Phenotype-considered kinematically aligned total knee arthroplasty for windswept-deformity-associated osteoarthritis: surgical strategy and clinical outcomes

( Cheng-en Hsu ),( Meng-hsueh Tsai ),( Hsin-ting Wu ),( Jen-ting Huang ),( Kui-chou Huang ) 대한슬관절학회 2024 대한슬관절학회지 Vol.36 No.-

Background Windswept deformity (WSD) in relation to advanced osteoarthritis (OA) presents a significant surgical challenge in total knee arthroplasty (TKA). The primary goal of this study is to investigate the Prevalance of WSD associated osteoarthritis who have undergone total knee arthroplasty. The secondary goal is to explore the causes of WSD and its association with spinal deformity or leg length discrepancy in these patients. Finally, we evaluate the surgical outcomes of phenotype-considered kinematically aligned TKA (KA-TKA) in treating patients with WSD. Methods A review was conducted on data from 40 knees of 33 WSD patients who underwent phenotype-considered KA-TKA from August 2016 to December 2020. Patient demographics, associated diseases, preoperative and postoperative knee alignment angles, range of motion (ROM), Oxford Knee Score (OKS), and Knee Society Score (KSS) were collected and analyzed. Subgroup analysis for comparing the results between valgus and varus knees were also performed. Results Within the studied cohort of WSD patients, a substantial 64% displayed concomitant coronal spinal imbalance and 21% evidenced leg length discrepancy. Postoperative improvements were notable in knee alignments, ROM, OKS, and KSS following the application of the phenotype-considered KA-TKA approach. There were significant differences in the knee alignment angles, including mHKA, LDFA, and MPTA, between the valgus and varus side of knees (P = 0.018). However, no statistically significant difference were observed in the functional scores, comprising ROM, OKS, and KSS, between valgus and varus knees. Conclusions A high percentage of patients with WSD exhibited coronal spinal imbalance and leg length discrepancy. Phenotype-considered KA-TKA effectively provided alignment targets for the treatment of both varus and valgus knees in patients with WSD, achieving excellent short-term outcomes and acceptable knee alignment.

Comedications and potential drug-drug interactions with direct-acting antivirals in hepatitis C patients on hemodialysis

( Po-yao Hsu ),( Yu-ju Wei ),( Jia-jung Lee ),( Sheng-wen Niu ),( Jiun-chi Huang ),( Cheng-ting Hsu ),( Tyng-yuan Jang ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Yi-hung Lin ),( Ming-ye 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Direct-acting antivirals (DAAs) have been approved for hepatitis C virus (HCV) treatment in patients with end-stage renal disease (ESRD) on hemodialysis. Nevertheless, the complicated comedications and their potential drug-drug interactions (DDIs) with DAAs might limit clinical practice in this special population. Methods: The number, class, and characteristics of comedications and their potential DDIs with five DAA regimens were analyzed among HCV-viremic patients from 23 hemodialysis centers in Taiwan. Results: Of 2,015 hemodialysis patients screened in 2019, 169 patients seropositive for HCV RNA were enrolled (mean age, 65.6 years; median duration of hemodialysis, 5.8 years). All patients received at least one comedication (median number, 6; mean class number, 3.4). The most common comedication classes were ESRD-associated medications (94.1%), cardiovascular drugs (69.8%) and antidiabetic drugs (43.2%). ESRD-associated medications were excluded from DDI analysis. Sofosbuvir/velpatasvir/voxilaprevir had the highest frequency of potential contraindicated DDIs (red, 5.6%), followed by glecaprevir/pibrentasvir (4.0%), sofosbuvir/ledipasvir (1.3%), sofosbuvir/velpatasvir (1.3%), and elbasvir/grazoprevir (0.3%). For potentially significant DDIs (orange, requiring close monitoring or dose adjustments), sofosbuvir/velpatasvir/voxilaprevir had the highest frequency (19.9%), followed by sofosbuvir/ledipasvir (18.2%), glecaprevir/pibrentasvir (12.6%), sofosbuvir/velpatasvir (12.6%), and elbasvir/grazoprevir (7.3%). Overall, lipid-lowering agents were the most common comedication class with red-category DDIs to all DAA regimens (n=62), followed by cardiovascular agents (n=15), and central nervous system agents (n=10). Conclusions: HCV-viremic patients on hemodialysis had a very high prevalence of comedications with a broad spectrum, which had varied DDIs with currently available DAA regimens. Elbasvir/grazoprevir had the fewest potential DDIs, and sofosbuvir/velpatasvir/voxilaprevir had the most potential DDIs. (Clin Mol Hepatol 2021;27:186-196)

