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Jeon, YK,Park, CH,Kim, K-Y,Li, YC,Kim, J,Kim, YA,Paik, J-H,Park, B-K,Kim, C-W,Kim, Y-N John Wiley Sons, Ltd. 2007 The Journal of pathology Vol.213 No.2
<P>NK/T-cell lymphoma (NKTL) is strongly associated with latent Epstein–Barr virus (EBV) infection. Recently, latent membrane protein 1 (LMP1), an EBV oncoprotein, was reported to activate the phosphatidylinositol-3 kinase (PI3K)/Akt pathway for cell survival. Because geldanamycin (GA) and its derivative, 17-allylamino-17-demethoxygeldanamycin (17-AAG), exhibit anti-tumour activity by degrading HSP90 client proteins, including Akt, we investigated the effect of GA and 17-AAG on the survival of NKTL cell lines. EBV-positive NKTL cell lines, Hank-1 and NK-YS, and an EBV-negative NK leukaemia cell line, NK-L, were treated with PI3K and Akt inhibitors, GA, and 17-AAG, and were subjected to apoptosis and cell viability assays, and immunoblot analysis. EBV-positive B-lymphoblastoid cell lines IM9 and LMP1-transfected IM9 (IM9-LMP1) were also included. Hank-1 and NK-YS cell viability was compromised and apoptosis was induced by LY294002 (PI3K inhibitor) or Akt inhibitor II. GA or 17-AAG administration resulted in the apoptosis of NKTL cells, accompanied by Akt and pAkt down-regulation, caspase 3 activation, and mitochondrial membrane potential disruption. The intrinsic level of pAkt was higher in EBV-positive NKTL cells than in EBV-negative NK-L, and GA or 17-AAG decreased the viability of NKTL cells more efficiently than NK-L. Moreover, IM9-LMP1 was more sensitive to Akt inhibitor II or HSP90 inhibitors than IM9. Importantly, GA showed little effect on the viability of normal peripheral NK cells as non-neoplastic counterparts for comparison. In conclusion, this study suggests that the PI3K/Akt pathway is frequently activated in EBV-positive NKTL and that therapeutic modalities based on targeting the PI3K/Akt pathway with HSP90 inhibitors could be useful for achieving NKTL control. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</P>
김동진,신영관,차용재,김준길,김준태,김태수 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
PTP는 동양인에서는 매우 드문 증후군으로서, 대부분의 경우 진단이 안되거나 ITP로 잘못 진단하는 경우가 많다. 특히 수혈을 많이하는 산부인과 의사로서 경산부에 수혈했을때 발병 가능성이 있으며 일단 PTP가 의심이 되면 즉시 치료를 시작해야 한다는 사실을 알아야 할 것으로 생각되며, 본 저자들은 경산부에서 발생된 PTP 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Post-transfusionpurpura(PTP) is believed to be a rare clinical syndrome characterized by the acute occurrence of severe purpura with thrombocytopenia approximately 1 week after blood transfusion. This syndrome occurs predominantly in patients who lack the platelet-specific alloantigen, and has been previously sensitized by prior transfusion or pregnancy. The typical patient is a middle-aged, multiparous white woman. Diagnosis may be suspected by normal clotting studies, bone marrow biopsy showing increased megakaryocytes, and demonstration of a potent antibody reactive against platelets by appropriate serologic tests. Treatment with corticosteroid and platelet transfusion is ineffective. Exchange trasfusion or plasmapheresis has led to improved survival in this disease. Recent reports indicate that IV IgG may become a effective treatment. We exprienced a case of PTP in a multiparous woman received first blood transfusion during Cesarean section. Here we report this case with brief review of literature.
김유곤,박양서,장봉림,이우영,김기태,김인수,박찬우,김경택 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
The 8 cases of severe ovarian hyperstimulation syndrome among 78 cases of ovulation induction by gonadotropins at the Department of Obstetrics and Gynecology, Hallym university from January 1, 1993 to August 31, 1995 were treated by ovarian cyste aspiration and reviewed. The results were summarized as follows: 1. The origin of ovarian hyperstimulation syndrome is in the ovaries. 2. Aspiration of the ovarian cysts in the severe ovarian hyperstimulation syndrome was safe and not only relieved the symptoms but also shortened the disease process, and allowed outpatient treatment.
김동진,신영관,김준태,윤미림,김태수,황호민 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.2
저자는 최근 본 병원 산부인과에서 제왕절개후 2년만에 발견된 태반 용종의 한 사례를 경험 하였기에 이에 대한 간단한 문헌적 고찰과 함께 보고하는 바이다. A placental polyp is an intrauterine, polypoid or pedunculated mass of placental tissue retained after an incomplete abortion or term pregnancy. While several cases of placental ployp after vaginal delivery and abortion have been reported, few cases of placental polyp after cesarian section were reported before. However, recently, we happened to meet such case, and we present here the history of the case and brief review of related literature.