Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes

Kim, Se-Jin,Ho Hur, Joon,Park, Channy,Kim, Hyung-Jin,Oh, Gi-Su,Lee, Joon No,Yoo, Su-Jin,Choe, Seong-Kyu,So, Hong-Seob,Lim, David J,Moon, Sung K,Park, Raekil Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.2

<P>Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice. Cisplatin increases the catalytic activity of caspase-3 and caspase-8 proteases and the production of free radicals, which were significantly suppressed by pretreatment with bucillamine. Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione (GSH), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2). However, knockdown studies of HO-1 and SOD2 suggest that the protective effect of bucillamine against cisplatin is independent of the enzymatic activity of HO-1 and SOD. Furthermore, pretreatment with bucillamine protects sensory hair cells on organ of Corti explants from cisplatin-induced cytotoxicity concomitantly with inhibition of caspase-3 activation. The auditory-brainstem-evoked response of cisplatin-injected mice shows marked increases in hearing threshold shifts, which was markedly suppressed by pretreatment with bucillamine <I>in vivo</I>. Taken together, bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH.</P>

Tudor 王朝期 救貧制度 形成過程에 關한 硏究

林湖洙 충남대학교 인문과학연구소 1982 인문학연구 Vol.9 No.1

On the formulation of relief system of the poor in Tudor Dynasty. Poverty can be devided into three classes, namely social poverty, moral poverty and pauperism. Before and during Tudor Dynasty, the relief of the poor meant pauperism. It is said that English poor law had influenced deeply upon posterity, unlike other country's poor law. When we make researches on English poor laws in early times, we can know that English poor laws don't differ from other Country's Poor laws. In 16th century of Europe, the relief system of the poor was come into being at the same time. It was connected closely with the collapse of Feudal system. In the middle age noblemen had many manors and the most of labourers of the times were employed by the owners of manors and at the same time they kept many servants to make provisions against personal strife each other. During 16th century in England, the feudal system was collapsed and the centralization of the power of the state was realized by kings so they can control all the feudal servants. If the dispute arose among noblemen, could not be settled by strife, but they cannot help taking legal proceedings to the king's court. As noblemen need not to keep many servants, they discharged them in a large quantities. Untill the dis charged servants can supports themselves, various social problems came into being. Thomas More said most of burglars of that time on highways were the dismissed knights. As the manufactured goods in middle age were made to order, notwithstanding good or bad times of trade workers didn't lose their possitions. As the world trade came into being about 16th century, woolen textile industry had sprung up, and according to the good or bad time of trade many workers get or lose their possitions. In addition to that, a large quantities of silver were brought from the new world, the price of commodities was exceedingly going up, and many poor men unemployed had to go out on to streets to make begging. The causes of appearance of poverty were the same in Europe, most of European countries considered how to cope with the similar situation by the similar poor laws. If we consider the causes of appearance of the poor men on a large scale in England, We can find that it originates from the enclo sure movement and the abolition of monasteries that was not occured in other European countries. Enclosure movement meant that the land owners enclosed the open field of tenants to make pastures of sheep, consequently the tenants were driven out from their arable land and had to go anywhere else. Until they found new arable land or new jobs in the Towns they had to wonder about and to make begging. At that time the new state centralized powers had become rich and concerned greatly about the relief of the poors. Finally they thought that the relief of the poors is the responsibility of state. Of course there were relief of the poors in middle age, but it was done by a individual person or by the name of churches. It was only charity to the poor men originated from Christianity. Such a way of charity originated in religion could not reduce the number of poormen. If it may go in the opposite directions, the poormen can live idle or help to have a lack of self-reliance. Accordingly true relief of the poors must be planed and be done by public body. The first instance of the relief of the poors by nation was the statuate of labourers enacted in 134p. according to it all poors who cannot live on themselves must works for living at the rate of the wage provided by laws. If they don't obeyed to the terms, they must be punished. And yet there were no provisions for the poors who have no ability to work. The first law distinguished the poors who can work from the poor men who cannot work has the one enacted in 1388, it has not yet positive provisions for the impotent poors by nation but it leave the relief of them to the free charity of every parishioners. It was in the reign of Tudor to know that only whipping the healthy beggars or placing them in rooms cannot attain the purpose for the relief of the poors It is necessary to give jobs to the healthy beggars and give charity to the impotent poors. In the reign of king Henry 7th a law was enacted in 1530 and licences were given to the impotent beggars which were available in a fixed district. However the law enacted in 1536 prohibits to beg entirely and according to the fundamental rule, it was possible to enforce the relief of the poors by nation. Improvements were done repeatly for the relief of the poor and finally Elizabethan poor law was enacted in 1601 and it influenced very much on the future poor laws.

