담관계암종 및 주변 전암병변의 면역조직화학적 특성

김지영,박영년,김호근 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.11

위선암에서 장형화생의 변이형에 관한 연구

제갈승주,최영자,곽효일,노정섭,최찬 대한임상병리사협회 2001 대한임상병리사회지 Vol.21 No.1

Case Report : Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

( Ji Ye Jung ),( Yoon Jae Kim ),( Hee Man Kim ),( Hong Jeoung Kim ),( Seung Woo Park ),( Si Young Song ),( Jae Bock Chung ),( Chang Moo Kang ),( Joo Yeon Pyo ),( Woo Ick Yang ),( Seung Min Bang ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.1

Hepatoid carcinoma is a primary extrahepatic carcinoma whose morphology, immunohistochemistry, and behavior are similar to those of hepatocellular carcinoma. The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature. We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man. Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas. He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin. Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma. The patient was healthy and had no evidence of recurrence at 4 months after the surgery. This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated. (Gut Liver 2010;4:98-102)

Helicobactor pylori Infection and Gastric Carcinoma in Korea

Kang, Seok Jin,Jee, Mi Kyung,Park, Yeon Joon,Choi, Yeong Jin,Kim, Byung Kee,Kim, Sun Moo CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.2

Gastric carcinoma is the most frequent malignant disease and the leading cause of cancer death in Korean. And the incidence of gastric carcinoma can change dramatically from place to place and from one generation to the next, if has been hypothesized that its incidence is determined largely by environmental rather than genetic factors. One specific histologic type of gastric carcinoma, the so-called intestinal type, is particularly prone to the regional and temporal variations of an environmentally related malignant condition. The recent identification of Helicobacter pylori (H. pylori) in chronic inflammatory conditions of the stomach, however, has stimulated interest in its potential role in carcinogenesis. H. pylori has been linked to chronic atrophic gastritis, and established precursor of intestinal type of gastric carcinoma. We designed a study to estimate the prevalence of H. pylori in 41 patients of intestinal type of gastric carcinoma and 42 patients of diffuse type gastric carcinoma and in 88 age and sex matched control persons by histologic examination of stomach in Warthin-Starry staining. The results were as follow; 1. In gastric carcinoma, 85.37% of 41 patients of intestinal type carcinoma, and 59.2% of 42 patients of diffuse type carcinoma were positive for H. pylori. In control group, 27.7% of 88 persons were positive for H. pylori. 2. To compare to control group, intestinal type of gastric carcimona was higher incidence of H. pylori infection to than that of diffuse type of gastric carcinoma. These findings suggest that H. pylori infection of stomach may be related to the gastric carcinoma in Korean. And H. pylori is more frequently found in the intestinal type of gastric carcinoma than diffuse type of gastric carcinoma.

대장의 용종성 암종과 침윤성 암종에서 p53, bcl-2, c-erbB-2 및 MIB-1 단백의 면역조직화학적 발현에 관한 비교연구

문정석,박성환,신봉경,이주한,신준호,염범우 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.8

Identification of candidate genes in basal cell carcinoma and differences in genetic mutations between indolent and aggressive type by whole exome sequencing

( So Yeon Yun ),( Min Ji Kang ),( Soo Young Lee ),( Joo Hee Lee ),( Dong Soo Yu ),( Young Bok Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Several genetic mutations such as those in TP53 and PTCH1 are associated with basal cell carcinoma development. Objectives: The aim of this study is to identify causative gene mutations of basal cell carcinoma arising on the face in a Korean population. Methods: This study analyzed genomic mutations of basal cell carcinoma using whole-exome sequencing of DNA specimens obtained from 20 Korean patients. After histopathological evaluations, 5 basal cell carcinomas were aggressive type with infiltrative pattern and 15 basal cell carcinomas were indolent type with nodular pattern. Results: 75% of basal cell carcinomas harbored somatic mutations in HH pathway genes and 45% harbored mutations in TP53. LRP1B and SMO were the most frequently mutated genes in basal cell carcinoma samples. Whereas LRP1B was the most frequently mutated gene in aggressive type basal cell carcinomas, SMO was the most frequently mutated gene in indolent type basal cell carcinomas. Specifically, LRP1B, ROS1, PTCH1, KMT2C, NSD1, ARID1A mutations were more frequent in aggressive type basal cell carcinomas than indolent type basal cell carcinomas. However, copy number gains of ROS1 gene were observed only in indolent type basal cell carcinomas. Other basal cell carcinoma related genes found in our study include KDR, KMT2D, FAT1, FAT4, GRIN2A, ERBB4, NOTCH2, PDE4DIP, TET1, ZFHX3, and PREX2. Conclusion: These results may provide insights for understanding basal cell carcinoma and treating the disease.

