하악 제1대구치 이소맹출의 치험례

소정원,이광희,라지영,안소연,김윤희,반재혁 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

Ectopic eruption is caused by an abnormal direction of eruptive path, most common in maxillary first molar, mandibular lateral incisor, and maxillary canine, and sometimes mandibular first molar. Ectopic eruption of first molar leads to abnormal root resorption of second deciduous molar, which, if left untreated, could cause premature loss of second deciduous molar; mesial tilting and rotation of first permanent molar; lack of space for eruption of second premolar; and occlusal problems. Therefore early treatment is advised when diagnosed as ectopic eruption. Treatment of ectopic eruption in the first permanent molar involves providing proper guidance for the direction of eruption using interproximal wedging and distal tipping methods while preserving second deciduous molar. This case report shows satisfactory results of the ectopic eruption of mandibular first molars in young patients who were treated with Humphrey appliance and Halterman appliance. 이소맹출은 치아가 비정상적인 위치로 맹출하는 경우를 말하며, 주로 상악 제1대구치, 하악 측절치, 상악 견치에서 발생하며 하악 제1대구치에서는 드물게 발생한다. 제1대구치의 이소맹출은 흔히 제2유구치의 비정상적인 치근흡수를 야기하며, 이를 방치하게 되면 제2유구치의 조기상실, 제1대구치의 근심경사 및 회전, 제2소구치의 맹출 공간 부족 및 교합문제 등을 야기하게 되므로 이소맹출로 진단될 경우 조기 치료가 추천된다. 이소맹출은 대개 통상적인 방사선검사를 통해 발견되나, 간혹 제2유구치의 치근흡수가 심할 경우 치수가 감염되어 동통을 야기하는 경우도 있다. 이소맹출의 치료는 제2유구치를 보존하면서 제1대구치의 맹출 방향을 바로 잡아 주는 것으로 크게 치간이개(interproximal wedging)와 원심경사이동(distal tipping)을 이용한 방법을 사용한다. 본 증례들은 하악 제1대구치의 이소맹출을 보이는 환아들로, Humphrey appliance와 Halterman appliance를 이용하여 양호한 치료 결과를 얻었기에 보고하는 바이다.

신이식환자에서 Thiopurine Methyltransferase의 활성이 Azathioprine 치료에 미치는 영향

조주연,배균섭,유경상,이소영,장인진,신상구,김상준,하종원,안규리 大韓臨床藥理學會 2000 臨床藥理學會誌 Vol.8 No.1

건초 섬유종 1예

문경원,김소연,최유원,명기범,김성현 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

미국의 식물유래약용물질(Plant-Made Pharmaceuticals, PMPs)의 안전성 규제

김태산,원소윤,이근표,류태훈,진용문,이길복,김현준 한국국제농업개발학회 2005 韓國國際農業開發學會誌 Vol.17 No.1

1. 식물유래 약용물질 (PMP)은 살아있는 식물에서 생산된 치료용 단백질로, 발효조에서 세포계통을 이용하는 것보다 적은 비용으로 높은 순도의 단백질을 생산할 수 있어 이에 대한 연구개발이 확대될 전망이다. 2. 식물유래 약용물질의 재배시험을 감독하는 주관부서는 미농무부(USDA)의 동식물 검역청(APHIS)이다. 3. PMP의 생산에는 알팔파. 옥수수, 벼 잇꽃과 담배 등이 이용되고 있다. 4. 현재 상업화된 PMP는 없으나 ProdiGene, Inc사 등 몇몇 생명공학 회사에서 이들의 연구개발이 진행되고 있다. 5. 2002년에 PMP 재배시험은 130에이커 규모로 34개 시험장에서 20건이 허가 되었으며 주별로는 애리조나, 네브라스카 등 14주에서 시험이 이루어 졌다. 6. 미국 USDA의 PMP 재배 지침에 의하면 PMP의 재배생산에는 안전성확보를 위한 별도의 전용장비를 필요로 하며 파종에서 생산까지 엄격하게 관리된다. 7. 미국 USDA의 APHIS는 2002년 PMP 옥수수를 생산하는 ProdiGene, Inc사에 대하여 2건의 포장시험허가 위반사항을 적발하여 벌금 조치를 한바있다. Plant-made pharmaceuticals(PMPs) are therapeutic agents(pharmaceutical proteins) produced in genetically engineered plants. To yield these valuable products plants offer several advantages that include large-scale production capacity at a reduced cost, equivalent purity/activity to other manufacturing systems, and freedom from contamination with animal pathogens, prions, or disease-causing germs. But there are risks of contamination of the food supply and unintended effects on ecosystems. In the U.S. PMPs are regulated under stringent requirement of the U.S. Department of Agriculture(USDA) and the Food and Drug Administration(FDA). In this article, contamination incident with PMP corn engineered by ProdiGene, Inc will be briefly introduced and regulations of PMPs will be discussed.

