다음과 같다.<br/> 1. 長壽者의 兩親의 死亡年齡을 比較하여 보면 『兩親이 70세 이상』이 전체의 20.3%이고, 『片親이 70세 이상』인 경우가 28.2%로서, 兩親이나 片親中에서 70세이상 長壽한 경우가 전체의 48.5%나 차지하고 있었다. 따라서 壽命과 遺傳的 要因사이에는 깊은 相關이 있음을 나타냈다.<br/> 2. 長壽者의 出生順位를 比較하여 보면 『첫번째』가 41.2%로 가장 많고, 그 다음이 『두번째』(25.1%), 『세번째』(13.7%)의 順으로 감소하고 있었다. 따라서 出生順位가 빠르면 빠를수록 長壽하는 傾向으로 나타냈다.<br/> 3. 長壽者의 兄弟姉妹의 數는 3~5명이 전체 장수자의 57.6%나 차지하고 있었으며, 子女의 數는 3~6명이 전체 장수자의 69.9%나 차지하고 있었다.<br/> 4. 長壽者의 結婚回數는 『1回』가 90.0%로 가장 많고, 그 다음이 『2回』(8.7%)로서, 全體 長壽者의 98.7%가 1回 또는 2回였으며, 長壽者의 結婚生活을 比較하여 보면, 『원만했다』가 전체의 87.6%로 대부분을 차지하고 있어서, 長壽者의 夫婦生活이 대단히 원만했던 것으로 나타났다. The present study was conducted as a part of the research on the investigation on daily life and consciousness of the longevous people in Korea. Surveys were carried out on their familial organization and the marriage life of longevous people in order to achieve the purpose of the research. The materials for 121 males and 258 females aged more than 80 were collected and analyzed from June to November 1985.<br/> The results are summarized as follows:<br/> 1. As for parents' mortality age of longevous people, 48.5% of them showed “both above 70”(20.3%) and/or “either father or mother above 70” (28.2%). Consequently, a significant difference was found between the life span and inherent factor.<br/> 2. By the birth order of longevous people, “1st” had the highest figure of 41.2%, and decreased in the order of “2nd”(25.1%) and “3rd”(l3.7%). It was observed that the more the birth order of longevous people preceded, the more life span of the aged increased.<br/> 3. Three to five persons in the number of brothers and sisters comprised 57.6% of total longevous people surveyed, while 63.9% of them were revealed to have three to six in the number of offsprings.
Ho Jong Ra,Hyun Jae Lee,Ho Seung Jo,Dae Cheol Nam,Young Bok Lee,Byeong Hun Kang,Dong Kyu Moon,Dong Hee Kim,Choong Jae Lee,Sun-Chul Hwang 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.1
We investigated whether betulin affects the gene expression, secretion and proteolytic activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as <i>in vivo</i> production of MMP-3 in the rat knee joint to evaluate the potential chondroprotective effect of betulin. Rabbit articular chondrocytes were cultured and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-1β (IL-1β)-induced gene expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), ADAMTS-5 and type II collagen. Effect of betulin on IL-1β-induced secretion and proteolytic activity of MMP-3 was investigated using western blot analysis and casein zymography, respectively. Effect of betulin on MMP-3 protein production was also examined<i> in vivo</i>. The results were as follows: (1) betulin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) betulin inhibited the secretion and proteolytic activity of MMP-3; (3) betulin suppressed the production of MMP-3 protein<i> in vivo</i>. These results suggest that betulin can regulate the gene expression, secretion, and proteolytic activity of MMP-3, by directly acting on articular chondrocytes.