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An Analysis of the Effects of University Freshmen's Extracurricular Programs for the Public Value
Seohyun Song(Seohyun Song),Younghee Pyo(Younghee Pyo),Jongpil Lee(Jongpil Lee) J-INSTITUTE 2022 Public Value Vol.7 No.2
Purpose: The purpose of this study is to provide the basic data for the operation of the extracurricular program by examining whether it is effective for university life adjustment and student competency improvement accord-ing to the motivation to participate in the extracurricular program and the participation in the extracurricular program. Method: As for the data collection, a survey was conducted with freshmen in the natural science department of O University O located in in the metropolitan area. 1. To analyze as to whether the motivation for participation in the extracurricular program has an effect on the university life adjustment, the validity of the motivation to participate and the university life adaptation fac-tors was verified, then the inter-individual effect was verified. 2. Group statistics were analyzed to analyze as to whether the participation in the extracurricular program has an effect on the university freshmen's adaptation to the university life. 3. To verify the effect of participation in the extracurricular program and the student competency enhance-ment, the O University’s 5L Core Competency Diagnostic Tool(2021) was used, and the competency evaluation scores for the 4 competencies except for L3 were compared on an ex ante and ex post basis. Results: The motivation to participate in the extracurricular program for Research Question 1 was verified to have an effect on the university freshmen's adaptation to the university life, and consequently, it was apparent that motivation is more important before publicity or program improvement for the participation in extracurric-ular program. As a result of analysis as to whether to participate in the extracurricular program for Research Question 2 and the university life adjustment of freshmen, the participation in the extracurricular program was effective for all questions about university life adaptation. As a result of analyzing the effect of the extracurricular program for Research Question 3, it was apparent that the extracurricular program related to the auditory per-sonality competency L1, future learning competency L2, and job-based competency L3 was effective in enhancing the student competency, and it is considered that the extracurricular program related to the competency L5 needs to be improved for quality control to strengthen the student competency. Conclusion: This study was conducted with freshmen in the natural science department, and hence, there are limitations to generalizing to all university students. In the future studies, if factors such as segmentation by category and program learning efficacy are considered together, it will be possible to present a more specific way to activate the extracurricular program.
Evaluation of the Feasibility and Efficacy of Forward-Viewing Endoscopic Ultrasound
( Seohyun Lee ),( Dong Wan Seo ),( Jun Ho Choi ),( Do Hyun Park ),( Sang Soo Lee ),( Sung Koo Lee ),( Myung Hwan Kim ) 대한소화기학회 2015 Gut and Liver Vol.9 No.5
Background/Aims: We aimed to evaluate the feasibility and efficacy of a forward-viewing linear endoscopic ultrasound (FV-EUS) in diagnostic EUS procedures compared to standard oblique-viewing EUS (OV-EUS). Methods: This study was a prospective, randomized study that permitted cross-over. Fifty-one patients with subepithelial pancreatobiliary and upper gastrointestinal lesions underwent FV-EUS and OV-EUS sequentially, in random order. The EUS visualization was performed by a novice endosonographer, and the image quality of specific lesions was scored by an expert endosonographer. If fine-needle aspiration (FNA) was indicated, it was performed using both echoendoscopes by an expert endosonographer. Results: Both of the EUS procedures had similar visualization times and image quality. In general, the visualization time was inversely related to the diameter of the specific lesions. In subepithelial lesions of the stomach and duodenum, the visualization time (98.8±62.2 seconds vs 139.0±66.6 seconds, p=0.008) and image quality (4.1±1.3 vs 3.3±1.7, p=0.02) of FV-EUS were significantly superior to OV-EUS. FV-EUS-guided FNA of pancreatic masses was successful in seven patients (87.5%). Conclusions: FV-EUS may increase the ease of access to gastrointestinal subepithelial lesions compared to conventional OV-EUS. The performance of FV-EUS for evaluating pancreatobiliary diseases and performing interventions was comparable to conventional OV-EUS. (Gut Liver 2015;9:679-684)
Ji-Su Lee,Jennifer K. Lee,Jae-Joon Lee,Seohyun Park,Sunyoon Jung,Hyun-Joo Lee,Jung-Heun Ha 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.6
High-fat diet (HFD) consumption is closely associated with an increased risk of metabolic syndromes (MetS), such as obesity, type 2 diabetes, and cardiovascular diseases (CVDs). Therefore, the consumption of alternative and functional fatty acids to replace saturated fatty acids and/or trans-fatty acids with polyunsaturated fatty acids has become an important dietary strategy for the prevention of MetS. Consumption of omega-3 fatty acids (n-3) reduces various physiological complications, including CVDs, nonalcoholic fatty liver disease, and insulin resistance, related to inflammatory responses. In this study, we investigated the partial replacement effects of HFD with beef tallow (BT) on dyslipidemia and endoplasmic reticulum (ER) stress in male db/db mice. The animals were grouped to one of four dietary intervention groups (n = 16 per group): (1) normal diet, (2) HFD, (3) HFD partially replaced with regular beef tallow (HFD+BT1), or (4) HFD partially replaced with beef tallow containing a relatively reduced omega-6 fatty acid (n-6)/n-3 ratio (HFD+BT2) than HFD+BT1. After 6 weeks of dietary intervention, 1 mg/kg of phosphate-buffered saline or tunicamycin (TM) was injected intraperitoneally. HFD+BT2 significantly suppressed the serum total cholesterol and non-high-density lipoprotein cholesterol levels more than HFD and HFD+BT1, and triglyceride levels in the epididymal adipose tissue (EAT) were remarkably decreased. Mice that received HFD+BT2 had elevated protein expressions of phospho-AMP-activated protein kinase (p-AMPK). Moreover, HFD+BT2 effectively inhibited ER stress in the liver and EAT. Consistent with our hypothesis, HFD+BT2 remarkably alleviated dyslipidemia and TM-inducible ER stress, while activating p-AMPK.
