가와사끼병에서 면역글로불린 사용 후 ASO 수치의 변동에 관한 고찰

황성욱,이지웅,송민섭,김철호 인제대학교 2006 仁濟醫學 Vol.27 No.-

Objective : Since Kawasaki disease was first described in 1967, the cause and prognostic factors have not been known despite many researches and efforts. The introduction of high-dose intravenous gamma-globulin (IVGG) was an epoch and IVGG is now a standard therapy. But the mode of action of IVGG in reducing inflammatory response is not clearly understood. Understanding of the mechanism should supply the clues that indicate the cause, prognosis, the better treatment of this disease. At present, the correlation of CRP, ESR and change of leukocyte numbers to Kawasaki diseases were known, but the correlation studies of ASO titers are rare. To discover this, we evaluated the interrelationship between the ASO titer and IVGG therapy. Methods and Materials : The subjects included 35 patients with Kawasaki disease who were treated by IVGG at department of pediatrics, Inje university, Busan Paik hospital from June, 2004 to December, 2005. Before and after IVGG administration, ASO titers were evaluated. Results: In the 32 among 35 patients, ASO titers checked before IVGG administration were increased prominently after IVGG therapy. Conclusion : Remarkably increased ASO titers after IVGG administration for the treatment of Kawasaki diseases were found. And changes of ASO titers seem to be due to immunoglobulin instead of streptococcal infection. Further studies will be necessary to clarify the pathogenic mechanisms of increased ASO titers.

韓國産 玄蔘科 植物에 關한 本草學的 硏究

황성연,변종호,송호준,신민교 대한본초학회 1998 大韓本草學會誌 Vol.13 No.1

For the purpose of developing Korean Herbalogy with the plants of Scrophulariaceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows: 1. There were totaled to 24 genera and 85 species in Korea and among them medicinal plants are 17 genera, 45 species, some 53% in total but, the number of species may be added because of the similiar plants. 2. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the Scophulariaceae family were classified as Herba 19, Radix 4, Foilum 3, Flos, Rhizoma, Fructus 2 each. Thus it was noticed that Herba was the main kind. 3. According to sum of 85 species in Scrophulariaceae family, they were classified into Veronica genera 22, Pedicularis genera 14, Melampyrum genera 7, Euphrasia genera 6, Scrophularia genera 5, Limnophila genera, Lindernia genera, Mazus genera, Veronicastrum genera 3 each. Thus it was noticed that Veronica genera was the main kind, some 25% in total. 4. According to the number of species of the origin plants about each chinese materia medicals, they were classified into RADIX SCROPHULARIAE 5, HERBA VERONICAE, HERBA PEDICULARIS 4 each. Ths the origin plants was not complexed reletively. 5. According to nature and flavour of medicinal plants, they were classified into warmth, heat; 10 each, cold,cold; 13 each, balance 2. Ths it was noticed that cold and cool is the main in nature and flavour of medicinal plans. 6. According to the Properties and Principal curtive action, they were classified into Drugs for removing toxic heat with febrifugal and detoxicant diaphoretics 7, to remove evil heat and resolve dampness 6, tonify the blood 3, to promote or activate blood circulation by removing blood stasis, to dispel pathogenic heat from blood with drugs cold in property, to stop bleeding drugs 2 each. Thus it was noticed that Febrifugal and detoxicant drugs was the main kind. 7. Comparing to whole medicinal plants 45 kinds, toxic drug was 1 kind, 2% of the whole. Thus toxic drugs were rare. From this result, it was revealed that the plants for medical purpose in Scrophulariaceae was 53% of the whole, in which Herba was mostly abundunt and toxic plants was so rare that it will be used for clinical treatments more easily. It is considered that many experiements and clinical approaches must be continued to use Scrophulariaceae plants widely.

개에서 발생한 척수질환에 대한 추적조사(70예)

황현민,이재연,지현철,이영원,최호정,박성준,김명철,정성목 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2006 動物醫科學硏究誌 Vol.14 No.-

This study was performed to evaluate the prevalence of spinal disorders in dogs, as well as their breed, age, gender and body weight distributions. Seventy cases of caine spinal disoreders presented in the period 2001 and 2006 were reviewed. The diagnosis was obtained by survey radiographs, myelogram, CSF analysis, CT and MRI. The most frequent breed was Maltese(15 cases), and followed by Yorkshire Terrier (10 cases), Pekingese (9 cases). Canine spinal disorders occurred from 7 month to 17 year old dog, mean age was 5.3±3.7 year-old. Canine spinal disorders occurred more often in females(59.7%) than males. Mean body weight was 5.87±7.02 kg. Degenerative (39 cases, 43.3%) and anomalous (24 cases, 26.7%) disorders were dominant in 90 specific disease distribution. This results can be a reference data for the further study.

부산지역 산성강우의 장기적인 화학적 성상의 변화

황성욱,전보경,김찬훈,서정민,최금찬 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

It is important to know the impacts of acid rain because of soil acidification, reduced biological productivity. Many researchers were interested in regional acid problems, and former research were focued in short-term trends of acid rain. It is not easy to evaluate acid rain problems because of many parameters relating to meteorological factors, which are wind, temperature, humidity and other factors. Rainfall sampling for this study was done from September 1933 to December 2000 in Dong-A University, Busan. All Samples were collected in separately to early fraction and succeeding fraction. Also, the samples were measured for pH, and EC, cations and anions were analysed by ion Chromatography.

