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      • Combination treatment for onychomycosis using 1,064-Nd:YAG laser and efinaconazole 10% topical Solution

        ( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

        Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery has been suggested till present. Systemic treatment with antifungal drugs for onychomysosis is effective. However, a long treatment time is required and it is not suitable for people with other systemic disease. Furthermore, it may cause many side effects such as liver diseases. For that reasons, topical drugs or physical treatments are preferred by many patients. Recently laser treatment for onychomycosis has been proposed. The efficacy of treatment is less than systemic drugs but, laser is more convenient, safe and accessible in treatment. As a result, the combination therapy using 1064 Nd:YAG laser and efinaconazole 10% topical solution was performed. Two patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. All three patients were treated successfully. We considered a combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% topical solutions would be an effective, safe, and convenient treatment method for onychomycosis.

      • Combination treatment for onychomycosis using 1,064 Nd:YAG laser and efinaconazole 10% topical solution

        ( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

        Background: Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery was suggested till present. Systemic antifungal drugs for onychomysosis are effective. However, they require a long treatment time and not suitable for people with other systemic disease. Furthermore, they may cause many side effects such as liver disease. Also, many patients prefer topical drugs or physical treatment. Objectives: The objective of this study was to evaluate the efficacy of combination treatment with a 1064 Nd:YAG laser and efinaconazole 10% Topical Solution. Methods: Ten patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. The effectiveness of treatment were evaluated with before and after photographs. Results: Improvement were shown in 90% of patients after the treatment. However, 10% of patients had no response. Conclusion: This clinical study suggests that combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% Topical Solutionis an effective, safe, and convenient treatment method for onychomycosis.

      • Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

        권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

        The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.

      • KCI등재

        열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

        배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

        Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

      • 밸브 벽면과 제트의 부착효과로 인한 질량유량 감소에 관한 연구

        이성호 ; 임동주 김천대학교 1999 김천대학교 논문집 Vol.20 No.-

        Flow characteristics of a compressible gas flow through a rotating disc-type rotary valve are investigated experimentally under various conditions. It is known that the mass flow rate through poppet valves of 4-stroke cycle engines and through piston valves of 2-stoke cycle engines decrease with increase in engine speed. Rotary valve is one means by which air may be made to flow intermittently through a pipe. In this paper an exhaust system simulator of engine was used to experimentally analyze the decrease in flow rate at high rotation speeds and to determine what variables, other than rotational speed, give rise to the observed behaviour. These variables have been included in an empirical equation which is representative of the measured flow characteristics.

      • KCI등재

        杜詩章法硏究

        李永朱 한국중국어문학회 2000 中國文學 Vol.33 No.-

        杜詩盡發古今之體勢, 而無所不備, 尤其是章法, 卓然獨高, 古今無比, 當謂詩家之模辯. 自筆者所窺而說之, 其章法略有三指向. 其一, 要融合相反相背之二律. 其二, 要探究所以貫通諸體之章法. 其三, 要試作變格,拙讀, 緣於地面限制, 不得不止於其一之一部分而已. 其餘期於下回續論. 此回所論, 大槪始 一, 杜誇融合相反之二律, 以造咸其所擅長之嚴密結構, 當展開誇想時, 置重於轉變, 又資脈絡應接, 因此文勢自有似斷不斷, 相應相避之妙, 恰如行雲流水, 或流暘, 或頓挫, 變化無窮, 而不露斧遊. 二, 杜誇, 無古律無長短, 每篇布置整密, 每段分界謹嚴, 行文自有起伏. 各段句數, 必訓於漏意, 多寡勻稱, 詳略相應. -篇之內, 必有開頭本論末謠之結構, 開頭破題以領下, 末尾承上暇或就題結, 彧開一步, 本論所言, 井幷有條, 意興迭出, 以示章法之妙諦.

      • 연령 및 가정에서의 인터넷 환경이 인터넷 이용행태에 미치는 영향

        이현주,심성훈,신동일 한국항공대학교 경영연구소 2001 경영연구 Vol.8 No.1

        인터넷이 확산되면서 정보접근에 있어 사회 계층별로 더 큰 격차를 보이게 되었다. 초고속 인터넷 접속서비스의 급속한 보급으로 우리나라가 세계 최고 수준의 인터넷 이용률을 보이게 되면서 가정에서의 초고속 인터넷 접속 서비스 이용여부가 가구원 개인의 정보이용에 적잖은 영향을 미치고 있으며, 또한 연령대에 따라서도 많은 차이를 보이고 있다. 본 연구에서는 실증분석을 통해 이 두 변수에 의한 집단구분이 인터넷 이용장소, 이용시간, 이용빈도, 즐겨 찾는 사이트, 전자상거래 이용경험과 같은 인터넷 이용행태에 유의적인 차이를 발생시킴을 보이고 있다. The growth of internet use makes larger difference in information access among social classes. Rapid diffusion of broadband internet access at home enables Korea the highest internet penetration among OECD countries. So the accessibility of broadband service effects a lot on the information usage and also great difference with age. This study shows that there is significant difference in internet access location, time, frequency of access, favorite site and use of e-commerce according to two variables through empirical investigation.

