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허근,신억섭,이상훈,안원효 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-
This study was done to determine the effect of lead acetate on the activities of the hepatic cytosolic xanthine oxidase and aldehyde oxidase which were well known as oxygen free radical generating enzyme in vitro. Lead ion accelerated the formation of lipid peroxide and the increment of xanthine oxidase(type O) activity and the type conversion ration from xanthine dehydrogenase to xanthine oxidase dose-dependently. But xanthine dehydrogenase(type D) activity was decreased. Aldehyde oxidase activity was not changed by lead ion. These data suggested that lead-induced cellular toxicity may be concerned partially with xanthine oxidase mediated lipid peroxidation.
하상호,노연섭,신동민,정원영 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
Although ganglion cysts are common, they rarely involve peripheral nerves. A case of intraneural ganglion of the peroneal nerve in a 40 years old woman was reported. The cystic ganglion was located at the region of the bifurcation of the peroneal nerve without communication of any joint or bursa, and was excised totally.
전덕인,윤보현,정한용,하규섭,신영철,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5
Objectives : This study aims to test the validity of the Korean version of Mood Disorder Questionnaire (K-MDQ), a Screening instrument for bipolar disorder. Methods : A total of 238 subjects (126 DSM-IV bipolar outpatients and 112 controls without psychiatric history) completed the K-MDQ. Results : The Cronbach's alpha, used to measure the internal consistency of the scale, was high (0.88). Principal component analysis with varimax rotation revealed three factors, which explained 59.5% of the variance. Individual item correlations with the total score were all statistically significant (p<0.001). The mean total score of the K-MDQ was 8.48 in bipolar disorder and 4.51 in non-clinical participants. A total K-MDQ score of 7 or more excluding further two questions was chosen as the optimal cutoff, as it provided good sensitivity (0.75) and specificity (0.69). Conclusion : The results of this study showed adequate validity of the K-MDQ, suggesting that this instrument is useful for screening of bipolar disorder.
Spontaneous reporting of adverse drug events by Korean regional pharmacovigilance centers
Shin, Yoo Seob,Lee, Yong-Won,Choi, Young Hwa,Park, Byungjoo,Jee, Young Koo,Choi, Sung-Kyu,Kim, Eung-Gyu,Park, Jung-Won,Hong, Chein-Soo John Wiley Sons, Ltd. 2009 PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol.18 No.10
<B>Purpose</B><P>Patterns of prescriptions are markedly influenced by regional disease entities, medical education, culture, economic status, and available pharmaceutical companies. Features of adverse drug reactions (ADRs) may vary in different countries. In this study, we analyzed the causative drugs and clinical manifestations of spontaneously reported ADRs in Korea.</P><B>Methods</B><P>Six Korean Regional Pharmacovigilance Centers collected 1418 cases of spontaneously reported adverse drug events (ADEs) by doctors, pharmacists, and nurses, and the clinical features and causative drugs were evaluated. The data were collected from general hospitals (76.5%), primary clinics, and pharmacies (23.5%).</P><B>Results</B><P>Based upon the World Health Organization (WHO)-Uppsala Monitoring Center criteria (certain—13.7%, probable—46.1%, possible—32.1%), 91.9% of the collected events were suspected to be ADRs and 15.8% of patients experienced serious ADRs. The most prevalent causative drugs were antibiotics (31.6%), followed by contrast dyes (14.0%), non-steroidal anti-inflammatory drugs (NSAIDs) (11.1%), anti-psychotics (5.4%), anti-convulsants (5.2%), cardiovascular agents (4.8%), anti-neoplastics (4.6%), and opiates and non-opiate pain killers (3.5%). Among the antibiotics, cephalosporins (8.1%) were the most common, followed by anti-tuberculosis agents (5.7%), quinolones (4.0%), vancomycin (3.1%), and penicillin (2.8%). The most common side effect was skin manifestations, which were seen in 42% of the patients, followed by neurologic manifestations (14%), gastrointestinal involvements (12.9%), generalized reactions (9.4%), and respiratory involvements (4.5%).</P><B>Conclusion</B><P>Antibiotics, contrast dyes, and NSAIDs were the most common causative drugs for ADRs, which reflects the prescription pattern and the prevalence of diseases in Korea. These data may be useful in establishing a Korean pharmacovigilance system. Copyright © 2009 John Wiley & Sons, Ltd.</P>
Shin, Won Sop,Yeoun, Poung Sik,Yoo, Rhi Wha,Shin, Chang Seob Japanese Society for Hygiene 2010 Environmental health and preventive medicine.['97. Vol.15 No.1
