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홍명기,이중희,신동호,김병극,고영국,최동훈,장양수 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.5
Purpose: The effects of short-term intensive lipid-lowering treatment on coronary plaque composition have not yet been sufficientlyevaluated. We investigated the influence of short-term intensive lipid-lowering treatment on quantitative and qualitative changes in plaque components of non-culprit lesions in patients with acute coronary syndrome. Materials and Methods: This was a prospective, randomized, open-label, single-center trial. Seventy patients who underwent both baseline and three-month follow-up virtual histology intravascular ultrasound were randomly assigned to either an intensivelipid-lowering treatment group (ezetimibe/simvastatin 10/40 mg, n=34) or a control statin treatment group (pravastatin 20 mg, n=36). Using virtual histology intravascular ultrasound, plaque was characterized as fibrous, fibro-fatty, dense calcium, or necrotic core. Changes in plaque components during the three-month lipid-lowering treatment were compared between the two groups. Results: Compared with the control statin treatment group, there was a significant reduction in low-density lipoprotein cholesterolin the intensive lipid-lowering treatment group (-20.4±17.1 mg/dL vs. -36.8±17.4 mg/dL, respectively; p<0.001). There were no statistically significant differences in baseline, three-month follow-up, or serial changes of gray-scale intravascular ultrasound parameters between the two groups. The absolute volume of fibro-fatty plaque was significantly reduced in the intensive lipid-loweringtreatment group compared with the control group (-1.5±3.4 mm3 vs. 0.8±4.7 mm3, respectively; p=0.024). A linear correlation was found between changes in low-density lipoprotein cholesterol levels and changes in the absolute volumes of fibro-fatty plaque (p<0.001, R2=0.209). Conclusion: Modification of coronary plaque may be attainable after only three months of intensive lipid-lowering treatment.
홍명기,홍성진,허애영,서용성,원호연,조덕규,조윤형,윤영원,이경훈,강웅철,김용훈,김상욱,신동호,김중선,김병극,고영국,최병욱,최동훈,장양수 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.5
Purpose: To evaluate the ability of coronary computed tomographic angiography (CCTA) to predict the need of coronary revascularizationin symptomatic patients with stable angina who were referred to a cardiac catheterization laboratory for coronary revascularization. Materials and Methods: Pre-angiography CCTA findings were analyzed in 1846 consecutive symptomatic patients with stable angina, who were referred to a cardiac catheterization laboratory at six hospitals and were potential candidates for coronary revascularizationbetween July 2011 and December 2013. The number of patients requiring revascularization was determined based on the severity of coronary stenosis as assessed by CCTA. This was compared to the actual number of revascularization procedures performed in the cardiac catheterization laboratory. Results: Based on CCTA findings, coronary revascularization was indicated in 877 (48%) and not indicated in 969 (52%) patients. Of the 877 patients indicated for revascularization by CCTA, only 600 (68%) underwent the procedure, whereas 285 (29%) of the 969 patients not indicated for revascularization, as assessed by CCTA, underwent the procedure. When the coronary arteries were divided into 15 segments using the American Heart Association coronary tree model, the sensitivity, specificity, positive predictive value, and negative predictive value of CCTA for therapeutic decision making on a per-segment analysis were 42%, 96%, 40%, and 96%, respectively. Conclusion: CCTA-based assessment of coronary stenosis severity does not sufficiently differentiate between coronary segments requiring revascularization versus those not requiring revascularization. Conventional coronary angiography should be consideredto determine the need of revascularization in symptomatic patients with stable angina.
