한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과

양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.

고압 커패시터의 고장 분석을 통한 신뢰도 예측

양석준,김진우,신승우,이희진,신승훈,유동수,장석원 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.6

본 논문은 고압 커패시터의 고장분석과 신뢰성 예측 결과를 다루고 있다. 부품의 수명과 고장률을 예측하기 위해서 두 가지 방법으로 고장 모드와 고장 메커니즘을 연구하였다. 에폭시 수지로 성형된 고압 커패시터가 절연내압 시험 하에서 저항이 제로로 되는 고장에 대하여, 근본원인 고장분석 체계를 효과적으로 수립함으로써 고장 메커니즘의 원인을 분석하였다. 특히 세라믹-에폭시 계면에서의 절연파괴 고장 현상이 강조되었으며, 본 연구에서 얻어진 결과의 타당성은 마그네트론에 장착된 고압 커패시터의 열사이클 시험 수행에 의한 가속시험 결과로부터 입증되었다. 시험 결과들은 결함이 있는 로트를 신속히 규명하고 B10수명을 결정하는데 유용하게 사용할 수 있다. 또한, 유전체의 절연파괴에 대해서 부하-강도 간섭모델을 이용하여 고장률을 예측하였다. This paper presents a result of failure analysis and reliability evaluation for high voltage ceramic capacitors. The failure modes and failure mechanisms were studied in two ways in order to estimate component life and failure rate. The causes of failure mechanisms for zero resistance phenomena under withstanding voltage test in high voltage ceramic capacitors molded by epoxy resin were studied y establishing an effective root cause failure analysis. Particular emphasis was placed on breakdown phenomena at the ceramic-epoxy interface. The validity of the results in this study was confirmed by the results of accelerated testing. Thermal cycling test for high voltage ceramic capacitor mounted on a magnetron were implemented. Delamination between ceramic and epoxy, which might cause electrical short in underlying circuitry, can occur during curing or thermal cycle. The results can be conveniently used to quickly identify defective lots, determine B10 life estimation each lot at the level of inspection, and detect major changes in the vendors processes. Also, thd condition for dielectric breakdown was investigated for the estimation of failure rate with load-strength interference model.

관광호텔 회계시스템의 품질요인에 대한 인식차이 연구

양승필,고동훈 제주관광대학 2004 論文集 Vol.10 No.-

The purpose of this study is as follows; First, this study developed the instruments of measurement to measure the quality of HAS(information quality, system quality, and service quality). Second, this study investigated statistically perception differences of the quality by t-test between hotel employees in Jeju and those in Seoul. The hypotheses were developed from reviewing the former literatures and tested empirically. The Questionnaires were collected from 214 middle or higher managers at deluxe hotels located in Seoul and Jeju during February 13 to March 10,2004. This study was conducted using frequency analysis, descriptive analysis, and t-test by statistical packages of SPSS SPSSWIN version 10.0. The results of this study showed that hotel employees in Jeju perceived positively the quality of HAS than those in Seoul.

Glycation 유발물질의 반응성의 비교

양용,이용갑,오두환,신동범,엄성용 한국노화학회 1993 한국노화학회지 Vol.3 No.1

클로르헥시딘 바니쉬의 적용이 교정용 브라켓의 전단접착강도에 미치는 영향

임동혁,김태우,장영일,남동석,양원식,백승학 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.2

본 연구의 목적은 클로르헥시딘 처리가 교정용 브라켓의 전단접착강도와 탈락 양상에 미치는 영향을 비교하는 것이다. 실험군으로 4주간 4회의 클로르헥시딘 바니쉬를 도포한 22개의 사람 소구치를 선택하였고, 대조군으로 아무 처리도 하지 않은 22개의 사람 소구치를 선택하였다. 모든 치아는 37%의 phosphoric acid gel로 부식시키고 교정용 브라켓을 같은 조건으로 부착시켰다. 전단접착강도의 측정을 위해 Instron universal testing machine(model 4466)을 이용하였고, 법랑질과 브라켓 표면은 SEM으로 관찰하였다. 결과의 분석은 t-test를 이용하였으며 결과는 다음과 같다. 1.클로르헥시딘의 법랑질 처리는 전단접착강도에 영향을 미치지 않았다. 2.클로르헥시딘으로 법랑질을 처리한 경우와 그렇지 않는 경우에 브라켓 탈락 양상에 차이가 없었다. 따라서, 클로르헥시딘으로 법랑질을 처리하여도 브라켓 접착에 유해한 작용이 없었고, 따라서 임상사용에 적합하다고 생각된다. The purpose of this study was to determine whether the application of chlorhexidine varnish affects the shear bond strength and failure pattern of orthodontic brackets or not. The experimental group consisted of 22 human premolars which extracted after chlorhexidine vanish application(4 times for 1 week interval) in vivo, and the control group consisted of 22 human premolars which extracted without any pre-treatment. After all teeth were etched with 37% phosphoric acid gel, metal orthodontic brackets (Q-3002, RMO, USA) were bonded to each tooth using auto-polymerizing orthodontic resin (Ortho-One, Bisco, USA) with the same bonding procedure. The shear bond strength was measured with Instron universal testing machine (model 4466, Instron Ltd., England), and the failure pattern of each bracket was examined with Scanning Electron Microscope (SM 840A, JEOL, Japan). The data were analysed statistically with t-test. The results were as follows : 1.Application of chlorhexidine varnish had no significant effect on the shear bond strength of the orthodontic bracket. 2.There was no significant difference in the failure pattern of orthodontic bracket between the experimental group and the control group.

