임신 오조증이 합병된 임신에서의 출생아의 성비에 관한 연구

조헌영 ( Hun Young Cho ),이정열 ( Jung Ryul Lee ),이유경 ( Yoo Kyong Lee ),구인상 ( In Sang Ku ),차진영 ( Jin Young Cha ),김승룡 ( Seung Ryong Kim ),박문일 ( Moon Il Park ),조삼현 ( Sam Hyun Cho ),정성로 ( Sung Ro Chung ),황윤영 ( 대한주산의학회 2002 Perinatology Vol.13 No.2

연구목적:임신 오조증이 합병된 임신부의 경우, 출생시 신생아의 성비가 정상산모의 그것과 차이를 보인다는 일부 보고가 있어, 본 연구에서는 임신 오조증과 출생 신생아의 성비와의 관련성 여부와 오조증의 정도에 따른 출생시 성비에 대해 조사를 시행하였다. 방법:1995년 1월부터 2000년 12월까지 한양대학병원 산부인과에서 임신 오조증으로 진단받고 입원 치료한 산모 중, 본원에서 최종 분만한 111명의 산모를 연구 대상으로 하고, 상기 질환력이 없이 만삭 분만한 1995명을 대조군으로 하여, 각 군의 신생아의 성비를 비교 하였다. 또한 임신 오조군을 그 정도에 따라 경증과 중증의 두 군으로 나누어, 각 군별 특성과 출생시의 성비에 대해 조사하였다. 자료의 통계적 처리는 student t-test와 chi-square test를 이용하였고 p-value가 0.05 이하인 경우에 임상적 의의가 있는 것으로 판단하였다. 결과:임신 오조군의 경우, 111명의 출생아의 성별은 65명이 여아(58.6%), 46명이 남아(41.4%)로서, 대조군에 비해 여아의 출생이 유의하게 높은 것으로 나타났다(p=0.0046). 한편 임신 오조증의경증군과 중증군 사이에서는 성비에서 유의한 차이를 보이지 않았다(p=0.4487). 결론:임신 오조증이 합병된 임신에서는 여아의 출생이 유의하게 많은 것으로 조사되었다. 한편, 임신 오조증과 여아 출생의 증가와의 관련 인자를 규명하기 위하여는 혈중 에스트로젠 또는 HCG 농도 등에 관한 조사를 시행할 필요가 있는 것으로 사료된다. Objectives:There are a few studies reporting difference in sex ratio at birth in pregnancies complicated with hyperemesis gravidarum but it has not been reported in domestic journals yet. The purpose of this study is to evaluate difference of sex ratio in hyperemesis gravidarum patients compared to normal pregnant women. Materials & Methods:We identified 111 women who were diagnosed as hyperemesis gravidarum and had delivered babies in Hanyang University Hospital between Jan. 1995 to Dec. 2000. The control group was 1995 women who had no obstetric problems including hyperemesis gravidarum during the pregnancy and had delivered baby at term. We compared the sex ratio of infant and the characteristics of these two groups. The study group was divided into two subgroups depending on the severity of disease, mild group and severe group, and difference of sex ratio in these group were also compared. We analyzed the data using student T-test and chi-square test and p-value<0.05 was considered as statistically significant. Results:Compared to sex ratio(female:male) of control group(44.8:55.2), hyperemesis gravidarum showed the sex ratio of 58.6:41.4(p=0.005). There was no further difference of sex ratio between two subgroups of hyperemesis gravidarum according to severity of disease. Conclusion:In pregnancies complicated with hyperemesis gravidarum the sex ratio of female was significantly high. The studies based on more variables and larger population would produce more accurate results.

4년간 호르몬 대체요법 후의 골밀도 변화

이정열 ( Jung Ryul Lee ),차진영 ( Jin Young Cha ),조헌영 ( Hun Young Cho ),이유경 ( Yoo Kyung Lee ),박민수 ( Min Soo Park ),이유석 ( Yoo Seok Lee ),나영정 ( Young Jeong Na ),조수현 ( Soo Hyun Cho ),조삼현 ( Sam Hyun Cho ),정성로 ( 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12

목적 : 폐경 여성을 대상으로 4년간의 호르몬 대체요법이 골밀도에 미치는 여러 영향을 분석하고자 하였다. 특히 호르몬 대체요법에도 골밀도가 감소하는 여성들의 특성을 알아보고자 하였다. 연구 방법 : 4년간 호르몬 대체요법을 완료한 총 100명의 폐경 여성을 대상으로 하였다. 이중에너지방사선흡수계측기를 이용하여 매년 요추골밀도를 측정하였다. 결과 : 대상환자의 평균연령은 53.3±3.6세, 폐경연령은 4.7±4.0세이었다. 치료 전 골밀도에 따라 분류하면 Objective : To evaluate the various effects of hormone replacement therapy (HRT) on bone mineral density (BMD) for 4 years in postmenopausal women and to compare the characteristics of non-responders to HRT. Methods : A total of 100 postmenopausal women h

