http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
시멘트 종류별 콘크리트의 적산온도에 의한 강도예측에 관한 연구
장종호,나철성,김재환,김용로,길배수,남재현,김무한 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
The purpose of this study is to exhibit fundamental data which can apply to quality and process management of structure concrete using special cement in the construction field investigating strength prediction by maturity method of concrete according to cement types. The activation energy value was derived from the experimental study that experimental factors were selected as W/C ratio of 45%, the kinds of cements of 3 levels of O.P.C, H.B.C, H.S.C and curing temperature of 3 levels of 5℃, 20℃, 35℃. Also, after investigating relationship between compression strength and equivalent ages of concrete according to cement types, the strength prediction was investigated by maturity method. As the above of results, differences between the prediction strength by strength prediction equation and the actual measurement strength were lower, therefore it is considered that the strength prediction by maturity method is possible not only concrete using normal portland cement but also concrete using special cement.
후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출
최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.
장혁,김영훈,김용수,김희철,나상동 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1
본 논문은 이질적 버스트 트래픽을 갖는 ATM(Asynchronous Transfer Mode) 망에서 실시간 연결 수락 제어를 위한 유체 흐름 모델(fluid flow model)에 기반을 둔 실시간 알고리즘을 제안한다. 셀 손실 확률은 QOS(Quality of Service)의 기준이 되므로 제안된 실시간 알고리즘은 일정한 메모리 크기와 연결 요청의 수락 여부 즉, 연결 수락 여부의 결정을 위한 하나의 영역을 필요로 한다. 이러한 트래픽 소스 각 타입에 대한 셀 손실 확률은 트래픽 소스 타입 전체에 하나만 존재하더라도 요구를 충족 시킬 수 없으므로, 본 논문에서 제안된 실시간 알고리즘에 의해 산출되는 각각의 셀 손실확률에 충분한 상한선을 제공하는 전형적 트래픽 매개변수를 사용하여 성능을 분석한다.
Simulations of KSTAR high performance steady state operation scenarios
Na, Yong-Su,Kessel, C.E.,Park, J.M.,Yi, Sumin,Becoulet, A.,Sips, A.C.C.,Kim, J.Y. International Atomic Energy Agency 2009 Nuclear fusion Vol.49 No.11
<P>We report the results of predictive modelling of high performance steady state operation scenarios in KSTAR. Firstly, the capabilities of steady state operation are investigated with time-dependent simulations using a free-boundary plasma equilibrium evolution code coupled with transport calculations. Secondly, the reproducibility of high performance steady state operation scenarios developed in the DIII-D tokamak, of similar size to that of KSTAR, is investigated using the experimental data taken from DIII-D. Finally, the capability of ITER-relevant steady state operation is investigated in KSTAR. It is found that KSTAR is able to establish high performance steady state operation scenarios; β<SUB>N</SUB> above 3, <I>H</I><SUB>98</SUB>(<I>y</I>, 2) up to 2.0, <I>f</I><SUB>BS</SUB> up to 0.76 and <I>f</I><SUB>NI</SUB> equals 1.0. In this work, a realistic density profile is newly introduced for predictive simulations by employing the scaling law of a density peaking factor. The influence of the current ramp-up scenario and the transport model is discussed with respect to the fusion performance and non-inductive current drive fraction in the transport simulations. As observed in the experiments, both the heating and the plasma current waveforms in the current ramp-up phase produce a strong effect on the <I>q</I>-profile, the fusion performance and also on the non-inductive current drive fraction in the current flattop phase. A criterion in terms of <I>q</I><SUB>min</SUB> is found to establish ITER-relevant steady state operation scenarios. This will provide a guideline for designing the current ramp-up phase in KSTAR. It is observed that the transport model also affects the predictive values of fusion performance as well as the non-inductive current drive fraction. The Weiland transport model predicts the highest fusion performance as well as non-inductive current drive fraction in KSTAR. In contrast, the GLF23 model exhibits the lowest ones. ITER-relevant advanced scenarios cannot be obtained with the GLF23 model in the conditions given in this work. Finally, ideal MHD stability is investigated for the ITER-relevant advanced scenarios in KSTAR. The methods and results presented in this paper are expected to contribute to improving the ITER and beyond ITER predictive simulations.</P>
