제2형 당뇨병 남성 환자에서 유리 테스토스테론과 성호르몬 결합 글로블린 농도

남기덕,김영설,박철영,오승준,김덕윤,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:인슐린저항성은 제2형 당뇨병과 심혈관질환의 주요한 위험 인자로 성호르몬과 상호 관계가 있다고 알려져 있다. 그러나 여성과는 달리 남성에서는 연령과 인슐린저항성에 따른 유리 테스토스테론과 성호르몬 결합 글로블린 농도의 변화에 대한 연구가 부족한 실정이다. 그러므로, 본 저자등은 제2형 당뇨병 남성 환자에서 정산인과 비교해서 유리 테스토스테론과 성호르몬 결합 글로블린 농도를 측정하고 연령에 따른 변화 정도를 알아보고자 하였다. 방법:대상 환자 모두에서 연령과 체질량지수, 총 콜레스테롤, 중성지방, 공복혈당과 인슐린 농도를 측정하였다. 혈중 유리 테스토스테론 농도는 방사면역측정법(radioimmunoassay)을 이용해서 측정하였고, 혈중 성호르몬 결합글로불린은 면역방사계측측정법(immunoradiometric assay)을 이용해서 측정하였다(Diagnostic System Laoratories, Wbster, TX, USA). 결과:1)제2형 당뇨병 남성 환자에서 정상 대조군 남성에 비해 성호르몬 결합글로불린은 104.1±35.0 vs 25.7±3.5 mole×10??로 의미 있게 높았으나(p<0.001), 유리 테스토스테론은 13.7±9.5 vs 13.6±6.5 ng/dL로 차이가 없었다. 2)연령과 성호르몬 결합 글로블린 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.40로 중등고의 양의 상관 관계를 보였고(p<0.001), 정상 대조군 남성에서 0.11로 유의한 상관 관계를 보이지 않았다. 연령과 유리 테스토스테론 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.08, 정상 대조군 남성에서-0.17로 모두에서 유의한 상관 관계를 보이지 않았다. 3)연령과 체질량지수를 보정한 후에 제2형 당뇨병 남성 환자와 정상 대조군 남성에서 혈중 인슐린 농도, 유리 테스토스테론과 성호르몬 결합 글로블린 사이에는 상관 관계가 없었다. 결론:제2형 당뇨병 남성 환자에서 정상 남성에 비해 성호르몬 결합 글로블린 농도가 증가되어 있었으며, 유리 테스토스테론은 차이가 없었다. 연령이 증가함에 따라 성호르몬 결합 글로블린이 제2형 당뇨병 남성 환자에서 정상 남성에 비해 증가 폭이 의미있게 컸으며, 유리 테스토스테론은 변화가 없었다. Background: Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone-binding globulin and age in type 2 diabetic men and control subjects. Method: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). Results: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significantly difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p <0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testosterone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. Conclusions: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations(J Kor Diabetes Asso 24:699~707,2000).

부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

韓國 四森林帶의 소나무林에 관한 植物社會學的 硏究

林暎得,姜鎬監,中越信和 仁川敎育大學校 1991 論文集 Vol.25 No.2

Four climatic forest zones were set up for the investigated areas in South Korea. A phytosociological study showed little differences in C, N and C/N ratio except for available phosphorus and pH. A correlation between DBH and tree height showed a similar tendency of DBH and age in all investigated areas. The nerer the villages, more human impact on vegetation was observed. In addition, men's impacts were considered to be a significant environmental foctor in growth rate of P. densiflora populations.

ANIMAL INFLUENCES ON PINE SEEDS OF THE FOREST FLOOR : Ⅲ. EFFECTS OF PHYSICAL FACTORS ; UNDERGROWTH CUTTING AND LEAF LITTER COVER

Rim,Young-Deuk 仁川敎育大學校 1975 論文集 Vol.10 No.-

Rim, Young-Deuk (Inchon Teachers Colleage). 1976. Animal influences on pine seeds of the forest floor. Ⅲ. effects of physical factors' undergrowth cutting and litter cover. Bull. Inchon Teachers Coll., 10:1-8 Effects of undergrowth cutting and leaf litter cover onth predation rate due to the forest animals were investgated. Undergrowth cutting improved light condition onthe forest floor. This is one of effectvie methods to promoet the emergence of pine seedlings on the forest floor. Litter cover was only protector when predators being birs, while pine seeds were very dangerous to fidld mice. Undergrowth cutting seems to improve light condition and to limit animal behaviour on the forest floor.