Ergostatrien-3β-ol (EK100) from Antrodia camphorata Attenuates Oxidative Stress, Inflammation, and Liver Injury In Vitro and In Vivo

Ting-Yu Chao,Cheng-Chu Hsieh,Shih-Min Hsu,Cho-Hua Wan,Guan-Ting Lian,Yi-Han Tseng,Yueh-Hsiung Kuo,Shu-Chen Hsieh 한국식품영양과학회 2021 Preventive Nutrition and Food Science Vol.26 No.1

Hepatic ischemia/reperfusion (IR) injury is a complication that occurs during liver surgery, whereby hepatic tissue is injured by oxygen deficiency during ischemia, then further damaged by a cascade of inflammatory and oxidative insults when blood is resupplied during reperfusion. Antrodia camphorata is an indigenous fungus in Taiwan and an esteemed Chinese herbal medicine with various bioactivities. This study examined the effect of ergostatrien-3β-ol (EK100), an active compound found in both the fruiting body and mycelia of A. camphorata, on IR injury pathologies in rats and cell models of oxidative and inflammatory stress. Male Sprague-Dawley rats were randomly assigned to receive a vehicle or 5 mg/kg EK100 prior to hepatic IR injury induced by 1 h ischemia followed by 24 h reperfusion, or a sham operation. RAW 264.7 murine macrophages and HepG2 hepatocytes were pretreated with EK100, then inflammation was induced with lipopolysaccharides in the former and oxidative stress was induced with hydrogen peroxide in the latter. EK100 decreased IR-induced elevation in serum levels of alanine aminotransferase and aspartate aminotransferase and lowered levels of the inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, and IL-1β. In addition, EK100 significantly reduced hepatic mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2, as well as nitrite production and iNOS gene expression in both hepatocyte and macrophage cell lines. We demonstrated that EK100 exhibits potent protection against hepatic IR injury, which may be used to design strategies to ameliorate liver damage during liver surgery.

Post-earthquake fast building safety assessment using smartphone-based interstory drifts measurement

Ting Y. Hsu,Cheng Y. Liu,Yo M. Hsieh,Chi T. Weng 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.2

Rather than using smartphones as seismometers with designated locations and orientations, this study proposes to employ crowds' smartphones in buildings to perform fast safety assessment of buildings. The principal advantage of using crowds' smartphones is the potential to monitor the safety of millions of buildings without hardware costs, installation labor, and long-term maintenance. This study's goal is to measure the maximum interstory drift ratios during earthquake excitation using crowds' smartphones. Beacons inside the building are required to provide the location and relevant building information for the smartphones via Bluetooth. Wi-Fi Direct is employed between nearby smartphones to conduct peer-to-peer time synchronization and exchange the acceleration data measured. An algorithm to align the orientation between nearby smartphones is proposed, and the performance of the orientation alignment, interstory drift measurement, and damage level estimation are studied numerically. Finally, the proposed approach's performance is verified using large-scale shaking table tests of a scaled steel building. The results presented in this study illustrate the potential to use crowds' smartphones with the proposed approach to record building motions during earthquakes and use those data to estimate buildings' safety based on the interstory drift ratios measured.

Effects of daily dosage of salvia miltiorrhiza extract supplementation on cardiac biomarkers after endurance exercise

( Shu-cheng Lin ),( Chien-yen Wang ),( Shu-ching Hsu ),( Ting-hao Liu ),( Kuei-hui Chan ) 대한운동사협회 2017 대한운동사협회 운동사대회자료집 Vol.2017 No.-

Colloidal processing of Pb(Zr,Ti)O3, Part I-Pb dissolution

Wen-Cheng J. Wei,Wen-Ting Hsu,Bang-Ying Yu 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.3

