간경변 환자에서 Oro-cecal Transit Time의 측정

원경준,이준,변유미,조민근,조주연,서정균,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background: Neurotransmitter like substances in the gut have been proposed to contribute to the overall portal systemic encephalopathy (PSE). The source of the ammonia in patients with PSE is mainly the small bowel, as a result of the conversion of glutamine in the diet to glutamate and ammonia. PSE is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides such as lactulose. This study was performed to evaluate the relationship between PSE and oro-cecal transit time. In addition, performed to evaluate the effect of severity, cause, complications of liver cirrhosis on oro-cecal transit time. Methods: Between August 2006 and February 2007, 48 cirrhotic patients consecutively was enrolled in study their oro-cecal transit time after informed consent was obtained. A non-invasive hydrogen breath test was used to study oro-cecal transit time (OCTT). Result: The OCTT were delayed in cirrhotic patients with PSE compared without PSE (123.3 ± 42.7 min vs 170.0 ± 58.3 min, p<0.05). OCTT tended to prolongate further as the damage in the liver got worse, nevertheless the result was statistically meaningless (p<0.111). Neither presence of ascites or cause of PSE had any influence on gastrointestinal transit. Conclusions: Cirrhotic patients with PSE have more delayed OCTT than without PSE. Further research is needed to find out the relationship between OCTT and severity of liver cirrhosis.

敎育大學 實科 實驗實習의 效率化를 위한 資料開發 硏究

鄭原圭,尙貞基,鄭模根,李時元 釜山敎育大學 1987 부산교육대학 논문집 Vol.23 No.1

This study is to research the better ways of management in the practical arts-education in primary schools. The primary school teachers' concrete experiences are made use of to improve their teaching methods in teachers college, a teacher training institute. Therefore this research is supposed to be able to fix on the aim of practical arts-education. Accordingly the questionaires of the problems caused on the scene of education are given to the present teachers in the seasonal system of Pusan Teachers College and Jinju Teachers College. The aim of this research is to develop the materials to improve the educational effectiveness in the practical art-education of teachers college. The result is as follows : 1. According to the questionaires, the problems in the education of the practical course for elementry schools are mainly due to the deficiency of its materials. On the other hand, the teaching methods depending on experiment and practice together should be applied to the class. 2. In the current practical textbook, experiment, practice and observation are shown in the units separately in the contents. The Fifth Educational Revised Plan compared to the current educational curriculum, the units of computer and life are newly showed in the life function scope of the sixth grade textbook. Besides the contents of teaching and the factors of teaching are revised a little. The current educational curriculum, therefore, should be supplied more faithfully. 3. In order to develop the textbook of the practical arts-education of the teachers college, the contents of practical arts-education textbook mainly by experiment and practice are made up of the five scopes of the departments of agriculture, commerce, fishing, household management, etc... 4. To get rid of the formal procedures of abstraction and theory, the practical arts-education of the teachers college quickly needs to make the practical application of audiovisual aids and to introduce the manufactured mechanical apparatus helpful to developing the practical materials by itself. 5. At the departments of practical arts-education of the nation-wide Teachers Colleges, the facilities and equipments of experiment and practice are now as follows : The Ministry of Education shows the standard of equipments, that is, the 7 kinds of laboratories and 179 kinds of experimental apparatus, but the average rates of laboratories of 11 Teachers Colleges is 10.37 percent. So the Ministry of Education should reconsider the standard of its equipments. 6. To develop the practical arts-education of the teachers college, the general institute of practical arts-education should be set up. The kinds of laboratory and its structure (or scale) are shown on each scope.

중국 프로축구 지도자의 지도성향과 리더십 행동 유형에 관한 연구

강동원,이천식,이정학 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of this study was to study of the teaching trend and leadership type of the prfessional soccer leaders of China. Regarding the questionnaire, the study of based on the leadership scale for sports (LSS) developed by Chelladurai arid Saleh(1980), was translated and restructured suitable to the purpose of this study. In summary, positive behaviors impacted the goal-oriented type of leadership most in terms of leadership type, and authoritative behavior and democratic behavior impacted less. The training and direction behavior element was the most influential to the morale enhancing type of leadership. Especially, the authoritative behavior element was shown to be negatively influential. The democratic behavior factor was the most influential to the reliability-oriented type of leadership. The positive behavior element impacted less. However, the training and directive behavior and authoritative behavior element did not influence.

