수중 시체에서 내부 장기 및 대조수에 대한 규조류의 분석

조갑래,서원준,함석훈,이종석,최동호,전병원,김양정,김광훈 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.

Analysis of the multi-dimensional transformation of the perspective of new media image artworks using the image stabilization system

Shu Yang Sun,장성갑 중앙대학교 영상콘텐츠융합연구소 2023 TechArt :Journal of Arts and Imaging Science Vol.10 No.1

New media image art, an essential branch of new media art, is characterized by the primary form of expression being an image and adopting various new means of production and communication. As an emerging art form, new media art has extensive connections to various fields due to the complexity of media and diversity of expression. New media image art has been shaped by the diverse expressions enabled by the development of various production technologies, among which is the Image Stabilization System (ISS). The ISS is a series of technical systems based on a camera stabilization device, thus integrated control of camera motion attitude to complete the camera motion shooting. Recently, the ISS has gained popularity in the film and television industry and is widely used in various video production processes. This article takes the multi-dimensional transformation of the perspective of new media image artworks, using the ISS, as the research subjects. The author briefly introduces some ISSs used in new media image art, analyzes the multi-dimensional transformation of shooting perspectives (the changes in the degree of freedom, immersion and interactivity) by the application of ISS through production examples, and explores the prospect of their application in new media image art.

Effects of Exercise on Sleep Quality in Pregnant Women: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Shu-Ya Yang,Shou-Jen Lan,Yea-Yin Yen,Yen-Ping Hsieh,Pei-Tseng Kung,Shao-Huan Lan 한국간호과학회 2020 Asian Nursing Research Vol.14 No.1

Purpose: Sleep quality was considered a priority concern facing pregnant women. Conventional wisdom argues that good sleep quality benefits pregnant women and their fetuses. The aim of this study is to assess the effects of a specific exercise program on the sleep quality in pregnant women. Methods: Searches were executed in seven databases since their inceptions until February 28, 2019, for randomized controlled trials evaluating the effects of an exercise program on the sleep quality and insomnia in pregnant women. A random-effects model was applied for meta-analysis, and odds ratio, mean differences (MDs), and 95% confidence intervals (CIs) are shown as parts of outcomes. Results: Seven studies were included for meta-analysis. Compared with their not-exercising counterparts, analyses showed that regularly exercising women had significantly enhanced sleep quality, with an odds ratio of 6.21 (95% CI, 2.02–19.11;p = .001; I2 = 80.2%), with a standardized MD of −0.93 (95% CI, −1.19 to −0.67; p < .001; I2 = 30.0%). However, exercising women showed no significant insomnia improvement, with an standardized MD of −2.85 (95% CI, −7.67 to 1.98; p = .250; I2 = 97.0%), relative to their not-exercising counterparts. Conclusion: This research indicated that exercise has a positive impact on the sleep quality of pregnant women. Despite the aforementioned positive impact on sleep quality, the present study did not find evidence to support that exercise may also improve insomnia for pregnant women.

An Empirical Study on the Decision-Making Process of Investigation-Initiation and Solvability Factors in Criminal Cases

