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In-vivo Imaging of Developing Wings in Butterfly Pupa by Using Optical Coherence Tomography
M. Kambe,S. Kinoshita,M. Ohmi,M. Haruna 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.2
Optical coherence tomography (OCT) is a non-invasive tomographic imaging technique and has been extensively used in biomedical and histological studies. Using OCT, we have succeeded, for the first time, in visualizing a developing wing in a butter y pupa. Comparing the cross sections of the pupa in each stage of development with those obtained by using conventional invasive methods, we have obtained overall agreement between these different methodologies. Although the spatial resolution is by far inferior, it should be emphasized that OCT essentially offers real-time information.
Decreased Brain Zinc Availability Reduces Hippocampal Neurogenesis in Mice and Rats
Suh, Sang Won,Won, Seok Joon,Hamby, Aaron M,Yoo, Byung Hoon,Fan, Yang,Sheline, Christian T,Tamano, Haruna,Takeda, Atsushi,Liu, Jialing SAGE Publications 2009 Journal of cerebral blood flow and metabolism Vol.29 No.9
<P> In the adult brain, neurogenesis occurs in the subgranular zone of the dentate gyrus (DG), where high levels of vesicular zinc are localized in the presynaptic terminals. To determine whether zinc has a role in modulating hippocampal neurogenesis under normal or pathologic conditions, we manipulated the level of vesicular zinc experimentally. To reduce hippocampal vesicular zinc, rats were either fed a zinc-deficient diet or treated with a zinc chelator, clioquinol (CQ). The number of progenitor cells and immature neurons was decreased significantly in the DG after 6 weeks of dietary zinc deprivation. Conversely, the number of progenitor cells and immature neurons was restored after a 2-week reversal to a normal zinc-containing diet. Similarly, a 1-week treatment with the zinc chelator, CQ, reduced the number of progenitor cells. The results of our previous study showed that hypoglycemia increased hippocampal neurogenesis. This study shows that zinc chelation reduced hypoglycemia-induced progenitor cell proliferation and neurogenesis. Finally, the role of vesicular zinc on neurogenesis was further assessed in zinc transporter 3 (ZnT3) gene deleted mice. Zinc transporter 3 knockout (KO) mice had significantly fewer proliferating progenitor cells and immature neurons after hypoglycemia. Our data provide converging evidence in support of the essential role zinc has in modulating hippocampal neurogenesis. </P>