두경부 편팡상피세포암 세포주에서 세포주기 조절인자의 활성 및 이상:후두편평상피세포암에서 종양억제 유전자 CDKN2 유전자 발현이상

송시연,한태희,배창훈,김용대,송계원 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Cyclin-dependent kinase (CDK) inhibitors are family of molecules that regulate the cell cycle. The CDKN2, a CDK4 inhibitor, also called p16, has been implicated in human tumorigenesis. The CDKN2, inhibits the cyclin/CDK complexes which regulate the transition from G1 to S phase of cell cycle. There is a previous repot that homozygous deletion of CDKN2 region on chromosome 9p21 was detected frequently in astrocytoma, glioma and osteosarcoma, less frequently in lung cancer, leukemia and ovarian cancer, but not detected in colon cancer and neuroblastoma. However, little is known about the relationship between CDKN2 and laryngeal cancer. Therefore this study was initiated to investigate the role of CDKN2 in human laryngeal squamous cell carcinoma development. Materials and methods: We used 5 human laryngeal carcinoma cell lines whether they have deletion or losses of CDKN2 gene expression by DNA-PCR or RT-PCR, respectively. We examined 8 fresh frozen human laryngeal cancer tissues to detect the loss of heterozygosity(LOH) of CDKN2 PCR was performed by using micosatellite markers of short arm of human chromosome 9 (D9S126, D9S144, D9S156, D9S161, D9S162,D9S166, D9S166, D9S171,D9S200 and D9SIFNA).For informative cases, allelic loss was scored of the signal of one allele was significantly decreased in tumor DNA when compared to eh same allele in normal DNA. Results: the CDKN2 DNA deletion was observed in 3 cell lines. The CDKN2 mRNA expression was observed in only one cell line, which was very weak. LOH was detected in 7 cases(87.5%) Conclusion: These results suggest that CDKN2 plays a role in the carcinogenesis of human laryngeal squamous cell carcinoma

신고리 지역 기상관측을 통한 계절별 대기안정도 특성분석

송상근,김유근,오인보,정주희,조윤미,우경은,강태훈 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

In this study, we analyzed the characteristics of atmospheric stability to investigate local environment change at an atomic power plant in Gori region. The used data was obtained from field observation of major meteorological variables such as wind direction and speed, air temperature, relative humidity, and solar radiation using AWS (Automatic Weather System) in Gori region from February to September in 2003. As a result, when strong northerly winds (more than 4~6 m/s) and weak northwesterly winds (2~3m/s) blow, atmospheric stability was neutral and stable from winter to spring, respectively. Atmospheric stability (neutral) in summer was similar to that in two other seasons (winter and spring), but it was stable for weak southwesterly winds (2~3 m/s). Finally, atmospheric stability was neutral for strong winds (over 4~6 m/s) in fall without respect to wind direction, while that was stable for very weak winds (less than 2 m/s).

十全大補湯의 免疫增强 및 抗癌 效果

崔承勳,吳旼錫,宋泰元,남기열 대전대학교 한의학연구소 2002 혜화의학회지 Vol.11 No.1

Objectives : Sipjundaebo-tang is prepared by ten medical herbs that tone the blood and vital energy, and strengthen health. This prescription has long been used traditionally against anemia, anorexia, extreme exhausion and fatigue. The purpose of this thesis was to review the effects of Sipjundaebo-tang that are about immunopotentiation effects, antitumor activities and potentiation, detoxification of antitumor drugs Methods : We studied the research methods and results of experiments which were selected from Korean, Japaness and American theses were on the topic of immunopotentiation effects, antitumor activities and potetiation, detoxification of antitumor drugs from Sipjundaebo-tang Results and conclusions : Sipjundaebo-tang not only potentiates the effects of the combined use of chemotherapy, but also reduces and elimimate the immunotoxicity of antitumor drugs and radiotherapy. And it strengthen immunity and improve QOL, S/OH of cancer patients.

Thiopental이 백서 자궁 평활근의 수축에 미치는 영향

안태훈,이세정,송창훈 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Background and Objectives: Thiopental has been used as an intravenous induction agent for cesarean section. The aim of the present study was to investigate the effects of thiopental on the isolated rat uterine smooth muscle. Materials and Methods: Uterine smooth muscle tissues were obtained from non-pregnant rats(n=20). The muscle strips were suspended in tissue baths and the isometric tension was recorded. After spontaneous uterine activity had been accomplished, thiopental in various concentrations was applied cummulatively to the bath and the effects were continuously monitored. Results: Thiopental induced a dose-dependent inhibition of spontaneous myometrial contractile activity, Complete muscular relaxation on the spontaneous uterine contractility was obtained at in a dose of 10_(-3)M of thiopental. Conclusions: The spontaneous contractile activity of the uterine smooth muscle is inhibited by thiopental.