Shu-Lung Yang 아시아경찰학회 2003 아시아경찰학회 국제학술회의 Vol.2003 No.-

The purpose of this study is to investigate how police detectives prioritize criminal cases, and what factors they consider in solving any given case in Taiwan. Factors related to the decision-making process of investigation initiation include: the seriousness of the offense, order from higher-ranking officers, media sensibility, etc. Convincing evidence, a suspect's confession, qualified/trained detectives, and cooperation among staff are identified as possible solvability factors in the study. The criminal cases in the study are limited to homicide, sexual assault and theft. The study sent questionnaires to 26 Criminal Investigation Divisions of each individual county-level police department in Taiwan, the Republic of China (ROC) between July 1 and August 15, 2003. In all, 1,072 police detectives were surveyed. Homicide, kidnapping, robbery, weapon use, and sexual assault were the most important criminal cases that the detectives initiated response to. On the other hand, cases of vandalism, anti-intellectual property, gambling, simple assault, and fraud tend to be suspended by the detectives, and will not dealt with actively. The critical factors influencing the decision to initiate an investigation are ranked accordingly as: the social harm, order from higher-ranking officers, the extent of damage, rewards and punishments, and media sensibility. For homicide case cleared, the important/critical factors are in order of importance: the weight of collected evidence, the presence of an eye-witness, the quality and experience of detectives, qualified forensic science personnel, and the a well-constructed criminal database. For sexual offense cases cleared, the important factors in order of importance are: the weight of collected evidence, the completeness of the DNA database, the victim's report, the relationship between offender and victim, the experience and quality of detectives. For thefts cleared, the important/critical factors are as follows: the weight of collected evidence, control of the fence, the suspects continued use of the stolen goods, the experience and quality of detectives, qualified forensic science personnel. To improve the quality of crime detection, the detectives' viewpoints argue that efforts should be made to promote the effectiveness of forensic science, provide advanced equipment for detection, reinforce legal training, increase official pay, and create specialized crime detection divisions.

Prognostic Role of Nucleophosmin in Colorectal Carcinomas

Yang, Yu-Feng,Zhang, Xi-Ying,Yang, Mei,He, Ze-Hua,Peng, Ning-Fu,Xie, Shu-Rui,Xie, Yan-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Aim: Recent research suggests that nucleophosmin (NPM) may be a prognostic marker in colorectal carcinomas (CRC). We here tested its use to predict the survival of CRC patients. Methods: We investigated NPM expression by immunohistochemistry in histologically normal to malignant colorectal tissues and evaluated its association with clinicopathological variables. Overall and disease-free survival after tumor removal were calculated by the Kaplan-Meier method, and differences in survival curves were analyzed by the log-rank test. The Cox proportional hazards model was used for multivariate analysis of prognostic factors. Results: NPM expression was found significantly upregulated in CRC compared to adjacent colorectal tissue, villous adenoma, tubular adenoma and normal colorectal mucosa (p<0.05 for all). NPM expression was statistically linked to cancer embolus, lymph node metastasis, differentiation grade, and recurrence of CRC. Overall and disease-free survival of NPM-negative CRC patients tended to be better than those for patients with NPM-positive lesions (log-rank statistic, p<0.05 for all). Multivariate analysis indicated NPM expression as an independent prognostic indicator for CRC patients (p<0.05 ). Conclusion: Our results suggest that NPM expression can predict the survival of CRC patients. Prognosis of CRC is determined by not only many known prognostic factors but also by NPM expression.

Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study

Shu-Hua Yang,Kai-Chiang Yang,Chih-Wei Chen,Ting-Chun Huang,Yuanhui Sun,Ming-Hsiao Hu 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.5

Study Design: In vitro cell culture study. Purpose: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus pulposus (NP)-like phenotype. Overview of Literature: MSCs offer a cell source to the cell-based therapy for intervertebral disc degeneration. TGF-β1 is used to induce MSCs to differentiate into NP-like cells; however, an undesired expression of collagen type I has been reported. Statins reportedly stimulate expression of bone morphogenetic protein-2 (BMP-2) and promote the chondrogenic phenotype to NP cells. However, the effects of statins with or without TGF-β1 on the differentiation of MSCs into NP-like cells remain unclear. Methods: Human MSCs were treated with TGF-β1 alone, lovastatin alone, and simultaneous or sequential treatment with TGF-β1 and lovastatin. After the proposed stimulation, the total RNA was extracted to assess the expression profile of NP cells-specific genes. Hematoxylin–eosin staining was used for examining the microscopic morphology. Furthermore, we detected the syntheses of S-100 protein, aggrecan , and collagen type II in the extracellular matrix using immunohistochemical staining. Results: Simultaneous or sequential treatment of TGF-β1 and lovastatin could further augment the BMP-2 overexpression compared with lovastatin-alone treatment. However, the mRNA expression of aggrecan and collagen type II was not compatible with the expression level of BMP-2 . Immunohistochemical studies revealed compatible production of aggrecan, collagen type II , and S-100 protein in all three groups treated with lovastatin. Cells in groups treated with lovastatin were less populated than that in the group treated with TGF-β1 alone. Conclusions: This study demonstrates a promising role of lovastatin in inducing human MSCs into NP-like cells. However, further optimization of cell density before lovastatin treatment, treatment duration, and combination with TGF-β1 are warranted to attain better stimulatory effects.

