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초등학생의 창의 과정과 산물의 관계를 탐색하기 위한 과학 창의성 검사 도구 개발 - 생명 영역을 중심으로 -
김민주 ( Kim¸ Minju ),임채성 ( Lim¸ Chaeseong ) 한국초등과학교육학회 2021 초등과학교육 Vol.40 No.4
이 연구는 초등학생의 창의 과정과 산물의 관계를 탐색하기 위한 과학 창의성 검사 도구를 개발하는 데 목적을 두고 있다. 이를 위해 연구자는 과학 창의성 관련 논문을 분석한 후, 창의 과정과 산물의 구성요인에 근거하여 문항을 개발하였다. 그리고 과학 교육 전문가 9명의 검토를 마친 검사 도구를 파일럿 테스트하였다. ‘동물’, ‘식물’의 두 세트로 이루어진 검사 도구는 수정과 보완을 거쳐 최종적으로 5학년 학생 105명에게 투입되었다. 투입 결과는 WinSteps, SPSS와 AMOS 통계프로그램으로 분석되었다. 이 연구의 주요 결과는 첫째, 과학 영역에서 창의 과정은 과학 지식, 탐구기능, 창의적 사고기능(확산적, 수렴적, 연관적 사고)을 포함한다. 창의 산물은 새로우면서 과학적으로 유용한 아이디어가 어떤 형태로 나타난 것이다. 둘째, 이 연구에서 대표 탐구기능으로 선정된 관찰은 구성 타당도 측면에서 창의적 사고기능과 연관성이 없어야 했다. 셋째, 유용성 항목은 다른 항목 중 가장 낮은 평균치를 기록하였는데, 평가자인 교사의 관점에서 과학적 타당성과 유용성을 만족시키기 어렵기 때문으로 사료된다. 넷째, 동형검사 신뢰도를 알아보기 위한 ‘동물’과 ‘식물’ 문항 간 스피어만 상관 계수는 독창성 항목을 제외하고 유의하게 나타났다. 다섯째, 검사 도구는 집중타당성, 판별타당성, 법칙타당성 세 가지 측면에서 구성 타당도를 대체로 만족시켰다. 연구 결과를 바탕으로 창의 과정과 산물의 관계를 탐색하고 학교 현장에서 실제적인 평가 도구로 역할을 할 검사 도구의 유용성을 논하였다. This study aims to develop a scientific creativity test for exploring the relationship between elementary students’ creative process and product. For this, the researcher reviewed the literatures of scientific creativity and developed the items based on the constructs of creative process and product. After a review conducted by nine science education specialists, a pilot test, and additional revision and supplementation of observation test, the test, consisting of two sets-“animals” and “plants”-was finally conducted on 105 fifth-grade students. The test results were analyzed by using statistical analysis software. WinSteps, SPSS, and AMOS. The main findings from this study are as follows. First, when it comes to scientific creativity, creative process consists of science knowledge, inquiry skills, and creative thinking skills (divergent, convergent, and associative thinking skills). Creative product in science is a new and scientifically useful idea realized in a certain form. Second, observation, which was selected as a representative inquiry skill in this research, should not be related to creative thinking skills. Third, among the rest of the items, usefulness had the lowest averages, as it was, perhaps, difficult to satisfy the teachers’ criteria for the scientific validity and usefulness. Fourth, the Spearman correlation coefficients between the items of “animals” and “plants” to find out the parallel-form reliability were significant, except for the item of originality. Fifth, the test was satisfactory with regard to the three aspects of construct validity―convergent, discriminant, and nomological. This study concludes by discussing the usefulness of this test, which has the possibility of exploring the relationship between creative process and product and of playing a role as an authentic evaluation tool in school.
Kim, Heon Seok,Lee, Kyungjin,Bae, Sangsu,Park, Jeongbin,Lee, Chong-Kyo,Kim, Meehyein,Kim, Eunji,Kim, Minju,Kim, Seokjoong,Kim, Chonsaeng,Kim, Jin-Soo American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.25
<P>Several groups have used genome-wide libraries of lentiviruses encoding small guide RNAs (sgRNAs) for genetic screens. In most cases, sgRNA expression cassettes are integrated into cells by using lentiviruses, and target genes are statistically estimated by the readout of sgRNA sequences after targeted sequencing. We present a new virus-free method for human gene knockout screens using a genome-wide library of CRISPR/Cas9 sgRNAs based on plasmids and target gene identification via whole-genome sequencing (WGS) confirmation of authentic mutations rather than statistical estimation through targeted amplicon sequencing. We used 30,840 pairs of individually synthesized oligonucleotides to construct the genome-scale sgRNA library, collectively targeting 10,280 human genes (<I>i.e.</I> three sgRNAs per gene). These plasmid libraries were co-transfected with a Cas9-expression plasmid into human cells, which were then treated with cytotoxic drugs or viruses. Only cells lacking key factors essential for cytotoxic drug metabolism or viral infection were able to survive. Genomic DNA isolated from cells that survived these challenges was subjected to WGS to directly identify CRISPR/Cas9-mediated causal mutations essential for cell survival. With this approach, we were able to identify known and novel genes essential for viral infection in human cells. We propose that genome-wide sgRNA screens based on plasmids coupled with WGS are powerful tools for forward genetics studies and drug target discovery.</P>
A case of idiopathic hypertrophic pachymeningitis presented with seizures
Kim, Minju,Kim, Joong-Goo,Kang, Chul-Hoo,Kim, Hong Jun,Kang, Sa-Yoon,Oh, Jung-Hwan The Korean Society of Clinical Neurophysiology 2022 Annals of Clinical Neurophysiology Vol.24 No.2
Idiopathic hypertrophic pachymeningitis (IHP) is a rare disease involving localized inflammatory thickening of the intracranial or spinal dura mater without an identified cause. Seizure is a very unusual presentation of IHP. We present a 58-year-old-female patient with seizures caused by IHP. This case indicates that although IHP is rare, it has the potential to cause seizures.
