A Case of Occupational Hypersensitivity Pneumonitis Associated with Trichloroethylene

Jae, Young,Hwang, Eu Dong,Leem, Ah Young,Kang, Beo Deul,Chang, Soo Yun,Kim, Ho Keun,Park, In Kyu,Kim, Song Yee,Kim, Eun Young,Jung, Ji Ye,Kang, Young Ae,Park, Moo Suk,Kim, Young Sam,Kim, Se Kyu,Chang, The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.2

Trichloroethylene (TCE) is a toxic chemical commonly used as a degreasing agent, and it is usually found in a colorless or blue liquid form. TCE has a sweet, chloroform-like odor, and this volatile chlorinated organic chemical can cause toxic hepatitis, neurophysiological disorders, skin disorders, and hypersensitivity syndromes. However, the hypersensitivity pneumonitis (HP) attributed to TCE has rarely been reported. We hereby describe a case of HP associated with TCE in a 29-year-old man who was employed as a lead welder at a computer repair center. He was installing the capacitors on computer chip boards and had been wiped down with TCE. He was admitted to our hospital with complaints of dry coughs, night sweats, and weight losses for the past two months. HP due to TCE exposure was being suspected due to his occupational history, and the results of a video-associated thoracoscopic biopsy confirmed the suspicions. Symptoms have resolved after the steroid pulse therapy and his occupational change. TCE should be taken into consideration as a potential trigger of HP. Early recognition and avoidance of the TCE exposure in the future is important for the treatment of TCE induced HP.

淸心地黃湯이 虛血性 心臟障碍와 高血壓 및 脂質代謝에 미치는 影響에 對한 實驗的硏究

張二洙,李京燮 慶熙大學校 1985 論文集 Vol.14 No.-

In the rate of endotoxin-induced ischemic hearts, Chungsimjihwang-tang result in the decrease sion and artherosclerosis, studies were performed to detect the drug effects on the rate of endotoxin-induced ischemic heart disease and spontaneously hypertensive rate, and rabbits of cholesterol-induced hyperlipemia. The following result were obtained. 1) In the rate of endotoxin-induced ischemic hearts, Chungsimjihwang result in the decrease of serum fibrinogen levels and blood platelet count, the extension of prothrombin time and the increase of serum F.D.P. level. 2) Chungsimjihwang got the blood pressure to show a fail in the spontaneously hypertensive rats. 3) Chungsimjihwang prevented the increase of cholesterol, triglyceride, phospholipid and free fatty acid levels in serum of the rate of cholesterol-induced typerlipemia rats. 4) the dried extract of Chungsimjihwang showed better result on every than the mixture of simple dried extract of the composed drugs of the prescription. With the generalization of the above-mentioned experimental results, it is thought that Chungsimjihwang will be for sure efficacious for the treatment of the ischemic heart disease, hypertension and artherosclerosis.

어린이에 흔한 癌

洪彰義 의학교육출판사 1988 Korean Journal of Family Medicine Vol.4 No.10

태권도 경기규칙 제정기 이전의 겨루기에 대한 고찰

진중의,박종창,한창효 용인대학교 무도연구소 2000 武道硏究所誌 Vol.11 No.1

Before 1962 Taekwondo was not a sport that concerned the protection and care of the players, the role of judges, and the understanding of the spectators. At that period, Taekwondo's playing rules varied with each gymnasium that provided sporting grounds. Taekwondo matches were held in gymnasiums; no protective gear was provided or in use. A match persisted until one of the players was quelled; a single round was played. Different morals and rules were practiced in each gymnasium according to their founders. The "Leader" department held more contests than any other type of gym. They were held both indoors and outdoors. In the "Blue" department, a procedure was followed; therefore, 80% of the training course had to do with the basic behavior and formal forms of Taekwondo. 20% of the procedure were contests, which were held after the end of the training. Training of the spirit was also undergone to emphasize the spirit of martial arts. Each gym had its own training methords and programs.

乳兒의 榮養問題

洪彰義 亞洲藥品 1988 臨床 醫藥 Vol.4 No.5

개별공조시스템의 열환경 특성에 관한 실험적 연구

윤창오,김용경,정순성,이정재 동아대학교 환경문제연구소 2000 硏究報告 Vol.23 No.1

It is recent trends that residents in office building demand more healthy and comfortable environment. To supply these good environment, The personalized air-conditioning system what can make thermal environment optimal has been researched. In this paper, we suggest the validity of a Personal Air-Conditioning System, and design Personal Air-conditioning System with specification guided by indoor environmental characteristics analyzed through the experiment.

2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화

김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.

국내 Epstein-Barr 바이러스 일차감염의 임상적 특성

김백남,곽이경,문치숙,김의석,박상원,이창섭 대한감염학회 2007 감염과 화학요법 Vol.39 No.6

In this study, the clinical features of 264 patients of primary Epstein-Barr virus (EBV) infection between the years of 2002-2006 were evaluated retrospectively. The median age of the patients was 6 years old (0-69), and the hospitalization rate was 78.0%. Fever (83.3%) and sore throat (50.4%) were the most common symptoms. Cervical lymphadenopathy (71.2%), tonsillitis (51.1%), splenomegaly (26.1 %), hepatomegaly (25.8%), rash (10.2%) and jaundice (1.5%) were observed. Cervical lymphadenopathy was less frequent in older age groups. The annual number of primary EBV infections according to the age group during the study period did not change significantly in this study.