Effects of spin-casting speed on solar cell performances and corresponding films morphology and optical properties using 2D perovskite of PEA2MA2Pb3I10

Yang Zhang,Zeyang Wang,Ting Liu,Bo Yang,Shu Hu,Heng Li,ChuanXiang Sheng 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.3

On hot substrates with a temperature of 100 °C, the qualities of two-dimensional perovskite PEA2MA2Pb3I10(PEA = phenethylammonium,MA = methylammonium) films have been explored which are constructed with different spin-casting speeds. These films are performed at the speed of 1000, 2000, 4000, and 6000 revolution per minute (RPM). Below 4000 r, a higherRPM results in higher crystalline quality with more uniform morphology. Correspondingly, 4000 r devices show better performanceon average (4.3% power conversion efficiency) and less hysteresis in the J-V curve than 1000 r (3.6%) and 2000 rdevices (3.4%). However, for devices that were fabricated at 6000 r, inferior performance (2.8% on average) may not bepredicted simply by the morphology characterization or optical measurement results at room temperature; instead, carriertrapping states can occur that result in thermally activated PL below 200 K with an activation energy of 18 meV, which donot occur in the 1000 r, 2000 r, and 4000 r films. Our results suggest that for evaluating 2D perovskite films prior to fabricatingoptimal devices, multiple morphology characterizations and optical measurements, including of low-temperature PL,will be helpful.

Association between expression levels and growth trait-related SNPs located in promoters of the MC4R and MSTN genes in Spinibarbus hollandi

Yang Yang,Zhaojun Lan,Hu Shu,Huiqiang Zhou,Xiaolu Jiang,Liping Hou,Pinghua Gu 한국유전학회 2018 Genes & Genomics Vol.40 No.11

Melanocortin 4 receptor: (MC4R) and Myostatin (MSTN) are two important growth trait-related genes in animals. In this study, we showed that two SNPs, MC4R-719A>G and MSTN-519C>T, found in the promoters of the MC4R and MSTN genes, respectively, are both associated with growth traits in Spinibarbus hollandi. Furthermore, we observed that there were significant associations between the expression levels of the MC4R and MSTN genes and these two growth trait-related SNPs. The expression level of MC4R gene in brain was lower in GG genotype fish with extremely high growth performance than that in AA genotype fish with extremely low growth performance. Expression level of the MSTN gene in muscle was lower in TT genotype fish with extremely high growth performance than that in CC and CT genotype fish with lower growth performance. The results indicated that these SNPs located in the promoters of MC4R and MSTN are associated with growthrelated traits through modification of gene expression levels. The MSTN and MC4R SNPs may have useful application in effective marker-assisted selection aimed to increase output in S. hollandi.

Fluid Solid Coupling Analysis of Large Underground Oil Storage Caverns in Containment of Groundwater

Yang Shang-Yang,Li Shu-Cai,Xue Yi-Guo,Zhang Qing-Song 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

Triaxial compression tests had been performed to determine the properties of the rock mass around unlining underground crude oil a storage cavern which was the first one in China. The execution situation of the tunnel project and the seepage law of groundwater were taken into account. The stress and the seepage field around the tunnel in different working states were simulated by applying Comsol around a underground crude oil storage caverns. According to the test results, it was found that the excavation process may arise the local damage. The extension of the loose zone induced by excavation ranged from 0 to 15.6 m, depending on the buried depth of the caverns. According to numerical simulation results, the crown settlement and stress concentration was depended on the buried depth and the water pressure distribution after excavation of the main cavity. This research results can provide the reference for analysis on the stability of the underground cavities under low stress level and on the water sealed underground petroleum storage rock caverns.