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      • SCOPUSKCI등재

        $Ca^{2+}$ Inhibitor가 생쥐난자 성숙에 미치는 영향

        정혜원,유한기,배인하,Chung, Hye-Won,Yoo, Han-Ki,Bae, In-Ha 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1

        In the present study, it was aimed to find the role of calcium on the maturation of mouse follicular oocytes as well as for the role of calcium inhibitors, $Ni^{2+}$ and $La^{3+}$. Mouse follicular oocytes were cultivated in different media at $37^{\circ}C$, in 100% humidified $CO_2$ incubator for 3 and 17 hrs. The results were as follows; 1. There was no differences in GVBD between the control and experimental groups during the 3 hr culture. 2. Mouse oocytes were matured to higher rate in MHBS rather than HTF for 17 hr culture. 3. Maturation rate was significantly lower in $Ca^{2+}$-free and $Ca^{2+}$ 0.4 mM which were tested, compared to other calcium concentration used in the present study. 4. Calcium inhibitor, $Ni^{2+}$, it showed highest degeneration rate at all calcium concentrations and additionally in $Ni^{2+}$ $100{\mu}M$ treated group next. Maturation rate was significantly decrease as the $Ca^{2+}$ inhibitor concentration increased. 5. In all Lanthanum treated groups of calcium-free, degeneration were significantly high treated groups at 0.4 mM $Ca^{2+}$ concentrations degeneration rates of all group were significantly lower than that of the control but maturation rates were not significantly different in any group. In lanthanum $100{\mu}M$ treated group at 0.4 mM and 0.8 mM calcium concentration, its maturation rate was significantly higher than that of the control. Maturation rates of all groups of lanthanum treated at 1.71 mM calcium concentration were not significantly different among groups. 6. In the calcium treated group (0.4mM-1.7 mM), the presence of phosphate does not seem to be needed for oocyte maturation. However, the presence of phosphate at $Ca^{2+}$ 0.8 mM only seems to stimulated maturation.

      • KCI등재

        텐터 신장률이 다른 면/스판덱스 능직물의 반복세탁에 따른 역학적 특성 및 태 비교

        정혜원,권진,김효정,석혜준,Chung, Hae-Won,Kwon, Jin,Kim, Hyo-Jeong,Seok, Hye-Joon 한국섬유공학회 2010 한국섬유공학회지 Vol.47 No.4

        The effects of the tentering-extension rates and repeated washing on the mechanical properties and hand values of cotton/ spandex twill were examined. A 3% spandex containing cotton twill was treated by tenter extension at different rates of 0%, 5%, 10% and 15%. The processed fabric with a 0% extension rate was also dyed using a reactive dye. The KES-FB system was utilized to measure the mechanical properties of the twill, and the basic and total hand values were determined using a KN-201-MDY and KN-301-WINTER, respectively. The fabrics treated with greater tentering extension and dried in a clothes tumble dryer showed lower bending and shear properties, and became softer and smoother. The greatest change in the mechanical properties and hand values occurred after the first wash, but the differences in the washed and unwashed state decreased with increasing number of wash cycles. These results show that cotton/spandex twill should be extended 5% during tentering to yield less deterioration of the T.H.V., and be dried in a clothes tumble dryer to maintain a soft and smooth hand without affecting the shrinkage and elasticity.

      • KCI등재후보

        급성 췌장염 이후 발생한 후복막강 농양에 속발된 위와 대장 누공의 1예

        정혜원(Chung Hye Won),이용찬(Lee Yong Chan),이준규(Lee Joon Kyu),백용한(Pack Yong Han),박인서(Park In Suh),문영명(Moon Young Myoung),김명진(Kim Myeong Jin) 대한내과학회 2000 대한내과학회지 Vol.58 No.6

        N/A According to several reports, the incidence of pancreatic and peripancreatic abscess after acute pancreatitits is quoted at about 5 percentage and this rare complication may cause fistulas with multiple intra-abdominal organs. Mortality rates are nearly 100 per cent, mostly due to sepsis and hemorrhage in the abscence of surgical intervention and even with surgical drainage and celiotomy, death rate of 30 to 50 percentage are noted due to recurrence. The pathogenesisi of these fistulas may be multifactorial ; activated pancreatic enzyme and the products of secondary infection penetrating visceral wall directly, and vascular thrombosis and shock causing ischemic necrosis of the gastrointestinal wall. The gastrointestinal fistulas after acute necrotizing pancreatitis have been reported rarely in Korea. The authors experienced a sixty three year old male patient case of gastric and colonic fistulas in communication with retroperitoneal pancreatic abscess after acute pancreatitis. The patient received broad-spectrum antibiotics and percutaneous catheter drainage without surgical intervention. After treatment, he recovered well complete. Conservative care with drainage procedure may be a suitable alternative for managing the gastrointestinal fistulas with the pancreatic and peripancreatic abscess after acute nectrotizing pancreatitis.(Korean J Med 58:675-680, 2000)