Short- and Long-Term Outcomes of Acute Severe Ulcerative Colitis in Korea : The 1999-2005 Cohort
Lee, Ho-Su,Yang, Suk-Kyun,Soh, Jae Seung,Lee, Seohyun,Bae, Jung Ho,Lee, Hyo Jeong,Park, Sang Hyoung,Yang, Dong-Hoon,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Yoon, Yong Sik,Yu, Cha Oxford University Press 2015 Inflammatory bowel diseases Vol.21 No.8
<P>No previous studies have evaluated the long-term outcomes of acute severe ulcerative colitis (ASUC) in non-Caucasian populations. The purposes of this study were to evaluate the short- and long-term outcomes of Korean patients with ASUC.</P>
Lee, Mak-Soon,Lee, Seohyun,Doo, Miae,Kim, Yangha The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.1
Green tea (Camellia sinensis) is one of the most popular beverages in the world and has been acknowledged for centuries as having significant health benefits. (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea, and it has been reported to have health benefit effects. Peroxisome proliferator-activated receptor ${\gamma}$ coactivator $(PGC)-1{\alpha}$ is a crucial regulator of mitochondrial biogenesis and hepatic gluconeogenesis. The objective of this study was to investigate whether EGCG from green tea can affect the ability of transcriptional regulation on $PGC-1{\alpha}$ mRNA expression in HepG2 cells and 3T3-L1 adipocytes. To study the molecular mechanism that allows EGCG to control $PGC-1{\alpha}$ expression, the promoter activity levels of $PGC-1{\alpha}$ were examined. The $PGC-1{\alpha}$ mRNA level was measured using quantitative real-time PCR. The -970/+412 bp of $PGC-1{\alpha}$ promoter was subcloned into the pGL3-Basic vector that includes luciferase as a reporter gene. EGCG was found to up-regulate the $PGC-1{\alpha}$ mRNA levels significantly with $10{\mu}mol/L$ of EGCG in HepG2 cells and differentiated 3T3-L1 adipocytes. $PGC-1{\alpha}$ promoter activity was also increased by treatment with $10{\mu}mol/L$ of EGCG in both cells. These results suggest that EGCG may induce $PGC-1{\alpha}$ gene expression, potentially through promoter activation.
Lee, Mak-Soon,Jung, Sunyoon,Shin, Yoonjin,Lee, Seohyun,Kim, Chong-Tai,Kim, In-Hwan,Kim, Yangha TaylorFrancis 2017 Food & nutrition research Vol.61 No.-
<P><B>ABSTRACT</B></P><P><B>Background</B>: Oleoresin capsicum (OC) is an organic extract from fruits of the genus <I>Capsicum</I>, and has been reported to have an anti-obesity effect.</P><P><B>Objective</B>: This study comparatively investigated lipolytic effects of single-layer nanoemulsion (SN) and alginate double-layer nanoemulsion (AN) containing OC in 3T3-L1 adipocytes.</P><P><B>Methods</B>: SN and AN were compared by analyzing the intracellular lipid accumulation, triglyceride (TG) content, release of free fatty acids (FFAs) and glycerol, and mRNA expression of genes related to adipogenesis and lipolysis were analyzed in fully differentiated 3T3-L1 adipocytes.</P><P><B>Results</B>: Compared with SN, AN exhibited higher efficiency in inhibiting the intracellular lipid accumulation and TG content, and enhanced the release of FFAs and glycerol into the medium. In AN-treated cells, mRNA levels of peroxisome proliferator-activated receptor-γ and the fatty acid-binding protein adipocyte protein-2, which are involved in adipogenesis, were down-regulated, whereas those of genes related to lipolysis, including hormone-sensitive lipase and carnitine palmitoyl transferase-1α, were up-regulated compared with SN-treated cells.</P><P><B>Conclusion</B>: The lipolytic effect of AN was greater than that of SN; this was partly associated with the increased TG hydrolysis via induction of lipolytic gene expression and suppression of adipogenic gene expression in 3T3-L1 adipocytes.</P>
Seohyun Park,Zheng Jiaxiang,Jihye Lee,Jae-Joon Lee,Jung-Heun Ha 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
PUFAs has been reported to alleviate diet-induced systemic inflammation, dyslipidemia in mammals. To understand the effects of replacement of saturated fatty acids (SFAs) with PUFAs to obese subjects, we supplemented a normal diet with perilla oil (PO) or corn oil (CO) to genetically obese mice for 12 weeks with LPS injection. 1) PUFAs improved lipid profiles. PUFAs consumption attenuated hepatic TG and LDL-C; however, HDL-C was significantly increased in PO or CO replaced than normal chow consumed group. 2) Intriguingly, PUFAs consumption decreased inflammatory responses in the epididymal adipose tissue(EAT). PUFAs decreased the secretion of adipokines (IL-1β, IL-6 and CXCL1). Attenuation of adipocyte inflammation maybe related to the post-translational modification by decreasing phosphorylation of MAPKs. Prolonged inflammation may trigger endoplasmic reticulum (ER) stress, therefore, we logically postulated that consumption of PUFAs may decrease ER stress. 3) As our expectation, PUFAs consumption attenuated LPS-inducible ER stress in the EAT by attenuation of BiP and CHOP. Therefore, PUFAs decreased hepatic lipids accumulation, inflammation and ER stress in the EAT.