      • KCI등재

        산국의 수량과 유효성분에 대한 NPK의 효과

        이경동,양민석,정연규,손보균,조주식,이성태,김필주 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.2

        본 연구는 3요소(N-PO_2O_5-K_2O)처리가 산국(Chysanthemum boreale M.)의 수량과 유효성분에 미치는 효과를 조사하여 효과적인 재배시스템을 개발하고자하였다. 처리구는 무처리, NPK(250-160-160), NK(250-0-160), PK(0-160-160kg/ha)의 5처리로 설정하여 산국을 재배한 결과, 건물수량은 NPK처리구가 PK처리구에 비하여 4.0배의 증수가 있었으며, 다른 처리구보다 무기이온의 흡수율, 생육 및 수량에서 NPK처리구가 가장 우수하였다. 식용으로 많이 쓰이는 꽃의 주요 아미노산은 proline, glutamic acid과 aspartic acid이였고, 다른 처리구들에 비하여 NPK처리구가 높은 함량을 보였다. 혈압강하효과가 우수한 cumambrin A는 PK처리구에 비하여 NPK처리구가 6.2배의 증수효과가 있었다. NK처리구는 NP처리구보다 cumambrin A의함량을 높이기 위해서는 인산의 시용보다 칼리의 시용이 더 요구되며, 야외포장에서의 인산과 칼리의 적정 시비량의 설정이 필요하다고 판단된다. To establish the fertilization condition to increase the productivity of Chrysanthemum boreale M. with high quality, the effects of three nutrients (N, P, K) on the yields and the effective components were investigated in the pot scale. NPK was applied by chemical fertilizers with N-P_2O_5-K_2O = 250-160-160 kg/ha as a main treatment, and NP (N-P_2O_5 = 250-160 kg/ha), NK (N-KO = 250-160 kg/ha), and PK (PO_2-KO_5 = 160-160 kg/ha) treatments were settled as comparison. Dry yields of C. boreale M. was increased significantly to 4 fold higher by nitrogen. Nitrogen increased apparently plant growth and inorganic nutrient uptake. In the flower, which is most useful and edible part as a herbal medicine, main amino acids were glutamic acid and aspartic acids, and the total content was increased significantly by three elements of application. In addition, the content of cumambrin A, which is known to have the effect of blood-pressure reduction, was increased source to 6.2 times by nitrogen higher than that in PK treatment. Potassium was more effective in biosyndiesis of cumatnbrin A than phosphorus, but the biological pathway was not clear, still.

      • 回轉굽힘을 받는 高周波硬化鋼의 疲勞壽命分布에 관한 尤度區間推定

        周東仁,李致雨 慶南大學校 附設 工業技術硏究所 1992 硏究論文集 Vol.10 No.-

        機械構造用炭素鋼SM45C를 高周波硬化熱處理하여 여러가지 作用應力아래에서 回轉굽힘疲勞實驗을 實施하여 疲勞壽命分布를 尤度區間推定法에 의하여 推定하면 從來의 區間推定法은 尤度區間推定法과 比較하면 有意側으로 推定될 可能性이 있으며 最尤推定法은 尤度區間推定法의 特別한 경우로서 尤度區間推定法중에 包含 될 수가 있는 것으로 思料된다. 또한 區間推定法은 주로 少數 샘플데이타의 評價에 必要하지만 尤度區間推定法도 少數샘플데이타의 評價에도 그 효(?)果를 기대할 수가 있다. The purpose of this study is due to test of rotating bending fatigue under the various stress of machanical structural carbon steel(SM 45C)hardened induction heat treatment. To estimation results of likelihood interval estimation for fatigue life distribution, interval estimation in the past is able to be estimated side of significance to compare likelihood interval estimation method, maximum likelihood estimation method is considered to include likelihood interval estimation method. Also, Interval estimation method largly needs to evaluate small sample fatigue data, however, likelihood interval estimation method can be expected its effect of evaluation of small sample fatigue data.

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