      • KCI등재

        The Impact of Sample Sizes on Multiple Membership Multilevel Modeling Estimation

        정혜원(Hye won Chung),김지선(Ji seon Kim),박령선(Ryoung sun Park),전현정(Hyeon jeong Jeon) 한국교육평가학회 2015 교육평가연구 Vol.28 No.1

        다중소속 다층자료가 교육현장자료에서 증가하고 있으나, 표본크기가 다중소속다층모형에 미치는 영향에 관한 연구는 매우 미흡하다. 이 시뮬레이션 연구에서는 표본의 크기가 다중소속다층모형의 모수 추정과 신뢰구간에 미치는 영향을 살펴보고자 하였다. 본 연구의 목적을 수행하기 위해 계층 내 상관계수 (ICC; 0.15, 0.25), 2수준 표본크기 (20, 30, 50, 100), 1수준 표본크기 (20, 30, 50, 100, 200)의 조건들이 고려되었다. 모든 실험조건에서 고정효과와 1수준 변량의 추정에서는 상대편의가 나타나지 않았다. 그러나 2수준 표본크기 조건에서는(<=50), 2수준 변량의 과대 추정되는 상대편의가 나타났다. 모든 실험조건에서, 고정효과와 변량의 95%신뢰구간 포함 비율은 명목수준인 5%보다 미만으로 나타났다. 본 연구에서는 연구자들에게 다중소속다층모형의 추정을 위해서 최소 50 그룹 및 각 그룹 당 30명 이상 참여자가 속해 있는 크기의 자료를 사용할 것을 제안하였다. Multiple membership data structures are increasingly encountered in the educational field, but few studies have investigated the impact of sample sizes on multiple membership multilevel modeling. This simulation study examines the parameter estimates and non-coverage rates of 95% credible intervals in multiple membership multilevel modeling under a variety of manipulated conditions including: the intraclass correlation coefficient (ICC; 0.15 and 0.25), the number of schools (20, 30, 50 and 100), and the number of students (20, 30, 50, 100 and 200). Across all conditions, no substantial relative bias was found for fixed effect and student level variance component estimates. However, in some of the smaller number of schools (<=50), school level variance component estimates were substantially positively biased. Across all conditions, non-coverage rates of 95% credible interval for the fixed effect and random variance component estimates were less than the nominal non-coverage rate (i.e., 5%). It is suggested that applied researchers should analyze sufficiently large dataset (at least 50 groups with 30 participants) for multiple membership multilevel modeling estimation.

      • KCI등재

        전이성 임신성 융모막암종에 의한 신장 파열 선택적 신장동맥색전술 보고

        정혜원 ( Hye Won Chung ),최준용 ( Jun Yong Choi ),신소진 ( So Jin Shin ),조치흠 ( Chi Heum Cho ),차순도 ( Soon Do Cha ),권상훈 ( Sang Hoon Kwon ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.11

        Choriocarcinoma is a rapidly growing tumor that characteristically outgrows its blood supply. We report a rare case of metastatic choriocarcinoma presenting with acute right flank pain due to kidney rupture secondary to renal metastasis. The renal metastasis was embolised to stanch blood for control of hemorrhage. A brief review of the imaging features and therapeutic options for the ruptured renal metastases is discussed along with the case.

      • KCI등재

        다중소속 다층자료에 대한 모형의 명세화 오류 연구

        정혜원(Hye won Chung) 한국교육평가학회 2016 교육평가연구 Vol.29 No.4

        본 연구는 교차분류 다중소속 다층모형을 소개하고, 교차분류 다중소속 다층자료에 대한 명세화 오류가 모수추정에 미치는 영향을 연구하였다. 구체적으로, 본 모의실험 연구는 이러한 교차분류 다중소속 다층자료의 특성을 무시하는 두 가지 다층모형(전통적 다층모형, 교차분류 다층모형)을 적용할 경우 발생되는 모수추정치의 상대편의성을, 교차분류 다중소속 다층자료를 올바르게 모형화한 교차분류 다중소속 다층모형의 모수추정치의 상대편의성과 비교하였다. 모의실험 결과 전통적 다층모형과 교차분류 다층모형을 적용하였을 경우, 다중소속과 관련된 고정효과가 상대적으로 과소 추정되었다. 임의효과 분산추정값은 교차분류 다중소속 다층자료의 특성을 올바르게 추정하지 못할 경우, 심각한 상대편의성이 발생하였다. 또한 모형적합도를 비교한 결과 모든 실험조건에서 준거모형인 교차분류 다중소속 다층모형이 비교모형인 두 가지 다층모형보다 교차분류 다중소속 다층자료에 더 적합한 것으로 나타났다. This study introduced a cross-classified multiple membership multilevel model and investigated the effects of mis-specifying cross-classified multiple membership multilevel data structure in multilevel modeling estimation. The simulation study compared the relative parameter biases across three multilevel models that ignored one or more facets of a cross-classified multiple membership multilevel data structure, including a conventional multilevel model and a cross-classified multilevel model to the biases of the correctly specified cross-classified multiple membership multilevel model. The results were as follows. The fixed effect associated with multiple membership exhibited negative biases under the conventional multilevel model and cross-classified multilevel model. Variance component estimates were substantially biased when any facet of the cross-classified multiple membership multilevel data structure was incorrectly modeled. Additionally, model fit values using deviance information criterion supported the cross-classified multiple membership multilevel model over the two multilevel models across all conditions.

