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Asiaticoside가 RAW 264.7 세포에서 Inducible nitric oxide synthase와 Cyclooxygenase-2에 미치는 항염증 작용에 관한 연구
주상섭,배옥남,정진호 한국독성학회 2003 Toxicological Research Vol.19 No.1
Asiaticoside has been tested for the ability as an anti-inflammatory drug using lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW 264.7 cell). LPS treatment induced dramatically inducible nitric oxide synthase (iNOS) in RAW cells. However, asiaticoside inhibited LPSstimulated iNOS induction in a concentration-dependent manner. Especially, higher concentrations (> 50 μM) of asiaticoside completely blocked iNOS induction. In addition, LPS-stimulated expression of inducible cyclooxygenase (COX-2) and interleukin-1α (IL-1α) was inhibited by asiaticoside treatment. Asiaticoside up to 50 μM still required to inhibit COX-2 and IL-1α induced by LPS. Consistent with these findings, treatment with asiaticoside suppressed de novo synthesis and cellular accumulation<br/> of prostaglandin E₂ to a lesser extent, suggesting that asiaticoside blocked the induction as well as the activity of COX-2. These results suggest the possibility that asiaticoside may be effective therapeutic agents for septic shock and other inflammatory diseases.
아시아티코사이드로부터 메칠 2β, 3β-에폭시-23-히드록시우르스-12-엔-28-오애이트의 합성 및 이의 환원적 에폭시환 개열반응
주상섭,임두연,서성기,남태규,박형근,김희두,김창민,이민희,백형근,이민정,정영훈 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Steroidal 2β, 3β-epoxy compound was prepared from asiaticoside via six steps and reduced regioselectively with lithium aluminum hydride. Epoxide ring opening furnished 9 as a sole product at reflux condition through axial hydride attack at C-3.
2-치환-1-Cyclohexenyl-1-acetic acid의 브롬락톤화 반응
주상섭(Sang Sup Jew) 대한약학회 1989 약학회지 Vol.33 No.3
Bromolactonization of 2-Substituted-1-cyclohexenyl-1-acetic acid (1) with 1,3-dibromo-5,5-dimethylhydantoin (dibromantin) in N,N-dimethylformamide gave the corresponding gamma-bromo-beta-lactone (2) and beta-bromo-gamma-lactone (3). The effect of the substituents, the reaction temperature, and the solvent on the regioselectivity was discussed.