간아세포종 환아의 임상적 특성과 예후

김민영,김대연,안효섭,김종재,김인원,정성은,이성철,박귀원,김우기,Kim, Min-Young,Kim, Dae-Yeon,Ahn, Hyo-Seep,Kim, Chong-Jai,Kim, In-One,Jung, Sung-Eun,Lee, Seong-Cheol,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 1997 소아외과 Vol.3 No.2

Hepatoblastoma is a rare pediatric malignancy which frequently presents at an advanced un resectable stage. With the neoadjuvant chemotherapy, improved resectability and survival have been reported. Twenty children with biopsy proven hepatoblastoma were treated during the period between January 1987 and June 1995. Median age at diagnosis was 13 months(2 months to 7 year and 10 months), and 13 were male. Histologic profile was 13 epithelial(5 fetal, 4 mixed, 1 embryonal, 3 undetermined), and 5 mixed mesenchymal and epithelial and 2 of undetermined type. Chemotherapy effectively reduced the tumor volume($p$=0.008), and was able to convert 7 out of 9 initially unresectable cases(78%) to resectable ones. Twelve radical and 2 palliative operations were done with or without adjuvant chemotherapy. The Median follow up period was 33 months and the median survival was 26 months. The group with curative resection had a 61.1% 5 year survival rate, but none of palliative resection group survived more than 13 months($p$=0.0001). In univariate analysis for prognostic factors revealed, large tumor size at diagnosis and abscence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Histological pure fetal type did not mean a better prognosis. Even with a recent neoadjuvant chemotherapy, the strategy should be focused on the radical resection as early as possible.

Application of Vendor-Neutral Iterative Reconstruction Technique to Pediatric Abdominal Computed Tomography

Woo Hyeon Lim,Young Hun Choi,Ji Eun Park,Yeon Jin Cho,이승현,Jung-Eun Cheon,Woo Sun Kim,In-One Kim,Jong Hyo Kim 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.9

ObjectiveTo compare image qualities between vendor-neutral and vendor-specific hybrid iterative reconstruction (IR) techniques for abdominopelvic computed tomography (CT) in young patients. Materials and MethodsIn phantom study, we used an anthropomorphic pediatric phantom, age-equivalent to 5-year-old, and reconstructed CT data using traditional filtered back projection (FBP), vendor-specific and vendor-neutral IR techniques (ClariCT; ClariPI) in various radiation doses. Noise, low-contrast detectability and subjective spatial resolution were compared between FBP, vendor-specific (i.e., iDose1 to 5; Philips Healthcare), and vendor-neutral (i.e., ClariCT1 to 5) IR techniques in phantom. In 43 patients (median, 14 years; age range 1–19 years), noise, contrast-to-noise ratio (CNR), and qualitative image quality scores of abdominopelvic CT were compared between FBP, iDose level 4 (iDose4), and ClariCT level 2 (ClariCT2), which showed most similar image quality to clinically used vendor-specific IR images (i.e., iDose4) in phantom study. Noise, CNR, and qualitative imaging scores were compared using one-way repeated measure analysis of variance. ResultsIn phantom study, ClariCT2 showed noise level similar to iDose4 (14.68–7.66 Hounsfield unit [HU] vs. 14.78–6.99 HU at CT dose index volume range of 0.8–3.8 mGy). Subjective low-contrast detectability and spatial resolution were similar between ClariCT2 and iDose4. In clinical study, ClariCT2 was equivalent to iDose4 for noise (14.26–17.33 vs. 16.01–18.90) and CNR (3.55–5.24 vs. 3.20–4.60) (p > 0.05). For qualitative imaging scores, the overall image quality ([reader 1, reader 2]; 2.74 vs. 2.07, 3.02 vs. 2.28) and noise (2.88 vs. 2.23, 2.93 vs. 2.33) of ClariCT2 were superior to those of FBP (p < 0.05), and not different from those of iDose4 (2.74 vs. 2.72, 3.02 vs. 2.98; 2.88 vs. 2.77, 2.93 vs. 2.86) (p > 0.05). ConclusionVendor-neutral IR technique shows image quality similar to that of clinically used vendor-specific hybrid IR technique for abdominopelvic CT in young patients.

