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Development of Flight Simulator for Human-Powered Aircraft (Second Report)
Yutaro Tsugawa,Yuzo Shimada,Akio Abe,Kenichi Abe 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
A special-purpose flight simulator of a human-powered aircraft (HPA) was planned and developed in 2005-2006. and installed for the first time at Nihon University in Japan in 2007 lor pilot training, the analysis of flight characteristics. and the optimal design of an HPA. Since the installation of the simulator, we have focused on improving its accuracy. However. unlike a general aircraft, an HPA generates the thrust through the pilot pedaling the propeller. Therefore, to develop a mathematical model of an objective HPA, we clarified the mathematical relationship between the torque generated by the pilot and the propeller thrust. In addition, to realize a more accurate simulation of the motion of an actual HPA, aerodynamic coefficients were evaluated using estimation equations for a conventional aircraft. The airframe data of the HPA used were those of Miiwe 22 produced by a Nihon University student team in 2004. The result of stability analysis showed that the HPA has an unstable spiral mode under lateral motion. This result coincides with the unstable behavior of another HPA (Mowe 24) flied in 2007 when subjected to lateral wind. To improve the instability of the lateral motion, we provide to a pilot with a voice command and verify whether the new method stabilizes the lateral motion using a flight simulator.
Recent advances in vitamin K-dependent Gla-containing proteins and vitamin K nutrition
Masataka Shiraki,Naoko Tsugawa,Toshio Okano 대한골다공증학회 2015 Osteoporosis and Sarcopenia Vol.1 No.1
Vitamin K is a multi-functional nutrient and various tissues modify their function in response to vitamin K bioavailability mainly through post-translational modification of vitamin K-dependent (VKD) proteins. In this review, we discuss five clinical topics of vitamin K nutrition and vitamin K-dependent Gla-containing proteins. Although the physiological roles of these VKD proteins need further elucidation, study of these proteins may open new avenues for therapy in the clinical field. The topics discussed in the review are focused on des-gammacarboxyprothrombin (DCP) in relation to the pathogenesis of hepatocellular carcinoma, osteocalcin (OC) and undercarboxylated OC (ucOC) in relation to bone fractures and insulin sensitivity, matrix Gla protein (MGP) in relation to vascular calcification, and growth arrest-specific protein-6 (Gas6) in relation to inflammation and platelet aggregation. Finally, interaction among vitamins were discussed.
Akiko Kuwabara,Naoko Tsugawa,Hiroshi Kondo,Misora Ao,Hitomi Fujiwara,Natsuki Hosokawa,Shiho Matsumoto,Kiyoshi Tanaka,Tetsuo Nakano 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.1
Objectives: One of the important risk factors of falling is decreased muscle mass and muscle strength. Recently, there has been an increasing concern on the role of vitamin D in muscle strength and physical activity. Aim of our study is to examine the relationships between vitamin D status and muscle mass and muscle strength in middle-aged healthy adults. Methods: Subjects were 40 healthy volunteers aged 42.0 ± 10.6 years old. Evaluation was made for serum vitamin D3 metabolites including 25- hydroxyvitamin D3 [25(OH)D3] and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] concentrations, lower limb muscle strength, and dietary intake by food frequency questionnaire. Body composition was measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal mass index (ASMI) was calculated as skeletal muscle mass/squared height. Results: 70% of the subjects had vitamin D insufficiency/deficiency (serum total 25(OH)D < 20 ng/mL), and female subjects had significantly lower serum total 25(OH)D level compared with males. Vitamin D insufficiency/deficiency group had significantly higher body fat, lower SMI and muscle strength, probably reflecting higher percentage of female subjects. Serum vitamin D3 metabolites levels were significantly correlated with whole and site-specific ASMI, and lower limb muscle strength, except for the correlation between serum 24,25(OH)2D3 concentration and lower limb muscle strength. In addition, serum 25(OH)D3 level was a positive significant predictor for both ASMI and lower limb muscle strength, while serum 24,25(OH)2D3 level was not their significant predictor. Conclusions: Serum 25(OH)D3 level was significantly correlated with both skeletal muscle mass and lower limb muscle strength.
Precision Medicine Approaches to Prevent Gastric Cancer
( Juntaro Matsuzaki ),( Hitoshi Tsugawa ),( Hidekazu Suzuki ) 대한간학회 2021 Gut and Liver Vol.15 No.1
Gastric cancer remains one of the most common causes of cancer-related death worldwide, although the incidence is declining gradually. The primary risk factor for gastric cancer is Helicobacter pylori infection. The Kyoto global consensus report recommends eradication of H. pylori in all infected patients. However, because it is difficult to stratify the risk of carcinogenesis among patients with a history of H. pylori infection, annual endoscopic surveillance is performed for everyone after eradication. This review summarizes the current approaches used to screen for novel molecules that could assist in the diagnosis of gastric cancer and reduce mortality. Most well-studied molecules are tissue protein biomarkers expressed by the gastric epithelium and associated with metaplasia-dysplasia-carcinoma sequences. Other strategies focus on the origin of cancer stem cell-related markers, such as CD44, and immune reaction-related markers, such as matrix metallopeptidases. Noninvasive methods such as blood-based approaches are more attractive. Serum pepsinogen levels predict the severity of gastric mucosal atrophy before H. pylori eradication, whereas plasma ghrelin levels are associated with atrophy even after eradication. Cell-free DNAs and RNAs are attractive tools for the early detection of cancer. These ideas could lead to the development of more personalized strategies for cancer prevention based on cuttingedge technologies. (Gut Liver 2021;15:3-12)
Tsujii, Toshiaki,Fujiwara, Takeshi,Kubota, Tetsunari,Satirapod, Chalermchon,Supnithi, Pornchai,Tsugawa, Takuya,Lee, Hungkyu Korean Society of Surveying 2012 한국측량학회지 Vol.30 No.6
Ionospheric anomaly is one of the major error sources which deteriorate the GNSS performance. In the equatorial region, effects of the ionospheric plasma bubbles are of great interest because they are pretty common phenomena, especially in the period of the high solar activity. In order to evaluate the GNSS performance under circumstance of the bubbles, an ionospheric scintillation monitor has been developed and installed in Bangkok, Thailand. Furthermore, a model simulating the ionospheric delay and scintillation due to the bubbles has been developed. Based on these developments, the effects of the simulated plasma bubbles are analyzed and their agreement with the real observation is demonstrated. An availability degradation of the GPS ground based augmentation system (GBAS) caused by the bubbles is exampled in details. Finally, an integrated GPS/INS approach based on the Doppler frequency is proposed to remedy the deterioration.