Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study

오은혜,Kim Ye-Jee,Minju Kim,박승하,김태오,박상형 대한장연구학회 2023 Intestinal Research Vol.21 No.2

Background/Aims: We conducted a nationwide population-based study to investigate incidence rates of colorectal and biliary cancers according to accompanying primary sclerosing cholangitis in Korean ulcerative colitis patients. Methods: We used the Health Insurance Review and Assessment claim database from January 2007 to April 2020. Standardized incidence ratios of colorectal and biliary cancers in ulcerative colitis patients were calculated. Results: Among 35,189 newly diagnosed ulcerative colitis patients, 1,224 patients were diagnosed with primary sclerosing cholangitis. During the study period, 122 and 52 patients were diagnosed with colorectal and biliary cancers, respectively. Incidences of colorectal cancer were not higher in ulcerative colitis patients than those in the general population (standardized incidence ratios, 0.83; 95% confidence interval, 0.69–0.99), regardless of accompanied primary sclerosing cholangitis (standardized incidence ratio, 0.73; 95% confidence interval, 0.24–1.71). While incidences of biliary cancer were not higher in ulcerative colitis patients than those in the general population (standardized incidence ratio, 1.14; 95% confidence interval, 0.80–1.58), these were much higher with accompanied primary sclerosing cholangitis (standardized incidence ratio, 10.07; 95% confidence interval, 5.75–16.36). Cumulative incidences of colorectal and biliary cancers increased in patients who were diagnosed with ulcerative colitis at an older age. Conclusions: In Korean ulcerative colitis patients, colorectal cancer incidences were not higher than those in the general population regardless of accompanied primary sclerosing cholangitis. However, biliary cancer incidences were much higher in ulcerative colitis patients with primary sclerosing cholangitis than in those without, or in the general population.

The identification of Korean vowels /o/ and /u/ by native English speakers

오은혜 한국음성학회 2016 말소리와 음성과학 Vol.8 No.1

The Korean high back vowels /o/ and /u/ have been reported to be in a state of near-merger especially among young female speakers. Along with cross-generational changes, the vowel position within a word has been reported to render different phonetic realization. The current study examines native English speakers’ ability to attend to the phonetic cues that distinguish the two merging vowels and the positional effects (word-initial vs. word-final) on the identification accuracy. 28 two-syllable words containing /o/ or /u/ in either initial or final position were produced by native female Korean speakers. The CV part of each target word were excised and presented to six native English speakers. The results showed that although the identification accuracy was the lowest for /o/ in word- final position (41%), it increased up to 80% in word-initial position. The acoustic analyses of the target vowels showed that /o/ and /u/ were differentiated on the height dimension only in word-initial position, suggesting that English speakers may have perceived the distinctive F1 difference retained in the prominent position.

Mandarin Chinese Speakers’ Production of English Vowel Duration as a Function of Coda Voicing and Syllable Number

오은혜 한국응용언어학회 2017 응용 언어학 Vol.33 No.1

The current study compared native English-speaking adults’ and native Mandarin-speaking adults’ ability to produce context-specific vowel duration differences under the assumption that variability is higher in non-native language learners’ production. A total of twenty native Mandarin and English speakers produced real English words in a frame sentence multiple times. The mean vowel and consonant closure duration and vowel duration variability were analyzed. The results were that Mandarin Chinese speakers produced considerably smaller contrasts but greater temporal variability than English speakers in their production of individual words. The results indicated that the phonological knowledge of L1 is likely to interfere with the temporal patterns of L2 production.

English-Speaking Children’s Knowledge of Stress Patterns

오은혜 한국외국어대학교 영미연구소 2014 영미연구 Vol.31 No.-

The developmental patterns of stress placement was examined in across-sectional study of native English-speaking children aged 5, 6, 7 and8 years old. A total of thirty five children produced two-syllabic nonwordsof varying syllabic structures in both noun and verb contexts. Children’scapability of combining two syllables and the proportion of first syllablestress responses were coded as a function of the developmental patterningof word stress. The results showed a significant effect of syllabicstructure on children’s stress placement. Lexical class was more likely tobe employed in older children with larger vocabularies. The effects of ageand lexicon size were discussed in relation to development of stresspatterns.