무증상 성인에서 발견된 발적성/삼출성 위염의 중증도를 기반으로 한 헬리코박터 파일로리 감염의 예측

김원중 ( One Zoong Kim ),이경훈 ( Kyoung Hoon Rhee ),오현우 ( Hyunwoo Oh ),손병관 ( Byoung Kwan Son ),정광현 ( Kwang Hyun Chung ),이효영 ( Hyo Young Lee ),오일환 ( Il Hwan Oh ),윤지영 ( Jiyoung Yoon ),김수형 ( Soo Hyung Kim ),박 대한소화기학회 2022 대한소화기학회지 Vol.80 No.3

목적: H. pylori 감염은 시드니 분류 시스템의 내시경적 소견 중 하나인 발적성/삼출성 위염과 높은 연관성을 가지고 있다고 알려져 있다. 본 연구는 발적성/삼출성 위염의 내시경적 중증도에 따른 H. pylori 감염률을 평가하고자 하였다. 대상 및 방법: 이 연구는 전향적 연구로 검진 목적의 위내시경으로 발적성/삼출성 위염을 진단받은 무증상의 성인을 대상으로 하였다. H. pylori 감염을 진단하기 위해 급속요소분해 검사가 시행되었다. 발적성/삼출성 위염의 중증도는 시드니 분류 체계를 사용하여 2명의 관찰자가 내시경 소견을 평가하였다. 연구의 일차결과지표는 경도 발적성/삼출성 위염을 중등도 또는 중증 발적성/삼출성 위염과 비교하여 H. pylori 감염률이 차이가 있는지로 하였다. 결과: 총 177명의 환자가 포함되었다. 발적성/삼출성 위염 전체 환자의 H. pylori 감염률은 86.4%였다. 177명의 환자 중 78명은 경도, 48명은 중등도, 51명은 중증이었다. 헬리코박터 감염률은 경도와 중등도-중증 발적성/삼출성 위염 모두 유사하였다(91.0% vs. 82.8%, p=0.115). 결론: 헬리코박터 감염은 발적성/삼출성 위염에서 흔하게 관찰되었다. 그러나 발적성/삼출성 위염의 중증도에 따라서는 헬리코박터 감염은 차이가 없었다. 따라서 경도의 발적성/삼출성 위염 환자에서라도 헬리코박터 감염에 대한 검사는 필요함을 알 수 있다. Background/Aims: Helicobacter pylori (H. pylori) infection highly correlates with erythematous/exudative gastritis, which is one of the endoscopic findings of the Sydney classification system. The present study aimed to evaluate the association between endoscopic severity of erythematous/exudative gastritis and H. pylori infection. Methods: We prospectively enrolled asymptomatic adults who were diagnosed with erythematous/exudative gastritis during screening esophagogastroduodenoscopy. A rapid urease test was performed in all participants to diagnose H. pylori infection. The severity of erythematous/exudative gastritis was determined based on the Sydney classification system. Two investigators independently evaluated the endoscopic findings. The primary endpoint was H. pylori infection rate according to the severity of erythematous/ exudative gastritis (mild vs. moderate-to-severe). Results: A total of 177 patients with erythematous/exudative gastritis were included. The rate of H. pylori infection was 86.4% in all patients. Of 177 included patients, 78 were at mild degree, 48 were at moderate degree, and 51 were at severe degree. The inter- observer variation was 4.6% and kappa value was 0.593. H. pylori infection rate was similar between patients with mild erythematous/ exudative gastritis and those with moderate-to-severe erythematous/exudative gastritis (91.0% vs. 82.8%, p=0.115). Even after adjusting potential confounding variables, the severity of erythematous/exudative gastritis was not associated with H. pylori infection rate. Conclusions: H. pylori infection is commonly observed in patients with erythematous/exudative gastritis. However, the severity of erythematous/ exudative gastritis is not associated with H. pylori infection rate. (Korean J Gastroenterol 2022;80:135-141)

