Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

편광현미경에 의한 형태와 구성성분에 의한 토양의 비교분석에 관한연구(Ⅱ)

김은호,김재균,김명덕,신윤열,장성길,박성우,김영만 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

연 착화제 효능에 관한 동물실험적 연구

김정만,김병권,김성환,서병성,김인식,김용규,정갑열,김준연 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

연 착화제 효능에 관한 동물실험적 연구

서병성,김준연,김정만,김용규,정갑열,김성환,김인식,김병권 동아대학교 부설 산업의학연구소 1997 산업의학연구소 논총 Vol.- No.3

This experiment was carried out to compare the efficacy of 2,3-dimercaptosuccinic acid(DMSA) and calcium ethylenediamine tetraacetate(CaEDTA) as chelating agents for lead poisoning. The rats had been fed water containing 0.5% lead acetate for 3 months and randomly divided into three groups. We administered DMSA only for group I(n=5), CaEDTA only for group II(n=5), and both DMSA and CaEDTA for group III(n=10), for 4 days. We evaluated urinary lead(PbU) level, blood lead(PbB) level and blood zinc protoporphyrin(ZPP) level before and after administration of the chelating agents. The results obtained were as follows; 1. After administration of chelating agents, the mean PbU levels, which were 248.2㎍/dl, 252.6㎍/dl and 270.0㎍/dl in group I, II and III before administration, were increased to 484.6㎍/dl, 479.9㎍/dl and 1,792.1㎍/dl in group I, II and III, respectively(p<0.05). 2. After administration of chelating agents, the mean PbB levels, which were 67.4㎍/dl, 59.9㎍/dl and 62.5㎍/dl in group I, II and III before administration, were decreased to 38.1㎍/dl, 36.3㎍/dl and 31.3㎍/dl in group I, II and III, respectively(p<0.05), but there were no different changes of ZPP level among groups. 3. The blood lead clearances, which were calculated by PbB level before and after administration of chelating agents, were 49.8%, 43.5% and 39.5% in group III, I and II, respectively.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Vector 合成法을 이용한 Booming Noise 低減에 關한 硏究

김재열,유신,오성민,장종훈,김갑중 조선대학교 생산기술연구소 1997 生産技術硏究 Vol.19 No.1

Booming Noise of a Automotive can be divided in Air Borne Noise and Structure Borne Noise. In this study, Booming Noise is reduced by the vector Synthesis method. The vibration that transferred by the engine is managed. The car that by the used model is composed of Mount system supported to three point with 2000 cc 14 engine FR vehicle. The vibration that is transmitted from propeller sharft and Differential Gear to Sub Frame and Suspention effect Booming Noise. but, The vibration that generated by the Mount has Booming Noise more than it. So, We research that sound generated by the Mount and reduce that Booming Noise used the Dynamic Damper. The Booming. Noise by the vector Synthesis. is reduced in 2000 ~ 4000 rpm front of vehicle. We know that Booming Noise is reduced into hoped for rpm by the vector Synthesis.

주관절 골절 - 탈구의 치료 결과

김동수,염재광,권칠수,정병현,안종국,성열보,정형진,황순호 대한골절학회 2000 대한골절학회지 Vol.13 No.1

Purpose: This study analyzed clinical and biomechanical data from patients with elbow fracture dislocation to correlate long-term objective result with the specific injury type and treatment rendered. This can provide a basis for the management of this difficult injuries. Materials and Methods: Fifteen patients with elbow dislocation were studied from October, 1992 to October, 1997 in Sang-Gye Paik Hospital. The average duration of follow up was 4.2 years. Results: On the basis of an objective functional grading score that included elements of pain, motion, strength, and stability, the results were excellent in five(33%), good in five(33%), fair in one(7%), poor in four(27%). Prolonged immobilization greater than four weeks was associated with poor results. The results were closely related to the combined injuries and duration of immobilization. In case of radial head fractures, the best result was obtained in patients with Mason type II fractures treated by open reduction and internal fixation using Herbert screw and early complete radial head excision. Summary and Conclusion: The most common combined injury is radial head fracture. Early complete radial head excision and encouraging early ROM had more satisfactory result than delayed radial head excision or internal fixation for Mason type III fracture.

멀티미디어 통계학

김정일,주상열 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

This paper describes a mechanism of applying statistical methods via multimedia through the world wide web. The popularization of the Internet provides researchers with an easier means for obtaining information via statistical methods. A paradigm of statistical analysis system, WingStat, is discussed and a demonstration is available on-line on the Internet.

특수간호단위와 일반간호단위의 간호업무별 작업부하 및 피로자각증상 조사

김성열,이성수,이병국 순천향대학교 산업의학연구소 1997 순천향산업의학 Vol.3 No.1

In order to investigate the level of workload of various nursing activity and the level of subjective symptom of fatigue of nurses who were engaged in special care unit and general nursing unit, 87 nurses were selected from one university hospital in Chunan Choognam. Because of personal reason, two nurses did not joined this study. The final study subject was 85 nurses who came from special nursing care unit such as intensive care unit and emergency room (42 nurses) and general nursing care unit such as general surgery ward, orthopedic surgery ward and neurosurgery ward (43 nurses). The period of this study was from January 16 to March 15, 1997. Structured questionnaire forms were provided to all study nurses to identify the level of workload of nursing activity (37 items) and the level of subjective symptoms of fatigue (31 items). As a part of evaluation of workload, heart rates of study subjects were measured with Polar Vantage XL heart rate monitors. The results of the study were as follows. 1. The mean score of questionnaire for the level of workload in special nursing unit were higher than those in general care unit in three different nursing activities (physical nursing activity, administrative nursing activity and functional nursing activity), but the statistical difference was observed only in the category of physical nursing activity(p<0.05). 2. In the physical nursing activity and functional nursing activity, the mean score for the level of workload of nurses with proper rest was lower than those without proper rest before regular duty(p<0.05). 3. The mean score of questionnaire for the level of subjective symptom of fatigue in special nursing unit were higher than those in general care unit in three different symptom categories (physical symptom, mental symptom and neurosensory symptom), but the statistical differences were observed only in the category of physical symptom and neurosensory symptom (p<0.05). The characteristie of fatigue symptom of study group was revealed as B dominant type which is night duty type. 4. The mean score of fatigue symptom of nurses who thought their work was overloaded were higher than those whose workload was adequate in neurosensory symptom (p<0.05). The mean score of fatigue symptom of satisfied nurses with their job were lower than those who were not satisfied with their job in all three cateogory symptoms. 5. The mean heart rates(beats per minute) of resting state and working state of special care unit were 75.6±7.7 and 90.4±7.4, whereas those of general care unit were 75.8±8.3 and 89.7±9.5, respectively. 6. There was statistical correlation between the level of workload of nursing activity and the subjective symptom level of fatigue (r=0.2301, p<0.05), but the working heart rate of study nurse and the heart rate difference (working heart rate - resting heart rate) did not correlate with above two variables (workload and symptom level of fatigue).

경남지역 벼 친환경재배시 고품질 유색미 생산을 위한 적정 품종

김상열,한상익,오성환,이종희,권영업 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2