수증기 활성화법으로 제조된 영월 석탄계 활성탄의 특성 연구

이송우,권태훈,나영수,최동훈,류동춘,송승구 한국환경과학회 2000 한국환경과학회지 Vol.9 No.4

Activated carbons were prepared from Youngwall coal by steam activation in this study. The feasibility of the Youngwall coal to commercial activated carbon was examined. The variation of pore structures and the development of porosity in activated carbons were investigated by changing activation conditions in batch type apparatus. The values of BET surface area and adsorption capacity of iodine and methylene blue of the resulting activated carbons were obtained as high as 1,000㎡/g, 900㎎/g, 150㎖/g, respectively. Youngwall activated carbon prepared in this study showed much higher pore volume in pore diameter over l0Å than that of commercial reference activated carbon(Ningxia Taihua ZJ-15C) produced from China anthracite.

상아질 접착제의 적용이 법랑질 접착에 미치는 영향

권태엽,권용훈,김교한,송근배 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.2

The objective of this study was to evaluate the effect of various enamel surface treatments on the bond strength of a composite resin to enamel (n=15). Ground bovine enamel specimens were divided into seven groups. A composite resin (Z250. 3M) was bonded to the specimens using different enamel surface treatments. Four groups examined the effect of application of all-in-one adhesives (Prompt L-Pop (POP), One-Up Bond F (ONE)) with respect to static priming (SP) or dynamic priming (DP). The other two examined use of the POP and ONE after phosphoric acid etching (PE). And the control group provided bond strength of the composite resin to phosphoric acid etched enamel with a resin bonding system (Single bond, SB, 3M). Shear bond strengths for the specimens were measured after 24 hours storage in water at 37 ℃. Effects of various surface treatments on enamel were examined by SEM. Dynamic priming resulted in higher enamel bond strengths than static priming and the best bond strengths were obtained when the enamel was etched with phosphoric acid. SEM analysis showed that depth of etching was related to the bond strengths measured. The enamel etch pattern after static priming showed little retentive surfaces. After dynamic priming, the enamel rod structure has become apparent in the shallow etch. SEM view showed that the resin tags and resin penetration were related to the bond strengths measured. SEM showed minimal resin penetration into enamel following static priming. After application of adhesives to phosphoric acid etched enamel, SEM showed more extended tags that are reflective of the deeper etch pattern.

고용량 및 저용량 ticlopidine의 혈소판 응집억제 효과 비교: 예비연구

김제,이훈복,송희정,이태용,김재문 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

내시경적 역행성 췌담관조영술중 췌선방 조영 후 발생한 중증 췌장염 1예

장세중,기승석,김훈일,신혜영,박장원,송은훈,태재웅 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

내시경적 역행성 담췌관조영술 후 발생한 급성췌장염의 발생인자로 여러 가지 인자들이 관여하지만 특히 담췌관조영술 시행 후 과도한 췌선방 조영화에 의한 중증의 췌장염 증례를 경험하였기에 보고하는 바이다 Endoscopic retrograde cholangiopancreatography (ERCP) has been considered as a valuable tool for the diagnosis and management of disease of the pancreas and biliary tree. Post-ERCP pancreatitis is the most frequent and clinically significant complication following ERCP. But a few complication associated with this procedure are unforeseeable. Specially, acinarization as a result of a careless cooperation between operator and assistant may be influenced in complications of ERCP. Severe post-ERCP pancreatitis is rare complication, and its prognosis will be poor. Therefore, careful process and good relationship between operator and assistant in ERCP may be prevented this complication, but is not clear. Neglect of acinarization may be resulted in more aggravation of pancreatitis. We have cared for one patient with severe post-ERCP pancreatitis with pseudocyst after water-soluble contrast media spreading into the acini (acinarization) via ERCP in resolving phase idiopathic pancreatitis.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한우 난소에서의 angiogenin분포와 mRNA발현에 관한 연구

이흥식,이인세,강태천,서제훈,송승훈 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1