국립생태원-서천특화시장 제휴할인사업의 효과에 대한 추정과 정책적 함의

홍성효 ( Hong Sung Hyo ),김진환 ( Kim Jin-hwan ),정강원 ( Jeong Kang-one ) KNU기업경영연구소 2021 기업경영리뷰 Vol.12 No.2

본 논문은 국립생태원과 서천특화시장 간 제휴할인 사업의 효과-즉, 제휴할인사업 참여업체의 매출액 증대의 효과-를 실증분석을 통해 추정한다. 제휴할인사업 참여업체의 상당수가 활어와 같은 수산물 취급업체이며 이들의 매출이 계절적 요인에 매우 민감하기 때문에 이를 통제하여 제휴할인사업의 순수한 효과를 분리해내기 위해 인근 전통시장의 유사한 업체들을 대조군으로 하는 이중차분(difference-in-differences) 분석틀을 적용한다. 실증분석은 상인의 매출액을 기준으로 하는 경우와 국립생태원 방문객의 소비지출액을 기준으로 하는 경우에 대해 이뤄지며, 전자의 경우 제휴할인사업을 통해 연간 791백만원에 해당하는 매출액 증가의 효과가 있는 것으로 분석되는 반면에 후자의 경우 연간 908~1,139백만원의 소비지출액 증가의 효과가 있는 것으로 추정된다. 비수도권 지방정부들은 지역 내 기업-특히, 제조업체-의 유치를 통한 일자리창출을 최우선 정책으로 추진하고 있다. 하지만, 이는 지역 간 불필요한 경쟁을 야기할 수 있으며 기업경영환경이 우수하지 못한 지역은 기업유치의 효과가 지속되지 못할 수 있다. 서천군은 우리나라의 모든 군지역들이 심각하게 직면하고 있는 저출산·고령화의 가속화에서 자유로울 수 없고, 이는 지역 내 젊은 층의 부족에 의한 제조업 입지로서의 경쟁력 하락을 예견하기 때문에 지역의 인구구조, 산업구조, 자연자원 등의 여건을 고려한 산업정책이 필요하다. This paper estimates the effect (i.e., the increase in sales of stores who participated in the project) of a joint discount project between National Institute of Ecology and Seocheon traditional market through empirical analyses. Since most participants belong to stores treating marine products like raw fish and their sales are very sensitive to seasonal factors, difference-in-differences framework where similar stores in a nearby traditional market are used as a comparison group is applied. The empirical analyses are performed one with merchants’ sales and the other with consumption expenditure of visitors to NIE. The effect of the joint discount project is estimated to have 791 million Won per year based on the former and between 908 and 1,139 million Won per year based on the latter. Local governments outside the capital region promote a policy of creating jobs by attracting firms (especially, manufacturers) with a priority. However, it could cause unnecessary competition and its effect would not last long if the area does not provide good business environments. Seocheon is not free from low fertility and aging which most counties in Korea are seriously confronting, and it predicts Seocheon’s decrease in competitiveness as a location of manufacturing industry due to a lack of young people. Thus, industrial policies which consider the area’s population composition, industrial structure, natural resources and so on are required.

Patch test results in Korea (2011-2018): A multicenter retrospective study

( Dong Hyo Kim ),( Seung Ho Lee ),( Seong Jin Kim ),( Hae Young Choi ),( Eun Joo Park ),( Jun Young Lee ),( Chul Hwan Bang ),( Jun-mo Yang ),( Se Jin Oh ),( Hye One Kim ),( Hee Joo Kim ),( Young Suk R 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1

Chemical Composition and Phytoestrogen Analysis of Iranian Black Pomegranate Juice Concentrate and Seeds