유두암과 여포 암에서 p53, Cylcin D1, Galectin-3 발현의 상관 관계

백운철 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.1

The thyroid is the organ that has the greatest risk of malignant tumors among the endocrine tumors. The papillary carcinoma occupies 80% of the entire thyroid tumors. Immunohistochemical staining of galectin-3 has usually been used in differentiating papillary carcinoma and follicular carcinoma. The p53 gene of the cell cycle is a tumor suppressor gene acting in on the control points. The cyclin D1 genes in the cell cycle, involved in the implementation of G1 and S phase, plays an important role in the progression of thyroid tumors. This research compares and analyzes correlation between papillary carcinoma, follicular carcinoma, p53, cyclin D1 and galectin-3 gene expression patterns. In a total of 30 cases from papillary carcinoma, 21 cases from p53 (70%), 27 cases in galectin-3 (90%), and 26 cases in cyclin D1 (86.7%) showed positive rate. The galectin-3 staining investigated, showed a significant difference between a papillary carcinoma and a follicular carcinoma. Follicular carcinoma from 15 cases, p53 in 13 cases (86.7%), galectin-3 in 5 cases (33.3%) and cyclin D1 in 12 cases (80%) showed a positive rate. The cyclin D1 in follicular carcinoma and staining between the p53 that had correlation was also investigated. In this study, as the examples of the expression of the 27 cases of galectin-3 (90%) in papillary carcinoma and 5 cases in follicular carcinoma (33.3%) indicate, it was concluded that there is a difference in the expression on both carcinoma. In addition, cyclin D1 and p53 has a positive rate in follicular carcinoma, when cyclin D1 in 12 cases (80%), there was a significant correlation that was investigated. Distinguishing between papillary carcinoma and follicular carcinoma can be identified by the expression of galectin-3. It is considered to get results that are more accurate in follicular carcinoma diagnosis depending on whether the cyclin D1 and p53 is expressed or not.

한국인 갑상선 질환의 병리학적 연구 : 1095 례의 외과적 절제물을 대상으로 Based on 1095 Surgically resected specimen

박성회,지제근,이현순,이정빈,안긍환,김용일,함의근,이상국 인제대학교 1983 仁濟醫學 Vol.4 No.4

A prospective morphological study was made on 1095 thyroid specimens which were removed surgically under various diagnoses at Seoul National University Hospital during a period of 6 years from 1976 to 1981. All thyroid specimens were carefully examined grossly by 3-5mm serial cutting after fixation. Almost entire thyroid specimen was submitted for microscopic examination. Therefore microscopic slides of one specimen ranged from 4 to 106 in number. Clinical records including operation notes were also referred to confirm the diagnosis. All of the material was examined and reviewed critically by the authors and was classified according to modified WHO classification. Among 1095 surgically removed thyroids, adenomatous goiter was the most common single disease which accounted for 43% of the entire cases. It was followed by papillary carcinoma and follicular adenoma. Of the malignant tumors, papillary carcinoma was the most frequently reported tumor, accounting for 259 cases (76%) of the entire malignancy. There were also 57 follicular carcinomas, 13 anaplastic carcinomas and 7 medullary carcinomas. Characteristic ground glass nuclei and psammoma bodies were seen fairly frequently showing the incidence of 64% and 65% of papillary carcinoma respectively. However, squamous metaplasia was present in only 17% of the papillary carcinoma. There were 56 occult sclerosing carcinomas. Most of these were detected in the thyroids of adenomatous goiter. The occult sclerosing carcinoma was found in 9.2% of adenomatous goiters while it was found in only 4.3% of follicular adenomas. It was interesting to note palpation thyroiditis seen in the thyroid specimens. It was seen in 24% of the adenomatous goiters, 17% of follicular carcinomas and 14% of the papillary carcinomas.

