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( Hidekazu Suzuki ),( Yoshimasa Saito ),( Toshifumi Hibi ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.2
In most H. pylori-positive patients, gastric low-grade mucosa-associated lymphoid tissue (MALT) lymphomas regress both endoscopically and histopathologically after H. pylori eradication, but no factors that can be predictive of the response to the eradication have been definitively identified, and there is little information on how to determine the optimal observation period before additional treatment can be started. Here, clinical studies dealing with the diagnosis and treatment of gastric MALT lymphomas and H. pylori published during the last 5 years were systematically reviewed, and studies identifying the molecular approaches involved in the pathogenesis were summarized. Most of the clinical studies indicate a favorable effect of H. pylori eradication on the clinical outcome of gastric MALT lymphomas. Some studies suggest the necessity of additional treatment in nonresponders to H. pylori eradication, while others suggest the adoption of a watch-and-wait strategy. The molecular characteristics of MALT lymphomas could play an important role in prognostic prediction and the selection of further therapeutic intervention after the eradication. This updated review of gastric MALT lymphomas illustrates the potential efficacy of H. pylori eradication in tumor remission, but further molecular characterization is necessary to establish the most suitable therapeutic strategy for patients who do not respond to eradication. (Gut and Liver 2009;3:81-87)
The Application of the Rome IV Criteria to Functional Esophagogastroduodenal Disorders in Asia
( Hidekazu Suzuki ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.3
The Rome criteria were amended as Rome IV. For functional esophageal disorders, the exclusion criteria have been more specifically revised based on further understanding of other esophageal disorders, including eosinophilic esophagitis and spastic and hypercontractile motor disorders. Another revised point is the more restrictive definition of gastroesophageal reflux disease, indicating that sensitivity to a physiological reflux burden may be placed more firmly within the functional group. For functional dyspepsia (FD), only minor changes were introduced, mainly to improve specificity. Among the major symptoms of FD, not only postprandial fullness, but also epigastric pain, epigastric burning, and early satiation should be “bothersome.” Investigation on the effect of meal ingestion on symptom generation has indicated that not only postprandial fullness and early satiety, but also epigastric pain, epigastric burning sensation and nausea (not vomiting) may increase after meals. Helicobacter pylori infection is considered a possible cause of dyspepsia if successful eradication leads to sustained resolution of symptoms for more than 6 months, and such status can be termed as “H. pylori-associated dyspepsia.” Prompt esophagogastroduodenoscopy and H. pylori testing and treatment would be more beneficial, especially in Asia, which has a high prevalence of gastric cancer. Acotiamide, tandospirone, and rikkunshito are the newly listed as treatment options for FD. For further therapeutic development, clinical studies based on the strict Rome IV criteria should be performed. (J Neurogastroenterol Motil 2017;23:325-333)
Hidekazu Suzuki,Okjin Kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
Chronic Helicobacter pylori (H. pylon) infection has an estimated world wide incidence of 50% and it has been associated with the pathogenesis of gastroduodenal diseases namely chronic gastritis, peptic ulcer, MALT lymphoma and gastric cancer. Apoptosis is related with cell death and oncogenesis. Two kinds of gastric cell lines (mucous and parietal cells) were exposed with water extract of H. pylori (HPE) of previously defined VacA, urease, CagE and CagA status. The mouse gastric parietal cell line MGE507 and gastric epithelial cell line GSMO6 cells were cultured and used to study the difference of apoptotic expression against HPE. The expression of apotosis was evaluated in two cell lines. Both mucous and parietal cell lines induced caspase-3-dependent apoptosis by HPE. However, the expressed amounts were higher in parietal cells than mucous cells. It is concluded that apoptosis is expressed strongly by parietal cells following H. pylori infection. On our knowledge, this is the first report about the apoptosis expression of gastric parietal cells by H. pylori infection.
