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Wenbo Liu,Shuguang Zhang,Boyi Sun 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.10
In consideration of the influence of energy dissipation on the rock compression process, the traditional elastic stress-strain relationship was improved by adding the energy release rate. The microintensity of the rock was assumed to satisfy the Weibull distribution. The improved stress-strain relationship was transformed into a triaxial stress-strain model in consideration of the loading damage combined with mesodamage mechanics. The characteristic points of the stress-strain curve and the experimental data were utilized to calculate the distribution parameters of the rock under different conditions. The model curve was compared with the experimental data. Results showed that the stress-strain curve of the rock has peak points in the conventional triaxial compression test, but the radial peak of the rock was not evident in the unloading test. The energy of the rock under the loading path was smaller than that under the unloading path. The model curve exhibited a high degree of fitting with the experimental data, and its correlation coefficient was relatively large (> 0.90), which indicated that the model can clearly represent the actual damage and evolution law of the surrounding rock. Furthermore, the established model can also reflect the rock’s stress-strain relationship, which can serve as a practical guide for relevant applications. Finally, the distribution parameters also reflected the evolution law of rock energy and provided a method for the assessment of rock energy and damage trend.
Caspase-3 inhibitor inhibits enterovirus D68 production
Wenbo Huo,Jinghua Yu,Chunyu Liu,Ting Wu,Yue Wang,Xiangling Meng,Fengmei Song,Shuxia Zhang,Ying Su,Yumeng Liu,Jinming Liu,Xiaoyan Yu,Shucheng Hua 한국미생물학회 2020 The journal of microbiology Vol.58 No.9
Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.
Angle-stable top-emitting white organic light-emitting devices employing a down-conversion layer
Shihao Liu,Xuemei Wen,Wenbo Liu,Wei Zhang,Jing-Yuan Wang,Wenfa Xie,Letian Zhang 한국물리학회 2014 Current Applied Physics Vol.14 No.11
Angle-stable white top-emitting organic light-emitting devices (WTEOLEDs) by the combination of a blue TEOLED with a down-conversion (DC) layer are demonstrated. The DC layer is composed of red fluorescent dye doped in a host of tris (8-hydroxy-quinolinato) aluminum. The TEWOLED shows a CIE coordinates of (0.240, 0.332) and a maximum current efficiency of 3.95 cd/A. Furthermore, theWTEOLED shows excellently angle-stable characteristic, the CIE coordinates at 20 mA/cm2 only shift by (0.023, 0.007) from 0 to 60. It can be attributed to the angle-stable blue TEOLED based on the Ag/Ge/Ag transparent cathode.
Two Types of Immunoassay Based on Nile Blue Labeling Polydopamine Nanospheres
Lili Liu,Wenbo Lu,Chang Liu,Ying Wang,Jian Dong,Weiping Qian 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.8
The sandwich-type immunoassays have been developed by using electrochemical and surface-enhanced Raman scattering (SERS) techniques for the detection of carcinoembryonic antigen (CEA). Nile blue as a kind of Raman dye has been decorated on nanospheres with polydopamine resin (PDR) via π-stacking interaction. The Nile blue displays the strong SERS signals as well as a characteristic electrochemical reduction peak at -0.33V (versus Ag/AgCl). The implementation of the PDR nanospheres mixing with Au nanoparticles (AuNPs/PDR) exhibits a better electrical conductivity and large SERS enhancement. The immunoassays based on Nile blue-labeled AuNPs/PDR nanospheres have been fabricated by using electrochemical and SERS techniques for the detection of CEA. The proposed immunoassay shows higher sensitivity, high selectivity, lower detection limit and long-term stability. The performances of the electrochemical immunoassay are better than that of SERS immunoassay. For the electrochemical immunoassay, the linear range occurs from 1 pg/mL to 100 ng/mL (R = 0.995) with a detection limit of 0.68 pg/mL and signal-to-noise ratio of 3 in the detection of CEA. The data for the analysis of human serum samples by using the electrochemical method are acceptably consistent with those obtained from the enzyme-linked immunosorbent assay (ELISA). The proposed immunoassay exhibits a promising potential for application in clinical diagnosis.