위 윤상근 세포의 Ca^2+-의존성 K^+-전류에 미치는 Ascorbate의 효과

배정원,이무열,방효원,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.2

In order to observe the effect of ascorbate on the Ca^2+-activated K^+ current in pyloric circular muscle cells which plays a critical role in generation and maintenance of repolarization and automatism, apart of pyloric circular muscle tissue was excised out, digested in collagenase containing Ca^2+-free physiological solution to get single circular muscle cells and the whole cell mode of patch-clamp experiment was conducted. Following results were obtained : 1. Oscillatory outward current was reduced by ascorbate in case of high intrapipette Ca^2+ concentration in whole voltage range and was enhanced in case of low intrapipette Ca^2+ concentration. 2. Oscillatory outward current was reduced in Ca^2+-free physiological solution with calcium channel blocker and not effected by ascorbate. 3. There were no qualitative differences among the control and ascorbate-treated group in effects of pH, steady state inactivation and the remaining component of the outward current. The above results could be concluded that ascorbate effects calcium-dependent component of the oscillatory outward current in the pyloric circular smooth muscle cells.

水稻의 生育時期에 따른 잎 損傷이 收量에 미치는 影響

金鎭雨,安元燮,金正洙,崔周鎬 진주산업대학교 1985 論文集 Vol.23 No.-

本 硏究는 水稻의 葉身損傷 時期및 程度가 收量과 玄米中의 無構質 含量에 미치는 影響을 究明하기 위하여 1985年 4月부터 1985年 10月동안에 걸쳐서 葉身損傷 時期를 8月2日, 8月12日, 8月22日로 하고 損傷程度는 止葉을 포함한 上位4枚의 葉을 完全切葉, 半切葉, 半折返으로 水稻의 收量 玄米의 無構質 含量을 調査한 것으로서 그 結果를 要約하면 다음과 같다. 1. 登熟比率과 精玄比率은 葉身의 處理時期가 늦을수록 높았고 損傷程度에서는 공히 半折返區에서 高度의 有意性이 認定되었다. 2. 玄米重量및 正租收量은 處理時期가 늦은 半折返區에서 가장 높았다. 3. 秕重과 重層未은 處理時期와 損傷程度間에 高度의 有意性이 認定되었지만 稈長, 穗長, 穗數, 粒數 및 玄米千粒重에서는 有意性이 認定되지 않았다. 4. 玄米의 無構質 含量은 T-N K_2O는 完全切葉區에서 半切葉區, 半折返區보다 약간 높았고 P_2O_5 CaO MgO SiO_2는 공히 半切葉區에서 完全切葉區와 半折返區보다 높았다. 處理時期로는 T-N性分은 時期가 가장늦은 8月22日區에서 약간 높았고 P_2O_5 CaO MgO K_2O는 공히 處理時期가 가장 빠른 8月 2日區에서 많았다. SiO_2만은 8月 12日區에서 多少 높았다. This experiment was conducted to find out the degree and time of leafblade in jury of rice affects on yield and quality of rice grain. The investigation was complied from April, 1985 to October, 1985. To investigate the yield of rice and quality of rice grain. The leaves were injured by the three Types of treatments like full cutting, half cutting and bending the each 4 leaves locatea in the top portion of rice including flag leaf at three different time August 2, August 12 and August 22. According to the analysis of the date collected in this experiment, the main result obtained was a follows; 1. The later the treatment, the more the percent of ripeness and the percentage of hulled and unhulled rice increased. And the degree of injury showed high significance in bending plot. 2. Brown rice weight and winnowed rice yield showed the highest rate in late treatment of bending plot. 3. Empty grains weight and rice screenings weight showed high significance between the treatment time and degree of injury but not in culm length, panicle length, panicle number per plant, number of grains per spikelet and brown rice 1,000 grain weight. 4. The result of an analysis of the quality of rice grain showed that full cutting plot produced greater quantity than half cutting plot and bending plot in the content of T-N, K_2O. But in the content of p_2O_5, CaO, MgO, SiO_2, half cutting plot showed greater quantity than full cutting plot and bending plot. On the other hand as for the treatment time the ingredient of the T-N showed a little higher rate in the plot of August 22 with latest treatment time. But the ingredient of the P_2O_5, CaO, MgC, K_2O showed high rate in the plot of August 2 with the earliest treatment time. But only SiO_2 showed a little higher rate in the plot of August 12.

