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논문 : 상변태 ; Alloy 690에서의 결정립계 형상 조절
이진규 ( Jin Kyu Lee ),장진성 ( Jin Sung Jang ),김도향 ( Do Hyang Kim ),이창규 ( Chang Kyu Rhe ),국일현 ( Il Hiun Kuk ) 대한금속재료학회 ( 구 대한금속학회 ) 1998 대한금속·재료학회지 Vol.36 No.7
The influence of heat treatments on the grain boundary morphology of alloy 690 (Ni-30Cr-9Fe) was studied. Serrated grain boundaries were produced by isothermal heat treatment at 800℃ after solution heat treatment at 1150℃ or by control cooling in the temperature range of 800℃ and 400℃ with a rate of 5℃/min or below. The amplitude and wavelength of serrated grain boundaries increased with longer isothermal heat treatment time or slower cooling rates, but showed maximum value at some extent, respectively. Precipitates on the serrated grain boundaries were revealed as Cr23C6 having semi-coherent cube-to cube relationship -{100}matrix//{100}ppt <100>matrix//<100>ppt -with one adjacent grain.
신장 ; 대장용종에서 ILK (Integrin-Linked kinase)와 beta-catenin의 발현
채현석 ( Hiun Suk Chae ),김진수 ( Jin Soo Kim ),손혜숙 ( Hye Sook Sohn ),노상영 ( Sang Young Rho ),김형근 ( Hyung Keun Kim ),조영석 ( Young Suk Cho ),이보인 ( Bo In Lee ),강진형 ( Jin Hyung Kang ),최규용 ( Kyu Yong Choi ),맹이소 ( 대한내과학회 2009 대한내과학회지 Vol.77 No.3
목적: ILK와 beta-catenin을 통한 세포전달은 여러 악성 질환의 시작과 진행에 있어서 중요하다. ILK는 beta-catenin의 전사를 조절하며 암세포에서 세포 이동 및 침습에 관여한다. 최근에 대장암과 전구 단계인 샘종에서 ILK와 beta-catenin이 발현한다는 연구가 있었다. 이에 저자들은 대장용종에서 육안적 및 병리학적 소견의 차이에 따른 ILK와 beta-catenin의 발현을 알아보았다. 방법: 비악성 질환으로 수술한 6명의 정상 대장 조직(6)과 대장용종절제술로 획득한 용종을 모양에 따라 유경성 용종(Ip, 16), 무경성 용종(Is, 22) 및 측방 발육형 종양(laterally spreading tumor LST, 24)으로 나누었다. 또한 현미경적 소견에 따라 관샘종(TA, 47)과 과형성 용종(HP, 15)으로 나누고 관샘종은 이형성의 정도에 따라 나누었다. 이들 조직에서 ILK와 beta-catenin의 발현을 면역화학염색법으로 비교하였다. 결과: 용종의 육안적 모양에 따라 Ip, Is, LST에서 ILK, beta-catenin의 발현의 차이는 통계적으로 차이가 없었다(p>0.05). 조직학적으로 ILK, beta-catenin의 발현은 과형성 용종보다 관상 샘종에서 발현이 증가하였다(p<0.05). 관상 샘종에서는 이형성의 정도가 심할수록 ILK와 beta-catenin의 발현이 높았다(p<0.05). 전체 용종에서 ILK의 발현이 높은 용종의 경우에 beta-catenin의 발현이 높은 경우가 많았다(p<0.01). 결론: 대장용종에서 ILK와 beta-catenin의 발현은 대장용종의 모양에 따른 차이가 없었고, 샘종이 과형성 용종보다 발현이 증가되었고 샘종의 이형성이 심할수록 발현율이 높았다. Background/Aims: Signaling pathways via integrin-linked kinase (ILK) and β-catenin are important in the initiation and progression of various malignant diseases. ILK modulates the transcription of β-catenin and is implicated in cell migration and invasiveness. Recently, premalignant colon polyps were found to express ILK and β-catenin. Therefore, we investigated the expression of ILK and β-catenin in colon polyps according to the gross morphology and pathologic type. Methods: Based on morphology, colon polyps (62) were classified as being a pedunculated polyp (Ip, 16), sessile polyp (Is, 22), or laterally spreading tumor (LST, 24). The colon polyps were classified pathologically as tubular adenomas (TAs, 47) and hyperplastic polyps (HPs, 15). The expression levels of ILK and β-catenin in colon polyps and normal colon (6) were evaluated with immunohistochemistry. Results: In normal colon, ILK was not expressed, and β-catenin stained in the cell membrane only. Based on the gross morphology of the colon polyps, no significant difference was seen in the expression of ILK and β-catenin (p>0.05). The expression of both ILK and β-catenin in TAs was greater than that in HPs (p<0.01): the greater the dysplasia in TAs, the more both ILK and β-catenin were expressed (p<0.05). The grade of expression of ILK was correlated with that of β-catenin in colon polyps (p<0.01). Conclusions: The expression of ILK and β-catenin did not differ according to the morphology of colon polyps, but was expressed more in TAs than in HPs, especially in severe dysplasia. (Korean J Med 77:315-320, 2009)
대장 내시경을 위한 장 세척 과정 중 발생한 Mallory-Weiss 증후군 2 예
최규용,정인식,이강문,최황,선희식,이창돈,한석원,김성수,송호진,채현석,방춘상,태현정,이보인,고경근 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.2
