Multi-objective Decision-making Method of Green Product in Manufacturing Based on Entropy-TOPSIS Method

Wei Xu,Lina Liu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.9

The green products in manufacture industry still differ from each other in terms of economics, technology, environmental friendliness, though they all reach the criteria of limitation. This paper expounds the necessity for product choice optimization and provides a model based on information entropy to judge different advantages of product groups. According to Entropy Weight Method and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), the basic theory of green product evaluation model is established. The index system includes selected evaluation indicators of green products, considering about the evaluation index of the critical values to construct a hierarchy criterion, which uses entropy to objectively determine the weight vector of each evaluation index. Then, combined with TOPSIS analysis approach and calculates the pros and cons of green products. It is concluded that the evaluation results based on the Entropy-TOPSIS evaluation model are consistent with the actual results, and the results are consistent with the evaluation results of fuzzy mathematics. The method comprehensively considered many influential factors of the green products, to avoid the limitation of single criterion, and the importance of various factors are analyzed and compared, the prediction result is more scientific, as the theoretical basis of green products, and provide a reliable guidance method for product improvement. This is objective to empower the law, which also fully embodies the idea of variable weights and overcome the past green products that exist in the evaluation process homogeneity empowering. That means fixed weights lead to the limitation of a lack of flexible evaluation.

The Effect of Polypropylene Fiber and Glass Fiber on the Frost Resistance of Desert Sand Concrete

Lina Hou,Shiliang Jian,Wei Huang 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1

To study the influence of polypropylene (PP) fibers and glass fibers on the frost resistance of desert sand concrete (DSC), the fast-freezing tests were carried out to investigate the freeze-thaw damage law using the apparent damage, mass loss, and relative dynamic elastic modulus as indicators; Based on the mercury intrusion method (MIP) and scanning electron microscopy (SEM), the microstructure evolution was analyzed to reveal the mechanism of fiber frost resistance enhancement. Fit the freeze-thaw damage process of fiber reinforced DSC (FRDSC) and predict the frost resistance life. The results show that fibers can greatly improve the freezing resistance of DSC. The hybrid fiber had the highest enhancing effect, followed by PP fiber and glass fiber. The dynamic elastic modulus of the DSC with 0.15% PP fiber and 0.05% glass fiber is as high as 95%. The pore distribution ratio of FRDSC changes faster, but it is still better than that of reference DSC after freeze-thaw. PP fiber and glass fiber can play a full role in the micro and macro stages of crack development of DSC respectively. The freeze-thaw damage model has high fitting accuracy and the DSC mixed with fibers can significantly improve the service life of buildings in northern China.

Mechanistic Insight into Phenolic Compounds Toxicity and State-of-the-art Strategies for Enhancing the Tolerance of Escherichia coli to Phenolic Compounds

Lina Liu,Xiaolong Ma,Muhammad Bilal,Linlin Wei,Shijie Tang,Hong-zhen Luo,Yuping Zhao,Xuguo Duan 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.4

Efficient use of lignocellulosic biomass is a prerequisite for sustainable biofuel production while simultaneously contributing to environmental protection. However, phenolic compounds produced during the chemical treatment of lignocellulose inhibit the growth and metabolism of microorganisms, such as Escherichia coli, which is one of the ideal strains for producing target products by microbial fermentation. To provide new ideas for studying microbial tolerance to environmental stress and providing technical support for constructing the engineering strains with high yields of phenolic compounds, this review elucidates the inhibition mechanism of phenols to E. coli. Secondly, a comprehensive and systematic review of current approaches for improving the phenolic-tolerance of E. coli is provided, including strain domestication, random mutagenesis, regulating the expression of outer membrane proteins, changing the composition of membrane fatty acids, accelerating the efflux of phenolic compounds, engineered bacterial biofloc formation, and transcriptome analysis. Finally, this review ends with some questions that still exist today, and prospective strategies are outlined for further improving the phenols-tolerance of E. coli. This review provided a theoretical basis for research into microbial tolerance to environmental stress and the development of engineered strains with high yield of phenolic compounds.

Prediction of secondary flow structure in turbulent Couette- Poiseuille flows inside a square duct

Wei Loa,Chao-An Lina 한국전산유체공학회 2006 한국전산유체공학회 학술대회논문집 Vol.2006 No.5

Insulin Resistance Is an Important Risk Factor for Cognitive Impairment in Elderly Patients with Primary Hypertension

Lina Ma,Yun Li,Ming Feng,Yuying Qian,Wei Yang,Jia Liu,Rui Han,Hong Zhu 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.1

