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Robotic Distal Pancreatectomy with Celiac Axis Resection
( Rong Liu ),( Sai Chou ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Methods: woman in her 70s found lesion in pancreatic neck by ordinary physical examination and denied abdominal discomfort, vomiting, nausea, fever or backache. undergone a robotic distal pancreatectomy with celiac axis resection (Appleby). Surgeon: Rong Liu, Sai Chou Results: operation time94 mins blood loss: 50ml hospital stay: 5 days postoperative pathology: pancreatic adenocarcinoma R0 without lymph(-) No postoperative pancreas fistula
유영영(Liu, Rong-Rong) 한국언어학회 2014 언어 Vol.39 No.3
The purpose of this paper is to make a point that "poda" should be divided into ‘poda1’ which indicates activity and ‘poda2’ which indicates state. ‘poda1’ has the features of activity, intention and duration, while ‘poda2’ which expresses instantaneous visual contact has the features of fortuity, passivity and instantaneite. This semantic difference about ‘poda1’ and "poda2" has a effect on their aspect. We can prove the necessity of distinguishing "poda1" from "poda2" by the combination of ‘poda’ and some adverbs such as "ilbureo‘, ’kyesok‘, ’uyeonhi‘, temporal adverbs such as ‘T-tongan’, ‘T-mane’, endings such as ‘-ko issda’, ‘-eo issda’, imperative sentences, ‘-lyeogo hada’ or negative sentences. Especially, "poida‘ can also be used to indicate state besides ‘poda2", and form corresponding relation with ‘poda2’ only, but not ‘poda1’. Furthermore, according to the aspectual properties of ‘poda‘, ‘poda1‘ can be defined as an activity verb, while ‘poda2‘ can be defined as an achievement verb. Both the composition verbs including ‘poda’ as a component and the comparison with Chinese can also be helpful to proving the rationality of distinguishing ‘poda1’ and ‘poda2’.
Senescence as A Consequence of Ginsenoside Rg<sub>1</sub> Response on K562 Human Leukemia Cell Line
Liu, Jun,Cai, Shi-Zhong,Zhou, Yue,Zhang, Xian-Ping,Liu, Dian-Feng,Jiang, Rong,Wang, Ya-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Aims and Background: Traditional chemotherapy strategies for human leukemia commonly use drugs based on cytotoxicity to eradicate cancer cells. One predicament is that substantial damage to normal tissues is likely to occur in the course of standard treatments. Obviously, it is urgent to explore therapies that can effectively eliminate malignant cells without affecting normal cells. Our previous studies indicated that ginsenoside $Rg_1$ ($Rg_1$), a major active pharmacological ingredient of ginseng, could delay normal hematopoietic stem cell senescence. However, whether $Rg_1$ can induce cancer cell senescence is still unclear. Methods: In the current study, human leukemia K562 cells were subjected to $Rg_1$ exposure. The optimal drug concentration and duration with K562 cells was obtained by MTT colorimetric test. Effects of $Rg_1$ on cell cycle were analyzed using flow cytometry and by SA-${\beta}$-Gal staining. Colony-forming ability was measured by colony-assay. Telomere lengths were assessed by Southern blotting and expression of senescence-associated proteins P21, P16 and RB by Western blotting. Ultrastructural morphology changes were observed by transmission electron microscopy. Results: K562 cells demonstrated a maximum proliferation inhibition rate with an $Rg_1$ concentration of $20{\mu}\;mol{\cdot}L^{-1}$ for 48h, the cells exhibiting dramatic morphological alterations including an enlarged and flat cellular morphology, larger mitochondria and increased number of lysosomes. Senescence associated-${\beta}$-galactosidase (SA-${\beta}$-Gal) activity was increased. K562 cells also had decreased ability for colony formation, and shortened telomere length as well as reduction of proliferating potential and arrestin $G_2$/M phase after $Rg_1$ interaction. The senescence associated proteins P21, P16 and RB were significantly up-regulated. Conclusion: Ginsenoside $Rg_1$ can induce a state of senescence in human leukemia K562 cells, which is associated with p21-Rb and p16-Rb pathways.