Kim Jeong-Whun,Kim Hyo sang,Kim Minju,Kim Su Hwan,Cho Sung-Woo,김진엽 대한의학회 2021 Journal of Korean medical science Vol.36 No.6
Background: The patients with coronavirus disease 2019 (COVID-19), a worldwide pandemic infection, frequently complain of olfactory disorders. However, psychophysical olfactory tests performed by an examiner are very difficult in these highly infectious patients. This study aimed to develop and validate a questionnaire for olfactory function that can be readily used to evaluate olfactory loss. Methods: Fourteen smell-related questions were created based on smells familiar to Koreans. Among them, questions with a κ value of 0.6 or higher were finally selected through a test-retest reliability analysis. The correlations between the scores of the olfactory questionnaire and those of olfactory function tests (Butanol Threshold Test [BTT] and Cross Cultural Smell Identification Test [CCSIT]) were analyzed. To evaluate the predictive ability of the questionnaire and elicit cutoff values, receiver operating characteristic (ROC) curves were generated. Results: Out of the 14 questions in the questionnaire, 11 (κ > 0.6) were selected for the olfactory questionnaire. We analyzed 2,273 subjects, and there was a significant correlation between the total score of the olfactory questionnaire and the BTT (r = 0.643, P < 0.001) or CCSIT (r = 0.615, P < 0.001) scores. ROC curves for the olfactory questionnaire, BTT, and CCSIT all demonstrated high predictive power to discriminate anosmia and severe hyposmia from normosmia. Regarding mild to moderate hyposmia, however, ROC curve for the olfactory questionnaire alone showed high predictive power of discrimination from normosmia. Based on the results of ROC curves among the subclasses, we suggest the classification of the total score of the questionnaire as 0–4, 5–17, 18–27, 28–41, and 42–44, for anosmia, severe hyposmia, moderate hyposmia, mild hyposmia, and normosmia, respectively. Conclusion: The total scores of the questionnaires correlated with the BTT and CCSIT scores. The symptom questionnaire for olfactory dysfunction may be useful as an alternative tool for olfactory function testing, when unavailable.
김민주(Minju Kim),김소연(So Yeon Kim),장근정(Geun Jung Jang),이용호(Yong Ho Lee),홍선희(Sun Hee Hong),김성문(Songmun Kim) 한국잡초학회 2021 Weed & Turfgrass Science Vol.10 No.3
전 세계적으로 많은 사람들이 잡초의 꽃가루로 인해 알레르기 결막염, 비염, 천식, 아나필락시스 등 다양한 알레르기 관련 질환으로 고통받고 있으며, 한국 인구의 30% 이상이 꽃가루 알레르기를 앓고 있는 것으로 보고되고 있다. 공중 보건에 대한 악영향에도 불구하고 알레르기 잡초와 한국 내에서의 분포에 대해서는 알려진 바가 거의 없기에 저자들은 알레르기의 작용기전, 알레르기를 유발하는 국내 잡초와 국내에서의 분포, 그리고 알레르기 유발 잡초가 주는 시사점을 소개한다. 잡초에 의해 발생하는 알레르기성 질환은 일반적으로 꽃가루로 인해 발병하며, 현재 미세먼지와 꽃가루 수가 증가함에 따라 실제로 알레르기성 비염의 진단율은 가파르게 상승하고 있다. 알레르기 잡초가 국민건강에 미치는 경제·사회적인 영향은 매우 크기에, 본 리뷰에서는 이와 같은 알레르기 질환을 유발하는 환삼덩굴속(Humulus), 소리쟁이속(Rumex), 명아주속(Chenopodium), 댑싸리속(Kochia), 갯능쟁이속(Atriplex), 비름속(Amaranhus) 질경이속(Plantago), 돼지풀속(Ambrosia), 도꼬마리속(Xanthium), 미역취속(Solidago), 개망초속(Erigenom), 쑥갓속(Chrysanthemun)에 속하는 식물들에 대해 다루었으며, 이들과 같은 알레르기 잡초는 향후 한국 잡초학회 회원들의 주요 연구 주제가 될 것이라 기대된다. Many people in the world are suffering from various allergy-related diseases, such as allergic conjunctivitis, rhinitis, asthma, and anaphylaxis, caused by the pollen grains of weeds. More than thirty percent of the population in Korea is reported to have been suffering from pollen allergies. Despite their adverse effects on public health, little is known about allergic weeds and their distribution in Korea. The authors introduce the mechanism of action of allergies, the domestic weeds that cause allergies and their distribution in Korea, and the implications of the allergy-causing weeds. Most of allergies are caused by the pollen from the flower of weeds, e.g., Humulus, Rumex, Chenopodium, Kochia, Atriplex, Amaranthus, Plantago, Ambrosia, Xanthium, Solidago, Erigenom, and Chrysanthemun plants, which are discussed in this review. Recently the increasing of the concentration of fine dust and pollen became a great cause of an allergic disease, just like the diagnostic yield of allergic coryza. The effects of weeds on people"s health are expected to become an important research topic among members of the Korean society of weed science.