退溪의 外交思想

宋琫圭 단국대학교 퇴계학연구소 1996 退溪學硏究 Vol.10 No.-

부신 결핵에 의한 Addison씨병 1예

송치운,구본정,안봉수,전준식,안미애,이진홍,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Addison's disease is a rare primary adrenal insufficient disorder resulting from chronic deficiency of adrenal cortical hormones. Clinical manefestations are generalized weakenss, weight loss, hyperpigmentation (especially sun exposed area and mucous membrane), hypotension, hyponatremia, hyperkalemia, gastrointestinal symptoms (involving anorexia, nausea, vomiting, abdominal pain). A 34-year-old woman has experienced slowly progressive generalized weakenss and skin pigmentation, anorexia, nausea, vomiting with ascites and diffuse abdominal pain. On the time of admission, her main clinical manifestations were anorexia, nausea, vomiting, fatigue, generalized weakness, amenorrhea, hair loss, diffuse abdominal pain revealed as Addison's disease due to bilateral adrenal tuberculosis. Her adrenal insufficient symptoms were recovered with the replacement of adrenocortical hormones and antituberculous medications. After treatment, Her skin pigmentation was decreased and menstruation was reappeared. Here we experienced one cases of Addison's disease with tuberculous peritonitis.

표피 종양에서 Epidermal Growth Factor Receptor의 발현 비교

송준영,이규석,정재봉 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Epidermal growth factor(EGF) and transforming growth factor alpha(TGFα) are important keratinocyte mitogens. Their effect are mediated by a cell membrane receptor(EGFR), quantitive and qualitive abnormalities of which may be responsible for deranged keratinocyte proliferation and differentiation. We have therefore examined EGFR expression immunohistochemically in a variety of benign and malignant epithelial neoplasms using monoclonal antibodies to the extracellular and intracellular receptor domains, In benign tumor(seborrheic keratosis), there was an ordered pattern of EGFR expression. In malignant tumors(basal and squamous cell carcinoma), there was loss of membrane labelling and cytoplasmic accumulation of the receptor. In premalignant prolifertation(Bowen's disease), there was loss of membrane receptor with absent cytoplasmic EGFR. In slot-blot analysis, the levels of EGFR mRNA in sguamous cell carcinoma and basal cell carcinoma revealed 3 fold elevation when compared to normal skin. We suggest that dysregulation of the EGFR may be important in the development of cutaneous epithelial malignancies.

MO이론에 의한 Diels-Alder 반응의 배향성과 반응성의 결정 (Ⅱ)

宋基東,朴聖珪,魯鳳五,朴基柱 조선대학교 기초과학연구소 1985 自然科學硏究 Vol.8 No.1

We applied frontier orbital theory to thermal and catalytic Diels-Alder reaction by means of CNDO/2 and EHT-spd methods, in order to predict the substituent and Lewis acid catalytic effect or reactivity on the regioselectivity of (4+2) cycloaddition reaction of the substituted-nitrosobenzenes. On the above reactions ρ>0. So it takes normal electron demand reaction. When electron withdrawing radicals are substituted, HOMO and LUMO energies of dienophiles are reduced, and the reactivity is increased. As the Lewis acid makes complexes of dienophile and polarizes LUMO coefficients of dienophile in an opposite way, the major regioisomer is predicted as B type. Linear correlation is indicated in the graph of E and σ.

레반다이어트 식품섭취가 비만여성의 신체구성성분, 혈중 렙틴 및 지질수준에 미치는 영향

이규성,유병렬,정락희,김문희,송봉준,이길자 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

This study was to varify the effects of levan diet administration on body composition, blood leptin level and lipids components (TC, TG, LDL-C, HDL-C) in obese women during 8 weeks. The subjects of study were divided into 20-29year group (n=15) and 30-39year group (n=15) randomly selected. Administration of Levan Diet in this study was 2 times (breakfast, lunch or dinner) per day, 11tablets per 1times. Statistical method for data processing produced mean and SD of total variable. To analyze difference between groups and periods had executed 2? ANOVA. This study was given conclusion as follows: First, systolic blood pressure showed decrease after administration of levan diet in 30-39years, but it was not statistically significant. Second, body weight and %fat gradually decreased according to the application period of levan diet administration in 20-29years and 30-39years, and it was statistically significant (p<.05). Third, blood leptin level and blood lipid levels (TC, TG, LDL-C) showed decrease after administration of levan diet in 20-29years and 30-39years, but it was not statistically significant. In conclusion, this study shows that the administration of levan diet play a positive role as assistant diet. Therfore, levan diet administration should be recommended as ergogenic aids for these who do obese adults.