<P>The aims of this study were twofold: to examine the empirical evidence supporting the positive contribution that a forest environment can make on human psychological health and well-being and to describe the theoretical framework within which the forest environment has this effect. Our review of the literature provides empirical evidence that a forest experience can contribute to improved emotional and cognitive health.This experience can be through a forest activity program and by experiencing the social and physical conditions of the forest environment and the therapeutic elements of the forest. Visiting or viewing a forest scene has been documented to have a positive effect on psychological healing and well-being in terms of recovering from stress, improving concentration and productivity, improving the psychological state, particularly for people from urban environments. Wilderness and related studies clearly demonstrate that being in a forest environment has a positive effect on people, while results from other studies indicate that contacts with forest environments provide multiple positive physiological and psychological effects on human health that included decreasing the blood pressure and heart rate and reducing anxiety and stress. There are several theories explaining the healing effects of the forest on human beings. Most hypothesize that restorative environments are settings in which recovery is associated with the reduction of stress and that the benefits of contact with natures include a wide range of positive physiological and psychological responses. These theories are based on an evolutionary perspective and share a number of similarities and differences. This article summarizes a number of these theories of restorative environments as well as addresses the current status of forest therapy and the challenges and opportunities for therapeutic effects of the forest in Korea.</P>
Shin, Na-Rae,Jung, Tae-Yang,Seo, Chang-Seob,Park, So-Won,Ko, Je-Won,Kim, Jong-Choon,Shin, In-Sik Korean Association for Laboratory Animal Science 2018 Laboratory Animal Research Vol.34 No.3
<P>Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to investigate the protective effects of GB on pulmonary inflammation induced by cigarette smoke (CS) and lipopolysaccharide (LPS). C57BL/6 mice were used to develop a pulmonary inflammation model by exposing them to CS for 1 h per day for 7 days. LPS was intranasally administered to mice under mild anesthesia on day 5. GB was administered 1 h before CS exposure at doses of 50 or 100 mg/kg for 7 days. Our results showed that GB suppressed the CS and LPS induced elevation in inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), with significant reductions in protein, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 levels. Histological studies revealed that GB decreased the inflammatory cell infiltration into lung tissue caused by CS- and LPS-exposure. GB also significantly decreased the CS and LPS-induced expression of inducible nitric oxide synthase (iNOS) in the lung tissue. Taken together, GB effectively attenuated airway inflammation caused by CS and LPS. These results indicate that GB is a potential therapeutic herbal formula for pulmonary inflammatory disease.</P>
Dong-Won Shin,Se-Won Lim,Young-Chul Shin,Kang-Seob Oh,Eun-Jin Kim,Yun-Young Kwon 대한소아청소년정신의학회 2016 소아청소년정신의학 Vol.27 No.1
Objectives: Children with attention-deficit hyperactivity disorder (ADHD) may have deficits in time perception, as assessed by the time estimation task and the time reproduction task, however its age-related trajectory is not yet determined. Therefore we examined the correlation between accuracy of time perception tasks and age, and the association between accuracy of estimation tasks and reproduction tasks. Methods: Sixty-three patients with ADHD, aged 8 to 18 years tested the tasks for five time durations (2, 4, 12, 45, and 60 seconds). Accuracy of tasks was assumed differences (absolute values) between raw results of tasks and original time durations. Spearman’s correlation analysis was performed to determine correlation between accuracy of time perception tasks and age. Multivariate regression was used to determine the association of accuracy of estimation tasks with accuracy of reproduction tasks. Results: Age showed correlation with accuracy of estimation tasks, but not with that of reproduction tasks. We observed that the higher the accuracy in 12, 45, and 60 seconds duration time reproduction, the higher the accuracy in longer seconds duration time estimation. Conclusion: Age was correlated with time estimation accuracy whereas there was no impact on time reproduction accuracy. Association of each of the two time perception tasks, particularly in longer time duration, suggested specific impairments in time perception.
( Yoo Seob Shin ),( Jin Seok Lee ),( Jae Won Choi ),( Byoung Hyun Min ),( Jae Won Chang ),( Jae Yol Lim ),( Chul Ho Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.4
Injection laryngoplasty is an option for treatment of glottic insufficiency following vocal fold paralysis, vocal fold atrophy or scarring. We intended to evaluate the plausibility of autologous chondrocytes cultured with fibrin/hyaluronic acid (HA) for permanent vocal fold augmentation. Chondrocytes from rabbit auricular cartilage were expanded and cultured with fibrin/HA composite gel. 0.1 mL dosages of fibrin/HA gel with autologous chondrocytes were injected into the left vocal folds of six rabbits. Four months postoperatively, the site was evaluated endoscopically, histologically, and radiologically. None of the six rabbits showed signs of respiratory distress. Computed tomography images and endoscopic evaluation revealed sufficient augmentation volume of the injected vocal fold. Histologic data showed that the injected material did not migrate from their original insertion site. Even though the number of chondrocyte that settled down and survived in the injected site was varying in rabbits, chondrocytes successfully formed neo-cartilage at four months postoperatively in all cases. Histologically, the grafts showed no signs of inflammatory reaction and were covered with ciliated epithelium. The chondrocytes cultured with fibrin/HA could be a plausible injection material for vocal fold augmentation.