Purpose: Insulin resistance plays a role in the development of dementia and hypertension. We investigated a possible relationship between cognitive impairment and insulin resistance in elderly Chinese patients with primary hypertension. Materialsand Methods: One hundred and thirty-two hypertensive elderly patients (>60 years) were enrolled in this study, and assigned into either the cognitive impairmentgroup (n=61) or the normal cognitive group (n=71). Gender, age, education,body mass index (BMI), waist hip ratio (WHR), total cholesterol (TC), triglyceride(TG), C-reactive protein (CRP), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), creatinine (Cr), fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis model of assessment for insulin resistance index (HOMA-IR), systolic blood pressure, diastolic blood pressure, smoking history, atherosclerosis and the proportion of uncontrolled hypertensionwere compared between the two groups. Multi-factorial logistic regressionanalysis was performed. Results: No significant differences were found in gender, age, TC, CRP, HDL-C, LDL-C, Cr, BP, smoking history, atherosclerosis and the proportion of uncontrolled hypertension between the two groups. The cognitiveimpairment group had lower education levels, and higher BMI, WHR, TG, FPG, FINS, and HOMA-IR levels than the control group. Logistic regression analysis revealed the levels of education, BMI, WHR, and HOMA-IR as independentfactors that predict cognitive impairment in patients. Conclusion: Our study demonstrates that poor education and increased BMI, WHR, and HOMA-IR are independent risk factors for cognitive impairment in elderly patients with hypertension. Insulin resistance plays an important role in the development of cognitive impairment in primary elderly hypertensive patients.

Enhanced low-temperature activity and huimid-SO2 resistance of MnFe-based multi-oxide catalysts for the marine NH3-SCR reaction

Yi Wei,Wenhua Li,Qi Wang,Mengyu Liu,Peiyuan Liang,Lina Wang,Tianjun Sun 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

Several MnFe-based multi-metal oxides were synthesized as NH3-SCR catalysts by a simple coprecipitationmethod for abating NOx of marine diesel exhausts. The Co and Nb-doped MnFeCeAl catalysts exhibitNOx conversion over 90% and N2 selectivity above 95% at 180–270 C, especially the MnFeCeAlCo catalystscan inhibit nearly all sulfate species growth within 150 ppm humid-SO2 gases at 225 C. The structuralcharacterization results revealed that Co, Nb, Sm, and Sb doping can enhance interactions amongdifferent components and promote active component dispersion. Temperature programmed analysisindicated that the Co doping is not only more favorable for improving redox properties, but can alsoenhance the surface acidity, which are advantageous to improve the activity, N2 selectivity, andhumid-SO2 resistance. Moreover, the XPS results implied that the binding energy shift or the valence variationof the Sm, Sb, Nb, and Co species on catalyst surfaces are favored to raise the atomic ratios of highvalentMn species and surface adsorbed oxygen, which can promote the redox property significantly andfurther facilitate SCR activity. Accordingly, the excellent activity and humid-SO2 tolerance of theMnFeCeAlCo catalyst should attribute to its lower redox temperature, strong interaction between oxides,47.3% surface Mn4+/Mn3+ species, and 71.8% adsorbed oxygen, which provide a method for improving theSCR performances of MnFe-based catalysts with humid SO2 resistance.

Ferromagnetic order and spin-glass behavior in multi-metallic compound Ni1.125Co0.375[Fe(CN)6] . 6.8H2O

Haifu Huang,Lina Wei,Yun He,Xiaogang Li,Fupei Liang 한국물리학회 2009 Current Applied Physics Vol.9 No.5

Multi-metallic Prussian blue compound Ni1.125Co0.375[Fe(CN)6] . 6.8H2O has been synthesized. The Mössbauer spectroscopy at room temperature and IR spectra study revealed that the metal ions are bonded through cyanide ligand and the presence of low spin FeIII(S = 1/2) and high spin FeIII(S = 5/2) ions, as showed in these structure: FeIII(S = 1/2)-CN-(CoII/NiII)(96%) and FeIII(S = 5/2)-NC-(CoII/NiII) (4%). The Curie constant of C = 3.00 ㎤ K mol-1 and Weiss paramagnetic Curie temperature of θ = 16.43 K were observed in fitting according to Curie–Weiss law. These results indicate that there existed a ferromagnetic exchange interaction in the complexes. The observed value of coercive field (Hc) and remanent magnetization (Mr) at 4 K for the compound are 497 Oe and 1.03 Nβ. The presence of spin-glass behaviours in the compound is ascribed mainly to domain mobility or domain growth under different cooling conditions. Multi-metallic Prussian blue compound Ni1.125Co0.375[Fe(CN)6] . 6.8H2O has been synthesized. The Mössbauer spectroscopy at room temperature and IR spectra study revealed that the metal ions are bonded through cyanide ligand and the presence of low spin FeIII(S = 1/2) and high spin FeIII(S = 5/2) ions, as showed in these structure: FeIII(S = 1/2)-CN-(CoII/NiII)(96%) and FeIII(S = 5/2)-NC-(CoII/NiII) (4%). The Curie constant of C = 3.00 ㎤ K mol-1 and Weiss paramagnetic Curie temperature of θ = 16.43 K were observed in fitting according to Curie–Weiss law. These results indicate that there existed a ferromagnetic exchange interaction in the complexes. The observed value of coercive field (Hc) and remanent magnetization (Mr) at 4 K for the compound are 497 Oe and 1.03 Nβ. The presence of spin-glass behaviours in the compound is ascribed mainly to domain mobility or domain growth under different cooling conditions.

