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Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.
Scaling up the in-hospital hepatitis C virus care cascade in Taiwan
( Chung-feng Huang ),( Pey-fang Wu ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Cheng-ting Hsu ),( Po-yao Hsu ),( Hung-yin Liu ),( Ying-chou Huang ),( Zu-yau Lin ),( Shinn-cherng Chen ),( 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1
Background/Aims: Obstacles exist in facilitating hepatitis C virus (HCV) care cascade. To increase timely and accurate diagnosis, disease awareness and accessibility, in-hospital HCV reflex testing followed by automatic appointments and a late call-back strategy (R.N.A. model) was applied. We aimed to compare the HCV treatment rate of patients treated with this strategy compared to those without. Methods: One hundred and twenty-five anti-HCV seropositive patients who adopted the R.N.A. model in 2020 and another 1,396 controls treated in 2019 were enrolled to compare the gaps in accurate HCV RNA diagnosis to final treatment allocation. Results: The HCV RNA testing rate was significantly higher in patients who received reflex testing than in those without reflex testing (100% vs. 84.8%, P<0.001). When patients were stratified according to the referring outpatient department, a significant improvement in the HCV RNA testing rate was particularly noted in patients from non-hepatology departments (100% vs. 23.3%, P<0.001). The treatment rate in HCV RNA seropositive patients was 83% (83/100) after the adoption of the R.N.A. model, among whom 96.1% and 73.9% of patients were from the hepatology and non-hepatology departments, respectively. Compared to subjects without R.N.A. model application, a significant improvement in the treatment rate was observed for patients from non-hepatology departments (73.9% vs. 27.8%, P=0.001). The application of the R.N.A. model significantly increased the in-hospital HCV treatment uptake from 6.4% to 73.9% for patients from non-hepatology departments (P<0.001). Conclusions: The care cascade increased the treatment uptake and set up a model for enhancing in-hospital HCV elimination. (Clin Mol Hepatol 2021;27:136-143)
Fa-Po Chung,Yenn-Jiang Lin,Ling Kuo,Shih-Ann Chen 대한심장학회 2017 Korean Circulation Journal Vol.47 No.2
Differentiating arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) from other cardiomyopathies is clinically important but challenging. Although the modified Task Force Criteria can facilitate diagnosis of ARVD/C according to clinical manifestations, histopathological examination plays a pivotal role in excluding other diseases that can mimic ARVD/C. Here, we report a patient with amyloidosis that initially presented similarly to ARVD/C. The diagnosis was confirmed by endomyocardial biopsy, and catheter ablation eliminated the ventricular tachyarrhythmias through an epicardial approach.
Fa-Po Chung,Chin-Yu Lin,Yenn-Jiang Lin,Shih-Lin Chang,Li-Wei Lo,Yu-Feng Hu,Ta-Chuan Tuan,Tze-Fan Chao,Jo-Nan Liao,Ting-Yung Chang,Shih-Ann Chen 대한심장학회 2018 Korean Circulation Journal Vol.48 No.10
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is predominantly an inherited cardiomyopathy with typical histopathological characteristics of fibro-fatty infiltration mainly involving the right ventricular (RV) inflow tract, RV outflow tract, and RV apex in the majority of patients. The above pathologic evolution frequently brings patients with ARVD/C to medical attention owing to the manifestation of syncope, sudden cardiac death (SCD), ventricular arrhythmogenesis, or heart failure. To prevent future or recurrent SCD, an implantable cardiac defibrillator (ICD) is highly desirable in patients with ARVD/C who had experienced unexplained syncope, hemodynamically intolerable ventricular tachycardia (VT), ventricular fibrillation, and/or aborted SCD. Notably, the management of frequent ventricular tachyarrhythmias in ARVD/C is challenging, and the use of antiarrhythmic drugs could be unsatisfactory or limited by the unfavorable side effects. Therefore, radiofrequency catheter ablation (RFCA) has been implemented to treat the drug-refractory VT in ARVD/C for decades. However, the initial understanding of the link between fibro-fatty pathogenesis and ventricular arrhythmogenesis in ARVD/C is scarce, the efficacy and prognosis of endocardial RFCA alone were limited and disappointing. The electrophysiologists had broken through this frontier after better illustration of epicardial substrates and broadly application of epicardial approaches in ARVD/C. In recent works of literature, the application of epicardial ablation also successfully results in higher procedural success and decreases VT recurrences in patients with ARVD/C who are refractory to the endocardial approach during long-term follow-up. In this article, we review the important evolution on the delineation of arrhythmogenic substrates, ablation strategies, and ablation outcome of VT in patients with ARVD/C.
정명희 ( Myung Hee Chung ),김연중 ( Yun Jung Kim ),이보영 ( Po Young Lee ),김용진 ( Yong Jin Kim ),정상열 ( Sang Yul Chung ) 대한내과학회 1969 대한내과학회지 Vol.12 No.7
Treatment of ameboma or ameobic granuloma is basically medical. However, because of the similarity in clinical manifeatations with malignant tumor of the colon, surgery has been applied from time to time- by mistake, which has caused frequent complications
Common Mode Voltage Reduction in Four-Leg Inverter with Multicarrier PWM Scheme
Chung-Chuan Hou,Po-Wei Wang,Ching-Chen Chen,Chen-Wei Chang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Three-phase three-leg inverter has an inherent common mode voltage (CMV) problem. Therefore, threephase four-leg inverter is presented to mitigate the CMV of the inverter. This study discusses the characteristics of multicarrier pulse width modulation (PWM) for threephase four-leg inverter. The multicarrier PWM scheme is utilized to reduce the CMV of the inverter. The analysis of sinusoidal PWM and space vector PWM with multicarrier is discussed. The experimental results are utilized to validate the performances of the proposed multicarrier PWM scheme.
