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아시아티코사이드로부터 메칠 2beta, 3beta-에폭시-23-히드록시우르스-12-엔-28-오애이트의 합성 및 이의 환원적 에폭시환 개열반응
주상섭(Sang Sup Jew)임두연(Doo Yeon Lim),서성기(Sung Ki Seo),남태규(Tae Gyu Nam),박형근(Hyeung Geun Park),김희두(Hee Doo Kim),김창민(Chang Min Kim),이민희(Min Hee Lee),백형근(Hyeung Geun Paik),이민정(Min Jung Lee),정영훈(Young Hoon J 대한약학회 1998 약학회지 Vol.42 No.5
Steroidal 2beta, 3beta-epoxy compound was prepared from asiaticoside via six steps and reduced regioselectively with lithium aluminum hydride. Epoxide ring opening furnished 9 as a sole product at reflux condition through axial hydride attack at C-3.
당이 THP로 단순화된 새로운 아시아티코사이드 유도체의 상처치유효과
장민선,박은희,김희두,Chang, Min-Sun,Park, Eun-Hee,Kim, Hee-Doo 대한약학회 2007 약학회지 Vol.51 No.6
Novel asiaticoside mimetics simplified the sugar moiety by tetrahydropyrans (THP) were designed, synthesized and tested their wound healing effects by tensile strength measurement. From this study, it is speculated that the sugar moiety of asiaticoside could be simplified to tetrahydropyrans without a significant loss of wound healing effect.
입체선택적인 분자내 [2+2] 환화반응을 이용한 광학활성 Bicyclo[4.2.0]octanone의 합성
심필종(Pil Jong Shim),김희두(Hee Doo Kim) 大韓藥學會 1997 약학회지 Vol.41 No.6
Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.
정주은(Ju Eun Jung),김희두(Hee Doo Kim) 大韓藥學會 1997 약학회지 Vol.41 No.6
We have synthesized and evaluated (1S, 2R)-1-0-(ethoxycarbonyl)methyl-2,3-0-isopropylidene-1-phenyl-1,2,3-trihydroxypropane(5a) as a novel chiral auxiliary for optically active alpha-hydroxyesters.
비정형 데이터 네트워크 기법의 수사 활용 연구 : 보이스피싱 대응 수사 지원을 중심으로
장광호(Jang, Kwang Ho),김희두(Kim, Hee Doo) 경찰대학 경찰학연구편집위원회 2020 경찰학연구 Vol.20 No.2
스마트치안과 데이터기반 경찰활동의 구호에도 불구하고 보이스피싱 범죄에 대한 대응은 개선되지 않고 있다. 보이스피싱은 경찰의 조직적 수사와 금융・통신기관과의 정보 공유에 따른 대응이 중요한 범죄이다. 여러 개선 제언들이 선행 연구로서 존재하나 실질적인 조치는 늦거나 이루어지고 있지 않다. 그 원인 중 하나는 경찰이 보이스피싱 데이터를 처리하는 방식이 아직 정교하지 않기 때문이다. 가장 중요한 정보인 범죄 이용 계좌・전화번호와 같은 핵심 정보가 비정형 데이터 중심으로 수집되고 있다. 본 연구는 비정형 데이터에서 전화번호・계좌번호, 범죄 수법 등 핵심 용어를 추출하는 기술을 연구했다. 파이썬(Python)을 통해 목표로 하는 정보를 추출해서 데이터셋을 구성하고 제피(Ghepi)프로그램을 활용해서 사칭인물・계좌・전화번호, 경찰에 접수된 사건번호를 네트워크로 시각화하는 사례를 제시했다. 이 기술은 수사팀으로 하여금 흩어진 여러 사건의 정보를 모아 수사할 수 있는 단어를 제공한다. 그리고 금융・통신기관들이 범죄 의심 계좌의 거래 정지와 지연을 할 수 있고, 통신회사도 범죄 이용된 전화번호를 정지시킬 수 있는 운영 틀로서 역할을 할 수 있다. Despite the policy of smart policing and data-based police activities, the response to voice phishing crimes has not improved. Voice phishing crimes are crimes in which an organized investigation by the police and countermeasures by sharing information with financial and communication agencies are important. Several suggestions for improvement exist as prior studies, but no practical action has been made or delayed. One of the reasons is that the way the police process voice phishing data is not yet sophisticated. The most important information, key information such as crimes and crimes, and phone numbers, are collected around unstructured data. This study studied the technology of extracting key terms such as phone numbers, account numbers, and criminal methods from unstructured data. We presented an example of constructing a dataset by extracting target information through Python and visualizing a person, account, number, and case number received by the police using a Gepi program. This technique gives the investigative team a way to gather information from several scattered events to investigate. In addition, financial and telecommunications organizations can stop and delay transactions in suspected crime accounts, and telecommunications companies can also act as an operating framework to stop phone numbers used for crime.
항암제로서의 (+/-)-3-데옥시제리쿠드라닌 A의 설계 및 합성
최윤정(Yoon Jung Choi),심필종(Pil Jong Shim),김희두(Hee Doo Kim) 대한약학회 1997 약학회지 Vol.41 No.1
(+/-)-3 Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.
새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성
박재호(Jae Ho Park),박경란(Kyoung Lan Park),호현순(Hyun Soon Ho),김희두(Hee Doo Kim),표명윤(Myoung Yun Pyo) 대한약학회 1999 약학회지 Vol.43 No.5
The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their anti-tumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.
Yakuchinone 과 그 유도체의 합성 및 Nitric Oxide 생성 저해효능
윤정화(Joung Wha Yoon),안한나(Hanna Ahn),류재하(Jae-Ha Ryu),김희두(Hee-Doo Kim) 대한약학회 2001 약학회지 Vol.45 No.1
Novel yakuchinone derivatives have designed, synthesized and evaluated their inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages. From this study, some enone compounds have been found to be highly active in the assay. In view of the importance of NO in septic shock and inflammation, these compounds may be useful candidates for the development of new drug to treat endotoxemia and inflammation accmpanying overproduction of NO.
2―Amino―1―(2―fluoro―4―methoxyphenyl)ethanol의 합성
김희두,최혜영 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.14 No.-
2-Amino-1-(2-f luoro-4-methoxy phenyl)ethanol(5), an analogue of synephrine having antidepressant activity, was synthesized via 4 steps starting from 2'-fluoro-4'-methoxy acetophenone (1).
첨가제가 Chiral Base를 이용한 Asymmetric Deprotonation에 미치는 영향
김희두 淑明女子大學校 1992 論文集 Vol.32 No.-
As increasing the demand for development of new drug, the synthesis of biologically active compounds play an important role in organic synthetic field. Because of inherent nature of enzyme and receptor in biological system, optical activity is essential for most of biologically active compounds to exert their biological activities. This is the reason why we should synthesize the biologically active compound in the optically active form for meaningful studies on their physical or biological properties. In this sense, asymmetric synthesis is a powerful tool to provide us chiral synthons for organic synthesis as well as informations for biological studies on natural products. chiral enolates, active form of chiral kletones which were founded in many biological active compound as the essential pharmacophoric moiety, were pre-pared by multi-step methods, or in diastereoselective fashion, which needs to modificate the functional group, to attach chiral auxiliary that shall be removed after reaction. Our project embrace the direct synthesis of chiral enolates from mesomeric ketones with chiral base to effect enantioselective deprotonation. We examined the additive effect on the asymmetric deprotonation using chiral base for the purposes of increasing the enantioselectivity and getting the available data concerning the mechanism of this reaction.