악성 임파종의 조직병리학적 관찰 : 106례의 분석 보고 및 비호지킨스 임파종의 IWF에 따른 분류 Analysis of 106 Cases and Reclassification of Non-Hodgkin's Lymphoma by International Working Formulation

조혜제,고일향 인제대학교 1989 仁濟醫學 Vol.10 No.4

인제의대 서울백병원 병리과에서 1978년 1월부터 1987년 12월 말까지 만 10년 동안 악성임파종으로 진단된 113례 중 임파계 타질환으로 사료되는 7례를 제외한 106례를 대상으로 재검색을 시행하였고 이 중 비호지킨스 임파종군은 1982년 제정된 International Working Formulation에 따라 재분류하였다. During an 10 years period from January 1978 to December 1987, there was a total 106 cases that were diagnosed and reconfirmed by Leukocyte Common Antigen as malignant lymphoma at the Department of pathology of Seoul paik Hospital. Among malignant lymphoma, non-Hodgkin's lymphoma accounted for 85% and Hodgkin's lymphoma was for 15%. The most frequent types of non-Hodgkin's lymphoma by International Working Formulation were diffuse large lymphocytic type(29%) in the nodal site and diffuse small cleaved lymphocytic type(34%) in the extranodal sites. Among Hodgkin's lymphoma by Rye classification, mixed cellularity type was the most common type. The international working formulation was used to faciliate for histologically subdividing non-Hodgkin's lymphomas into categories which carry prognostic implication in relation to recent therapeutic modalities.

Oral Extranodal Non Hodgkin's Lymphoma: Series of Forty Two Cases in Malaysia

Ramanathan, Anand,Mahmoud, Hagir Abd Rahman,Hui, Lew Pit,Mei, Ng Yan,Valliappan, Valliammai,Zain, Rosnah Binti Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Background: Lymphoma is a malignant neoplasm of lymphoid tissue classified into Hodgkin's and non- Hodgkin's types. It mostly affects lymph nodes although a considerable proportion of Non-Hodgkin's cases occur in extranodal sites. Materials and Methods: Selected cases diagnosed as non-Hodgkin's lymphoma (NHL) during the period of 1980 to 2012 were retrieved from the archives of the Oral Pathology Diagnostic Laboratory, Faculty of Dentistry, University of Malaya. The sections from the formalin-fixed paraffin embedded tissue blocks were stained with H&E as well as with LCA, CD20, and CD3. Results: The mean age was 41.6 years with a male: female ratio of 1.3:1. Out of the forty two cases, nineteen were Malays, eighteen were Chinese, followed by Indians (3) and Indonesians (2). The most common site of involvement was the mandible (22.2%), followed by the maxilla and palate (19.4% each). Most of the lesions presented as a painless progressive swelling. Only thirty six cases were further subdivided into B or T cell types. The majority were B-cell type (26 cases), of these 6 cases were Burkitt's lymphomas. Only ten cases were T-cell lymphoma, with three cases of NK/T-cell lymphoma. Conclusions: In this series of 42 patients diagnosed as extranodal non-Hodgkin's lymphoma, the lesions appeared as painless swellings, mostly in men with the mandible as the most frequent site of involvement. Majority were B-cell lymphomas with Malays and Chinese being equally affected whereas lymphomas were rare in the Indian ethnicity. T-cell lymphomas were found to be common in the Chinese ethnic group.

비 호지킨씨 임파종 300예에 대한 병리조직학적 연구

안희정,정순희,정현주,신동환,이광길,최인준 대한병리학회 1988 Journal of Pathology and Translational Medicine Vol.22 No.3

비호지킨림프종의 임상상과 예후인자

김태원(Tae Won Kim),이정신(Jung Shin Lee),최성준(Sung Jun Choi),최종수(Jong Soo Choi),장대영(Dai Young Zang),이제환(Je Hwan Lee),김성배(Sung Jun Choi),김상위(Sang We Kim),서철원(Cheol Won Suh),이규형(Kyoo Hyung Lee),김우건(Woo Kun Ki 대한내과학회 1997 대한내과학회지 Vol.52 No.2

