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( Yoon Seob Kim ),( Yu Mee Song ),( Hyun-min Seo ),( Chul Hwan Bang ),( Tae-yoon Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Pseudoxanthoma elasticum (PXE) is a rare, inherited, multisystemic disorder characterized by progressive calcification and degeneration of elastic fibers. PXE is characterized by progressive calcification in the medial layers of medium and small sized arteries. Herein, we present an interesting case of PXE in a 75-year-age-old male. Diagnosis was delayed in spite of typical cutaneous findings and ocular and cardiovascular complication. Physicians should suspect PXE in cases of yellowish papules with typical distribution. A 75-year-old man was referred from department of neurosurgery for asymptomatic, yellowish papules and plaques on the neck and axillae detected since about age of 20. He did not have a family history of PXE. He admitted to our hospital via emergency room for management of cerebral hemorrhage. He underwent brain operation due to brain tumor 6 years ago, and had a history of diabetes mellitus, macular degeneration 9 years ago, pulmonary embolism 8 years ago and vascular dementia and cerebral infarction 2 years ago. A punch biopsy specimen from the neck showed short, irregularly thickened, basophilic fibers in the mid-dermis. Accumulations of swollen and irregularly clumped fibers stained deep black with Verhoeff`s stain. Staining for calcium with von Kossa was positive in the abnormal fibers. Based on clinical and histological findings, he was diagnosed with PXE.
Age estimation by pulp/tooth area ratio in a Korean sample on digital panoramic radiographs
( Byung-yoon Roh ),( Chang-gyum Kim ),( Sang-seob Lee ),( Won-joon Lee ),( Yo-seob Seo ),( Ji-won Ryu ),( Jong-mo Ahn ),( Chang-lyuk Yoon ) 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 2020 Oral Biology Research (Oral Biol Res) Vol.44 No.4
Age estimation based on the change in the size of the pulp due to secondary dentin deposition can be conducted non-invasively using radiographic photographs. Among these methods, age estimation using the pulp/tooth area ratio is highly accurate. The present study was conducted to apply this method using the panoramic radiographs of a Korean sample population and to evaluate its applicability in the Korean population. The study was conducted using panoramic radiographic images of 349 Koreans aged 20-79 years. The pulp/ tooth area ratio was calculated by measuring the area of the pulp and tooth. Teeth with a single canal, such as maxillary central incisor, lateral incisor, canine, and mandibular canine, were selected. Correlations between this ratio and age were calculated and regression formulas were derived. Age and pulp/tooth area ratio showed relatively low correlations compared with other studies. In particular, men showed lower correlations than women, and upper teeth showed a higher correlation than lower teeth. The regression formulas derived in this study also showed higher errors than those reported in other studies. Age estimation using pulp/tooth area ratio in a Korean using digital panoramic radiographs showed larger errors when compared with previous studies. Morphological diversity of tooth and pulp, indistinct anatomical details in panoramic radiograph, reduction in crown size due to attrition, and ethnic differences are believed to have affected the results.
( Yoon Seob Kim ),( Hyun-min Seo ),( Chul Hwan Bang ),( Ji Hyun Lee ),( You Jeong Kim ),( Gyong Moon Kim ),( Chul Jong Park ),( Hyun Jeong Park ),( Dong Soo Yu ),( Jun Young Lee ),( Young Min Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: There have been numerous population-based studies regarding herpes zoster (HZ) using health insurance claims or other databases. However, evidence regarding validation of the definition of HZ is scarce. Objectives: The aim of this study was to assess the accuracy of various screening criteria for HZ in hospital-based electronic databases. Methods: We extracted the medical records of patients with HZ or herpes simplex as the primary diagnosis in 2013 from five affiliated university hospitals. 500 HZ patients and 250 herpes simplex patients were randomly selected. Each randomly extracted subject was classified as definite, possible, or false-positive HZ by chart review. We proposed an operative definition to identify HZ of (1) one or more primary diagnoses of HZ and (2) prescription with oral antiviral medication for HZ for five or more days or intravenous acyclovir one or more times. The positive predictive value (PPV) of HZ was calculated for the following criteria: (1) primary diagnosis of HZ, (2) two or more primary diagnoses of HZ (3) suggested operative definition of HZ, and (4) primary diagnosis of herpes simplex. Results: We demonstrated that the PPV of primary diagnosis of HZ for definite or possible HZ with was 86.2%, whereas the PPV of our suggested operative definition was 99.5%. Conclusion: This study demonstrated that our operative definition using both diagnosis code and medication history has a much higher PPV for HZ than the definition using diagnosis code only.
Seo, Hyun-Min,Kim, Yoon Seob,Bang, Chul Hwan,Lee, Ji Hyun,Lee, Jun Young,Lee, Dong-Gun,Park, Young Min ELSEVIER 2017 ANTIVIRAL RESEARCH Vol.140 No.-
<P>The optimal duration of prophylaxis for the varicella-zoster virus following hematopoietic stem cell transplantation (HSCT) remains unclear. The purpose of this study was to systematically review the available literature to determine the optimal duration of antiviral prophylaxis for preventing herpes zoster (HZ) in allogeneic and autologous HSCT recipients. The MEDLINE and EMBASE databases were searched to identify relevant studies. The relative risk (RR) of HZ was calculated using fixed effects or random effects models depending on heterogeneity across the included studies. We analyzed six observational studies comprising a total of 3420 patients. In all HSCT recipients, the overall incidence of HZ in the prophylaxis group and the control group was 7.8% and 25.6%, respectively, with a pooled RR of 0.31 (95% CI, 0.26-0.37). The incidence of HZ in the subgroup wherein prophylaxis was given for at least 1 year and in the subgroup wherein prophylaxis was given for less than 1 year was 2.1% and 15.4%, respectively, with a pooled RR of 0.23 (95% CI, 0.04-1.39). Taken together, our results demonstrate that antiviral prophylaxis can significantly reduce HZ in HSCT recipients, and suggests that long-term prophylaxis given for at least 1 year may be recommended for better preventive effects. (C) 2017 Elsevier B.V. All rights reserved.</P>
( Yoon Seob Kim ),( Kyung Do Han ),( Ji Hyun Lee ),( Nack In Kim ),( Joo Young Roh ),( Seong Jun Seo ),( Hae Jun Song ),( Min Geol Lee ),( Jee Ho Choi ),( Young Min Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: To our knowledge, there have been no previous reports regarding the association between chronic urticaria (CU) and autoimmune thyroid diseases (AITD) in a nationwide population based study. Objectives: The aim of this study is to evaluate the risk of CU development after diagnosis with AITD including Grave’s disease and Hashimoto’s thyroiditis. Methods: National registry data which were collected fromthe Korean National Health Insurance Research Database from 2002 to 2013, comprising 1,025,340 (2.2%) randomly selected subjects were used. We compromised AITD cohort (N= 2,473) who had been diagnosed in 2003. The comparison cohort which was composed of randomly selected patients (N= 12,365) who were matched to the AITD group according to age and sex based on a 1:5 ratio. Each sampled patient was tracked whether CU occurs until 2013 or not. The risk of CU development was estimated using the Cox proportional hazards model and Cox proportional hazard regressions. Results: After adjusting for age, sex and co-morbidities,the people with AITD had a 1.648-fold greater risk of developing CU compared to comparison cohort (HR 1.648, 95% CI 1.417-1.918, P < 0.0001). In particular, Grave’s disease group had a more significantly increased risk of developing CU (HR 1.622) than Hashimoto’s thyroiditis one (HR 1.432). Conclusion: This study demonstrates that the presence of AITD is significantly associated with an increased risk of the future development of CU.