Polyethylene glycol solutions have been usually available for clinical use since 1980 and been considered a standard method of bowel preparations for colonoscopy. There have been many reports about minor complications such as nausea and bloating associated with their use, which are frequently occurred. After ingestion of polyethylene glycol, vomiting occurrs less frequently but it can make major complication such as Mallory-Weiss syndrome and aspiration pneumonia. We have reported here two cases of Mallory-Weiss syndrome, which were occurred after ingestion of polyethylene glycol solution for colonoscopy.
Helicobacter pylori에 감염된 십이지장궤양과 비궤양성 소화불량에서 ABO 혈액형과 HLA의 연관
채현석(Hiun Suk Chae),김태규(Tai Gyu Kim),한훈(Hoon Han),김성수(Sung Soo Kim),최규용(Kyu Yong Choi),정인식(In Sik Chung),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
N/A Background/Aims: It has been known that genetic factors, for example, blood group, non-secretor and HLA system, are associated with duodenal ulcer and that Helicobacter pylori infection is the major cause of peptic ulcer. However, Helicobacter pylori is also found in non-ulcer dyspepsia and asyrnptomatic patients without ulcer formation. But, it is still not known regarding what kind of genetic factors have an effect on ulcer formation at the time of Helicobacter pylori infection. This study was performed to make clear wbich genetic factors are re1ated with duodenal ulcers among Koreans, and what kind of genetic factors could influence on the ulcer formation in the patients with Helicobacter pylori infection according to ABO blood groups and HLA antigen.'.. Methods: The duodenal ulcer patients (36), non-ulcer dyspepsia (19) and norraal healthy controls (103) were included in this study. Helicobacter pylori infection was detected with phenol red spray method in vivo which was confirmed with Warthin-Starry silver stain. HLA antigen expression (HLA-A,B) of peripheral blood T lymphocytes was studied with microlymphocytotoxicity teclmique. Results: Tbe frequency of HLA-A 33 was higher in duodenal ulcer patients (l4/36, 38.9%) compared with the control group (21/103, 20.4%). On the contrary, no difference in HLA-B has been shown between duodenal ulcer patients and controls. Among patients with Helicobacter pylori infection, blood group 0 was significant1y more frequent in patients with duodenal ulcers (21/36, 58.3%) than in non-ulcer dyspepsia (5/19, 26.3%). In patients with HLA-A 33, blood group 0 was significantly more frequent in duodenal ulcer patients (7/)4, 50%) than in non-ulcer dyspepsia patients (0/7, 0%). Conclusions: In Helicobacter pylori-infected patients, HLA-A 33 is related with duodenal ulcers and the patients with both blood group 0 and HI.A-A 33 are more likely to have duodeual ulcers than those with HLA-A 33 and without blood groop O. (Korean J Gastrnenterol 1996; 28:623 - 631)
최규용,정인식,이성원,박두호,차상복,한석원,전은정,채현석,채은영 대한소화기학회 1999 대한소화기학회지 Vol.34 No.5
Acanthosis nigricans is a mucocutaneous eruption that occurs in a strikingly exuberant form as a marker for a highly malignant and rapidly fatal internal cancer. A case of poorly-differentiated adenocarcinoma (Borrmann type 3) observed in the stomach of a 24-year-old man was associated with the typical skin manifestations of acanthosis nigricans. The advanced tumor in antrum to high body was unresectable due to extensive metastasis. The cutaneous lesions were characterized by hyperpigmentation and papillary hypertrophy at both axilla and inguinal areas without oral mucosal involvement. In spite of the systemic chemotherapy, there was no response about the tumor burden and the cutaneous lesions. Three months after diagnosis, he died of continuous blood oozing from the tumor mass, hepatic failure and malnutrition.