Carbon Black이 시멘트 Paste 및 Mortar의 물리적 특성에 미치는 영향

홍원표,황의환,조헌영 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.2

This study was performed to determine the most desirable carbon black and it's content in ordinary porland cement for the increase of physical properties of the cement and mortar. The various contents of carbon black were used for this study such as 0.2wt%, 0.5wt%, 1.0wt% and 3.0wt%. The different particle size and structure of carbon black were used. The physical properties of the cement paste and mortar were tested by KS methods. The experimental results are as follow; 1) The contents of 0.5-1.0wt% carbon blacks in cement increased most apparently the setting time of cement paste, flow value, compressive and flexural strengths of mortar, whereas decreased the water absorption ratio of mortar by about 10%. 2) SNP and D company's carbon black which have smaller numbers of I₂adsorption and DBP absorption and heavier pour density than those of others showed to be the most effective carbon blacks. 3) The soundness of cements remained unchanged regardless to the different kinds and contents of carbon blacks.

Asphalt와 Carbon Black을 처리한 TYPE Ⅰ,Ⅱ,Ⅴ 시멘트의 몰탈 및 콘크리트 특성

황의환,조헌영,홍원표 忠南大學校 産業技術硏究所 1987 산업기술연구논문집 Vol.2 No.2

ACTPC(Asphalt and Carbonblack Treated Portland Cement) Ⅰ, Ⅱ, Ⅴ were made with TYPEⅠ, TYPEⅡ and TYPEⅤ cements by treating 0.5% straight asphalt and 0.4% carbon black, and their characteristics of paste, mortar and concrete were compared with those of TYPEⅠ, Ⅱ, Ⅴ cements. The results are as fallows. 1. The cumulative hydration hear of ACTPCⅠcement was appeared to be the middle stage of TYPEⅠand TYPEⅡ cements. 2. During the hydration reaction, the dorment period of ACTPCⅠ cement is longer than that of TYPEⅠ cement, but the hydration heat of ACTPCⅠ cement measured after 16hours from water mixing increased more than that of TYPEⅠ cement. 3. ACTPCⅠ cement mortar showed nearly same resistance against H₂SO₄solution as that of TYPEⅤ(sulfur resisting cement). 4. The concrete flexural strength of ACTPCⅠ cement is increased to 60∼65% than that of TYPEⅠ cement and 20∼23% than that of TYPEⅡ cement. 5. The concrete tensile strength of ACTPCⅠ, Ⅱ and Ⅴ cements are increased to 5∼7% than that of TYPE Ⅰ, Ⅱ and Ⅴ cements.

발효된 고화하수 슬러지의 지반공학적 특성연구

황윤재,김명학,조헌영 인제대학교 2010 仁濟論叢 Vol.25 No.1

More than 7,000 ton of sewage sludge was produced daily in korea, of them more than 80 percent reclaimed in land and dumped into ocean, while less than 7 percent were recycled. In this study, geotechnical and environmental laboratory tests were accomplished to evaluate material characteristics of solidified sewage, which fermented first, as possible civil construction materials, Geotechnical tests included liquid and plastic limit test, sieve analysis, compaction test, and shear strength thest, while environmental tests were pH test, heavy metal content and elution test. The results of tests said that geotechnical characteristics of solidified sewage sludge were satisfied the standard specification of covering materials for waste dumping ground, pH test said that pH of solidified sewage sludge was about 7.7 which is weak alkaline, Each elution concentration of heavy metals, which are Cd, Cu, Pb, Cr, and Zn, were also satisfied with the geotechnical and environmentally safe as civil construction material such as covering materials for waste dumping ground and seaside reclamation materials.

Self-Leveling재의 최적 결합재비 산정을 위한 기초적 연구

김진만,조성현,조헌영,한기석,서정목 공주대학교 방재연구센터 1998 공주대학교 방재연구센터 논문집 Vol.2 No.-

Self-leveling material is the floor finishing material that is able to make surface level by itself, it can go on a next construction in a short time. Self-leveling materials are composed of various binders and chemical additions, and it is difficult to catch suitable mixing proportion of composion materials. This study is to investigate and analyze consistency and strength properties of according to component ratio of main materials and we endeavor to get suitable mixing propertion of binders by experimental design and statistical analysis. The results of this study are showed that suitable mixing proportions of binders are OPC(Ordinary Portland Cement) 70~80%, AC(Alumina Cement) 5~10%, AG)Anhydrous Gypsum) 5~20%.

