Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

비만 개선 효과를 지닌 탄수화물 및 지방 흡수 억제 기능성 식이조성물 개발

윤유식,최선미,홍순복,홍정미,김정원,이홍석,홍성길 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

In a previous study, we developed a new food additive as an egg yolk antibody (IgY) against carbohydrate digestion enzymes for the regulation of blood glucose level and weight control. The IgY delayed and decreased the increment of blood glucose level after administration of sucrose in human being by 30% in 20∼30 min. We also developed a lipase inhibitor as a water extract of two kinds of herb, Platycodon grandiflorum and Solanum melongena. Twenty three volunteers were subjected to the intake of the egg yolk IgY plus the herbal extracts for 50 days. In average, the treated subjects appeared to lose 1.96 ㎏ of body weight and 3.4 ㎏ of body fat mass during the treated period. Furthermore, Panniculus adiposus and breech size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of egg yolk IgY and natural herbal extract improve the obesity by the decrement of body weight and body fat mass.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

Rat 전지 상완의 근섬유형 구성에 대한 연구

정명래,김홍선,신태균 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

This study was to determine the fiber-type populations and calculate the cross-sectional areas in each fiber-type in the muscle of the brachium of the rat. For 20 rats, the flexors (brachialis and biceps brachii) and extensors (triceps brachii) of the elbow taken from dissection. The fibers were classfied histochemically as fast-twitch oxidative glycolytic fiber(FOG), fast-twitch glycolytic fiber (FG), or slow-twitch oxidative fiber(SO), and their populations were determined. The cross-sectional areas of each type muscle fibers were calculated with microcomputer image analyzer. The results were as follows ; I. The variations in fiber-type population of various muscles with which their positions were observed as well as those reported in ot4er studies. 2. In both extensor and flexor groups, the deep region of the muscles was consisted of higher populaions of SO fibers, while more superficial regions of the same muscles were more FG fibers. 3. The percentage of SO fibers were larger in the extensors than that of flexors. 4. Except the SO fibers, the cross-sectional areas of FOG and FG fibers in the extensors were larger than that of flexors.

KLEINE-LEVIN 증후군 2례

홍순형,정인과,김순범,한선호,곽동일,이병윤 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.2

The Kleine-Levin syndrome is composed of recurring episodes of sleepiness lasting days, associated with excessive appetite and often with abnormal behavior. The authors reported two cases of the Kleine-Levin syndrome. The results were as follows: 1. They were adolescent male patients. 2. The onsets were predisposed by psychological stresses of school examinations. 3. Their electroencephalograms revealed abnormal findings only during episodes of hypersomnolence. 4. One of them was improved by treatment with imipramine and lithium.

혈액 내 구리, 아연 및 ceruloplasmin 농도에 흡연, 음주 및 신체적 활동이 미치는 영향

홍연표,강은용,신인철,최병선,박정덕,장임원,박진완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases. Methods : At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regression analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron. Results : In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker(P=0.0678). There was no difference between high physical activity with mild smokers and lower physical with heavy smokers. Conclusions : This study suggested that copper, zinc and ceruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

지하공동구의 연소방지설비에 관한 연구

홍경표,이영재,김선정 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.4

최근 지하공동구내의 화재가 자주 발생, 도시의 기능이 마비되는 등 국민생활을 위협하고 있으며, 막대한 재산 및 인명피해를 초래하고 있다. 지하공동구 화재로 인한 조기진압은 소방법의 연소방지설비 기준에 적용하였을 경우 화재진압시 많은 문제가 있다고 판단된다. 지하공동구의 연소방지설비 중에는 여러 방식을 적용할 수 있으나, 본 연구에서는 물을 이용한 방식 중에 국내 및 소방법에서 적용되지 않고 있는 워터 미스트(water mist)방식에 대해서 연구하고 그 설치 방안을 제시하고자 한다. Due to frequent fire incidents in underground culverts, many live are lost and the function of city is paralyzed, and consequently they bring tremendous damages to fortunes and live of people. It brings my attention that there are many problems presented when the current standard of smoke prevention facility is applied to prevent fire. Among many methods to prevent smoke in underground culverts this study concentrates on water-mist method witch is not currently applied in Korea and introduces installation method. Keywords : Underground culverts, Smoke prevention facility Water-mist method

초등 사회과 3학년 지역화 교수·학습자료개발 연구

홍기대,손정선,김언식,김용조,이광성,김경운 光州敎育大學校 初等敎育硏究所 2002 初等敎育硏究 Vol.17 No.-

The purpose of this study is in developing locally-oriented teaching-learning materials to motivate students to effectively take part in activities using map and in improving the field work of social studies to plan a map learning and to give them the ability of practice. It represents the right order involved in teaching the activities using map after doing preceding learning : classroom, playground, and the environs of the school including to some learning methods such as a puzzle map, a correlative of learning. Field trip study planning and lesson-plan are designed in case of Sewage disposal plant, Duknam filtration plant, Bonchon industrial complex relating to field trip study. There are some effects expected which follow through this study. First, teachers are able to draw learner's interest in finding learning sources directly through the community where they live. Second, learners have active participation in class, motivation, drawing their interests through map learning by doing preceding study of learner-centered. Third, teachers can make use of it as useful tools to get high achievement goal with self-direct learning.

A Study on Effect of the Elderly s Leisure Life upon Psychological Loneliness and Life Satisfaction and Social Support s Mediating Effect

Jung,Myung-Hee,Kim,Hong-Sun 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-

This study, it is intended to obtain a theoretical understanding on the relationship among the elderly s leisure activity, social support, life satisfaction and mental loneliness while, together with this, it is also intended to draw policy implications for enhancing the psychological well-being of the elderly in a practical dimension. The objective of this study consists in doing research on the influence of leisure activity exerted upon both life satisfaction and mental loneliness of the elderly over 60 and also on the moderating role of social support. The purpose of this study was to search for the influence of leisure activity and social support being exerted upon life satisfaction and mental loneliness as well as the moderating role of social support. In this study, as leisure activities, the 2 types of productive leisure activity and consumptive leisure activity, and as social support, the 3 types of spouse support, children support and friend support, and the 2 factors of life satisfaction and mental loneliness have been reviewed. The result of this study is suggesting policy implications that are important for enhancing life satisfaction in senescent period of the elderly.

모바일 사전을 위한 효율적인 선인출 기법

홍순정,문양세,김혜숙,김진호,정영준 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

In the mobile Internet environment, we need to perform frequent accesses between a mobile device and a content server for searching or downloading learning materials. In this paper, we propose an efficient prefetching technique to reduce the network cost and to improve the communication efficiency in the mobile dictionary. Contributions of the paper can be summarized as follows. First, we propose an overall framework for the prefetching-based mobile dictionary. Second, we present a method of determining the amount of prefetching data for each of packet-based and flat-rate billing cases. Third, by focusing on the English-Korean mobile dictionary for middle or high school students, we propose a method of determining the words to be prefetched in advance. Fourth, based on these determination methods, we propose an efficient prefetching algorithm. Fifth, through experiments, we show superiority of our prefetching-based method. Experimental results show that, compared with the traditional on-demand method, our prefetching-based method improves the average performance by 9.8%~19.7% for the packet-based billing and by 19.0%~33.2% for the flat-rate billing. These results indicate that our framework can be widely used not only in the mobile dictionary but also in other mobile Internet applications that require the prefetching technique.