규산질 비료의 참외 흰가루병 발생 억제 효과

류나현,최미영,류연주,조현종,이용세,이영득,정종배 한국환경농학회 2003 한국환경농학회지 Vol.22 No.4

토양에 시용한 규산의 참외 흰가루병에 대한 직접적인 억제 효과와 살균제의 방제 효과를 증진시킬 수 있는 보조효과를 조사하였다. 규산질 비료의 처리는 철가루병 균에 의해 감염된 참외 잎에서 균사의 생장과 분생포자의 형성을 억제함으로써 흰가루병 발생을 일부 억제할 수 있는 것으로 조사되었다. 물론 규산질 비료 자체만의 흰가루병 발생 억제 효과는 매우 미약한 수준이었으나 살균제의 흰가루병 방제 효과를 크게 증진시켜줄 수 있는 것으로 나타났다. 따라서 현재 농가 현장에서 밝혀지고 있는 규산질 비료의 참외 병해 발생 억제 효과는 주로 이러한 살균제의 효과를 증진시킬 수 있는 규산의 보조적인 작용에 기인하는 것으로 판단된다. 따라서 토양에 대한 적절한 수준의 규산질 비료의 시용은 살균제의 방제 효과 증진을 통하여 과다한 약제의 사용과 그에 따른 부작용을 경감시킬 수 있을 것으로 보인다. 규산질 비료의 흰가루병 발생 억제 효과를 증진시키기 위해서는 앞으로 병의 발생을 최대로 억제할 수 있는 참외 잎 중의 적정 규소 함량에 대한 검토 등의 추가적인 연구가 필요할 것이다. Silicon is known to accumulate in plants and results in greater resistance to diseases and insect pests. In this study, we investigated the effect of silicate fertUizer applied in soil on the development of powdery mildew of oriental melon Oriental melon seedlings of four-leaf stage were transplanted and grown in a plastic film house. silicate fertilizer was applied to maintain soil available SiO₂ level of 200 ㎎/㎏ one week before transplanting. Fungicide trinumizol was sprayed three times; one, two, and three weeks after transplanting. Sphaerotheca fuliginea was inoculated 2 weeks after transplanting. The number of infected leaf and the number of fungal colony in leaves were measured one, two, and three weeks after the inoculation. Three weeks after the fungal inoculation, in the treatment of fungicide triflwnhl, infected leaf numbem and number of colony per leaf were reduced by 10 and 58% respectively. In the silicate fertilizer treatment, infected leaf numbers and numbers of colony per infected leaf were suppressed only by 6 and 16%, respectively, and the efficacy was lower than that of the fungicide triflumizol. The combined treatment of silicate fertilizer and the fungicide suppressed powdery mildew more effectively, and infected leaf numbem and numbem of colony per leaf were reduced by 31 and 80%, respectively. These results indicate that although silicate fertilizer itself is not much effective in the suppression of powdery mildew, it can significantly enhance the efficacy of the fungicide.

한글문자 모양의 改善을 위한 完全字形 出方方式의 한 방안

文榮得,李忠鎬 부산외국어대학 1985 논문집 Vol.3 No.-

Generally, Korean characters have been displayed on the CRT by using the pattern combination output method. But, The quality of Korean characters on the CRT is not good. In this paper, The Full Character Output Method is proposed for the development of Korean character form on the CRT, and also it is suggested that 33 character elements for the input key can be used in the same output method.

