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김윤아(Yun Ah Kim),정명호(Myung Ho Jeong),주신배(Shin Bae Joo),최명자(Myung Ja Choi),김인수(In Soo Kim),김남호(Nam Ho Kim),김건형(Kun Hyung Kim),이승욱(Seung Uk Lee),조장현(Jang Hyun Cho),안영근(Young Keun Ahn),조상기(Sang Ki Cho),조정 대한내과학회 2001 대한내과학회지 Vol.60 No.5
N/A Background : Previous reports have mentioned the increased mortality of percutaneous coronary intervention (PCI) in elderly female patients compared with elderly male. The purpose of this study was to evaluate the clinical characteristics, coronary lesion, characteristics and differences of success rate of PCI between male and female elderly patients. Methods : Three hundred sixty six elderly patients (454 lesions), including 210 male (255 cases, 73.4±2.45 year-old) and 156 female (199 cases, 73.5±2.55 year-old) who underwent PCI at Chonnam National University Hospital between Jan '96 and Dec '98 (out of 3,030 patients during same period). We compared clinical characteristic, coronary artery lesion morphology, success and complication rates of PCI in elderly male and female patients. Result : Clinical diagnosis and risk factors for atherosclerosis were not different between two groups. Right coronary lesions were more common in female and left circumflex artery lesion less common in female patients. The success rate of balloon angioplasty was 93.2% (110/118) in male and 93.3% in (98/105) in female patients, and the success rates of stenting were 99.2% (136/137) in male and 100% (94/94) in female. Success rates of PCI were not different between two groups. Procedure-related mortality was one cardiac death (1/255, 0.39%) in male group only. Complications of elderly male were two occlusive dissection (OD: 2/255, 0.8%), three thrombotic occlusion (TO: 3/255, 1.2%) and two ventricular arrhythmia (VA) with shock (2/255, 0.8%). In 199 female patients, three OD (3/199, 1.5%), three TO (3/199, 1.5%) and two VA (2/199, 1.0%) developed. The complications rates were not different two groups. Conclusion : PCI in female patients older than 70 years can be performed with comparable success and complication rates to those of elderly male patients.(Korean J Med 60:456-462, 2001)
망막중심정맥폐쇄에 동반된 황반부종에서 유리체강내 덱사메타손삽입물 치료의 1년 효과
김태훈(Tae Hoon Kim),윤창기(Chang Ki Yoon),이지은(Ji Eun Lee),이주은(Joo Eun Lee),정인영(In Young Chung),사공민(Min Sa gong),김건형(Kun Hyung Kim),김현웅(Hyun Woong Kim) 대한안과학회 2016 대한안과학회지 Vol.57 No.12
목적: 망막중심정맥폐쇄에 동반된 황반부종에서 유리체강내 덱사메타손삽입물의 1년 효과를 알아보고자 하였다. 대상과 방법: 망막중심정맥폐쇄에 동반된 황반부종으로 유리체강내 덱사메타손삽입물 주입술을 1년 동안 2회 이상 시행 받은 22명(22안)의 의무기록을 조사하여, 최대교정시력, 중심황반두께 및 안압의 1년간 변화를 분석하였다. 백내장 발생, 안압 상승 등의 이상반응여부도 확인하였다. 결과: 전체 환자의 평균연령은 64.3 ± 9.5세이며, 남성이 10명이었다. 주입술 시행 횟수는 평균 2.4 ± 0.6회였으며, 첫 주입술과 두 번째 주입술 사이의 간격은 22.0 ± 6.4주였다. 평균시력(logMAR)은 시술 후 8개월까지는 유의하게 좋아졌으나 1년째에는 0.72 ± 0.62로 시술 전 0.82 ± 0.50과 비교하여 유의하게 호전되지는 않았다(p=0.638). 중심황반두께의 경우 1년에 걸쳐 전 구간에서 유의하게 감소하였다(p<0.05). 위험군별 다변량 분석을 시행하였을 때, 유리체강내 덱사메타손의 농도가 유지되는 구간에서 시력이 유의하게 더 호전되었고, 중심황반두께 역시 유의하게 더 감소하였다. 또한 고혈압군과 허혈성 망막중심정맥폐쇄군에서 중심황반두께가 유의하게 더 감소하였다(p=0.006, p=0.032). 경과관찰기간 동안 6명(27.3%)의 환자가 22 mmHg 이상으로 안압이 증가하였고 3명(13.6%)에서는 백내장 진행이 있었다. 결론: 유리체강내 덱사메타손삽입물 주입술은 망막중심정맥폐쇄에서 심각한 부작용 없이 시력의 안정과 황반부종을 감소시키는 효과를 보였다. Purpose: In the present study, 1-year outcome of intravitreal dexamethasone implant in macular edema secondary to central retinal vein occlusion (CRVO) was evaluated. Methods: The medical records of 22 patients (22 eyes) with macular edema secondary to CRVO were reviewed retrospectively. All patients were treated with intravitreal dexamethasone implant more than twice a year and followed up at least for 1 year from the first dexamethasone implant injection. The best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) were measured every 2 months after the first injection. Adverse effects, including cataract formation and elevation of IOP, were analyzed. Results: The mean patient age was 64.3 ± 9.5 years and 10 patients (45.5%) were