내시경적 방법으로 교체된 Buried Bumper Syndrome 1예
최규용,김진일,정인식,김성수,김윤태,황인식,김혜원,선희식,이창돈,안창혁,한석원,채현석,장정원,방춘상 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.3
Percutaneous endoscopic gastrostomy (PEG) is used for nutritional support to the patients who cannot maintain the adequate oral intake. Compared with operative gastrostomy, PEG is a safe, rapid, and less expensive technique. Among several complications, buried bumper syndrome is a late complication in which internal bumper erodes into the gastric wall or migrates into the abdominal wall due to improper compression to the gastric wall. We here report a patient with peritubular leakage, resistance of tube feeding, and abdominal pain which were developed 13 months after percutaneous endoscopic gastrostomy. On endoscopic examination, the gastrostomy lumen could not be found. The gastrostomy tube was replaced successfully to new one with single procedure endoscopic technique. No complication was occurred and the function of tube has been well preserved.
정명선,최규용,김재광,최명규,박순민,선희식,한남익,한석원,윤종구,김성수,채현석,최주연 대한소화기학회 1999 대한소화기학회지 Vol.33 No.4
Background/Aims: Most of foreign bodies in the gastrointestinal tract are passed spontaneously, bu 10-20% of those needs treatment. We evaluated the role of endoscopy for removal of foreign bodies in the gastrointestinal tract. Methods: We investigated retrospectively 118 cases with foreign bodies in the gastrointestinal tract. They had been treated at Holy Family Hospital, The Catholic University of Korea, from January, 1990 through December, 1996. Results: The age ranged from 3 month to 78 years. Patients under 15 years were 76 cases and male was more prevalent than female (M:F= 1.68:1). Half (59 cases) of the patients had no symptom. Two most common foreign bodies were coins (45 cases) and sharp materials (18 cases) in children, while gastric bezoars (15 cases) and bones (10 cases) in adults. The most common location was esophagus (61 cases). In eighty-eight cases (74.6%), foreign bodies were removed by rigid or flexible endoscopy or anoscopy. Conclusions: Rigid and flexible endoscopy are useful tools for removal of foreign bodies in the gastrointestina tract.
( Jeong Seon Ji ),( Kyu Yong Choi ),( Won Chul Lee ),( Bo In Lee ),( Soo Heon Park ),( Hwang Choi ),( Byung Wook Kim ),( Hiun Suk Chae ),( Yong Moon Park ),( Young Jun Park ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3
Background/Aims: Although colorectal adenoma is reported to recur frequently, this may result from missing it at baseline. However, few studies of recurrence have considered the miss rate. This study evaluated the recurrence rate prospectively and clinical predictors of recurrence in colorectal adenoma after lowering the miss rate. Methods: The study population comprised 128 patients who underwent baseline colonoscopy with resection of colorectal adenomas. Re-examination to lower the miss rate was performed within 2 months. Follow-up colonoscopy to detect recurrence was done more than 1 year after removal. Results: The mean follow-up period was 35.1 months (range, 12 to 84 months). Thirty patients had a recurrent adenoma, for a recurrence rate of 23.4%. Older patients (over 60 years) had a two-fold greater risk of recurrence than younger patients (hazard ratio, 2.39; 95% confidence interval [CI], 1.16-4.90). Patients with three or four adenomas at baseline colonoscopy had a two-fold greater risk than those with one adenoma (hazard ratio, 2.44; 95% CI, 1.11-5.35). Patients with advanced adenoma had a two-fold greater risk than those with no advanced adenoma (hazard ratio, 2.88; 95% CI, 1.40-5.95). In multivariate analysis, only the presence of three or four adenomas independently predicted the recurrence of adenoma (hazard ratio, 3.19; 95% CI, 1.04-9.79). Conclusions: The recurrence rate of colorectal adenoma corrected by lowering the miss rate was lower than reported rates. The presence of multiple adenomas on initial colonoscopy was an important predictor of recurrence. (Korean J Intern Med 2009;24:196-202)