Choi,One-Kyun,Kim,Yong-Seong,Yu,Hye-Kyoung,Lee,Chan,Bang,Hyo-Pil,Yang,Deok-Chun,Kim,Young-Kee 한국자원식물학회 2003 Plant Resources Vol.6 No.1

In this study, as preliminary research for the development of natural estrogen supplement the chemical properties of Iranian black pomegranate juice concentrate and seeds were evaluated. Proximate compositions of pomegranate juice concentrate and seeds were as follows; crude lipid 0.4% and 8.2%, moisture 39.9% and 6.6%, crude protein 0.9% and 12.2%, ash 1.4% and 1.7%, and carbohydrate 42.0% and 84.5% respectively. Major amino acids are glutamic acid (1310.0ppm) and aspartic acid (896.2ppm) in juice concentrate, and glycine (611.1ppm) and arginin (401.6ppm) in seeds. Ascorbic acid has the highest concentration of 20.0mg/l00g in juice concentrate and 0.23mg/l00 in seeds. The compositions of unsaturated fatty acids such as linoleic acid and linolenic acid were higher than those of saturated fatty acids such as stearic palmitic acid. Major minerals were potassium, calcium and sodium, potassium was highest in both juice concentrate and seeds. Vitamins were composed of ascorbic acid (20.0mg/l00g), vitamin B$_1$ 수식 이미지(0.12mg/100g) and niacin (0.80mg/l00g) in juice concentrate, and only ascorbic acid(0.23mg/l00g) in seeds. Organic acids such as citric and L-malic acid were detected only in pomegranate juice concentrate. The contents of total polyphenols were 4.55g/L in juice concentrate and 3.5mg/l00g in seeds, respectively. Phytoestrogens detected in pomegranate juice concentrate and seeds were daidzein, quercetin, genistein and 17β-estradiol.

환원황화합물의 분석과 검량기준의 선택에 따른 오차발생의 특성

조효재(Hyo-Jae Jo),홍원필(One-Feel Hong),김기현(Ki-Hyun Kim) 한국대기환경학회 2011 한국대기환경학회지 Vol.27 No.2

콩 품종별 감식초 절임 중 성분의 변화와 항산화 효과

방효필 ( Hyo Pil Bang ),최원균 ( One Kyun Choi ),조규성 ( Gyu Seong Cho ),손종연 ( Jong Youn Son ),류기형 ( Gi Hyung Ryu ) 한국식품영양학회 2006 韓國食品營養學會誌 Vol.19 No.4

배출원에서의 Tedlar-bag 시료채집법을 이용한 황화합물의 경시적 농도 변화에 대한 연구

조효재(Hyo-Jae Jo),손장호(Zang Ho Shon),홍원필(One-Feel Hong),김기현(Ki-Hyun Kim) 한국대기환경학회 2011 한국대기환경학회지 Vol.27 No.3

스키지도자 교육프로그램 및 평가에 대한 해외 선진사례 비교 분석 연구: 캐나다를 중심으로

문황운(Moon, Hwang-Woon),김효림(Kim, Hyo-Rim),서명석(Seo, Myung-Seok),김제원(Kim, Ze-One) 한국체육과학회 2023 한국체육과학회지 Vol.32 No.6

The purpose This study compared the ski instructor education system of Canada, known as an advanced country in overseas skiing, to strengthen the capabilities and cultivate leadership of domestic ski instructors. Accordingly, the purpose of the study is to derive implications for the curriculum, content, and evaluation of domestic ski instructors. This study analyzed data using a literature analysis method. In order to select cases for study in this study, Canadas ski instructor system was set as an advanced example based on countries that have consistently maintained winning records in various world competitions. Canadas ski instructor curriculum, content, and evaluation were set as a unit of analysis to collect data and conduct content analysis. As a result of the study, there is no pre-certification education program in the domestic ski instructor training program, and the qualification system is implemented through written experiments and practical ability tests. Accordingly, it is believed that if new field-centered ski instructor education programs and certification contents are developed and managed through the Canadian ski instructor qualification system, the ski participation population will increase and the educational capabilities of ski instructors will be improved.