大防風湯의 LPS誘發 關節炎 緩和效果에 관한 實驗的 硏究

田元準,辛吉祚,李源哲 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.9 No.-

본 실험은 大防風湯이 혈관생성과 세포유착인자발현 억제를 통해 LPS(lipopolysaccharide)유발 관절염 완화에 미치는 영향을 조사하기 위해 LPS주사로 관절염이 유발된 생쥐에게 大防風湯 추출액을 음용 투여하였다. 실험동물은 20g된 female Balb/c계 생쥐암컷을 선별하여 아무런 처치를 하지 않은 대조군, 무릎관절에 LPS를 주사한 LPS군, LPS주사후 大防風湯 추출액을 투여한 DBP군으로 나누어, 다시 LPS와 DBP군을 LPS처리 후 시간의 경과에 따라 3, 7, 14일로 구분하였으며, 실험군 각각에는 실험동물을 10마리씩 배정하였다. 광학 현미경(BX50)으로 大防風湯 추출액 투여가 LPS주사 후 증가된 윤할 관절막내 혈관분포 증가에 미치는 영향과 아울러 윤활세포, 섬유화 및 섬유모세포, 비만세포와 염증관여세포, 세포유착인자 등의 윤활 관절막에서의 형태변화를 관찰하였다. DBP군에서는 자유면에서 윤활세포과형성의 억제와 침윤 림프구의 감소, 낮은 섬유화 양상과 침적 섬유모세포의 감소, 모세혈관 주변의 림프구 침적 감소와 비만세포 분포감소, 자유면과 섬유지지역분포 ICAM과 혈관주변분포VCAM 등과 같은 세포유착인자의 감소 등이 관찰되었다. 이상의 결과로 볼 때 大防風湯은 관절염 유발시 발생되는 혈관생성과 세포유착인자의 발현증가 등을 억제함으로써 이후 발생되는 윤활 관절막 손상을 완화하는 것으로 사료된다. Purpose : This study is to investigate the alleviation effects of Daebangpoongtang in LPS induced arthritis in mice knee joint. Methods : Daebangpoongtang was chosen to treat the arthritis caused by injecting 300 μg/kg LPS to mice knee joint. The control group had no treatment, while the LPS group was injected 300μg/kg LPS to mice knee joint and the DBP group was oral administrated of Daebangpoongtang. After injection of 300μg/kg LPS to mice knee joint, the alteration of synovial lining cell, vessel, fibrosis, distribution of collagen fiber, fibroblast, mast cell, infiltration of inflammation component cell and distribution of ICAM and VCAM was observed by light microscope(BX50). Results : In the DBP extract treatment group, the distribution of vessel, the enlargement of synovial lining cell layer, the synovial lining cells with filopodia, the fibrosis, the distribution of fibroblast in synovial membrane, the distribution of ICAM and VCAM on the knee joint was less than that of LPS group. Infiltrated lymphocyte into the apical surface had not observed in the DBP extract treatment group. The distribution of mast cell was as same as control group(no treatment group) and it showed granulated type. Conclusion : According to the above results, it might be considered that the administration of Daebangpoongtang has a curative effect on synovial membrane injury in arthritis by inhibiting increase of vessel, cell adhesion molecule(1CAM and VCAM) in LPS induced arthritis.

果樹栽培에 있어서 深耕의 效用과 그 方法

全源俊 건국대학교 농과대학 연합학회 1970 건농 Vol.- No.3

대학생의 학업소진, 가족기능, 삶의 만족감과 우울감의 관계

전원준,조은상,심민규,최경민,이가영 한국성인간호학회 2023 성인간호학회 학술대회 Vol.2023 No.7

머신 러닝 회귀 모델과 딥러닝 모델을 활용한 산사태 취약성 분석

전원준,송원준,윤아영,전찬미,이정현,박혁진 대한지질공학회 2023 대한지질공학회 학술발표회논문집 Vol.2023 No.2

偏頭痛 患者 1例에 관한 證例報告

전원준,김민석,신길조,이원철 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1

Migraine is one of common diseases clinically. The location of headache is most prominent on bifrontal region and pulsating type is the most common headache nature. Among the auras of migraine with aura, visual aura is most common. Migraine is combined one or more associated symptoms. Among thease symptomes, anorexia, nausea and vomiting are most common. Its accurate pathogenesis is still unknown. Recently we have experienced a 47-years old woman who is diagnosed as Classic Migraine or Migraine with aura and whose condition was prominently improved through Oriental medical treatment.