만응환 에탄올 추출물의 메티실린 내성 포도상구균에 대한 항균활성 및 내성억제 효과
나용수 ( Yong-su Na ),김종규 ( Jong-gyu Kim ),송용선 ( Yung-sun Song ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.1
Objectives In this study, we investigated the antimicrobial activity of a 70% ethanol extract of Maneung-hwan (MEH), which is prescribed by practitioners of oriental medicine for use against methicillin-resistant Staphylococcus aureus (MRSA). Methods The antibacterial activity of MEH against MRSA strains was evaluated using the disc diffusion method, broth microdilution method (minimal inhibitory concentration, MIC), checkerboard dilution test, and time-kill test. The mechanism of action of MEH was investigated by bacteriolysis using detergents or ATPase inhibitors Additionally, mRNA and protein expression were investigated by quantitative reverse transcription-polymerase chain reaction and western blot assay, respectively. Results The MIC of MEH was 25~1,600 μg/mL against all the tested bacterial strains. We showed that MEH extract exerts strong antibacterial activity. In the checkerboard dilution test, the fractional inhibitory concentration index of MEH in combination with antibiotics indicated synergism or partial synergism against S. aureus. The time-kill study indicated that the growth of the tested bacteria was considerably inhibited after a 24-h treatment with MEH and selected antibiotics. To measure the cell membrane permeability, MEH (3.9 μg/mL) was combined with Triton X-100 (TX) at various concentrations N,N-dicyclohexylcarbodimide (DCCD) was also tested as an ATPase inhibitor. TX and DCCD cooperation against S. aureus exhibited synergistic action. Accordingly, the antimicrobial activity of MEH in the context of cell membrane rupture and ATPase inhibition was assessed. Additionally, the expression of genes and proteins associated with resistance was reduced after exposing MRSA to MEH. Conclusions These results suggest that MEH possesses antibacterial activity and acts as a potential natural antibiotic against MRSA. (J Korean Med Rehabil 2020; 30(1):31-45)
Ka, Na-Lee,Na, Tae-Young,Na, Hyelin,Lee, Min-Ho,Park, Han-Su,Hwang, Sewon,Kim, Il Yong,Seong, Je Kyung,Lee, Mi-Ock American Association for Cancer Research 2017 Cancer Research Vol.77 No.9
<P>These findings show how a nuclear receptor and its ligands blunts repair of double-strand DNA breaks, suggesting their candidacy as therapeutic targets in cancer patients.</P><P>DNA repair capacity is critical for survival of cancer cells upon therapeutic DNA damage and thus is an important determinant of susceptibility to chemotherapy in cancer patients. In this study, we identified a novel function of nuclear receptor NR1D1 in DNA repair, which enhanced chemosensitivity in breast cancer cells. NR1D1 inhibited both nonhomologous end joining and homologous recombination double-strand breaks repair, and delayed the clearance of γH2AX DNA repair foci that formed after treatment of doxorubicin. PARylation of NR1D1 by PARP1 drove its recruitment to damaged DNA lesions. Deletion of the ligand binding domain of NR1D1 that interacted with PARP1, or treatment of 6-(5H)-phenanthridinone, an inhibitor of PARP1, suppressed the recruitment of NR1D1 to DNA damaged sites, indicating PARylation as a critical step for the NR1D1 recruitment. NR1D1 inhibited recruitment of the components of DNA damage response complex such as SIRT6, pNBS1, and BRCA1 to DNA lesions. Downregulation of NR1D1 in MCF7 cells resulted in resistance to doxorubicin, both <I>in vitro</I> and <I>in vivo</I>. Analysis of four public patient data sets indicated that NR1D1 expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients. <I>Cancer Res; 77(9); 2453–63. ©2017 AACR</I>.</P>