급성 진행형 국소 신경학적 증상을 보인 쯔쯔가무시병 1예에서 고용량 스테로이드의 사용

최현철,위성헌,이소연,김상일,박성경,정연주,정소령,전정수,강문원 대한감염학회 2002 감염 Vol.34 No.6

NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

Youn, So Won,Song, Hyoung Sub,Park, Jong Hyub The Royal Society of Chemistry 2014 Organic & biomolecular chemistry Vol.12 No.15

<P>An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.</P> <P>Graphic Abstract</P><P>An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3ob42546k'> </P>

Pd(II)/Ag(I)-Promoted One-Pot Synthesis of Cyclic Ureas from (Hetero)Aromatic Amines and Isocyanates

Youn, So Won,Kim, Yi Hyun American Chemical Society 2016 ORGANIC LETTERS Vol.18 No.23

<P>A simple and facile one-pot reaction has been developed to afford a diverse range of N,N'-disubstituted benzimidazolones and imidazopyridinones containing two differently substituted N atoms. A cooperative Pd(II)/Ag(I) system promotes the sequential addition/intramolecular C-H amidation reaction of (hetero)aromatic amines and isocyanates, leading to the formation of two C-N bonds. A mechanism involving radical intermediates generated by single-electron transfer (SET) in the presence of a Ag2CO3 oxidant and Pd(OAc)(2) Lewis acid is proposed. This protocol offers an operationally easy, simple, and robust approach with the use of readily available starting materials, good functional group tolerance, and high efficiency.</P>

Characterization of chrysanthemum genome by NGS

So Youn Won,Seulki Lee,Jae-A Jung,Jung Sun Kim,Sangho Kang,Seong-Han Sohn 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

The Asteraceae/Compositae family is one of the biggest families in flowering plants and has more than 23000 species including the economically important lettuce, sunflower, and chicory as well as the agronomic weeds. With its significance and the progress in sequencing technology, its species have been subjected to the genome sequencing project worldwide. Although chrysanthemum is an important plant in the floricultural industry, however, it has been less studied at the level of genomics, compared with other species in the Asteraceae. There were only several reports on comparative analysis of transcriptome for chrysanthemum. Actually, the genome of Chrysanthemum species is known to be gigantic and complex with diverse status ranging from diploid to decaploid. Since the cultivated and commercial chrysanthemum exhibits hexaploid genome, we decided to select the diploid species with smaller genome as a material for reference genome sequencing. Thus, we launched a genome sequencing project with C. boreale which was previously reported to be diploid by cytogenetic analysis. We constructed sequencing libraries with insert size 300bp and 500bp and sequenced them from the paired end in 100bp read length with Illumina’s HiSeq platform. After quality checking, we preprocessed raw reads by removing duplicated reads and trimming reads with low quality value. Kmer frequency analysis with the cleaned reads showed that the genome is heterozygous, highly repetitive and gigantic, ranging from 2.9Gb to 5.8Gb. The cleaned reads were further subjected to error correction and primary assembly with SOAPdenovo2. Here, we’ll report the result of Kmer frequency analysis and genome assembly.

Metal-Catalyzed Synthesis of Substituted Indoles

Youn, So Won,Ko, Tae Yun Wiley (John WileySons) 2018 Asian journal of organic chemistry Vol.7 No.8

Comparative transcriptome analysis reveals whole-genome duplications and gene selection patterns in cultivated and wild <i>Chrysanthemum</i> species

Won, So Youn,Kwon, Soo-Jin,Lee, Tae-Ho,Jung, Jae-A,Kim, Jung Sun,Kang, Sang-Ho,Sohn, Seong-Han Springer Netherlands 2017 Plant Molecular Biology Vol.95 No.4

<P><B>Key message</B></P><P>Comparative transcriptome analysis of wild and cultivated chrysanthemums provides valuable genomic resources and helps uncover common and divergent patterns of genome and gene evolution in these species.</P><P><B>Abstract</B></P><P>Plants are unique in that they employ polyploidy (or whole-genome duplication, WGD) as a key process for speciation and evolution. The <I>Chrysanthemum</I> genus is closely associated with hybridization and polyploidization, with <I>Chrysanthemum</I> species exhibiting diverse ploidy levels. The commercially important species, <I>C. morifolium</I> is an allohexaploid plant that is thought to have originated via the hybridization of several <I>Chrysanthemum</I> species, but the genomic and molecular evolutionary mechanisms remain poorly understood. In the present study, we sequenced and compared the transcriptomes of <I>C. morifolium</I> and the wild Korean diploid species, <I>C. boreale</I>. De novo transcriptome assembly revealed 11,318 genes in <I>C. morifolium</I> and 10,961 genes in <I>C. boreale</I>, whose functions were annotated by homology searches. An analysis of synonymous substitution rates (Ks) of paralogous and orthologous genes suggested that the two <I>Chrysanthemum</I> species commonly experienced the Asteraceae paleopolyploidization and recent genome duplication or triplication before the divergence of these species. Intriguingly, <I>C. boreale</I> probably underwent rapid diploidization, with a reduction in chromosome number, whereas <I>C. morifolium</I> maintained the original chromosome number. Analysis of the ratios of non-synonymous to synonymous nucleotide substitutions (Ka/Ks) between orthologous gene pairs indicated that 107 genes experienced positive selection, which may have been crucial for the adaptation, domestication, and speciation of <I>Chrysanthemum</I>.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s11103-017-0663-z) contains supplementary material, which is available to authorized users.</P>