불화물의 첨가가 아연화유지놀의 압축강도, 이차 우식에 대한 저항성, 변연누출에 미치는 영향에 관한 실험적 연구

정호석,김대업,이광희 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

The purpose of this study was to investigate the effect of addition of fluoride to conventional zinc oxide eugenol on compressive strength, resistance of enamel to secondary caries and marginal leakage. Groups were divided by adding materials and their content. Group 1 was control group that did not contain fluoride, Group 2 was 10% sodium fluoride group, Group 3 was 20% sodium fluoride group, Group 4 was 10% stannous fluoride group and Group 5 was 20% stannous fluoride group. Each of four experimental groups was compared with control group. The results were as follows : 1. In compressive strength after 3 days, 10% stannous fluoride group was highest and then 20% sodium fluoride group, 10% stannous fluoride group, 10% sodium fluoride group, and non-fluoride group were in order. Compressive strength after 1 day water soakong after 3 days was stastically not significant(p>0.05). 2. In resistance of enamel to secondary caries, hardness reduction rate of experimental groups was lower than control group. There was no significant difference among groups (p>0.05). 3. Sodium fluoride group showed less marginal leakage than stannous fluoride group(p<0.05). 4. The amount of fluoride release was largest in 20% sodium fluoride group, and then 10% sodium fluoride group, 20% stannous fluoride, 10% stannous fluoride group were in order.

Non-Hodgkin's Lymphoma 환자에서 Doxorubicin(Admycin^R) 정맥주입에 따른 약동학적 특성에 대한 연구

이정애,장인진,방영주,이경훈,임동석,조광재,허대석 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

초등학교 아동의 치과치료장면 그림의 주조색과 불안도의 연관성에 관한 연구

조중한,이광희,김대업,배상만 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

The purpose of the study was to observe the association between the main colors of school chidlren's drawings of dental treatment situation and their dental anxiety. The subjects of study were 688 school children from 2nd to 4th grade. Caries experience was investigated by oral examination. Questionnaire survey was done regarding children's attitude toward the dentist and dental treatment and their experience of pain and fear during the dental treatment. Colors with high frequency of use were green, blue, yellow, orange, pink, purple, gray, brown, yellow ochre, red, white and black in order. Boys used green and blue, and girls used yellow and orange, more than each other. As the grade increased, white, yellow, and blue increased and brown decreased. Colors with high dental anxiety level were black, brown, red, white, blus, orange, yellow and green, yellow ochre, gray, pink, and purple in order, and the upper four represented 10.5% of the subjects. Children with high decayed teeth rate had a tendency to use colors of high dental anxiety level. Black color had the most obvious association with the pain and fear of dental treatment.

거주지역 특성에 따른 어린이의 우식활성과 우식유발요인의 차이

이광희,정영석,정은영,김대업 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

The purpose of this study was to compare the caries activity and cariogenic factors in children in different residence areas. The subjects of the study were 268-kindergarten children who were selected from the downtown area(D), apartment area(A), suburban area(S), and rural area(R), in and around the city of Iksan, Korea. Caries activity was measured as past caries experience (dft index and dfs index) and salivary reductase activity (Resazurin Disc Test scores). Cariogenic factors were investigated by a questionnaire. The results were as follows: Reductase activity S > R > D > A dt index R, S > D, A ft index D - the highest dft index A - the lowest ds index R - the highest fs index D - the highest Toothbrushing frequency A - the highest, R - the lowest Toothbrushing before bed D, A > S, R Toothbrushing by parents S, R > A, D Sweets intake frequency A - the highest, S - the lowest Distance to dental office D < A < S < R Dental treatment experience D - the highest, A - the lowest Foluride application rate D > S > R > A Sealant application rate D > A, S > R Birth order A,S > R, D Age D > S > R, A

유아 모친의 우유병우식증 및 치아우식증 예방에 대한 지식 및 태도 조사

김대업,이지영,이광희,조중한 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.1

The purpose of this study was to investigate the knowledge and attitude of a group of mothers who had infants about baby bottle tooth decay(BBTD) and dental caries prevention. The sample consisted of 261 mothers who had infants from 6 to 36 months from certain areas of Dae-jeon city. The mothers were asked to answer a questionnaire which included a series of questions regarding general information concerning the infant and his mother, knowledge about BBTD and methods of prevention using fluoride, knowledge about behavioral risk factors contributing to caries of the infant, attitude toward oral health care of the infant, opinions regarding the effectiveness of methods to prevent dental caries and sources of oral health information. The results of this study were as follow. 1. 85.4% of the respondents thought that prolonged bottle feeding would harm the teeth of the infant, but 77% of the respondents had never heard of baby bottle tooth decay. 2. Levels of knowledge about methods of prevention using fluoride were relatively low and there were significant relationships between the levels of this knowledge and the educational level of the respondents(P<0.05). 3. Only 7.3% of the respondents thought that prolonged breast feeding would harm the teeth of the infant. 4. Overall oral health care of the infants was relatively insufficient. 5. Only 28.7% of the respondents selected either when the first tooth erupt or deciduous dentition complete as the time a infant should first be seen by a dentist. 6. 64.6% of the respondents thought that toothbrushing should be instituted once the first tooth appears. 7. Among the six methods of preventing caries in infants, respondents ranked the effective of fluoride lower than making regular dental visits and reducing intake of sugared foods. 8. Most frequently cited sources of information about dental health were newspapers, magazines and books (65%), followed by friednds, neighborhoods and families(55%).