리스페리돈과 올란자핀이 투여된 정신과 환자들에서 간 효소 변화에 대한 후?적 연구

임현국,배치운,박석준,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

이차구순열 결손의 치료

임석균,박인순,여환호,지재휴,김영균,김수관 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Despite the current accomplishments with the repair of cleft lips, the surgical management of the nasal deformity remains a functional and aesthetic dilemma for patients, their families, and reconstructive surgeons. Recent improvements in the understanding and technical execution of te primary cleft lip repair have significantly reduced secondary sequelae and the consequent need for secondary surgical correction. But, secondary surgical corrections are necessary according to numerous factors. Such factors include the secondary surgical corrections are necessary according to numerous factors. Such factors include the severity of the initial deformity, the surgical plan, precision of execution of the primary repair, and success of the postoperative management. We preformed the secondary correction of cleft lip and palate in 11 patients via various methods. In conclusion, primary repair of cleft lip and palate patients is the most important to prevent the secondary deformities, and most of cleft lip and palate with secondary deformities must be treated with combined cheiloplasty and rhinoplasty.

일차 양측성 구순열의 일단계 재건에 대한 증례보고

임석균,이기혁,김영균,김수관,이병준,여환호,서재훈 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Bilateral cleft lip reconstruction can be performed in one-or two-stages. The choice depends on the surgeon's proficiency and experience. However the type and severity of the cleft must be considered. Complete or incomplete symmetric, bilateral clefts in which the premaxilla is within the alveolar arch or slightly protruded can be successfully treated with simultaneous lip reconstruction on both sides. There are some advantages that one-stage lip reconstruction facilitates creation of a symmetric and balanced lip, retraction of protruding premaxilla and the parent's psychologic satisfaction. However, there are some disadvantages such as micrognathia of the upper jaw by severe scar formation and poor adaptation of flap margins by severe tension. The surgeon must be able to judge and exploit the advantages offered by one-stage approach. We present the case report of one-stage reconstruction of primary bilateral cleft lip with literature reviews.

입원한 기분장애 소아청소년의 임상특성 : 주요 우울증과 양극성장애의 우울삽화 비교를 중심으로

임명호,조수철,백기청,이경규,김현우,홍강의 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.2

본 연구는 소아청소년에서의 우울증 및 조울증의 우울삽화에 대한 임상특성을 알아보고자 하였다. 1993년 3월 1일부터 1999년 10월 31일까지 ○○대학교 어린이 병원 소아청소년 정신과에 입원하였던 34명의 우울증 환아와 17명의 조울증 우울삽화 환아를 대상으로 병록지 기록을 통해서 이들의 사회인구학적 특성, 진단적 분류, 입원시 주 증상 및 문제점, 증상의 빈도, 주산기 모 병력과 아동기 발달력, 공존정신 질환 및 신경 심리학적 검사 가족의 임상적 특성, 가족 정신병리 및 가족 병력, 치료반응등에 대하여 조사하였다. 1) 우울증에서 남자의 비율이 여성의 경우보다 높았으며, 조울증 우울삽화에서는 남녀의 비율이 비슷하였다. 2) 평균 발병 연령은 조울증 우울삽화에서 14.1세, 우울중에서 12.8세로 우울증에서 일찍 발병하는 양상을 나타냈으며, 입원 횟수에 있어서는 조울증 우울삽화에서 우울증에 비해서 많았다. 3) 조울증 우울삽화와 우울증 모두에서 식물증상의 호소가 신체증상보다 많았으며, 자살사고 증상은 우울증에서, 공격적인 증상은 조울증 우울삽화에서 많았고, 정신병적 증상에서는 망상은 우울증에서 환각은 조울증 우울삽화에서 많이 나타났다. 4) 두 집단 모두에서 불안장애가 가장 많이 동반되었으며, 신체형 장애, 정신지체, 인격장애 등이 동반되었다. 5) 조울증 우울삽화와 우울증 모두 높은 가족력을 보였고, 특히 우울증은 아동 학대력과 가족의 부적절한 양육과 관련성을 보였다. 성인에서 조울증과 우울증이 분명한 임상적 차이를 갖고있는 것처럼 소아에서도 조울증 우울삽화와 우울증은 발병연령, 신체증상 및 식물증상을 비롯한 임상증상의 차이, 공존질환 등에서 서로 다른 임상 양상을 나타내었다. 중심 단어 : 주요 우울증ㆍ우울 삽화ㆍ임상 특성. The purpose of this study is to find out the characteristics of depressive episode about major depression and bipolar disorder in child and adolescent. The subjects of this study were 34 major depression patients and 17 bipolar disorder patients hospitalized at child and adolescent psychiatry in ○○ university children's hospital from 1st March 1993 to 31st October 1999. The method of this study is to review socio-demographic characteristics, diagnostic classification, chief problems and symptoms at admission, frequency of symptoms, maternal pregnancy problem history, childhood developmental history, coexisting psychiatric disorders, family psychopathology and family history and therapeutic response through their chart. 1) The ratio of male was higher than that of female in major depressive disorder while they are similar in manic episode, bipolar disorder. 2) Average onset age of bipolar disorder was 14 years 1 month and it was 12 years 8 months in the case of major depression As a result, average onset age of major depression is lower than that of bipolar disorder. 3) The patients complained of vegetative symptoms than somatic symptoms in both bipolar disorder and depressive disorder. Also, the cases of major depression developed more suicide idea symptom while the case of bipolar disorder developed more aggressive symptoms. In the respect of psychotic symptoms, delusion was more frequently shown in major depression, but halucination was more often shown in bipolar disorder. 4) Anxiety disorder coexisted most frequently in two groups. And there coexisted symptoms such as somartoform disorder, mental retardation and personality disorder in both cases. 5) The influence of family loading was remarkable in both cases. Above all, the development of major depression had to do with child abuse history and inappropriate care of family. It is apparent that there are distinctive differences between major depression and bipolar disorder in child and adolescent through the study, just as in adult cases. Therefore the differences of clinical characteristics between two disorders is founded in coexisting disorders and clinical symptoms including onset age, somatic symptoms and vegetative symptoms. KEY WORDS : Major depressive disorderㆍDepressive episodeㆍClinical characteristics.