N/A Objectives: The advent of intense combination chemotherapy has transformed aggressive non-Hod-gkins lymphoma from a disease that was once uniformly fatal to one that is now often curable. Remission rates and survival may be improved by using intensive chemotherapy regimens. However, this more aggressive approach is inevitably associated with increased toxicity, and an accurate pretreament prognostic assessment of patients is required to guide the physician in selecting the most appropriate therapeutic regimen. Many studies have reported prognostic factors of non-Hodgkins lymphoma in western countries, but there are few reports on prognostic factors in Koreans and it is suggested that clinical characteristcs of non-Hodgkins lymphoma in Korea differ from those in western countries. The purpose of this study was to illustrate clinical characteristics, prognostic factors and treatment outcome in non-Hodgkins lymphoma in Korea. Methods: Clinical features of 151patients (age over 15years) with non-Hodgkins lymphoma registered at Asan Medical Center from March 1989 to December 1993 were retrospectively reviewed. Prognostic factors and treatment outcome were evaluated among 121previously untreated patients. Multi variate analysis of potential pretreatment prognostic factors was performed using Coxs proportional hazards model. Results: Of the 151patients evaluated, 55% had diffuse large cell type, while low-grades were encountered in less than 1% of the patients. Extranodal involvement was noted in 76% of the patients. Cental nervous system was the commonest primary extranodal site, followed by stomach. Complete remission was achieved in 73 of 121patients (60%). The median follow-up for 121patients was 24months and the actuarial overall survival was 48% at 3years and 44N at 5years with a median overall survival of 33months. At the median followup of 32months, the actuarial 5year disease-free survival rate among 73patient with complete remission was 65% and median remission duration was not reached. Presence of systemic B symptoms and advanced clinical stages were associated with a low complete remission rate. None turned out to be associated with the remission duration. The Coxs proportional hazards model identified age above 60years, presence of systemic B symptoms and elevated LDH level as significant independent poor prognostic factors influencing overall survival. Conclusion: This study reveals a low prevalence rate of the low-grades lymphoma and a higher propensity of diffuse large cell type. These results suggest that clinical characteristics of non-Hodgkins lymphoma in Korea are different from those in the western countries. Our data also show that certain pretreatment clinical factors can help in predicting survival and in planning treatment.

한국인 악성 림프종의 Epstein-Barr Virus 분포에 관한 연구

고영혜,이중달 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.11

비호지킨 림프종의 REAL 분류와 cyclin D1, bcl-2, p53및 bcl-6 단백발현

이미자,전호종,정종달,박유환,김민 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives : There has been a continuous evolution of the lymphoma classification and recently a Revised European-American Lymphoma (REAL) classification was proposed by the International Lymphoma Study Group. This new classification requires information on immunophenotypic and molecular biologic markers in addition to the usual histologic findings. The distinction between mantle cell lymphoma (MCL) and other low grade B cell lymphomas is important because MCL has a more aggressive clinical course. The aim of this study is to determine the clinical characteristics and the relative frequency of malignant non-Hodgkin’s lymphomas (NHL) and analyze the expression of the cyclin D1, bcl-2, p53 and the bcl-6 protein. Materials and Methods : One hundred and twelve cases of NHL were recategorized by the newly described REAL classification categories and investigated for the expression of the cyclin D1, bcl-2, p53 and bcl-6 protein by the immunohistochemical method. Results : There were higher rates of extranodal lymphoma, diffuse large B cell lymphoma, and angiocentric lymphoma and lower rates of T cell lymphoma and follicular center lymphoma compared with Western countries. Cyclin D1 is expressed in all cases of MCL. But no cases except for MCL showed positive for cyclin D1. The expression of bcl-2 had decreased in high-grade lymphomas. Conclusion : It suggests that the cyclin D1 expression in mantle cell lymphoma could be reliably distinguished from its expression in other non-Hodgkin’ s lymphomas. In addition, bcl-2 may be useful for the differentiation of the low grade lymphoma from the high grade lymphoma.

원발성 골반 비호지킨 림프종 3예

황현주 ( Hyun Ju Hwang ),강호영 ( Ho Young Kang ),한유정 ( Yu Jung Han ),조현철 ( Hyun Cheol Jo ),박지권 ( Ji Kwon Park ),신정규 ( Jeong Kyu Shin ),이순애 ( Soon Ae Lee ),이종학 ( Jong Hak Lee ),백원영 ( Won Young Paik ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.2

Primary pelvic non-Hodgkin`s lymphoma is a rare malignancy that has been reported in the retroperitoneum, ovary, uterine corpus, uterine cervix, vagina and vulva. Although primary pelvic lymphoma is rare, this may be encountered more frequently as the incidence of extranodal non-Hodgkin`s lymphoma increases. We experienced three cases of primary non-Hodgkin`s lymphoma of the pelvis. Two cases are primary non-Hodgkin`s lymphoma of the ovary and one is primary non-Hodgkin`s lymphoma of the retroperitoneum. We report these cases with a brief review of literature.

