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RISS 인기검색어
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- 저자 : Naoko Tsugawa (검색결과 2 건)
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Akiko Kuwabara,Naoko Tsugawa,Hiroshi Kondo,Misora Ao,Hitomi Fujiwara,Natsuki Hosokawa,Shiho Matsumoto,Kiyoshi Tanaka,Tetsuo Nakano 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.1
Objectives: One of the important risk factors of falling is decreased muscle mass and muscle strength. Recently, there has been an increasing concern on the role of vitamin D in muscle strength and physical activity. Aim of our study is to examine the relationships between vitamin D status and muscle mass and muscle strength in middle-aged healthy adults. Methods: Subjects were 40 healthy volunteers aged 42.0 ± 10.6 years old. Evaluation was made for serum vitamin D3 metabolites including 25- hydroxyvitamin D3 [25(OH)D3] and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] concentrations, lower limb muscle strength, and dietary intake by food frequency questionnaire. Body composition was measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal mass index (ASMI) was calculated as skeletal muscle mass/squared height. Results: 70% of the subjects had vitamin D insufficiency/deficiency (serum total 25(OH)D < 20 ng/mL), and female subjects had significantly lower serum total 25(OH)D level compared with males. Vitamin D insufficiency/deficiency group had significantly higher body fat, lower SMI and muscle strength, probably reflecting higher percentage of female subjects. Serum vitamin D3 metabolites levels were significantly correlated with whole and site-specific ASMI, and lower limb muscle strength, except for the correlation between serum 24,25(OH)2D3 concentration and lower limb muscle strength. In addition, serum 25(OH)D3 level was a positive significant predictor for both ASMI and lower limb muscle strength, while serum 24,25(OH)2D3 level was not their significant predictor. Conclusions: Serum 25(OH)D3 level was significantly correlated with both skeletal muscle mass and lower limb muscle strength.
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Recent advances in vitamin K-dependent Gla-containing proteins and vitamin K nutrition
Masataka Shiraki,Naoko Tsugawa,Toshio Okano 대한골다공증학회 2015 Osteoporosis and Sarcopenia Vol.1 No.1
Vitamin K is a multi-functional nutrient and various tissues modify their function in response to vitamin K bioavailability mainly through post-translational modification of vitamin K-dependent (VKD) proteins. In this review, we discuss five clinical topics of vitamin K nutrition and vitamin K-dependent Gla-containing proteins. Although the physiological roles of these VKD proteins need further elucidation, study of these proteins may open new avenues for therapy in the clinical field. The topics discussed in the review are focused on des-gammacarboxyprothrombin (DCP) in relation to the pathogenesis of hepatocellular carcinoma, osteocalcin (OC) and undercarboxylated OC (ucOC) in relation to bone fractures and insulin sensitivity, matrix Gla protein (MGP) in relation to vascular calcification, and growth arrest-specific protein-6 (Gas6) in relation to inflammation and platelet aggregation. Finally, interaction among vitamins were discussed.
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