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- 저자 : Miho (검색결과 148 건)
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Miho Ota,Junko Matsuo,Noriko Sato,Toshiya Teraishi,Hiroaki Hori,Kotaro Hattori,Yoko Kamio,Norihide Maikusa,Hiroshi Matsuda,Hiroshi Kunugi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11
Objective Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. Methods Subjects were 41 healthy male subjects who underwent the social responsiveness scale-adult (SRS-A) and magnetic resonance imaging. Results There was significant positive correlation between the total score of SRS-A and the regional cerebral blood flow (CBF) in posterior cingulate cortex (PCC). Also, there were changes in functional network such as in cingulate corti, insula and fusiform cortex. Further, we also found the significant difference of functional networks between the healthy male subjects with high or low autistic spectrum trait, and these points were congruent with the previous perceptions derived from autistic-spectrum disorders. Conclusion These findings suggest a biological basis for the autistic spectrum trait and may be useful for the imaging marker of autism symptomatology.
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Miho Nozue,Hiromi Ishida,Sayaka Hazano,Akemi Nakanishi,Taeko Yamamoto,Aya Abe,Nobuo Nishi,Tetsuji Yokoyama,Nobuko Murayama 대한지역사회영양학회 2016 Nutrition Research and Practice Vol.10 No.3
BACKGROUND/OBJECTIVES: This study aimed to examine the association of Japanese schoolchildren’s involvement in at-home meal preparation with food intake and cooking skill. SUBJECTS/METHODS: We included 1,207 fifth-grade children aged 10-11 years and one parent of each child. A cross-sectional survey was used to collect data on involvement in at-home meal preparation. Correspondence analysis was used to classify involvement in at-home meal preparation into three groups: food-related activities (cooking only or with other activities such as shopping, table-setting, clean up, and dishwashing), non-food-related activities (table-setting and/or clean up), and no (helping) activities. Food intake was assessed using a food frequency questionnaire. Logistic regression models were used to examine involvement in at-home meal preparation associations. RESULTS: The sample consisted of 1,207 fifth-grade children. Vegetable intake was lower in the no (helping) activities group than the food-related activities group (95% CI; boys: 1.2, 5.1, girls: 2.0, 8.9). Fewer children in the non-food-related activities group reported they were able to make a portion of their meals compared with the food-related activities group (95% CI; boys: 1.6, 3.5; girls: 1.5, 3.2). CONCLUSIONS: Children in the food-related activities group showed more favorable food intake and cooking skills than children in the no (helping) activities or non-food-related activities group.
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miho takahashi 한국일본어교육학회 2022 日本語敎育 Vol.- No.101
本稿は想起のノダッタ文を研究対象とし、その文法的な意味と特徴について考察したものである。またノダッタの3つのバリエーションとシタ形の想起文との違いも扱っている。主な論点を整理すると次のようになる。まず一つ目は、ノダと関連して想起のノダッタはノダの説明の構造から離れ、ノダの説明という機能を失っている。想起の機能を持つノダッタは形態論的には「んだった」に形式化している。二つ目は想起のノダッタ文は、忘れていた記憶情報を発話現場で思い出して述べるもので、述語にノダッタを後接し、「そうだ/そういえば」「たしか」と共起することがある。三つめは、現在や未来のできごとを状態性述語で表したノダッタ文の場合、三つのバリエーションのどの形式を用いても意味的には変わらない。四つ目はノダッタは記憶情報を想起した時だけでなく、話し手が全く忘れていた記憶情報を発話現場の外的な要因で想起した時にも使用される。シタ形の想起文より、ノダッタ文の方が「忘れていた」という意味が強くあらわされる。
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Studies on Bioactivity of Food Factors through Regulation of the Innate Immune System
Miho Chikazawa 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The innate immune system is the initial defense mechanism to prevent infection by viruses, pathogens and so on. In this study, we focused on endogenous antigens, which are antigens of the innate immune system derived from the self, to clarify the effects of endogenous antigens on the innate immune system. Natural antibodies recognize a variety of endogenous antigens, including oxidized proteins, using their surface charge as an indicator, and contribute to homeostasis. It was also suggested that the reaction of food factors with proteins also generates natural antibody epitopes, which contribute to the activation of immune responses. The recognition of endogenous antigens by the innate immune system has also been confirmed to be involved in biological responses in tissues, such as the fusion of muscle cells in skeletal muscle. The innate immune system is expected to contribute to the maintenance of health by performing various functions through regulation by endogenous antigens and food factors.