스트레스 대처방식이 조혈모세포 이식 환자의 우울과 불안에 미치는 영향

윤수정,이철,임성후,채정호,전태연,김광수 한국정신신체의학회 2002 정신신체의학 Vol.10 No.1

우리나라 논 관개용 지하수 수질 특성

김진호,조광래,임수정,이경자,경기천,엄미정,김희권,김찬용,이영한,이신찬,윤순강 한국환경농학회 2003 한국환경농학회지 Vol.22 No.4

This study was carried out to evaluate the status of the groundwater quality for paddy fields irrigation in Korea. Water samples were collected at 130 sites throughout the country. Samples were collected at three seasons-April, July and October-in 2000. According to our survey, the groundwater was found to be suitable for irrigation purpose. Average EC was shown 0.286 dS/m. Nitrate-nitrogen and Cl^(-) concentration was 5.6 ㎎/L, 32.95 ㎎/L which satisfied the Korean Standards for Irrigation Water. Nitrate-nitrogen concentration in each province was shown as following orders: Jeju (11.17 ㎎/L) > Chungnam (8.16 ㎎/L) > Gyeongbuk (6.64 ㎎/L) > Gyounggi (5.91 ㎎/L) > Chungnam (4.95 ㎎/L) > Gyeongnam (3.91 mgk) > Jeonbuk (3.50 ㎎/L) > Jeonnam (3.27 ㎎/L) > Gangwon (2.91 ㎎/L). The concentration by sampling seasons were October (6.62 ㎎/L) > July (5.88 mg&) > April (4.78㎎/L). As the soil of Jeju Province is usually derived from volcanic ash soils mainly used for upland drops, it may influence the nitrate-nitrogen concentration of groundwater. The amount of rainfall also influence the water quality. But the COD_(Cr), were shown April (3.17㎎/L) > July (2.91 ㎎/L) > October (2.40 ㎎/L), it is highly related in the basal dose of organic matter fertilizers. This study demonstrated that groundwater quality was suitable for irrigation, but continuous monitoring is recommended for agricultural policy and developing OECD agricultural environment indicators.

양측 쇄골하동맥 및 양측 신동맥 협착을 동반한 Takayasu 동맥염 1예

임선호,임수빈,오석규,이재홍,정진원,박양규,박옥규,소병준,노병석 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

차세대 인터넷 도입을 위한 경계 라우터의 성능분석에 관한 연구

이수욱,황성호,임해진 三陟大學校 2004 論文集 Vol.37 No.-

The IPv6(Internet Protocol version 6), a next generation internet protocol. was standardized to solve the problems of the IPv4(Intemet Protocol version 4). However. the IPv4 could not be actually converted to the IPv6 at one time. Therefore. the transition mechanism is thought to be very much important to be compatible with the IPv4 naturally and convert to the IPv6 network gradually. Despite of the development of various kinds of the transition mechanism, the IPv6 network was not expanded. The research was mainly made not for current system environment but for technical purposes. This paper investigated the performances through the transition mechanism and examined proper ways being applicable to current environment.