숙명박물관 브랜드 프로모션을 위한 통합적 브랜드 개발 -2D, 3D, 4D 디자인 프로세스를 중심으로-

길혜경,김보현,오정은,이서연,이지원,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 여성생활사 중심의 유물 박물관인 숙명박물관의 인지도와 브랜딩의 문제를 해결하기 위해 브랜드·스페이스·마케팅을 활용한 통합 브랜드 개발 프로세스를 제안하는데 목적이 있다. 아울러 본 연구는 박물관의 브랜드를 프로모션하고 그래픽, 제품, 공간의 통합 브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구의 시간적 범위는 2017년 3월부터 6월까지 총 15주간 숙명여대 환경디자인학과 <브랜드·스페이스·마케팅>수업에서 진행된 수업의 결과물로서 4개 팀 중, 1개 팀의 작업물로 한다. 본 연구의 대상적 범위는 ‘숙명여자대학교 숙명박물관'의 2D~4D까지의 전반으로 설정한다. 그 결과, 제품부터 공간까지 숙명박물관의 통합된 브랜딩은 일 관성과 객관성, 스토리성을 얻을 수 있었다. ’숙명박물관'은 학교의 박물관이라는 장점을 극대화시켜 가치와 스토리를 부여하고 하나의 브랜드로 리뉴얼했다는 점에서 의의가 있다. 또한 향후 보편적인 박물관들의 차별화된 브랜드 개발의 참고자료로 활용될 수 있을 것으로 기대하며 브랜드 개발에 있어서 G·I, P·I, S·I의 통합 브랜드 메뉴의 기초 자료로 활용될 것으로 사료된다.

천마의 항 불안 효과

김여환,최형철,손의동,이광윤,김원준,박형배,하정희 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

천마(Gastrodia elata Blume)의 근경을 말린 것은 한방에서 오래전부터 여러 형태의 간질발작 치료 목적으로 이용되어지고 있었으나 어떤 활성물질에 의해 또 어떤 작용 기전을 통해 약리작용을 나타내는지를 충분하게 설명하지 못하고 있다. 최근 항경련 작용기전 연구 결과 천마추출물의 GABA성 신경전달계에 대한 조절작용과 관련이 있을 것이라는 연구 결과가 보고되었으며, 소량으로도 뇌억제 및 진정작용이 있다는 문헌을 참고하여 볼 때 천마의 항불안 작용 가능성이 시사되었다. 이에 본 연구를 통하여 천마를 사용하여 실험동물에서 항불안 작용을 검색하고 그 작용기전의 일부를 밝히고자 항불안작용 기전에 중요한 benzodiazepine 수용체와의 상호작용을 관찰하였다. 실험 결과, 천마 추출물의 경구 장기투여는 생쥐의 elevated plus maze 검사에서 개방 통로에로의 진입 및 개방통로에서의 체류시간을 증가시킴으로써 항불안 효과를 나타내었다. 천마의 에탄올 추출물은 benzodiazepine수용체 길항제인 [³H] Ro15-1788결합을 억제하였으며, 천마 추출물은 [³H] Ro15-1788의 수용체 결합에 대한 최대 결합력(Bmax)은 변화시키지 않고, 친화력(affinity)을 감소시킴으로써 상경적인 결합 양상을 나타내었다. 또 천마의 에탄올 추출물은 benzodiazepine 수용체의 효현제인 flunitrazepam의 수용체 결합반응을 억제시켰는데, 이러한 억제는 GABA 존재하에서 항진되는 것을 관찰하였다. 이상의 결과로 미루어보아 천마의 에탄올추출물 내에는 항불안작용을 나타내는 성분이 함유되어 있을 가능성을 예상케한다. Gastrodia elata Blume is a medicinal plant which has been used as anticonvulsant in oriental medicine, and has been used as sedatives. A survey of the relevant literature has indicated that the putative anxiolytic activity of G.elata Bl. has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic property and interaction with benzodiazepine receptor of G. elata BI. The putative anxiolytic activity of ethanol extract of G. elata BI. was performed in mice using an elevated plus maze paradigm. Chronic oral administration of G. elata BI. showed anxiolytic action in mice. It was suggested that regulation of GABAergic neurotarnsmission may be important in the action of G. elata BI. The interaction of G. elata BI. with benzodiazepine receptor was investigated using rat cortices. Ethanol extract of G. elata inhibited the binding of [³H] Ro15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor. The inhibition of [³H] Ro15-1788 binding by G. elata BI. appeared to be competitive. Further, GABA significantly enhanced the potency of this extract in inhibiting [³H] flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic property of G. elata BI.