Wenbo Zhao,Xianye Qin,Bing Han,Biao Liu,Peichao Lian,Shuisheng Wu 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
The catalytic synthesis of dimethyl carbonate from methyl carbamate and methanol was investigated in a batch reactor. All of the homogeneous Brönsted acid catalysts show favorable catalytic activity. As homogeneous Brönsted acid catalyst is difficult to separate after reaction, it is converted to heterogeneous catalyst by grafting sulfonic acid groups to MCM-41 with three different methods. Their catalytic activity investigation indicated that sulfonic acid groups grafted by sulfonating with chlorosulfonic acid directly showed activity near to that of homogeneous sulfuric acid catalyst. It was further selected as a model catalyst to investigate the effect of acid amount on its catalytic activity. The results indicated that its activity was positively correlated with its acid amount.
Study of Deflection of Buried HDPE Corrugated Pipeline under the Uneven Settlement of Soil
Wenbo Gu,Kai Wu,Liyuan Tong,Songyu Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.1
This paper aims to study the deflection of high-density polyethylene (HDPE) corrugated pipeline subjected to differential settlements of the ground using the finite difference method-discrete element method (FDM-DEM) coupling simulation method in 3D. Various physical characteristics of the pipeline, including diameters, corrugations, and elastic modulus have been investigated. Soil particles with different shapes are considered. The variation of soil settlement of soil particles with three different shapes under the uneven settlement condition is studied. The soil arching effects, including positive soil arch and negative soil arch, have been respectively analyzed. The results reveal that the change in pipe corrugation influences the stiffness of the pipe and the friction between the pipe and soil to some extent, which also causes the change of vertical deflection of the pipe. The soil composed of four particles is easier to form soil arch, which makes the soil more self-stabilized, thus alleviating the circumferential deformation of the pipeline.
Group-Sparse Channel Estimation using Bayesian Matching Pursuit for OFDM Systems
( Yi Liu ),( Wenbo Mei ),( Huiqian Du ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.2
We apply the Bayesian matching pursuit (BMP) algorithm to the estimation of time-frequency selective channels in orthogonal frequency division multiplexing (OFDM) systems. By exploiting prior statistics and sparse characteristics of propagation channels, the Bayesian method provides a more accurate and efficient detection of the channel status information (CSI) than do conventional sparse channel estimation methods that are based on compressive sensing (CS) technologies. Using a reasonable approximation of the system model and a skillfully designed pilot arrangement, the proposed estimation scheme is able to address the Doppler-induced inter-carrier interference (ICI) with a relatively low complexity. Moreover, to further reduce the computational cost of the channel estimation, we make some modifications to the BMP algorithm. The modified algorithm can make good use of the group-sparse structure of doubly selective channels and thus reconstruct the CSI more efficiently than does the original BMP algorithm, which treats the sparse signals in the conventional manner and ignores the specific structure of their sparsity patterns. Numerical results demonstrate that the proposed Bayesian estimation has a good performance over rapidly time-varying channels.
GTP Binding Is Required for SEPT12 to Form Filaments and to Interact with SEPT11
Xiangming Ding,Wenbo Yu,Ming Liu,ShuQing Shen,Fang Chen,Lihuan Cao,Bo Wan,Long Yu 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.3
Septins are a family of filament-forming GTP-binding proteins involved in a variety of cellular process such as cytokinesis, exocytosis, and membrane dynamics. Here we report the biochemical and immunocytochemical characterization of a recently identified mammalian septin, SEPT12. SEPT12 binds GTP in vitro, and a mutation (Gly56 to Asn) in the GTPbinding motif abolished binding. Immunocytochemical analysis revealed that wild-type SEPT12 formed filamentous structures when transiently expressed in Hela cells whereas SEPT12G56A generated large aggregates. In addition, wild-type SEPT12 failed to form filaments when coexpressed with SEPT12G56A. We also observed that GTP-binding by SEPT12 is required for interaction with SEPT11 but not with itself.