( Hidekazu Suzuki ),( Tatsuhiro Masaoka ),( Toshifumi Hibi ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.2
Ghrelin, a novel gastrointestinal peptide with 28 amino acids, is secreted from the A-like cells of the gastric fundus. This peptide hormone does not only promote the release of growth hormone, but also stimulates food intake, gastric motility and cardiac output. Increased plasma ghrelin level has been reported in patients with upper gastrointestinal (GI) disease or in their disease animal model, suggesting its important role in the pathogenesis of upper GI disease. (Korean J Gastroenterol 2006;48:82-88)
( Hidekazu Suzuki ),( Toshifumi Hibi ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.4
Among functional gastrointestinal (GI) disorders, functional dyspepsia (FD) and irritable bowel syndrome (IBS) are important to public health around the world and are frequently encountered in general practice. Upper GI symptoms such as heartburn, postprandial fullness, early satiety, epigastric pain or burning and lower GI symptoms such as constipation and diarrhea often coexist. Although the prevalence of FD-IBS overlap would be influenced by the selection of the study population, the overlap rate of FD-IBS could be in the range of 11%-27%. Specifically, FD-IBS overlap is associated with more severe symptoms than FD alone or IBS alone. Since clinical overlap, especially FD-IBS overlap, is very common, the 2 syndromes should not be treated in a mutually exclusive fashion. (J Neurogastroenterol Motil 2011;17:360-365)
Hidekazu Suzuki,Okjin Kim 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Based on the central role of cells in the expression of toxicity and pathogenesis, several mammalian in vitro models have received regulatory acceptance by the Organization for Economic Co-operation and Development (DECO) as alternatives to whole animal tests in human health science. In this study, we used in vitro cell culture system to study the effect of H. pylori infection in gastric cells. Two kinds of gastric cell lines (mucous and parietal cells) were infected with H. pylori organisms of previously defined cagE and cagA status. The production of inflammatory chemokine was measured in cultured cells using RT-PCR and the amounts of expressed mRNAs were evaluated by semi-quantitative analysis using NIH image program. Both mucous and parietal cell lines produced inflammatory chemokine, especially macrophage inflammatory protein-2 (MIP-2), by H. pylori infection. However, the expressed amounts were higher in parietal cells than mucous cells. In this study, we establish alternatives to animal tests for assessing the pathogenesis by H. pylori infection. The mouse MIP-2 was considered functional homologues of human IL¬8 in mice. It is concluded that inflammatory chemokine is expressed strongly by parietal cells following H. pylori infection. It may contribute to inflammation present in gastric mucosa associated with H. pylori infection. On our knowledge, this report is first report of the effect of gastric parietal cells by H. pylori infection.
Characteristics of Sagittal Spino-Pelvic Alignment in Japanese Young Adults
Kenji Endo,Hidekazu Suzuki,Hirosuke Nishimura,Hidetoshi Tanaka,Takaaki Shishido,Kengo Yamamoto 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.5
Study Design: Radiological analysis of normal patterns of sagittal alignment of the spine. Purpose: This study aimed to clarify the characteristics of normal sagittal spino-pelvic alignment in Asian people. Overview of Literature: It is known that there are differences in these parameters based on age, gender, and race. In order to properly plan for surgical correction of the spine for Asian patients, it is necessary to understand the normal spino-pelvic alignment parameters for this population. Methods: This study analyzed 86 Japanese healthy young adult volunteers (48 men and 38 women; age 35.9±11.1 (mean±standard deviation [SD]). The following parameters were measured on lateral standing radiographs of the entire spine: sagittal vertical axis (SVA), horizontal distance between the C7 plumb line and the posterior superior corner of the superior margin of S1, thoracic kyphotic angle (TK), lumbar lordotic angle (LLA), sacral slope (SS), pelvic tilt (PT), and pelvic incidence (PI). Results: The values (mean±SD) of SVA, TK, LLA, SS, PT, and PI were 8.45±25.7 mm, 27.5±9.6°, 43.4±14.6°, 34.6±7.8°, 13.2±8.2°, and 46.7±8.9°, respectively. The Japanese young adults evaluated in this study tended to have a smaller PI, LLA, TK, and SVA than most Caucasian people. Regarding gender differences, SVA was significantly longer and TK was significantly smaller in men; however, there was no statistically significant difference in LLA, SS, PA, and PI. Conclusions: Japanese young adults apparently have smaller PI and LLA values than Caucasian people. When making decisions for optimal sagittal spinal alignment, racial differences should be considered.