지역사회에서 형성된 사회적 지지와 근로자의 사회심리적 스트레스간의 관련성

임화영,김형수,최영환,장성훈,이건세,정최경희,오원기,최재욱,정춘화 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

Objective: This study was performed to examine the relationship between community-based social support and psychosocial distress in workers. Methods: The study subjects were 596 workers recruited from 11 companies in Chungju city. A structured questionnaire was used to assess sociodemographics, health-related behaviors, job characteristics, job stress, work-based social support, community-based social support and level of psychosocial distress. Results: Hierarchical multiple regression analysis showed that workers with no chronic disease, exercise and sufficient sleep had a higher score of psychosocial distress than those with chronic disease, no exercise, and not enough sleep. Coworker's work-based social support and community-based social support were negatively associated with psychosocial distress. The R square value of total independent variables on psychosocial distress was 0.409, and that of community-based social support on psychosocial distress was 0.052. Conclusion: This study showed that community-based social support served as a protective factor against psychosocial distress in some workers. We recommend the establishment of a worksite stress reduction program in occupational level as well as community-based social support.

Development and clinical evaluation of a rapid diagnostic kit for feline leukemia virus infection

Won-Shik Kim,Chom-Kyu Chong,김학용,Gyu-Cheol Lee,정우석,Dong-Jun An,Hye-Young Jeoung,이재인,Young-Ki Lee 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1

Feline leukemia virus (FeLV) causes a range of neoplasticand degenerative diseases in cats. To obtain a more sensitiveand convenient diagnosis of the disease, we preparedmonoclonal antibodies specific for the FeLV p27 to develop arapid diagnostic test with enhanced sensitivity andspecificity. Among these antibodies, we identified two clones(hybridomas 8F8B5 and 8G7D1) that specifically bound toFeLV and were very suitable for a diagnostic kit. The affinityconstants for 8F8B5 and 8G7D1 were 0.35 × 109 and 0.86 ×109, respectively. To investigate the diagnostic abilities of therapid kit using these antibodies, we performed severalclinical studies. Assessment of analytical sensitivity revealedthat the detection threshold of the rapid diagnostic test was 2ng/mL for recombinant p27 and 12.5 × 104 IU/mL for FeLV. When evaluating 252 cat sera samples, the kit was found tohave a kappa value of 0.88 compared to polymerase chainreaction (PCR), indicating a significant correlation betweendata from the rapid diagnostic test and PCR. Sensitivity andspecificity of the kit were 95.2% (20/21) and 98.5% (257/261),respectively. Our results demonstrated that the rapiddiagnostic test would be a suitable diagnostic tool for therapid detection of FeLV infection in cats.

Henoch-Scho¨nlein 자반증에서 신 침범 위험인자에 대한 다변량 분석

정민지,임형은,유기환,홍영숙,이주원,김순겸 대한소아과학회 2004 小兒科 Vol.47 No.4