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아시아티코사이드로부터 메칠 2β, 3β-에폭시-23-히드록시우르스-12-엔-28-오애이트의 합성 및 이의 환원적 에폭시환 개열반응
주상섭,임두연,서성기,남태규,박형근,김희두,김창민,이민희,백형근,이민정,정영훈 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Steroidal 2β, 3β-epoxy compound was prepared from asiaticoside via six steps and reduced regioselectively with lithium aluminum hydride. Epoxide ring opening furnished 9 as a sole product at reflux condition through axial hydride attack at C-3.
맥엽 및 항산화 조성물의 생리 기능적 특성에 관한 연구 : 아질산염 소거능을 중심으로 Study on the Nitrite Scavenging Effect
이성희,홍이진,박형근,주상섭,김경탁 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4
맥엽과 이를 이용한 항산화 조성물을 제조하여 이에 존재하는 nitrite scavenging 효과와 이에 따른 발암원으로 부터의 보호 효과를 조사한 결과는 다음과 같다. 맥엽과 항산화 조성물 모두 수층에 비하여 메탄올층에서 아질산염 소거능이 2배 이상 높게 나타나 M-BL50의 0.01㎎/㎖ 농도에서 약 64.3%, M-AM 0.01㎎/㎖의 처리군이 이보다 약간 높은 68.3% 정도로 나타내었다. 마우스 단핵구 기원인 RAW 264.7(macrophage, mouse)에 맥엽과 항산화 조성물의 수층과 메탄올층을 처리하고 세포 생존율을 측정한 결과 수층 처리군에 비해 메탄올층 처리군에서 모두 세포 생존율이 더 낮게 측정되었으며 모든 시료에서 농도의존적으로 세포 증식이 억제되었다. 특히, M-AM을 처리한 군의 경우 모든 농도에서 가장 낮은 세포 생존율을 나타내어 항산화물 첨가에 의해 세포 증식 억제 효과가 상승됨을 알 수 있었으며, IC_(50) 수치 또한 메탄올층과 A-AM 시료 처리군에서 현저히 낮은 수치를 나타내었다. 또한 세포 내 아질산염 소거능을 측정한 결과 역시 마찬가지로 맥엽 입자 크기에 따른 차이는 나타나지 않았으며 수층 처리군에 비해 메탄올층 처리군과 항산화물을 첨가한 군에서 모두 높은 소거능을 나타내어 맥엽 및 기타 항산화물을 섭취함으로써 체내에서의 니트로사민 생성을 억제시킬 수 있을 것으로 예상된다. This study was conducted to estimate the biofunctional characteristics, namely nitrite scavenging effect of barley leaves (BL) and their mixture (AM) with other antioxidants. Aqueous or methanol extracts were obtained from BL and AM. Aqueous and methanol extracts from barley leaves had relatively higher nitrite scavenging effects and its activities and contents increased in a concentration-dependent manner. The activities and contents of methanol extracts obtained from BL and AM were higher than those of aqueous extracts. Especially, AM containing BL and other antioxidant mixture had the highest activities and contents increased in a concentration-dependent manner. BL or AM were added to macrophage cells of RAW 264.7 Survival rates of the cells treated with BL and AM were measured to be different. IC_(50) value decreased in a concentration-dependent manner by the addition of aqueous or methanol extracts from BL and AM. Especially, methanol extracts of AM had the highest nitrite scavenging effects. Thus, BL and AM may have protective effect against carcinogen and immune ability against reactive molecules through NO (nitric oxide) signal pathway. From the above results, barley leaves appear to contain natural anticancer and immune-related agents and may have potentiality to be used as functional food ingredients.
Jew, Sang-Sup,Lim, Dooyeon,Seo, Sung Ki,Nam, Tae Gyu,Park, Hyeung geun,Kim, Hee-Doo,Kim, Chang Min,Lee, Min Hee,Paik, Hyeung Geun,Lee, Min Jung,Jung, Young Hoon 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Asiaticoside 1 has been used for wound healing treatment for a long time (Lawrence et al., 1967;Anne et al, 1968). As part of our program toward the development of new wound healing agents, we modified asiatic acid 2, the aglycone of 1 which can be easily prepared from 1 (Shim et al., 1996). Mechanistic investigations have shown that the wound healing effect is associated with the control of the collagen biosynthesis (Bonte et al., 1994). Structurally the three hydroxyl groups of asiaticoside 1 and asiatic acid 2 make less efficient in transportation into the skin due to their high polarity. So we started the structure-activity relationship study by elimination of hydroxyl groups regioselectively to enhance the topical wound healing activity.