Liu, Liu,Fan, Yan-Hua,Wu, Lan-Zhi,Zhang, Huai-Min,Yang, Li-Rong Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
Two 3D isomorphous and isostructural complexes, namely, $[Zn(BDOA)(bpy)(H_2O)_2]_n$ (1) and $[Cd(BDOA)-(bpy)(H_2O)_2]_n$ (2); (BDOA = Benzene-1,4-dioxyacetic acid, bpy = 4,4'-bipyridine) were synthesized under hydrothermal conditions and characterized by means of elemental analyses, thermogravimetric (TG), infrared spectrometry, and single crystal X-ray diffraction. Complexes 1 and 2 crystallize in the triclinic system, space group P-1 and each metal ion in the complexes are six-coordinated with the same coordination environment. In the as-synthesized complexes, $BDOA^{2-}$ anions link central metal ions to form a 1D zigzag chain $[-BDOA^{2-}-Zn(Cd)-BDOA^{2-}-Zn(Cd)-]_{\infty}$, whereas bpy pillars connect metal ions to generate a 1D linear chain $[-bpy-Zn(Cd)-bpy-Zn(Cd)-]_{\infty}$. Both infinite chains are interweaved into 2D grid-like layers which are further constructed into a 3D open framework, where hydrogen bonds play as the bridges between the adjacent 2D layers. Luminescent properties of complex 1 showed selectivity for $Hg^{2+}$ ion.
Liu, Xiao-Rong,Xu, Jie,Wang, Yi-Min,Ji, Ming-Suo,Liu, Fu-Shan The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.6
Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in a rat model of sepsis. Wistar rats were divided into Normal, Model, and PAE groups (n=20 each). Endotoxin was administrated at 5 mg/ml/kg in Model and PAE rats to establish rat sepsis model. 1 h after endotoxin administration, PAE was administrated at 4 ml/kg in PAE group once per day for 3 days. Routine blood tests and biochemical indexes were assessed, including aspartate aminotransferase (AST) and creatine kinase-MB (CK-MB). The plasma sTREM-1 level was measured using quantitative ELISA. At the end of experiment, the small intestine, liver, kidney and lung were subjected to pathological examinations. A rat model of sepsis-induced multiple organ dysfunction syndrome (MODS) was established successfully with endotoxin administration (5 mg/ml/kg), evidenced by histo-pathological examinations, routine blood tests and biochemical indexes: platelet count decreased and white blood cell count increased (p<0.05), CK-MB and AST increased (p<0.05). PAE treatment significantly reduced the plasma levels of AST, CK-MB, and sTREM-1, compared to Model group (p<0.05). Meanwhile, sepsis-induced damages in the liver, lung, stomach and intestinal mucosa were also markedly ameliorated by PAE treatment. PAE demonstrated a significantly protective effect in a rat model of sepsis by decreasing plasma sTREM-1 level, reducing inflammation, preventing MODS and protecting organ functions.
Stress Redistribution of Headed Stud Connectors Subjected to Constant Shear Force
Rong Liu,Zhiqiang Feng,Hengda Ye,Yuqing Liu 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.2
In order to evaluate the stress concentration of stud shear connectors considering creep effect of concrete, finite element analysis of the push-out specimen is carried out. The rate of creep method is used in the solid model to reflect the creep property of concrete. Local bearing stress and splitting stress of concrete are analyzed. The stress concentration of steel beam and stud near the weld toe are obtained. Results show that owing to the creep effect of concrete, the local stresses of the stud are redistributed, even under constant shear force. The stress concentration factor (SCF) of concrete bearing stress in front of the weld collar decreases by about 52%, while the bending deformation of the stud increases due to the stress redistribution given 10 years of creep time. SCF at the weld toe of steel beam increases about 1.5 times of short-term, and SCF of stud shank increases about 3 times. The stress concentration at the root of studs become more obvious under constant shear force due to concrete creep, which is adverse for the long-term behavior of studs in the normal service stage.