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Miho Nozaki,Ian Y Wong,Ryo Kawasaki,Joo Eun Lee,Yoshihiro Takamura,Ji Eun Lee,Shigeo Yoshida,Jae Pil Shin,Teruyo Kida,Woohyok Chang,Eiko Tsuiki,Hidetaka Noma,Kiyoshi Suzuma 한국망막학회 2022 Journal of Retina Vol.7 No.2
Purpose: To compare the efficacy of a combination of anti-vascular endothelial growth factor (VEGF) and endpoint management (EpM) grid laser versus monotherapy with anti-VEGF in the management of diabetic macular edema (DME). Methods: This was a prospective, multicenter, open-label, nonrandomized interventional study (NCT02462304). Anti-VEGF therapy consisted of one initial injection administered pro re nata in both groups. EpM laser was performed within 1 month after the first anti-VEGF injection. The main outcome evaluated was the number of anti-VEGF injections performed in 6 months. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were also evaluated monthly. The anti-VEGF agent used in Japan and Hong Kong was ranibizumab, while bevacizumab was used in Korea. Results: This study enrolled a total of 42 subjects, with 19 (45.2%) allocated to the monotherapy arm and 23 (54.8%) allocated to the combination arm (EpM group). Overall, there was no significant difference in the number of injections between patients in the two groups (+0.12, p = 0.81). Mixed regression analysis with all the covariates plus an interaction term for the ranibizumab/bevacizumab and the monotherapy/combination arm showed that the EpM group needed 0.94 less injections (95% confidence interval [CI], -1.73 to -0.15; p = 0.02). The logarithm of the minimum angle of resolution BCVA at 24 weeks was significantly improved in the monotherapy arm (p = 0.03), but not in the EpM group (p = 0.09). CFT at 24 weeks was significantly improved in both groups (p < 0.01). Conclusions: These data suggest that combination therapy with the EpM laser may be effective for reducing the number of anti-VEGF injections required for DME treatment.
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Miho Kato,Shunya Hayashi,Yuji Tasaki 한국버섯학회 2017 버섯 Vol.21 No.2
Tricholoma matsutake is a representative mushroom species with a characteristic pleasant aroma. The characteristic aroma component is methyl cinnamate, which is also produced in many plants. In basil, cinnamic acid is produced from l-phenylalanine (l-Phe) by phenylalanine ammonia-lyase (PAL) and converted to methyl cinnamate by a cinnamate/p-coumarate carboxyl methyltransferase. Two PAL genes, Tmpal1 and Tmpal2, have been isolated from T. matsutake. In this study, we aimed to clarify the relationships between l-Phe, methyl cinnamate production, and PAL expression in the mycelium of T. matsutake strain NBRC 30605. For this purpose, methyl cinnamate content, PAL activity, and transcript levels of Tmpal1 and Tmpal2 were examined in the mycelia of T. matsutake supplemented with l-Phe. The mycelia were cultured in 20 mL of a liquid medium (2% glucose, 0.15% yeast extract, and 0.15% Bacto Soytone) at 20 °C for 45 d, supplemented with 0.5-6 mM l-Phe, and then grown for a further 15 d. Mycelia cultured without l-Phe supplementation for 60 d in the medium were used as a control. Crude extracts were prepared from the mycelia harvested for enzymatic, protein, and methyl cinnamate assays. Methyl cinnamate was measured using gas chromatography. PAL activity was assayed by measuring the rate of trans-cinnamic acid formation as the absorbance at 290 nm (ɛ290 = 10,000 M−1 cm−1). The transcript levels of Tmpal1 and Tmpal2 were examined by performing real-time reverse transcriptase-quantitative PCR on the total RNA. Methyl cinnamate was detected in very low levels in cultures without l-Phe supplementation, but its content per mg of protein increased markedly with increasing concentrations of l-Phe, especially at 4-6 mM. When 6 mM l-Phe was added to the culture medium, the methyl cinnamate content was approximately 55-fold higher than that of the control sample. The specific activity of PAL also increased in cultures supplemented with l-Phe, especially at 4-6 mM. When l-Phe was added to the culture medium, the methyl cinnamate content in the mycelia was relatively well correlated with PAL activity. These results indicated that supplementation with l-Phe, a precursor of methyl cinnamate, increases the specific activity of PAL, leading to an increase in methyl cinnamate production in the mycelia of T. matsutake. The transcript level of Tmpal1 did not change markedly with l-Phe supplementation. In contrast, the transcript level of Tmpal2 increased greatly in cultures supplemented with 4-6 mM l-Phe. These results suggested that the expression of Tmpal1 and Tmpal2 was controlled by different regulatory mechanisms and that they may have different biological functions in T. matsutake. In addition, the pattern of PAL activity in the presence of l-Phe was similar to that of the transcript level of Tmpal2, but not Tmpal1, suggesting that the increase in PAL activity was dependent on the increased transcription of Tmpal2.
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