도시하천도로의 EAP수립을 위한 침수특성분석 - 중랑천 동부간선도로를 중심으로 -

이종태,전원준,허성철,Lee, Jong-Ta,Jeon, Won-Jun,Hur, Sung-Chul 한국방재학회 2006 한국방재학회논문집 Vol.6 No.3

본 연구에서는 침수위험이 큰 도시하천내에 건설된 도로의 침수로 인한 피해를 미연에 방지하고 적절한 교통통제계획, EAP 등을 수립하기 위한 수문, 수리학적 분석과정을 제시하였다. 연구대상지역으로 우리나라의 대표적 도시하천인 중랑천 유역의 좌우안에 위치한 동부간선도로를 선정하고 비상대처계획 수립을 위한 기초자료를 작성하였다. HEC-HMS에 의하여 유출 해석을 실시하였으며, UNET을 이용하여 주요 지점 및 구간별 침수특성을 분석하였다. 이문철교부근(하구에서 약 9.5 km)과 월릉교부근(하구에서 약 11.5 km)에서 침수위험이 가장 높아 이문철교부근은 10년 빈도시에, 월릉교부근의 좌안도로는 20년 빈도시에 각각 침수가 되는 것으로 나타났다. 누가강우량과 지속시간을 고려한 침수특성 분석결과 강우 지속시간 7시간 이하에서 누가강우량이 250 mm이상일 경우에는 월계1교지점의 위험홍수위(EL.17.84 m)를 초과하는 것으로 분석되었다. 한강의 배수위를 고려하지 않은 경우에는 C2(월계1교-중랑교, 좌안), C1(월계1교-중랑교, 우안), D(중랑교-군자교)구간순으로 침수위험이 높은 것으로 나타났으나 배수위를 고려한 경우에는 D2(중랑교-군자교, 좌안), E(군자교-용비교)구간의 침수위험이 오히려 높은 것으로 분석되었다. An hydraulic and hydrologic analysis procedure was proposed to reduce the inundation damage of highway in urban stream, that could contribute the EAP and Traffic control planning of Dongbu highway in the Jungrang stream basin which is one of the representative urban area in Korea. We performed the HEC-HMS runoff analysis, and the UNET unsteady flow modeling to decide the inundation reaches and their characteristics. The high inundation risk areas were of Emoon railway bridge and the Wollueng bridge, which are inundated in the case of 10 year and 20 year frequency flood respectively. We also analyze the inundation characteristics under the various conditions of the accumulation rainfall and the duration. Flood elevation at the Wolgye-1 bridge exceed over Risk Flood Water Level(EL.17.84 m) when the accumulation rainfall is over 250 mm and shorter duration than 7 hr. When neglecting backwater effect from the Han river, inundation risk are highly at the reach C2(Wolgye-1 br. ${\sim}$Jungrang br., left bank), C1(Wolgye-1 br. ${\sim}$Jungrang br., right bank), D(Jungrang br. ${\sim}$Gunja br.) in order, but when consider the effect, the inundation risk are higher than the others at the reach D2(Jungrang br. ${\sim}$Gunja br., left bank) and E(Gunja br. ${\sim}$Yongbi br.), which are located downstream near confluence.

부정류 모형을 이용한 중랑천 동부간선도로의 침수특성분석

허성철(Hur Sung-Chul),전원준(Jeon Won-Jun),이종태(Lee Jong-Tae) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10

생지황(生地黃) 추출물(抽出物)이 DNCB로 유발(誘發)된 생쥐의 Allergy성(性) 접촉피부염(接觸皮膚炎)에 미치는 영향(影響)

신광식,손정숙,김동은,전원준,정승현,신길조,이원철,Shin Gwang-Sik,Son Jeong-Suk,Kim Dong-Eun,Jeon Won-Jun,Jeong Seung-Hyeon,Sin Gil-Jo,Lee Won-Cheol 대한한의학방제학회 2000 大韓韓醫學方劑學會誌 Vol.8 No.1

Allergic contact dermatitis is a common skin disease resulting from specific immunologic to topically applied various allergen. After Dinitrochlorobenzene (DNCB) secondary sensitization, the ICR mice administered Rhemanniae radix extract (RRE) was observed to ascerstain the effect of RRE on allergic contact dermatitis. Purpose of this study was to investigate contact hypersensitivity assay, abdominal skin morphologic changes. Including mast cells and cell-surface glycoconjugates. The change of interleukin 2 (IL-2) receptor (CD25R). ICAM in abdominal skin, lymph node of inguinal region, and electro microscope-morphologic changes of abdominal skin. The results of this study were as follows: 1. The contact hypersensitivity assay, the ear swelling in the RRE had lesser probability than in the ACD Group. 2. In the general morphologic change of skin, hyperplasia of keratinocytes, distribution of vasculogenesis and epidermal lymphocytes infiltration were decreased in the RRE group compared with the ACD group. In epidermal basal layer and prickle layer, cell damage was decreased in the RRE group compared with the group painted with ACD. 3. MasT-cell in dermis was decreased in the RRE group compared with the group painted with DNCB. 4. Distribution of interlukin-2 Receptior positive cell and ICAM positive cell in dermis was decreased in the RRE Group compared with the ACD group. 5. Distribution of helper T-lymphocyte and cytotoxic T-lymphocite in inguinal nodes was decreased in the RRE group, and was observed well in paracortical area and cortical cord. 6. Distribution of apoptotic cell was appeared in the RRE group compared with the ACD group, in skin, dermis. in inguinal nodes, paracortical area observed well. With above results, the restarint of immunosuppression occuring in Allergic contact dermatitis is resulted in the slow progress the effect of Allergic contact dermatitis, and it is thought that ithis fact has a series of relation with apoptosis.

어휘성향에 의한 남녀 분류

이승철(SeungCheol Lee),김대원(Daewon Kim),원규연(KyuYeon Won),전원준(WonJun Jeon),강태원(TaeWon Kang) 한국정보기술학회 2017 Proceedings of KIIT Conference Vol.2017 No.12