강진만 해역의 다모류 군집의 종조성 및 계절변동

윤성민,김춘철,서원일,황선영,이성훈,한경호,이우범 國立麗水大學校 環境問題硏究所 2004 環境硏究論文集 Vol.6 No.-

To detemine seasonal fluctuations in abundance and speices composition, polychaete samples were collected by Van Veen grab form March to November 2003 in Kangjin Bay. A total of 25,119.3 ind./㎡ polycaete were sampled and identified into 48 species. 25 families and 10 orders. Of the 10 orders. Phllodocida, Spionida, Eunicida and Sabellida accounted for approximately 79.9% of the polychaete fauna in this area. Phyllodocida, Nereidae, Nephtyidae ans Spionidae were dominant representing every moment 4 species. Of 48 species identified Neanthes japonica, Prionospio pinnate, Cirratulus cirratus and Palola siciliensis for 54.0% individuals collected. Season succession of dominant species was evident in study area: Neanthes japonica, Prionospio pinnata. Cirratulus cirratus. Nephtys oligobranchia in March, Neanthes japonica, Lumbrineris japonica. Cirratulus cirratus, Prionospio pinnata in May, Ncanthes japonica, Cirratulus cirratus, Lumbrineris nippnica. Lumbrineris japonica in August and Neanthes japonica, Prionospio pinnata, Laonice cirrata, Palola siciliensis in November, respectively. The diversity index was the highest value in March(H'=3.0059) and the lowest value in May(H'=2.7305). The eveness index was the highest in August(J=0.9184) and lowest in May(J=0.8524). The dominance index was the highest in May(D=0.3843) and the lowest in March(D=0.2275).

냉동마쇄고추를 첨가한 깍두기의 저장기간에 따른 이화학적 성분 변화 및 관능적 특성

설민숙,황성연,박소희,이현자,김종군 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.5

The purpose of this study was to examine the physico-chemical and sensory characteristics of Kakdugi made with mashed red pepper. With regard to the pH of the Kakdugi. those of the juice from Kakdugi with red pepper powder and of the liquid with mashed red pepper were the highest and lowest immediately after preparation. respectively, but thereafter both slightly decreased, but were similar after the fifth week. Generally. the total acidity of Kakdugi liquid was the higher than that of Kakdtegi juice. With regard to the L value, that of the Kakdugi juice was higher than that of Kakdugi liquid and that of Kakdugi with mashed red pepper washigher than that of Kakdugiuitlr red pepper powder. From the third week, the values of all samples generally decreased. The 'a' value of the Kakdugi liquid with mashed red pepper during fermentation was highest During early fermentation, the juice of Kukdugi with red pepper powder showed a higher value than that of Kakdugi with mashed red pepper, but conversely, from the second week that of Kakdugr with mashed red pepper was higher than that of Kakdugi with red pepper powder. The 'L' value of the juice from Kakdugi with red pepper powder was highest until the second week, but trout the third week that of Kalotugi with trashed red pepper was highest. With respect to the organic acids contents, those of citric, quinic and malic acids decreased, but those of lactic and acetic acids increased during tcrrnentatton progression. In addition, the citric, lacticand malic acids contents of the Kakdugi with mashed red pepper werethe highest, whereas that of quinic acid of the Kakdugi with red pepper powder was the highest. From the forth week, the acetic acid content of the Kakdugi with mashed red pepper was further increased. As a result of the sensory test. Kakdugi with mashed red pepper showed significantly higher values with regard to redness and fresh flavor, hut in overall acceptability in the QDA, appearance and taste in the acceptance test. 'Therefore, our results indicate that mashed red pepper particularly increased the 'a' value and organic acid contents of Kakdugi compared to those of red pepper powder, leading to an increased overall acceptability.

태권도 남자경기의 체급별 공격기술 분석

김도호,황영성,조원민,차성웅 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

The purpose of this study was to analyze attack frequency and scores of men(16 persons) Taekwondo players who joined the final games(32 games) of the 12th and 13th Taekwondo Championships The results obtained from this analysis were as follows; 1. In case of fin weight class, The total attack skill frequency of men players turned out to be 116 times, scores was 9 points and success rate was 7.76%. 2. In case of fly weight class, The total attack skill frequency of men players turned out to be 112 times, scores was 16 points and success rate was 13.11%. 3. In case of bantam weight class, The total attack skill frequency of men players turned out to be 149 times, scores was 16 points and success rate was 10.76%. 4. In case of feather weight class, The total attack skill frequency of men players turned out to be 101 times, scores was 9 points and success rate was 8.91%. 5. In case of light weight class, The total attack skill frequency of men players turned out to be 82 times, scores was 10 points and success rate was 12.20%. 6. In case of welter class, The total attack skill frequency of men players turned out to be 140 times, scores was 15 points and success rate was 10.71%. 7. In case of middle weight class, The total attack skill frequency of men players turned out to be 97 times, scores was 14 points and success rate was 14.43%. 8. In case of fin weight class, The total attack skill frequency of men players turned out to be 87 times, scores was 12 points and success rate was 13.79%.

열공성 경색 환자의 경동맥 초음파소견 및 혈청지방의 분포

여상준,민병국,황성남,석종식,김영백,박승원,권정택,최덕영 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.1

한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구

이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.