구진상괴사성 결핵진 3례

손보성,송준영,정재봉,김병천,이상숙,류영욱,이규석 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Papulonecrotic tuberculid is an eruption of necrotizing papules, particularly affecting the extremities and occurring in more or less symmetrical crops, and responding to antituberculosis therapy. Individual lesions heal with scarring. Histologically, vascular involvement is seen in early lesions. Late lesions are divided into two forms. In superficial forms, wedge shaped area of necrosis forms in epidermis and upper dermis. Epithelial and lymphoid cells gather around its periphery. In deep forms, with no epidermal change, granulomatous changes surrounded by well defined palisading histiocyte and lymphoid, epithelioid cells are seen. In mid-dermis and perivascular area, vessel shows vasculitis. In the first case, leukocytoclastic vasculitis and early granuloma formation were seen. In the second case, palisading granuloma formation was seen. In the third case, tuberculoid granuloma formation was seen. We report three cases of papulonecrotic tuberculid showing three different stages of histological finding, in individual cases.

中國과 臺灣의 統一政策比較

정재일,송봉규 尙志大學校 1998 論文集 Vol.20 No.-

This paper is purposed to comparative studying on the unification policy between Taiwan and PRC(People Republic of China). On the unification policy. Taiwan suggests 'Two Regions in One Country', but PRC suggests 'Two Systems in One Country'. What are the meanings of two regions and two systems? What are the differances between 'two regions' and 'two systems'?

한국어 판 구조화 임상면담도구 개발 : 신뢰도 연구

한오수,안준호,송선희,조맹제,김장규,배재남,조성진,정범수,서동우,함봉진,이동우,박종익,홍진표 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 정신장애의 정확한 진단과 평가는 임상에서뿐만 아니라 신뢰성 있는 연구를 위해서도 매우 중요하다. Structured Clinical Interview for DSM-IV(SCID)는 임상전문가들이 사용하는 진단도구로서, 비교적 짧은 시간에 정확한 진단을 내릴 수 있다. 본 연구는 한국어판SCID를 개발하고 그 신뢰도를 평가하기 위해 수행되었다. 방법: 국문학자가 포함된 번역위원회를 통하여 연구용판 SCID를 번역한 후, 정신과 의사 2인과 임상심리학자 1인에게 한국어판SCID 실시방법을 교육시킨 뒤 한국어판SCID를 이용한 면담의 평가자간 신뢰도 (interrater reliability)를 검증하였다. 면담 대상은 1999년 2월에서 3월까지 2개 병원 정신과에 치료중인 환자 90명(남:41명, 여:29명)이었다. 결과: 현재 장애(current disorder) 평가에서 주요 우울장애, 기분부전장애, 정신분열병, 알코올 남용 및 의존, 기타 물질 남용 또는 의존, 여러 불안장애들 및 섭식장애 등과 같은 대부분 장애의 kappa값은 .70이상으로 매우 높았다. 그 이외의 양극성 장애, 망상장애, 광장공포증, 감별 불능 신체화 장애 및 건강염려증의 kappa값도 .69에서 .40사이로 수용할 수 있는 정도였다. 평생 장애(lifetime disorder)에서는 양극성 장애(k=.69)와 감별 불능 신체화장애(k=.59)를 제외한 다른 모든 장애의 kappa값이 .70이상이었다. K-SCID 면담시 Ⅰ축 질환에 대하여 흔하게 다중 진단이 내려졌으며, 평균 진단 수는 1.5∼1.7개로 나타났다. 결론: 한국어판 SCID는 신뢰도가 높은 진단도구로 생각되며, 향후 정신질환의 정확한 진단과 임상연구에 유용하게 사용될 수 있다. Objectives: Accurate diagnosis and assessment for psychiatric disorders is crucial for research, as well as for clinical practice. Structured Clinical Interview for DSM-Ⅳ(SCID-RV) is a less time-consumimg and more accurate structured diagnostic interview form. It can be used by clinical professions and is known for a reliable diagnostic tool. Present study was conducted to develop Korean version of SCID-RV and to test the inter-rater reliability. Methods: The authors have translated original SCID-RV into Korean, and revised in parallel with sociocultural background of Korea. Ninety patients from two psychiatric hospitals, both outpatient and inpatient, were interviewed and rated independently by three raters. Results: The kappa coefficients for most of illnesses, such as major depressive disorder, dysthymia, schizophrenia, alcohol abuse and dependency, anxiety disorder and eating disorder were excellent(>0.70) in the evaluation of current disorders. And the kappa coefficients for bipolar disorder, delusional disorder, agoraphobia, undifferentiated somatoform disorder, and hypochondriasis were acceptable(>0.40) in the evaluation of current disorders. In the evalua-tion of lifetime disorders, the concordant rates of all the diagnoses except bipolar disorder and undifferentiated somatoform disorder were excellent. Lack of hierarchy in DSM-Ⅳ allows for multiple Axis I diagnoses. Mean numbers of Axis I diagnoses per subject assigned by the three raters were 1.5-1.7. Conclusions: Our findings confirm that SCID-RV yields highly reliable diagnoses. SCID-RV is recommended for accurate diagnosis in clinical practice and research on psychiatric disorders.