임상 추론: 두통과 복시로 내원한 38세 남자

오은혜,최재환 대한신경과학회 2018 대한신경과학회지 Vol.36 No.4

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은퇴 노인소비자의 소비 행위를 통한 정체성 찾기

오은혜,최혜경 한국소비자학회 2014 한국소비자학회 학술대회 Vol.2014 No.5

The effect of L2 experience on the perception of L1 prosody

오은혜 한국음운론학회 2017 음성·음운·형태론 연구 Vol.23 No.2

The effects of second language experience on adult learners’ perception of native language prosody are investigated. Three sets of 13 sentences produced in Korean, Mandarin, and Japanese, respectively, by three female speakers were low-pass filtered and presented to three groups of 10 participants with different language backgrounds: Native Korean speakers with no L2 experience (NK), native Mandarin Chinese speakers (NC) and Korean learners of Chinese (KC) with an average LOR in China of 1 year. The participants were instructed to listen to each stimulus and decide whether it was Korean or not based on the suprasegmental features. Overall, the NK group (76%) revealed significantly higher accuracy than the KC (65%) or the NM group (57%). However, the NM participants with extensive Korean experience showed a significantly high accuracy for both Korean (75%) and Chinese (84%). The results indicate a significant effect of L2 experience on the acquisition of L1 prosody, yet the KC group’s lower accuracy for Korean, on the other hand, suggests that too much attention may have been directed towards acoustically salient L2 cues (e.g., F0 range) in the perception of L1 prosody.

지역거점 병원의 소아청소년 감염 예방과 통제를 위한 공간 분석 연구

오은혜,권지훈 한국청소년시설환경학회 2017 청소년시설환경 Vol.15 No.1

Incidence and Clinical Significance of Positional Downbeat Nystagmus in Posterior Canal Benign Paroxysmal Positional Vertigo

오은혜,이재훈,김효정,최서영,최광동,최재환 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.2

Background and Purpose The aim of this study was to determine the incidence and clinical significance of positional downbeat nystagmus (pDBN) after treatment of posterior canal (PC) benign paroxysmal positional vertigo (BPPV). Methods We recruited 77 patients with a diagnosis of PC BPPV, and assessed the presence of pDBN during follow-up positional tests after performing the Epley maneuver. Results An immediate response to the Epley maneuver was exhibited by 57 of the 77 patients, with resolution of their positional torsional upbeat nystagmus (pT-UBN). Twenty-two (39%) of them exhibited pDBN during follow-up tests performed 1 hour later. The latency and duration of pDBN were 3.2±2.0 and 12.0±10.0 s (mean±SD), respectively. The maximum slowphase velocity of pDBN was 5.1±2.5 degrees, and ranged from 2.0 to 12.2 degrees. A torsional component was also observed in six patients. The patients with pDBN were much more likely to develop a typical form of PC BPPV again at a 1-week follow-up (5/22, 23%) compared to those without pDBN (1/31, 3%; p=0.036). pDBN disappeared in all patients within 6 months. Conclusions Our study found transient pDBN in 40% of patients with PC BPPV after the immediate resolution of positional vertigo and pT-UBN. pDBN may be attributed to residual debris in the distal portion of the PC, which can move toward the ampulla producing an ampullopetal flow of endolymph during positioning.

Effects of L2 experience on the production of Korean stop contrasts by Mandarin Chinese learners

오은혜 경희대학교 언어정보연구소 2018 언어연구 Vol.35 No.1

Effects of L2 experience on the segmental and prosodic production of second language were investigated. Thirty two Chinese learners of Korean varying in the amount of experience (3 months vs. 2 years) were compared to sixteen age-matched native Korean speakers in their production of three-way contrastive stops (aspirated, lenis, tense). Korean four-syllable phrases (i.e., Accentual Phrase) beginning with each stop type in a word-initial position were elicited. VOT, F0, H1-H2 values of the segments as well as an Accentual phrase-initial boundary tones were analyzed and compared across groups. The results showed significant differences in F0 and H1-H2 as a result of experience, albeit F0 was not native-like in the experienced group’s production. The Accentual phrases-initial boundary tones, however, were produced with a native-like F0 pattern regardless of the amount of L2 experience. The native-like production of VOT and F0 in the tonal context in both L2 groups is likely to be the influence of L1, whereas the improved cues, H1-H2 and F0 in the segmental context, are the result of L2 experience.