male. The average number of injections was 2.4 ± 0.6 and the interval between the first and second injection was 22.0 ± 6.4 weeks. The mean BCVA (log MAR) was 0.82 ± 0.50 and 0.72 ± 0.62 at baseline and after 1 year, respectively. Vision was significantly improved for 8 months after the first injection (p < 0.05). However, vision was not different from baseline after 1 year. The CMT was significantly decreased compared to baseline (p < 0.001). Subgroup analysis revealed that BCVA was improved and CMT decreased significantly when intravitreal dexamethasone concentration was presumed sufficient. Moreover, CMT decreased significantly in hypertensive and ischemic groups compared with normotensive and non-ischemic groups, respectively (p < 0.001). Elevated IOP was observed in 6 eyes (27.3%), but all 6 eyes became normal after topical agent was applied. Cataract formation was observed in 3 eyes (13.6%). Conclusions: Intravitreal dexamethasone implant resulted in visual acuity stabilization and macular edema reduction in patients having macular edema secondary to CRVO without significant adverse events.
정희정 ( Hee Jung Jung ),최준용 ( Jung Yong Choi ),박지은 ( Ji Eun Park ),김건형 ( Kun Hyun Kim ),최선미 ( Sun MI Choi ),오달석 ( Dal Seok Oh ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.2
Objectives: This study is to establish the appropriate assessment of causalities from adverse events (AEs) which are related to acupuncture treatment. Methods: We assessed thirty AEs which were caused in the early phase trial on concomitant use of acupuncture and herbal medicines. We scored each AE on the questionnaire in Naranjo and SNU algorithm scale which are for drug causality assessment in pharmacoepidemiology. Results: In Naranjo scale, there were consistencies among the evaluators qualitatively with "Probable", "Possible" degree. In reliability test, parameters, such as, gamma and kendall`s tau-b revealed the degrees of 73%, and 32%, respectively. There were disaccordant tendency in SNU algorithm scale. Conclusion : A new algorithm which reflects acupuncture properties should be developed and elucidated.
혈소판 당단백 2b / 3a 수용체 차단제 부착 스텐트의 돼지 관상동맥 스텐트 재협착 억제 효과
강경태(Kyung Tae Kang),정명호(Myung Ho Jeong),김남호(Nam Ho Kim),류제영(Jay Young Rhew),이상현(Sang Hyun Lee),박종철(Jong Cheol Park),이승욱(Seung Uk Lee),김건형(Kun Hyung Kim),최명자(Myung Ja Choi),안영근(Young Keun Ahn),조정관(Jeon 대한내과학회 2001 대한내과학회지 Vol.60 No.4
N/A Background: The problems of coronary stent thrombosis and restenosis still remain to be solved. The glycoprotein Iib/IIIa receptor blocker, Abciximab (ReoPro), plays import ant roles in the treatment of high-risk patient with acute platelet-rich thrombus and in the inhibition of smooth muscle cell proliferation. The aim of this study was to determine whether the use of ReoPro-coated stents could reduce the neointimal formation in a porcine coronary stent restenosis model. Methods: ReoPro was coated on the surface of stent by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13), and ReoPro-coated stents (Group II, n=14). Follow-up quantitative coronary angiogram was performed at 4 weeks after stenting and histopathologic assessment were compared in both groups. Results: The diameter stenosis by QCA between two groups was significantly higher in Group I (23±5 % vs. 15±7 %, p=0.003). On histopathologic examination, no in-stent thrombus was observed. The percent area stenosis was significantly higher in Group I than in Group II (48±17 % vs. 30±16 %, p=0.01). The area of neoinima was larger in Group I than in Group II (3.2±1.2 mm vs. 2.0±1.0 mm, p =0.01). By immunocytochemistry, proliferation cell nuclear antigen indices were higher in Group I (4.2±2.1 %, vs 2.4±1.8 % p =0.03). Conclusion: The ReoPro-coated stent is safe and effective in the prevention of in-stent thrombus and restenosis, which may be related with the inhibition of platelet thrombus and neointimal cell proliferation.(Korean J Med 60:314-323, 2001)