대장선암에서 Metallothionein과 p53의 표출

강동하,양승하 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Colonic adnocarcinoma is common malignant tumor in Korea. Many oncogenes have been found in malignant tumor cells. Among these oncogenes, MT has high affinity for metals such as copper and zinc. The fuction of MT is metabolism and detoxification of copper and zinc. The relation between the expression of MT and prognosis of patients in various cancers are reported but is controversial. p53 is a regulator of cellular proliferation, and the over expression of p53 relates to malignant trasformation and prognosis. To evaluate the expression of MT and p53 according to histopathologic features in colonic adenocarcinoma, we have performed immune staining, using mouse anti-MT and mouse anti-p53. The results were as follow; 1) The expression rates of MT in hyperplastic polyp, adenoma, and adenocarcinoma of colon were 100%, 64.1%, and 46.6%, p53 were 0%, 64.1%, and 48.9%, respectively. 2) MT and p53 in colonic adnoma showed increased espressionrat according to severity of dysplasia 3) MT incolonic adenoarcinoma showed statisfically significant higher expressionrates in female9P=0.04), in cases showing lymph node metastasis(P=0.012), and in stage C(P=0.0001), but there is no significant difference according to age, site, differentiation, and invasion depth. 4) p53 in colinic adenocarcinoma showed statisfically significant higher expression rates rates in cases showing lymph node metastasis(P=0.047), but there is no statisfically significant difference in age, sex, site, invasion depth, stage. 5) In colonic adenocarcinomas expressing MT(+)p53(+) there is more many cases in carcinomas within the wall, in carcinoma showing lymph node metastasis, and stage C, but no statisfically significant difference. 6) Correlation between MT and p53 in colonic adenocarcinoma were not seen.

성장과 운동수행능력 향상에 도움을 주는 식이조성물의 개발

윤승원,정은희,양동식,이홍석,윤유식 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

We developed a dietary supplement using natural herbs and nutrients for the growth and exercise performance improvement. It called JR-22 supplement containing distilled extracts of natural herbs to remove bitterness and the addition of Vitamin B1, B6, Ca and xylitol. We investigated on the effect of JR-22 supplementation on the maximal exercise performance, IGF-1 (insulin like growth factor-1) concentration and antioxidant activity in SD rat model. In result, JR-22 supplement group was better than control group about 10% in exercise performance test and increased about 63% of IGF-1 concentration in blood. In addition, the oxidative damage induced by exercise was reduced by JR- 22 supplementation. Therefore, we suggested that JR-22 supplementation enhanced effectively exercise performance and IGF-1 concentration and reduced to oxidative stress in muscles. Also, we analysed biochemical factors in blood for the safety of JR-22 supplement. We known that there is no change of blood lactic acid, ammonia, inorganic phosphorous ion and creatine kinase activity.

온도변화에 따른 알루미늄합금 용접부의 피로수명에 관한 연구

이동길,양승훈,김건호,정재강 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

본 연구에서는 저온용기 등에 많이 사용되고 있는 알루미늄 합금 A15083-0재에 대한 보호가스 혼합비율과 피로수명과의 관계를 규명하고자 혼합가스 비율을 여러 가지로 달리하여 GMA 용접을 실시하였다. 시험온도는 상온에서 극저온까지 단계적으로 낮추어가며 실시하였다. 용접재의 피로수명은 모든 불활성가스 혼합비율 및 노치 가공위치에서 모재보다 높은 피로수명을 보였으며, 영향부, 용융선 및 용착금속부 순으로 피로수명이 증가하였다. 상온에서부터 -85℃까지는 온도가 낮아짐에 따라 피로수명은 모재 및 Ar33%+He67%의 경우 증가한 반면, 다른 불황성 가스혼합비에서는 감소하는 경향을 나타내었며, -196℃ 극저온에서는 피로수명 크게 증가하여 저온재료로서 유용한 성질이 나타났다. The influence of mixing shield gas ratio and test temperature on fatigue life of welding zone were examined experimentally for a AI5083-O aluminum alloy. The GMA(Gas Metal Arc) welding was carried out for weld specimen with various mixing gas ratio(Ar100% + He0%, Ar67%+He33%, Ar50%+He50%, and Ar33%+He67%). The tested temperature range was from room temperature(+25℃) to cryogenic temperature(-192℃). The welding zone was divided into four sub-zones for analysis ; weld metal, fusion line, HAZ, and base metal. In the influence of mixing gas ration, fatigue life of weld metal was decreased with higher Argon gas ration, but fusion line and HAZ specimens were not influenced greatly, The fatigue life increased at lower temperatures, particularly at -196℃. It was known availability that the A15083-O is appropriate for used low temperature material.

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.