임신성 융모성 질환에서 혈청 β-hCG의 소실기간과 양상에 관한 연구

강정권,구인상,차진영,김현희,김영재,이유석,배은경,나영정,김경태,조수현,조삼현,문형,조헌영,황윤영 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4

목적 : 혈청 융모성 성선자극 호르몬 (hCG)은 임신성 융모성 질환에서 종양 활성도를 반영하는 가장 보편적인 지표로 사용되고 있으며 연속적 혈청 β-hCG 소퇴양상의 분석은 이 질환의 경과를 평가하는데 중요하다. 이에 본 연구에서는 임신성 융모성 질환을 포상기태와 악성 융모성 질환으로 나누어 혈청 β-hCG 소실기간을 분석하고 그 값들의 소퇴양상을 보고자 하였다. 연구 방법 : 1990년 1월초부터 2000년 12월말까지 한양대학병원 산부인과에서 병리조직학적으로 임신성 융모성 질환으로 진단 받고 치료받은 46예의 환자를 대상으로 하였다. 비교분석을 위하여 19예의 포상기태군과 27예의 악성 융모성 질환군, 두 군으로 대별하였으며 후자를 다시 비전이성군 17예와 전이성군 10예로 나누었다. 이들은 혈청 β-hCG가 음성 (<3 mIU/ml)이 될 때까지 1주일 간격으로 추적 검사를 하였으며 3회 연속 혈청 β-hCG 값이 음성이 나온 경우 1달 간격으로 1년간 추적 검사를 시행하였다. 혈청 β-hCG 정량은 이중접합 면역측정법 (Chiron Diagnostics Automated Chemoiluminescence System 180)으로 측정하였으며 통계학적 분석은 SPSS에 의한 t-test와 ANOVA test를 이용하였다. 결과 : 임신성 융모성 질환의 빈도는 182.7분만수당 1건이었다. 포상기태에서 혈청 β-hCG의 소실기간은 평균 12.8±1.1 (SEM)주 (7-26주) 이었으나, 악성 융모성 질환에서는 평균 17.9±1.4 (SEM)주 (8-34주) 이었다. 혈청 β-hCG 평균 소실기간은 악성 융모성 질환보다는 포상기태에서 통계학적으로 유의하게 짧았다 (P<0.01). 그러나 비전이성군 (18.0주)과 전이성군 (17.8주)간의 혈청 β-hCG 평균 소실기간은 통계학적으로 유의한 차이가 없었다 (P=0.946). 포상기태군과 악성 융모성 질환군의 혈청 β-hCG 평균 측정값은 로그지수 소퇴곡선을 따라 감소하는 양상이었다. 결론 : 본 연구에서의 혈청 β-hCG 값의 소퇴양상은 서구의 혈청 β-hCG 값의 소퇴양상과 비슷하였으며, 또한 1980년대 우리나라의 혈청 β-hCG 값의 소퇴곡선과도 비슷하였다. 또한 개개인의 연속적 혈청 β-hCG 값의 소퇴양상은 향후 치료방침 결정과 악성 융모성 질환 진단을 용이하게 하는데 그 효용성이 있음을 유추할 수 있었다. Objectives : It is now conventional practice to use human chorionic gonadotropin (hCG) as the marker of tumor activity in gestational trophoblastic disease (GTD). The interpretation of serial serum β-hCG regression patterns is important in monitoring the course of the disease. The purpose of this study was to establish a regression time and pattern of the serum β-hCG in which GTD is divided into hydatidiform mole and malignant trophoblastic disease. Materials & Methods : During the period from January 1990 through December 2000, 46 patients with GTD were histopathologically diagnosed and treated at the department of Obstetrics and Gynecology in Hanyang University Hospital. For the purpose of analysis and comparison, patients were divided into 19 cases of hydatidiform mole and 27 cases of malignant trophoblastic disease which was subdivided into nonmetastatic (17) and metastatic (10). Patients were followed clinically and by weekly estimations of quantitative serum β-hCG until negative (<3 mIU/ml). After three consecutive negative β-hCG, serum β-hCG were drawn monthly in all patients for one year. The level of serum β-hCG was detected by two-site sandwich immunoassay (Chiron Diagnostics Automated Chemiluminescence System 180). The obtained data were analyzed using t test and ANOVA test by SPSS. Results : The incidence of the GTD compared with delivery was one per 182.7 deliveries. The mean value of serum β-hCG regression time in hydatidiform mole was 12.8±1.1 (SEM) weeks (7.0-26.0 weeks) and 17.9±1.4 (SEM) weeks (8.0-34.0 weeks) in malignant trophoblastic disease. The regression time was significantly shorter in hydatidiform mole than that of malignant trophoblastic disease (P<0.01). The differences of mean value of serum β-hCG regression time between the groups with nonmetastatic (18.0 weeks) and metastatic (17.8 weeks) were not statistically significant(P =0.946). The mean values of serum β-hCG in both hydatidiform mole and malignant trophoblastic disease declined following a log-normal distribution. Conclusions : The regression pattern of serum β-hCG in present study was similar to that of which in Western and also similar to that of which in Korea in 1980s. The present study supports the continued use of individual patients serum β-hCG regression curve to make treatment decision and to recognize malignant trophoblastic disease promptly.