Effect of Reynolds number on compressible convex-corner flows
Chung, Kung-Ming,Chang, Po-Hsiung,Chang, Keh-Chin Techno-Press 2014 Advances in aircraft and spacecraft science Vol.1 No.4
An experimental study was conducted to investigate the effect of Reynolds number on compressible convex-corner flows, which correspond to an upper surface of a deflected flap of an aircraft wing. The flow is naturally developed along a flat plate with two different lengths, resulting in different incoming boundary layer thicknesses or Reynolds numbers. It is found that boundary layer Reynolds number, ranging from $8.04{\times}10^4$ to $1.63{\times}10^5$, has a minor influence on flow expansion and compression near the corner apex in the transonic flow regime, but not for the subsonic expansion flow. For shock-induced separated flow, higher peak pressure fluctuations are observed at smaller Reynolds number, corresponding to the excursion phenomena and the shorter region of shock-induced boundary layer separation. An explicit correlation of separation length with deflection angle is also presented.
정호선,이상진,손미영,권혁포,황미수,김선용,장재천,박복환 영남대학교 의과대학 1989 Yeungnam University Journal of Medicine Vol.6 No.2
30례의 종격동 종양의 CT분석 결과, 저자들은 다음과 같이 요약 할 수 있었다. 1. 가장 흔한 종양은 흉선질환 이었으며, 그 다음으로는 기형종, 림프종, 기관지성 낭종, 신경종, 심막낭종의 순이었다. 2. 5례의 흉선종은 균일한 충실성 음영의 종괴로 보였으며, 석회침착, 소엽형성이 각각 1례에서 보였다. 악성흉선종 중 1례에서 피낭형성이 잘된 낭성 종괴로 보였으며, 흉선암종은 주위 경계의 소엽형성을 보인 균일한 음영의 종괴로 보였다. 3. 전 례의 기형종은 모두 낭성종괴로 보였으며, 지방과 석회음영은 각각 2례, 4례에서 보여졌다. 4. 신경종은 4례 모두에서 후종격동에 위치한 균일한 음영의 종괴로 보여졌다. 5. 기관지성 낭종은 기관분기부 하방, 부흉곽지역에 각각 1례, 후기관부에 2례 있었으며, 모두 균일한 음영의 낭성 종괴로 보여졌다. 6. 심막낭종은 심장 주위 경계를 따라 난형모양의 낭성 종괴로 보여졌다. 결론적으로 종격동 종괴의 진단에 CT를 실시 함으로써 종괴의 정확한 위치, 크기및 특징적인 구성성분을 관찰할 수 있으며, 이러한 소견으로 종괴의 감별진단에 도움을 얻을 수 있다. Computerized Tomography is now well established and important noninvasive method of diagnosting mediastinal mass lesions because of its superior imaging of their size, location and internal composition. Authors analysed and present CT findings of 30 surgically proven mediastinal tumors and cysts that were studied and treated at the Yeungnam University Hospital during recent years. The most common tumor was thymona(9cases), and teratoma(6 cases), lymphoma(6 cases), bronchogenic cyst(4 cases), neurogenic tumor(4 cases), pericardial cyst(1 case) were next in order of frequency. There were 5 cases of thymoma showing homegenous solid density mass, 2 cases were malignant thymoma and myasthenia gravis was present in 2 cases, A case of thymolipoma and a case of thymic carcinoma were included. All teratomas were cystic masses but pathognomic fat, and calcified density were seen only in 4 cases, 5 cases were located in anterior mediastinum and 1 case was in posterior mediastinum. Lymphoma(3 Hodgkin's and 3 non-Hodgkin's) appeared as irregular lobulated mass in anterior mediastinum. Neurogenic tumor(2 ganglioneuroma and 2 neurilemmoma) appeared as homogenous density mass located in posterior mediastinum. Among the 4 bronchogenic cysts, 2 were located in retrotracheal area, I was located in subcarinal and I was in parathoracic area. One case of pericardial cyst was oval shaped cystic mass located in left pericardiac border.
A Simple Bridge Resistance Deviation-to-Frequency Converter for Resistive Sensor Bridges
Po Lee,Min-Young An,Chang-soo Won,Jin-Woong Jung,Won-Sup Chung,Sang-Hee Son 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
A bridge resistance deviation-to-frequency (BRDto-F) converter is presented for interfacing resistive sensor bridges. It consists of a linear operational transconductance amplifier (OTA), a current-controlled oscillator (CCO). A prototype circuit built using discrete components exhibits a conversion sensitivity amounting to 16.90 ㎑/ Ω and a linearity error less than ±0.03%. Its application to a load cell is also presented.