Sex Comb on Midleg Like-2 Accelerates Hepatocellular Carcinoma Cell Proliferation and Metastasis by Activating Wnt/β-Catenin/EMT Signaling

Lei Du,Lina Wang,Hong Yang,Jianping Duan,Jianming Lai,Wei Wu,Shaohua Fan,Xiaoli Zhi 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.12

Purpose: The purpose of this study was to investigate the influences of sex comb on midleg like-2 (SCML2) on hepatocellular carcinoma (HCC) and potentially related mechanisms. Materials and Methods: SCML2 expression in tumor tissues and cells was analyzed using the TCGA database and/or qRT-PCR. The proliferation of HCC cells was detected by CCK-8, colony formation, and EdU assays. The migration and invasion of HCC cells were detected by transwell and wound healing assays. Apoptosis of HCC cells was determined by flow cytometry. Additionally, qRT-PCR and Western blot were used to detect the expression of SCML2 and Wnt/β-catenin/epithelial–mesenchymal transition (EMT) signaling. A xenograft model in mice was established to verify the in vitro findings. Results: We found that SCML2 was highly expressed in HCC tissues and cells and that high expression of SCML2 was correlated with poor prognosis in HCC patients. SCML2 overexpression promoted proliferation, invasion, and migration and repressed apoptosis of HCC cells. The reverse results were obtained in SCML2-silenced cells. Further, we found that SCML2 activated the Wnt/β-catenin/EMT pathway. SCML2 silencing reduced the protein levels of Wnt3a, β-catenin, N-cadherin, Vimentin, and Snail and enhanced E-cadherin protein expression both in vivo and in vitro. Conclusion: SCML2 silencing inhibits the proliferation, migration, and invasion of HCC cells by regulating the Wnt/β-catenin/EMT pathway.

Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC

Xiaoping Song,Lina Wang,Wei Tang,Luyao Yuan,Qingchao Liu,Jing Li,Daidi Fan 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.12

Gefitinib, as the first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has achieved great advances in the treatment of non-small cell lung cancer (NSCLC), but drug resistance will inevitably occur. Therefore, exploring the resistance mechanism of gefitinib and developing new combination treatment strategies are of great importance. In our study, the results showed that selumetinib (AZD6244) synergistically inhibited the proliferation of NSCLC with gefitinib. Selumetinib also enhanced gefitinib-induced apoptosis and migration inhibition ability in gefitinib-resistant lung cancer cell lines. Subsequently, the negative regulation between MIG6 and STAT3 was observed and verified through the STRING database and western blotting assays. Sustained activation of STAT3 was significantly downregulated when co-treatment with selumetinib in gefitinib-resistant cells. However, the downregulation of p-STAT3, resulting from the combination of selumetinib and gefitinib was counteracted by the deletion of MIG6, suggesting that selumetinib enhanced gefitinib sensitivity by regulating MIG6/STAT3 in NSCLC. In contrast, p-STAT3 was further inhibited after treatment with gefitinib and selumetinib when MIG6 was overexpressed. Furthermore, the combined administration of selumetinib and gefitinib effectively promoted the sensitivity of lung cancer xenografts to gefitinib in vivo, and the tumor inhibition rate reached 81.49%, while the tumor inhibition rate of the gefitinib monotherapy group was only 31.95%. Overall, MIG6/STAT3 negative regulation plays an important role in the sustained activation of STAT3 and the resistance to EGFR-TKIs. Our study also suggests that EGFR-TKIs combined with MEK1/2 inhibitors, such as selumetinib, may be beneficial to those NSCLC patients who develop a primary or acquired resistance to EGFR-TKIs, providing theoretical support for combining TKIs and selumetinib in clinical cancer treatment.

Coupling reaction of carbon dioxide and epoxides efficiently catalyzed by one-component aluminum–salen complex under solvent-free conditions

Dawei Tian,Binyuan Liu,Li Zhang,Xiaoyang Wang,Wei Zhang,Lina Han,Dae Won Park 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.4

Four novel bifunctional aluminum–salen complexes (2a, 2b, 2c, and 2d) containing both Lewis acidic metal center and Lewis base quaternary phosphonium salt sites within one molecule and an aluminum–salen complex with a neutral tert-butyl group (2f) for comparison were synthesized and characterized by UV–vis, IR, 1H, 13C, 27Al NMR spectroscopy and Elemental analysis (EA). Their catalytic efficiencies as single-component catalysts toward the coupling reaction of carbon dioxide and propylene oxide were evaluated. These complexes exhibit catalytic activity in the order 2d > 2a > 2b > 2c 2f. 27Al NMR spectra reveal the existence of five- and six-coordinated metal centers in the aluminum–salen complexes bearing a quaternary phosphonium salt group, whereas only five-coordinate aluminum species were found in the aluminum–salen complex with a neutral tert-butyl group. This indicates the importance of the six-coordinate aluminum center in enhancing the catalytic activity as well as an intramolecular cooperative effect in bifunctional aluminum–salen complexes 2a–d. The effects of reaction variables on the catalytic performance were investigated in detail. These new catalysts are highly stable to moisture and air and robust to impurities in the coupling reaction.