The dissolution behavior of aqueous Pb(Zr,Ti) O3(PZT) suspensions were studied by Atomic Adsorption (AA) and Inductively Coupling Plasma (ICP) spectroscopies, specially emphasizing the change of solution acidity within pH 2 to 12, the effects of polymeric dispersant, and comparing with the dissolution behavior of PbO. The iso-electric-point (IEP) of a 2.0 wt % PZT solution was measured and compared to the minimal dissolution case (less than 10 ppm) to be in the range of pH 7 to 10. The effects of one dispersants, poly (α-N,N-dimethyl-N-acryloxyethyl) ammonium ethnate acrylamide (PMAA/DAAE) was investigated in comparison with a commercial anionic dispersant, an ammonium salt of polymethylacrylic acid (PMAAN). A possible dissolution model and the thickness of the Pb depletion zone on PZT particles are proposed based on the experimental observation. The dissolution behavior of aqueous Pb(Zr,Ti) O3(PZT) suspensions were studied by Atomic Adsorption (AA) and Inductively Coupling Plasma (ICP) spectroscopies, specially emphasizing the change of solution acidity within pH 2 to 12, the effects of polymeric dispersant, and comparing with the dissolution behavior of PbO. The iso-electric-point (IEP) of a 2.0 wt % PZT solution was measured and compared to the minimal dissolution case (less than 10 ppm) to be in the range of pH 7 to 10. The effects of one dispersants, poly (α-N,N-dimethyl-N-acryloxyethyl) ammonium ethnate acrylamide (PMAA/DAAE) was investigated in comparison with a commercial anionic dispersant, an ammonium salt of polymethylacrylic acid (PMAAN). A possible dissolution model and the thickness of the Pb depletion zone on PZT particles are proposed based on the experimental observation.

Chinese Translation and Validation of the Child and Adolescent Sleep Checklist for Parents

Yang Ya-Ting,Chang Han-Yun,Hsu Chung-Yao,Lin Cheng-Yu,Zeitzer Jamie M. 대한수면학회 2020 sleep medicine research Vol.11 No.2

Background and ObjectiveaaThe Child and Adolescent Sleep Checklist (CASC) for parents was originally developed and published in Japanese and has served as a valid and effective tool for the assessment of a parent’s perspective of their adolescent child’s sleep behaviors. To allow for comparisons of such perspectives among parents of different cultures, and with different linguistic backgrounds, reliable and valid measurement tools are necessary. The purpose of this study was to translate and validate a Chinese language version of this questionnaire. MethodsaaInternal consistency, factor structure, and criterion validity data were tested using 497 parent/adolescent dyads in Taiwan. Exploratory factor analysis (EFA) and internal consistency reliability were examined in a subset of the cohort (n = 241), while criterion validity and conduct confirmatory factor analysis (CFA) was examined in a second subset of the cohort (n = 256). Preliminary criterion validity was established through a comparison with a measure of chronotype, Morningness- Eveningness Scale for Children. ResultsaaEFA resulted in four factors, consistent with the original version, with the four factors accounting for 60% of the total variance. The results of CFA presented good fit to the data. The questionnaire demonstrated also acceptable to good internal consistency (α = 0.84–0.89). Preliminary criterion validity was evident as the total score and each of the subscale scores on the questionnaire were significantly higher (worse sleep-related behavior) in evening-types. ConclusionsaaThe Chinese language version of the CASC for parents appears to be a psychometrically sound measure to evaluate sleep behaviors in Chinese-speaking adolescents.

Effect of polyolefin fibers on the permeability of cement-based composites

Hui-Mi Hsu,Wei-Ting Lin,An Cheng 사단법인 한국계산역학회 2012 Computers and Concrete, An International Journal Vol.9 No.6

This study evaluates the permeability of cement-based composites, which are a mix of polyolefin fibers and silica fume. Test results indicate that permeability increases as the water/cementitious ratio increases. Silica fume in cement-based composites produced hydrated calcium silicate and filled the pores. However, permeability decreased as the addition of silica fume increased. Specimens containing polyolefin fibers also provided higher permeability resistance. The polyolefin fiber length did not have a significant effect on permeability. The decrease in the permeability is mainly due to the addition of silica fume and lower water/cementitious ratio. Addition of fibers marginally decreases the permeability. Incorporating polyolefin fiber and silica fume in composites achieved more significant decreases in permeability. The correlated test results reveal the interrelationship between them.

Responsivity and Noise of the AC-Excited Giant-Magnetoresistance Magnetic Field Sensor

Jen-Tzong Jeng,Ting-Yu Hsu,Chih-Cheng Lu 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

A novel regression prediction model for structural engineering applications

Lin, Jeng-Wen,Chen, Cheng-Wu,Hsu, Ting-Chang Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.5

Recently, artificial intelligence tools are most used for structural engineering and mechanics. In order to predict reserve prices and prices of awards, this study proposed a novel regression prediction model by the intelligent Kalman filtering method. An artificial intelligent multiple regression model was established using categorized data and then a prediction model using intelligent Kalman filtering. The rather precise construction bid price model was selected for the purpose of increasing the probability to win bids in the simulation example.