汚加皮 抽出液이 마우스의 抗腫瘍 免疫反應에 미치는 影響

成載煥,權文鉉,金炯均 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1

Ogapi(Acanthopanax senticosus) is being used for a tonic in the oriental medicine from ancient times, Even though it being used frequently for a tonic in the clinical medicine, basic study to make sure the mechanism of its action is the rare. Therefore, in this study, the author tried to know the effects of ogapi on the innate and specific immune systems in association with antitumor activity. The results obtained in this study are as follows: 1) Ogapi increased the phagocytic activities of murine peritoneal macrophages in vivo and in vitro. 2) Ogapi enhanced the production of such reactive oxygen intermediates as superoxide and hydrogen peroxide from the macrophages in vivo and in vitro. 3) Ogapi enhanced such humoral immune responses as hemagglutinin and hemolysin formations. 4) Administration of ogapi increased the number of rosette forming cells in the spleen. 5) Ogapi decreased the contact hypersensitivity against dinitrofluorobenzene. 6) Ogapi showed cytotoxic activity against human leukemia cell line (K562) 7) Ogapi increased the ratio of helper T cell versus suppressor T cell by increasing CD4^+ T cells and decreasing CD8^+ T cells. The above results show that ogapi increase the host antimicrobic and antitumor activities by the action on individual innate and specific immune systems in vitro. So this is considered as experimental results back up powerfully that ogapi can be used for a tonic in such a case when administered to a person lacking vital energy.

골프스윙시 근육협응관계 구명을 위한 EMG 분석

심태용,신성휴,오승일,문정환 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

T. Y. SHIM, S. H. SHIN, S. I. OH, J. I-. MUN. EMG Analysis for Investigation Muscle-Collaborated Relationship during Golf Swing. Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 177-189, 2004. Kinematic and kinetic analysis using 3D Motion Capture system are common, yet there is little in the literature that discuss the relationship and coactivity between muscles during the golf swing. The purpose of this study was to describe the relationship between the employed 16 muscles during golf swing. We could observe 3 muscle patterns such as 'Line' shape, 'L' shape, and 'Loop' shape for the golf swing activity. The 'Line' shape indicates that two muscles act almost perfectly in phase, and the 'L' shape represents that two muscles act in a reciprocating manner(When one is active, the other is quiescent and vice versa). And the 'Loop' shape indicates that two muscles act sequently(After one is active, the other act). In these results, we knew the muscle patterns during golf swing is similar to the patterns during gait. And we presented it was possible to show the consistence of golf swing through the frequency analysis of muscle patterns. We believe that the results potentially useful for the golf players and coaches to analyze their performance.

항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

Should pTlb Gallbladder Cancer be Treated Radically?

Seong-Pyo Mun,Seong-Hwan Kim 대한외과학회 2005 대한외과학회 학술대회 초록집 Vol.2005 No.10

Knowledge Evolution in Construction Automation Research

( Mun Seong-hwan ),( Kim Taehoon ),( Lee Ung-kyun ),( Cho Kyuman ),( Lim Hyunsu ) 한국건축시공학회 2020 한국건축시공학회지 Vol.20 No.6

Construction automation and robotics have been widely adopted in the construction industry as a promising solution to such issues like a shortage of skilled labor and the difficulties workers face in harsh working environments. The analysis of the knowledge structure and its evolution from the existing articles helps identify essential knowledge elements and possible future research directions. This study attempts to (1) construct keyword networks from the papers published in the International Symposium on Automation and Robotics in Construction (ISARC), (2) investigate how keywords and keyword communities are associated with each other, and (3) examine the changes in the crucial keywords over time. Through cluster analysis, 79 keywords were categorized into four groups (BIM, Building construction, Sensing, and GPS as representative keywords) with similar structural positions. Research trends show that research themes related to Infrastructure, Construction equipment, and 3D have consistently received a large amount of attention, regardless of geographical region. Research on as-built status model utilization through BIM and Laser scanning and improving Energy performance is taking place more frequently. In contrast, research studies related to problem-solving based on Neural networks are not as common as previously. This study provides useful insights into the construction automation field, at both the macro and micro levels.

The Diversity of The Definition of Hemodynamic Stability

Seong-Pyo Mun,Seong Hwan Kim,Nam Gyu Choi,David A Spain 한국간담췌외과학회 2012 한국간담췌외과학회 학술대회지 Vol.2012 No.4

기관지내 호지킨씨 림프종

문성진 ( Mun Seong Jin ),문진욱 ( Mun Jin Ug ),한창훈 ( Han Chang Hun ),정재호 ( Jeong Jae Ho ),박무석 ( Park Mu Seog ),김영삼 ( Kim Yeong Sam ),장준 ( Jang Jun ),김성규 ( Kim Seong Gyu ),신동환 ( Sin Dong Hwan ),김세규 ( Kim Se 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.54 No.6

상관관계 분석을 통한 건설관리 분야와 자동화기술간 연관성 분석

문성환 ( Mun Seong-hwan ),조규만 ( Cho Kyu-man ),김태훈 ( Kim Tae-hoon ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.2

The construction industry is in the process of changing from the existing labor-intensive production system to a construction automation system using advanced information and communication technologies. Accordingly, in order to identify key research areas and utilization technologies in the field of construction automation, this study collected the latest 17 years (2000-2016) of papers published in International Symposium on Automation and Robotics in Construction (ISARC) and conducted a correlation analysis between the construction management areas and automation technologies based on the keyword frequency. As a result, the BIM, WSN, and Augmented reality were extracted as the technology keywords with high correlation with various areas of construction management.

국내 동물용 의약품의 사용과 품질관리 현황

손성완 ( Seong Wan Son ),이광직 ( Kwang Jick Lee ),이명헌 ( Myoung Heon Lee ),장환 ( Hwan Jang ),정갑수 ( Gab Soo Chung ),위성환 ( Seong Hwan Wee ),이주호 ( Joo Ho Lee ),강문일 ( Mun Il Kang ) 한국수의공중보건학회 2006 예방수의학회지 Vol.30 No.2

열화상카메라 기반 콘크리트 온도 측정을 위한 이미지 프로세싱 적용 기초 연구

문성환 ( Mun Seong-hwan ),김태훈 ( Kim Tae-hoon ),조규만 ( Cho Kyu-man ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.1

Accurate estimation of concrete strength development at early ages is a critical factor to secure structural stability as well as to speed up the construction process. The temperature generated from the heat of hydration is considered as a key parameter in predicting the early age strength. Conventionally, concrete temperature has been measured by temperature sensors installed inside concrete. However, considering the measurement on building structures with multiple floors, this method requires reinstallation and repositioning of hardware such as sensors, data loggers and routers for data transfer. This makes the temperature monitoring work cumbersome and inefficient. Concrete temperature monitoring by using thermal remote sensing can be an effective alternative to supplement those shortcomings. In this study, image processing was carried out through K-means clustering technique, which is a unsupervised learning method, and the classification results were analyzed accordingly. In the future, research will be conducted on how to automatically recognize concrete among various objects by using deep learning techniques.