디젤분진이 체세포에서의 DNA 손상에 미치는 영향

허찬,김남이,정규혁,문창규,허문영 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4

Diesel exhaust panicle (<25μm, DEP_(2.5)) is known to be probarbly carcinogenie (IARC group 2A) DEP_(2.5) contains organic compounds such as polycyclicatomatic hydrocarbon (PAH), heterocyclic compounds, phenols, and nitroarenes Reactive oxygen species (ROS) are generated by DEP_(2.5) without any biological activation system Therefore, an alternative mechanism by which DEP_(2.5) could be carcinogenic is known by the generation of oxidative DNA damage The aim of this study was to investigate genotoxic effects of DEP_(2.5) using single cell gel electrophoresis In order to evaluate the mechanisms of DEP_(2.5) genotoxicity, the rat microsome mediated and DNA repan enzyme treated comet assays together with routine comet assay were performed DEP_(2.5) was collected from diesel engine bus and dichloiomethane extract was obtained The organic extract of DEP_(2.5) revealed DNA damage itself in NIH/3T3 cells And it showed both oxidative and microsome mediated DNA damages Vitamin C as an model antioxidant reduced DNA damage in endonuclase Ⅲ treated comet assay One of flavonoid, galangin as a CYP[A] inhibitor reduced DNA damage in the presence of S-9 mixture Our results show that DEP_(2.5) ate genotoxic and a great source of oxidative stress, but antioxidants can significantly reduce oxidative DNA damages And DEP_(2.5) may contain indirect mutagens which can be inhibited by CYP inhibitors.

쯔쯔가무시병에서 가피의 위치와 복장과의 관계

김백남,곽이경,문치숙,김의석,박상원,이창섭 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 쯔쯔가무시병의 예방을 위하여 위험지역에서 긴소매 윗옷을 입고 바지 끝을 양말 속에 넣는 것이 권장되고 있다. 이러한 예방조치의 효용성을 알아보기 위하여 우리는 쯔쯔가무시병에서 가피의 위치와 신발과 복장과의 관계를 살펴보았다. 재료 및 방법 : 2005년 10-12월 사이 6개 병원에서 전형적인 임상양상, 가피의 존재, 혈청검사 결과로 쯔쯔가무시병이 의심되거나 확진된 159명의 성인을 대상으로 가피의 위치, 추정 감염일, 야외활동, 당시 착용한 신발과 복장 등 을 조사하였다. 결과 : 혈청검사는 5명에서 시행되지 않았고 99명이 양성이었으며, 가피는 142명에서 발견되었다. 몸의 두 군데에서 발견된 6명을 제외한 136명 중 82명(60.3%)에서 가피는 하반신(아랫배, 엉덩이, 서혜부, 생식기, 넓적다리, 종아리)에 있었다. 감염일이 추정가능하고 가피가 1개만 있는 44명을 대상으로 하였을 때, 가피가 하반신에서 발견된 17명에서 슬리퍼를 신거나 맨발인 경우는 5명이었으나 상반신에 있는 27명 중에는 아무도 없었다(P=0.006). 바지아랫단을 양말 속에 집어 넣은 4명 중 1명은 하반신에서 3명은 상반신에서 가피가 발견되었다. 42명이 긴 소매 윗옷을 입었는데, 이중 16명은 하반신에서 26명은 상반신에서 가피가 발견되었다(P=1.00). 결론 : 쯔쯔가무시병 환자에서 신발을 신지 않거나 발이 잘 보호되지 않았을 때 가피는 하반신에 더 잘 생겼다. 바지 아랫단의 처리방법이나 긴 소매 윗옷의 착용은 가피의 위치와 통계적으로 유의한 연관관계는 발견되지는 않았다. 그러나 표본수가 적고 유충의 침범경로에 영향을 줄수 있는 다른 요인이 있기 때문에 가피의 위치와 연관관계가 없다고 이 연구에서 단정할 수는 없다. 따라서 쯔쯔가무시병의 예방을 위한 실용적인 권고를 위해서는 더 많은 연구가 필요하다. Background:Wearing a long-sleeved shirt and tucking the pants legs into the socks is recommended to prevent scrub typhus. This study investigated associations between the location of eschar and the type of clothes and shoes to evaluate the efficacy of these protective measures. Materials and Methods:One-hundred and fifty nine patients in whom scrub typhus was confirmed or suspected based on the typical clinical manifestations, presence of eschar, or positive results of serologic tests at 6 Korean hospitals from October to December 2005 were included in this study. We collected the information on the location of eschar, presumed exposure date to chiggers, and the clothes and shoes which they had worn. Results:Serologic tests were positive in 99 patients. Eschars were observed in 142 patients and 6 of them exhibited more than 2 eschars. Eighty-two (60.3%) of 136 patients with a single eschar had an eschar on the lower half of the body. Of the 44 patients whose exposure date could be estimated, and who had only a single eschar, 5 of the 17 patients with eschars in the lower half of their bodies, and none of the 27 patients with eschars in the upper half of their bodies went barefoot or wore open footware (P=0.006). Only 4 patients tucked the pants into their socks, and an eschar was found in the lower half in one patient, and in the upper half of the body in the other 3 patients. Of 42 patients who wore long-sleeved shirts, eschars were found in their lower bodies in 16, and on their upper bodies in 26 (P=1.00). Conclusion:When the feet were not protected properly with shoes, eschars were found more frequently on the lower half of the body than on the upper half. Wearing a long-sleeved shirt or tucking the pants legs into the socks was not found to be significantly correlated to the location of eschars. Further studies involving larger samples are necessary for the development of practical guidelines of protective measures to prevent scrub typhus.