Pathologic Finding of Thymic Carcinoma Accompanied by Myasthenia Gravis

Kim, Se Hoon,Koh, Im Suk,Minn, Yang-Ki 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.4

<P><B>Background and Purpose</B></P><P>The World Health Organization (WHO) has classified thymic carcinoma and other thymomas (types A, AB, and B) as different neoplasms. Myasthenia gravis (MG) is an early sign of thymoma and theoretically does not accompany thymic carcinoma; however, cases of thymic carcinoma with MG have been reported. Whether thymic carcinoma can accompany MG has yet to be established.</P><P><B>Methods</B></P><P>The medical records of patients who underwent thymectomy for MG between 1990 and 2011 in a single hospital were reviewed. All cases with the diagnostic code of 'thymic carcinoma' or 'thymoma type C' (old terminology) were selected. A pathologist re-reviewed the pathologic specimens using the new WHO criteria. The rate of thymic carcinoma among these MG patients was then calculated.</P><P><B>Results</B></P><P>A total of 81 patients with MG had thymic tumors, 10 of whom had thymic carcinomas or thymoma type C. Seven cases of well-differentiated thymic carcinomas (type B3) were excluded, leaving three (3.7%) cases of thymic carcinoma with MG. All three of these cases were type B3 thymoma with a focal squamous cell carcinoma component that was very small and well demarcated. In addition, two out of the three tumors were found to be at an early clinical stage. All of the cases survived without recurrence over follow-up periods of at least 5 years.</P><P><B>Conclusions</B></P><P>Thymic carcinoma transformation from thymoma can occur during the early stages of thymoma. The association of this condition with MG is not as rare as was previously thought. Thymic carcinomas accompanying MG had a predominant B3 thymoma component with a focal thymic carcinoma area (squamous cell carcinoma).</P>

유방의 화생성 편평상피세포암종 17예에 대한 임상 및 병리학적 분석

이선아,이경은,문병인,한운섭,성순희 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.1

Background : Squamous cell carcinoma of the breast is very rare and it is considered to arise from metaplastic change of ductal carcinoma. Metaplastic squamous cell carcinoma (MSC) of the breast includes pure squamous cell carcinoma, metaplastic adenosquamous carcinoma and low grade adenosquamous carcinoma. Most of the cases of MSC of the breast were reported to have lymph node metastasis and this has a worse prognosis than that of conventional invasive ductal carcinoma. Methods : We collected 17 cases of MSC of the breast from 1,173 cases of breast cancer and analyzed the clinicopathological characteristics. Results : The age range was 31 to 69 years (mean age: 47.2). The mean tumor size was 3.6 cm. Twelve cases (70.6%) had a negative nodal status. The majority of the cases were of a high nuclear grade (grade III: 76.5%), and a high histologic grade (grade III: 88.2%). All the cases had no amplification of HER2, and they were negative for hormonal receptors, except for 2 cases with weak positivity. All the cases showed positivity for EGFR (3+: 14 cases, 1+: 3 cases). Clinical relapse was found in 3 patients on follow up and two of them expired due to lung and bone metastasis. Conclusions : MSC is associated with high nuclear and istologic grades, a high EGFR expression and they are triple negative for ER, PR, and HER2. The EGFR immunopositivity of MSC suggests a basal-like subtype. Background : Squamous cell carcinoma of the breast is very rare and it is considered to arise from metaplastic change of ductal carcinoma. Metaplastic squamous cell carcinoma (MSC) of the breast includes pure squamous cell carcinoma, metaplastic adenosquamous carcinoma and low grade adenosquamous carcinoma. Most of the cases of MSC of the breast were reported to have lymph node metastasis and this has a worse prognosis than that of conventional invasive ductal carcinoma. Methods : We collected 17 cases of MSC of the breast from 1,173 cases of breast cancer and analyzed the clinicopathological characteristics. Results : The age range was 31 to 69 years (mean age: 47.2). The mean tumor size was 3.6 cm. Twelve cases (70.6%) had a negative nodal status. The majority of the cases were of a high nuclear grade (grade III: 76.5%), and a high histologic grade (grade III: 88.2%). All the cases had no amplification of HER2, and they were negative for hormonal receptors, except for 2 cases with weak positivity. All the cases showed positivity for EGFR (3+: 14 cases, 1+: 3 cases). Clinical relapse was found in 3 patients on follow up and two of them expired due to lung and bone metastasis. Conclusions : MSC is associated with high nuclear and istologic grades, a high EGFR expression and they are triple negative for ER, PR, and HER2. The EGFR immunopositivity of MSC suggests a basal-like subtype.