AlGaAs/GaAs계 VSIS 레이저 다이오드의 종방향 특성해석을 위한 Simulation

김득영 동국대학교 산업기술연구원 1997 산업기술논문집 Vol.9 No.-

GaAs계 정보처리용 고출력 반도체 레이저 다이오드의 소자설계를 위한 시뮬레이션을 수행하였다. 본 연구에 이용된 레이저 다이오드의 구조는 굴절률 도파형의 V-grooved substrate inner stripe 구조이며, 광출력, 활성층의 두께 및 광도파층의 두께 등을 변수로 설정하였다. 시뮬레이션은 이들 변수에 의한 유효굴절률, 소광계수, 이득분포 및 필드패턴 등의 특성을 레이저 다이오드 구조에서의 종방향 거리에 따라 분석하는 방법으로 수행하였다. 도파층과 활성층의 두께가 일정할 때 광출력이 높아질수록 중심에서의 유효굴절률은 높아지고 소광계수는 낮아짐을 알 수 있었다. 근시야상의 세기는 광출력, 활성층의 두께 및 도파층의 두께 변화에 따라 중심에서의 값이 다르게 나타났으나 원시야상의 세기는 이들 조건에 무관하게 중심에서는 일정한 값으로 나타났다. In this work, the index guided type of AlGaAs/GaAs laser diode was simulated for device modeling. The V-grooved substrate inner stripe structure was used as a modeling structure. The output power, thickness of active layer, and thickness of guided layer were varied as a simulation parameters. The equivalent refractive index, extinction coefficient and field patterns are simulated as a function of lateral distance using these simulation parameters. Under constant thickness of active layer and guided layer, equivalent index is increase and extinction coefficient is decrease for high output power. The intensities of near field pattern are different at center with variation of parameters, howerver the intensities of far field pattern are same having a no connection with simulation parameters.

고속가공 시스템의 정밀도 평가방법에 관한 연구

손덕수,이안호,이정길,이우영 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

KS and ISO have proposed several evaluation methods of conventional machine tools. Even though the accuracy of the tools can be evaluated with those methods, there are still no proper evaluation methodsofhigh speed machining. Because it is hard to evaluate characteristics of high speed machining such as decrease of cutting temperature, cutting force, and reduced machining time. Therefore, new evaluation method for high speed machine should be developed. In this paper, several shapes of model have been proposed to evaluate cutting accuracy of high speed machine.

林床植生의 現存量에 關한 硏究

林暎得,辛昌男 仁川敎育大學 科學敎育硏究所 1976 科學敎育硏究所論文集 Vol.3 No.-

本 硏究는 京畿道 光陵의 落葉松幼令林 · 落葉松巨木林 · 방크스소나무林, 그리고 소나무林에 있어서의 undergrowth現存量의 裸地의 그것과를 比較硏究한 것으로 결과는 다음과 같다. 1. 各地所中 出現種이 가장 많은 곳은 裸地로서 30種, 그리고 가장 적은 곳은 소나무林의 林床植生이었다. 2. 林床植生中 가장 높은 現存量을 보여준 곳은 落葉松의 幼令林이었고 소나무林에서 가장 낮은값을 보여주었다. 3. 裸地의 現存量은 比較的 높은 편이었으나 落葉松林에 比하면 낮은 곳으로 open area의 性格을 가졌다기보다는 forest margin의 뜻을 지니고 있다고 생각된다. 4. daily net productivity의 最高値는 어느 群落에 있어서나 6月과 7月사이에 보여주고 있으며 이 사이에 林床植生의 生長이 가장 왕성한 것으로 推測된다. This study was carried out at the Kwangnung Experimental Forests to investigate the standing crop of undergrowth and that of open area. The results obtained are as follows: 1. Open area showed the most plant species, while pine forest did the least. 2. The highest value in standing crop was revealed at Larix young forest, while pine forest did the lowest. 3. The standing crop of open are was comparatively high, out in this case open are is supposed to be a forest margin. 4. Each plant community which was investigated showed the highest value in daily net productivity between June and July, and one of the reasons is supposed to be the vigorous growth at this time.

분산 객체지향 환경에서 병행 개발 지원을 위한 모델링

황득영,허계범 三陟大學校 1999 論文集 Vol.32 No.1

This paper presents a new method for concurrent design on the distributed object-oriented systems. Such, method is organization of development team, grouping of class, permission and control structure of information access in cooperative work, measurement of class similarity and complexity, concurrent design method, analysis of operational cost information of local class objects, deductive management method for object model, dynamic model and functional model in object-oriented software life-cycle, and version management method due to class update. This method supports the rapid-prototyping technology in a distributed object-oriented environment. So, this method can reduce the cost of total system development, increasing the productivity of software development. Also, it enhances the software quality so that it can easy the reuse and maintenance.