아시아티코사이드로부터 메칠 2beta, 3beta-에폭시-23-히드록시우르스-12-엔-28-오애이트의 합성 및 이의 환원적 에폭시환 개열반응
주상섭(Sang Sup Jew)임두연(Doo Yeon Lim),서성기(Sung Ki Seo),남태규(Tae Gyu Nam),박형근(Hyeung Geun Park),김희두(Hee Doo Kim),김창민(Chang Min Kim),이민희(Min Hee Lee),백형근(Hyeung Geun Paik),이민정(Min Jung Lee),정영훈(Young Hoon J 대한약학회 1998 약학회지 Vol.42 No.5
Steroidal 2beta, 3beta-epoxy compound was prepared from asiaticoside via six steps and reduced regioselectively with lithium aluminum hydride. Epoxide ring opening furnished 9 as a sole product at reflux condition through axial hydride attack at C-3.
비스에칠헥실옥시페놀메톡시페닐트리아진(BEMT)을 봉입한 고형지질나노입자(Solid Lipid Nano-particle)의 화장품 응용
이근수 ( Geun-soo Lee ),이동환 ( Dong-whan Lee ),표형배 ( Hyeung-bae Pyo ),최태부 ( Tae-boo Choi ) 대한화장품학회 2007 대한화장품학회지 Vol.33 No.4
비스에칠헥실옥시페놀메톡시페닐트리아진(Bis-ethylhexyloxyphenolmeth oxyphenyltrizine; BEMT)은 식품의약품안전청 고시 기능성 원료로 자외선 차단 제품에 널리 사용되는 UVA와 UVB의 화학적 자외선 흡수제이다. 그러나 BEMT는 실제 적용에 있어 여러 가지 결점이 있어 사용이 제한되고 있다. 본 연구의 목적은 BEMT가 적용된 고형지질나노입자(BEMT- SLN)의 자외선차단제품 응용에 있다. 제조된 고형지질나노입자의 입도는 약 330 nm, 봉입율은 93.3 %, 결정화지표는 4.3 %였다. In vitro 방출 및 투과 실험 결과에서, BEMT는 SLN보다 O/W 에멀젼이 대체로 높았다. In vivo 실험에서 SLN의 BEMT 방출비는 80 % 감소하였다. 또한 in vitro UV 방어 효과 실험에서 SLN이 적용된 처방의 자외선방어지수(SPF) 값은 약 2.5배 증가하였다. 결국 SLN은 BEMT를 효과적으로 봉입하고 있었으며, 자외선 차단 상승 효과를 나타낸다. Bis-ethylhexyloxyphenolmethoxyphenyltrizine (BEMT) is one of the most widely used chemical UVA + UVB double absorbers in sunscreen products. But topical application of BEMT is restricted due to its defects in product. The purpose of this study is to adopt the sunscreen product of solid lipid nano-particles containing BEMT (BEMT-SLN). The particle diameters, the encapsulation efficiencies and the crystallization index (C.I.) are about 330 nm, 93.3 % and the 4.3 %. As a result, in vitro penetration and release of BEMT were generally higher in O/W emulsion than the SLN formulation. However in vivo study, it was shown that the rate of release could be decreased by 80 % in the SLN formulation. The sun protection factor (SPF) of the SLN formulation increased by 100 % in the in vitro UV protection test. Therefore, SLN formulation potentiated the UV-blocking power of BEMT. This study suggest that SLN can be used for the encapsulation of BEMT.
Implant system의 매몰조건과 소환온도에 대한 조사
박근형,Park, Geun-Hyeung 대한치과기공학회 2001 대한치과기공학회지 Vol.23 No.1
This study was investigated on effect of implant system about investment condition and burn out temperature. Posterior bridges were fabricated by using plastic sleeve and gold sylinder. The results were as follows; In plastic sleeve test and fitting cast copings. the phosphate bonded investment showed better gypsum bonded investment. The pure special liquid showed better margin fitness compared with mixed liquid (special liquid + distilled water). In gold cylinder test. the good burn out temperature of Ceramic PFG and Crown Gold was evaluated $0^{\circ}C$ to $820^{\circ}C$ and was decreased on $780^{\circ}C$ for 30 minutes. $0^{\circ}C$ to $750^{\circ}C$ and was decreased on $650^{\circ}C$ for 30 minutes.