Aspergillus niger SFN-416으로부터 생산한 Xylanase 2의 분리정제 및 특성

성찬기,이상원,박석규,손봉수 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

Aspergillus niger SFN-416으로부터 생성된 xylanase Ⅱ를 분리·정제하여 특성을 조사하였다. Aspergillus niger SFN-416의 배양액을 ethanol(70%) 침전, (NH_4)_2SO_4(30~90%) 침전, Sephadex G-100 chromatography 및 DEAE-Sephacel chromatography 등의 정제과정을 거친 결과, specific activity가 38.2 units/ mg protein으로 4.3배 정제되었고, 정제효소의 최적 활성온도는 50℃였다. 최적 pH는 5.5이었고, pH 4.5~6.0 사이에서 비교적 안정하였다. 또한 금속이온에 대한 효소의 활성은 대부분 억제를 보였고, 특히 Hg^2+에서는 3.7%로 강하게 효소활성이 저해됨을 보였고, Fe^2+에서는 100%의 상대활성을 나타내었다. 정제 효소의 분자량은 SDS-PAGE에 의하여 42,000 daltons이었으며, 유기용매에 대한 활성은 10%의 methanol, ethanol, isopropanol 및 1-butanol에 대하여 모두 낮은 활성을 나타었다. Xylanase (EC 3.2.1.8) was purified approximately 4,3 fold from Aspergillus niger SFN-416 by ammonium sulfate fractionation, Sephadex G-100 gel filtration and DEAE-Sephacel ion exchange chromatography. Molecular weight of the enzyme was approximately 42,000 daltons. The optimum pH and temperature of the enzyme activity were 5.5 and 50℃, respectively. The enzyme activity was enhanced by Fe^2+, and inhibited by Hg^2+. The activity was decreased by addition of methanol, ethanol, isopropanol and 1-butanol at a concentration of 10%(v/v).

배기 저항의 능동제어를 통한 배기 시스템의 최적화에 관한 연구

임경빈,류봉조,이규섭,김상덕,송시영,이상훈 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1

Automobile exhaust system has difficulty in concentrating contrary technology, which has diminishing effect of maximum exhaust noises and mininum exhaust pressure for output efficiency improvement into on system. This thesis has the purpose in management of basis study for silence and output efficiency improvement which can be satisfy low noises and low exhaust pressure at the same time through maximizing engine efficiency dealing with activity as the condition of engine controlling exhaust impedance actively. In this thesis, we obtained positive result by making experiment high efficiency exhaust induced shaped silencer in order to satisfy contrary matters which device the improvement of engine efficiency and low perception of exhaust noises at the same time. That is, we proved that it has more excellent in low perceiving noises of exhaust system and output improving efficiency than existing muffler by active controlling the exhaust impedance.