호흡기 알레르기 환자에서의 쌀겨에 대한 피부반응도 및 특이 IgE 측정
홍명기,이미경,박해심,홍천수 대한천식알레르기학회 1990 천식 및 알레르기 Vol.10 No.1
To evaluate the allergenic importance of ricebran as a causative allergen in respiratory allergy diseases, skin prick test with ricebran, other cereal grain extracts and housedust mite and ricebran radioimmunoassay were performed in 188 patients with bronchial asthma and /or allergic rhinitis visiting the Allergy Clinic in the Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine from March 1988 to Feb. 1989. 1. The positive rate(>=1+) to the extracts of ricebran on skin prick test was 46.8% in respiratory allergy patients. 2. In comparison to negative responders on skin prick test to ricebran, positive responders on skin prick test(>=2+) were significantly more in young age and students(p=0.01).There were no significant differences in the kinda of used pillows, duration of respiratory symptoms, serum total IgE and total eosinophil counts between two groups. 3. The concurrent positive rates on skin tests were 90.7%(r =0.23) to D. farinae, 96.3%(r=0.36) to threshing mixture and 75.9% (r=0.41) to Tyrophagus putrescentiae in positive responders on skin test to ricebran(>=2+). 4. On the radioimmunoassay for detection of specific IgE to ricebran(rieebran-RIA), 23 cases (29.5%) in 78 cases with positive skin reactivity ( >=21+ ) of ricebran noted positive reaction. 5. The detection rate of ricebran specific IgE were 30.6% in the group of positive skin test to the ricebran and 27.6% in group of negative akin test. There were no specific correlation between wheal size of skin prick test to ricebran and bound radioactivity(%) of ricebran-RIA. 6. The detection rate of ricebran specific IgE were 64.0% in 25 sera with more than 500IU / ml of total serum IgE and 73.6% in 53 sera with less than 500IU / ml. It was suggested that total IgE did not influence to deteet the specific IgE by ricebran- RIA. 7. There were remarkable cross-allergenicities among ricebran, ricehusk, brown rice and barley bran on ricebran-RIA inhibition tests. There was moderate cross allergenicity between ricebran and rice, but no cross allergenicities between ricebran and storage mite(T. putrescentiae). The refore, ricebran aa an inhalant allergen, which shows frequent positive reactions on skin prick test and of which specific IgE are detected in respiratory allergy patients, must be further evaluated carefully on its activities as an offending allergen on respiratory allergic diseases and on its cross allergenicity with allergenic pollens.
주거지원 대상자의 중도탈락 위험에 대한 연구 : 자율중도탈락과 강제중도탈락의 경쟁위험 분석을 중심으로
홍명기,공정식 사단법인 한국안전문화학회 2020 안전문화연구 Vol.- No.10
This study explored factors that affect the risk of dropout within support period of the housing support project among the rehabilitation protection projects of Korea Rehabilitation Agency. The subjects of this analysis were 3,128 people who supported by the project from 2005 to September 2009. As for the analysis method, survival analysis was used to consider the difference in the support period of each subject. Also, the dropout was classified into autonomous dropout and forced dropout according to each cause, and the competing-risk analysis was conducted considering that the two events are in competition with each other. The summary of the analysis results is as follows. When the risk of total dropout was used as a dependent variable, it was found that the support before release, age, education level and ex-crime type had statistically significant. In the result of competing-risk analysis, only age and education level were significant in the case of autonomous dropout. On the other hand, in case of forced dropout, the support before release, the time of revision, age, number of ex-crime and type of ex-crime were statistically significant. The two types of dropouts were compared. 1) The variables put in this study were better predicted the risk of forced dropout than the risk of autonomous dropout. 2) The support before release, the time of revision, and the previous disposition of criminal justice institutions were significant only in the forced dropout model. Finally, the interpretation of the above results and policy implications were discussed in conclusions and suggestions.
홍명기,공희경,김태성 한국경영정보학회 2014 한국경영정보학회 학술대회논문집 Vol.2014 No.1
자동차 내부에 ECU가 증가하고 메시지를 주고 받기 위한 내,외부 네트워크가 증가하면서 자동차는 기계 중심에서 전자제어 중심으로 변모하고 있다. 이러한 IT와 자동차의 융합은 인간에게 편리한 서비스를 제 공하기도 하지만 이와 못지 않게 보안위협 또한 증 가하게 만들었 다. 이에 자동차에 대한 보안위험관리 를 통한 대책이 필요한 시점이다. 보안위험관리를 위해서는 우선 보안위협에 대한 제대로 된 평가가 바탕이 되어야 할 것이 다. 본 논문에서는 자동차에 대한 보안위협평가를 위해서 보안위협이 무엇이 있 는지 식별하였으며 분석을 위한 프레임워크를 구성 하였다.