위 MALT 림프종으로 오인된 경부 악성 림프종 1예

도복태,김동현,모태규,김명준,장윤식 인제대학교 2001 仁濟醫學 Vol.22 No.1

The gastrointestinal tract is the most common site of primary extranodal lymphoma, and gastric lymphoma accounts for the majority of the cases. The primary lymphoma of gastrointestinal tract is about 4∼20 percent of all non-Hodgkin's lymphoma and 30 ∼ 40 percent of extranodal lymphoma. Microscopically, the majority of gastric lymphoid tumors are non-Hodgkin's lymphomas of B cell origin. Hodgkin's disease involving the stomach is extremely uncommon. Histologically, this tumor may range from well-differentiated, superficial processes (mucosa-associated lymphoid tissue) to high-grade, large cell lymphoma. Gastric lymphomas spread initially to regional lymph nodes(often to Waldeyer's ring)and may then disseminate We experienced a case of metastatic cervical lymphoma misdiagnosed as gastric mucosa-associated lymphoma.

에이즈 환자에서 병발한 위장 비호지킨 림프종 1예

오인균,김병엽,이민영,김도형,한승혜,김상억,김학찬,신동훈,이재용,김현철,이병두,오명돈,최강원,김철우 대한내과학회 2002 대한내과학회지 Vol.62 No.2

Non-Hodgkin's lymphoma (NHL) is the secondary most common tumor in HIV-infected individuals. The AIDS-related lymphomas are a late manifestation of HIV infection and may increase in frequency as patients live longer with highly active antiretroviral therapy and effective prophylaxis of opportunistic infections. Histologically AIDS-related NHL are either high (2/3) or intermediate (1/3) grade lymphoma. We report a case of gastric Non-Hodgkin's lymphoma in AIDS patient. Two years ago, she was diagnosed as HIV-infected individual in public hospital. She presented with epigastric pain and mass-like sensation. Under the impression of gastric cancer, subtotal gastrectomy was done. But, she diagnosed as diffuse large B cell lymphoma by histologic finding, immunohistochemical study. This is the first report of gastric Non-Hodgkin's lymphoma from AIDS patients in Korea(Korean J Med 62:223-229, 2002) 저자들은 인간면역부전바이러스 감염환자에서 이전에 에이즈로 정의되는 질환없이 지내던 63세 여자 환자에서 위장관에 발생된 비호지킨 림프종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Rare Non-Hodgkin Lymphoma in Childhood; A Single Center Experience

김현진,이다래,고경남,강성한,김혜리,임호준,서종진 대한소아혈액종양학회 2016 Clinical Pediatric Hematology-Oncology Vol.23 No.2

Background: Among pediatric non-Hodgkin lymphomas, there are 4 major subtypes: Burkitt lymphoma, lymphoblastic lymphoma, diffuse large B-cell lymphoma, and anaplastic large-cell lymphoma. Understanding of other rare subtypes derives only from small pediatric case series. We report our institutional experience with rare pediatric NHLs. Methods: Thirty-six cases of rare NHL subtypes diagnosed at the Asan Medical Center from 1995 to 2015 were evaluated. We retrospectively reviewed the clinical and pathologic features and outcomes of these patients, excluding peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), and extranodal NK/T-cell lymphoma (ENKL), on which we have previously reported. Results: There were 23 cases of T-cell lineage (13 PTCL, 6 ENKL, 2 subcutaneous panniculitis-like T-cell lymphoma, 1 primary cutaneous CD4+ small/medium sized T-cell lymphoma, 1 enteropathy-associated T-cell lymphoma) and 13 cases of B-cell lineage lymphoma (5 marginal zone lymphoma, 6 primary mediastinal large B-cell lymphoma, 2 immunoblastic and plasmablastic lymphoma). All patients were treated with chemotherapy with or without surgery, except 4 out of 5 patients with marginal zone lymphoma who received surgery only. Two patients died and 6 patients relapsed. One patient with primary mediastinal large B-cell lymphoma received autologous peripheral blood stem cell transplantation. The 5-year overall survival and event-free survival rates of rare pediatric NHL excluding PTCL, NOS, and ENKL was 80.0% and 72.0%, respectively. Conclusion: Children diagnosed with rare pediatric NHL other than PTCL, NOS, and ENKL showed variable incidence and treatment outcomes. Multicenter studies in larger cohorts are needed for better understanding of these rare NHL subtypes in childhood.