      • KCI등재후보

        폐경 여성에서 갑상선 기능과 골밀도의 연관성

        정혜원 ( Hye Won Chung ),강병문 ( Byung Moon Kang ),김미란 ( Mee Ran Kim ),윤병구 ( Byung Koo Yoon ),이병석 ( Byung Seok Lee ),최훈 ( Hoon Choi ),박형무 ( Hyoung Moo Park ),김정구 ( Jung Gu Kim ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.1

        연구목적: 골다공증은 가장 흔한 대사성 질환 중의 하나로, 연령이 증가함에 따라 골량이 감소하고 골의 미세구조 변화로 인한 골의 강도가 약화되어 골절의 위험성이 증가되는 전신성 골격계 질환이다. 최근 갑상선 호르몬이 골밀도와 연관성에 대한 보고가 있는데, 갑상선 자극호르몬이 낮은 경우 골밀도가 낮으며 티록신이 높을수록 골밀도는 낮아진다는 보고도 있다. 따라서 한국 폐경 여성에서 갑상선 질환이나 갑상선 기능의 변화가 골밀도에 미치는 영향을 알아보고자 본 연구가 진행되었다. 연구재료 및 방법: 서울 소재 8개 대학병원의 건강검진 센터에서 검진을 한 2,279명의 폐경 후 여성의 의무기록과 신장, 체중, 골밀도와 갑상선 기능검사결과를 조사하였다. 모든 자료는 SPSS 로 분석하여 그 유의성을 검증하였다. 결과: 다기관에서 조사한 비교적 대규모 수의 폐경 여성을 대상으로 한 본 연구에서 갑상선 기능 검사 중 혈청트리요오드사이로닌과 티록신은 골밀도와 연관성이 있으며 갑상선 자극호르몬은 유의한 연관성이 없었다. 이러한 연관성은 연령을 보정한 후에는 유의하지 않아 혈청 트리요오드사이로닌과 티록신의 골밀도 연관성은 연령에 따른 변화에 의한 것으로 추정된다. 갑상선 질환의 유무에 따라 요추 골밀도와 대퇴골 및 total hip 골밀도의 평균값은 차이가 없었다. 갑상선 자극호르몬이 0.5mU/L 미만인 group에서 갑상선 자극호르몬이 정상이거나 증가된 그룹보다 골감소증이 유의하게 높았다. 결론: 한국 폐경 여성에서 갑상선 기능과 골밀도는 연관성이 있었다. Objectives: Osteoporosis, defined as decreased bone mass and structural deterioration of bone, increases the incidence of fractures. Recently, there have been reports suggesting that thyroid hormones are related to bone mineral density (BMD). It has been reported that low normal circulating thyrotropin (TSH) levels correlate with lower BMD and that thyroxine (T4) and bone density are negatively related. This research aims to examine the relationship between BMD and thyroid diseases and other functional changes in postmenopausal women. Methods: The medical records of 2,279 postmenopausal women who attended the health care clinic in eight university hospitals between March 2001 and December 2007 were reviewed retrospectively. We determined the baseline characteristics of the women, including age, height, weight, and body mass index (BMI). The BMD was measured by dual-energy X-ray absorptiometry (DEXA). The correlation between the thyroid status and BMD was analyzed using the SPSS 12.0 program. Results: This research used data from a relatively large number of postmenopausal women gathered in a multicenter approach. Of the thyroid functional tests, thyroid stimulating hormone (triiodothyronine or T3) and T4 correlated with BMD, while free T4 and TSH did not show a statistically signifi cant correlation. After adjusted age, thyroid function test did not correlate with BMD. Osteopenia was signifi cantly higher in the group with TSH below 0.5mU/L compared with groups that had normal or high TSH. There was no statistically significant difference in lumbar BMD and total hip BMD among patients with thyroid diseases and healthy patients. Conclusion: The level of T3 and T4 correlated well with BMD in Korean post-menopausal women.

      • KCI등재

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