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Sunyoon Jung,Mak-Soon Lee,Yoonjin Shin,Chong-Tai Kim,In-Hwan Kim,Yangha Kim 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.4
Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptor-gamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.
Jung, Sunyoon,Lee, Mak-Soon,Shin, Yoonjin,Kim, Chong-Tai,Kim, In-Hwan,Kim, Yangha The Korean Society of Food Science and Nutrition 2015 Preventive Nutrition and Food Science Vol.20 No.4
Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80~110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptor-gamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-${\alpha}$, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.
Eun-Byeol Jo,Eun Jung Lee,Hyeri Won,Sunyoon Jung,Hee-Kyong Son,Jung-Heun Ha,Misook Kim,Youngseung Lee,Yoonhwa Jeong 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
NAFLD is now widely agreed as a metabolic associated fatty liver disease. Accumulation of excess fats in the liver elevates free fatty acids as a first hit and the prolonged first hit may triggers the second hit (i.e. oxidative stress, inflammation and/or ER stress). Gryllus bimaculatus (GB) contains a great sources of protein, unsaturated fatty acids, and essential fatty acids which possesses anti-oxidative and -inflammatory properties. Therefore, we raised an extended research hypothesis that GB would prevent tunicamycin-inducible ER stress and relevant pathological consequences. Regardless of GB consumption, tunicamycin injection induced a catabolic process by decreasing serum triglycerides, cholesterols and free fatty acids, but increased an anabolic process by increasing hepatic TG accumulation. Interestingly, hepatic ApoB, a strong predictor of inflammatory status, mRNA expression was suppressed by the GB supplementation. Therefore, we logically postulated that GB would prevent second hit in NAFLD; therefore, we focused on hepatic ER stress. As our expectation, GB consumption remarkably attenuated hepatic BiP, a cytosolic chaperone protein, expression.
Lee, Mak-Soon,Jung, Sunyoon,Shin, Yoonjin,Lee, Seohyun,Kim, Chong-Tai,Kim, In-Hwan,Kim, Yangha TaylorFrancis 2017 Food & nutrition research Vol.61 No.-
<P><B>ABSTRACT</B></P><P><B>Background</B>: Oleoresin capsicum (OC) is an organic extract from fruits of the genus <I>Capsicum</I>, and has been reported to have an anti-obesity effect.</P><P><B>Objective</B>: This study comparatively investigated lipolytic effects of single-layer nanoemulsion (SN) and alginate double-layer nanoemulsion (AN) containing OC in 3T3-L1 adipocytes.</P><P><B>Methods</B>: SN and AN were compared by analyzing the intracellular lipid accumulation, triglyceride (TG) content, release of free fatty acids (FFAs) and glycerol, and mRNA expression of genes related to adipogenesis and lipolysis were analyzed in fully differentiated 3T3-L1 adipocytes.</P><P><B>Results</B>: Compared with SN, AN exhibited higher efficiency in inhibiting the intracellular lipid accumulation and TG content, and enhanced the release of FFAs and glycerol into the medium. In AN-treated cells, mRNA levels of peroxisome proliferator-activated receptor-γ and the fatty acid-binding protein adipocyte protein-2, which are involved in adipogenesis, were down-regulated, whereas those of genes related to lipolysis, including hormone-sensitive lipase and carnitine palmitoyl transferase-1α, were up-regulated compared with SN-treated cells.</P><P><B>Conclusion</B>: The lipolytic effect of AN was greater than that of SN; this was partly associated with the increased TG hydrolysis via induction of lipolytic gene expression and suppression of adipogenic gene expression in 3T3-L1 adipocytes.</P>