불소가 함유된 세마제가 법랑질의 내산성에 끼치는 영향에 관한 생체외 연구

조중한,김대업,이광희 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

The purpose of study was to know the effect of addition of fluoride to prophylaxis paste on caries prevention. 2% sodium fluoride solution and 8% stannous fluoride solution were applied topically to enamel blocks made from human teeth. Also, 2% sodium fluoride-containing pumice and 8% stannous fluoride-containing pumice was applied to enamel blocks using rubber cup for ten seconds. Enamel surface hardness was measured before and after demineralization by 0.01 N lactic acid. The results were as follows ; 1. Enamel solubility was increased in NaF group and nearly unchanged in SnF₂group by prophyaxis with plain pumice after fluoride application. 2. Enamel solubility was increased in NaF group and decreased in SnF₂group by prophylaxis with fluoride-containing pumice after fluoride application. 3. Enamel solubility was lower in case of prophylaxis with fluoride-containing pumice after fluofied application and after no fluoride application than in case of prophyalxis with plain pumice after fluoride application. 4. Enamel solubility was lower incase of no prophylaxis after fluoride application than in case of prophylaxis with fluoride-containing pumice in NaF group, and vice versa in SnF₂group.

고령 작업자를 위한 농작업 편이장비의 인간공학적 개선에 관한 연구

이창민,오연주,김대웅,유중현,신광현 東義大學校産業技術開發硏究所 2009 産業技術硏究誌 Vol.23 No.-

우리나라의 농업은 작업자의 고령화와 여성작업자의 증가 그리고 비정형화로 구성된 작업형태로 인해 근골격계질환의 위험성이 매우 높은 업종이다. 특히 과수업은 작업점이 작업자의 머리위에서 형성되어 지속적으로 이루어지고, 수확기에는 작업량이 집중되어 농업분야 중에서도 근골격계질환의 유병율이 가장 높게 나타난다. 본 연구에서는 고령농작업자에게 집중적으로 발생되는 근골격계질환을 예방하기 위해 수확기에 집중되는 대표작업 세 가지 운반 작업, 선별작업 그리고 포장작업을 선정하여 유해요인을 분석하고 공학적 개선책을 제시하고자 한다. 배농업의 수확기 작업에서 근골격계질환 유해요인으로 나타나는 중량물 운반 작업과 불필요한 작업 자세를 개선할 수 있는 자바라 컨베이어 벨트와 높이조절식 작업대의 도입을 통하여 고령 작업자뿐만 아니라 여성 작업자들이 효율적인 시스템에서 안전하게 작업할 수 있기를 기대하며 근골격계질환 발생으로 인한 사회․경제적 손실도 감소시킬 수 있을 것이다.

만성 B형 간질환에서 라미부딘 내성의 임상경과 및 예측인자

박능화,신정우,박종호,방성조,김대현,주광로,김도하 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.4

목적: 라미부딘의 투여기간이 길수록 약제내성 변이형 바이러스의 발생률이 증가하게 된다. 변이형의 장기적인 임상적 의의는 논란이 많다. 본 연구는 B형 간염 바이러스에 의한 만성 간질환자에서 변이형이 생긴 뒤의 임상적 경과와 변이형의 발생을 예측할 수 있는 인자를 알아보고자 하였다. 대상과 방법: 만성 B형 간 질환자로 진단 받은 환자 중 라미부딘 치료도중에 viral breakthrough가 생긴 124명을 대상으로 하였다. 평균 연령은 40세였고 남녀 비는 105:19였다. 치료 전 혈청 평균 ALT치는 223 IU/L, 혈청 평균 AST치는 127 IU/L, 혈청 평균 HBV DNA치 1216 pg/mL, 치료 전 정량적 평균 HBeAg치 259이였다. 라미부딘은 1일 100 ㎎씩 breakthrough가 발생한 124명에게 계속 투여하였으며 1, 2개월 간격으로 간기능 검사, HBeAg, anti HBe, HBV DNA 검사를 시행하였다. 라미부딘 총 평균투여 기간은 30.5개월(범위: 10-59개월)이었으며 breakthrough 후 라미부딘 평균 투여기간은 12.5개월(범위: 1-42개월)이였다. 결과: 라미부딘 투여 환자 519명 중 124명에서 viral breakthrough가 5-41개월 사이에 발생하였으며 누적발생률은 12개월 후 8%, 18개월 후 24%, 24개월 후 36%, 36개월 후 52%였다. Viral breakthrough가 생긴 6개월 이내에 120명에서 혈청 ALT치가 상승하였으나 4명에서는 계속 정상으로 유지되었다. 혈청 ALT치는 대부분 상승한 뒤 5개월 내에 최고치에 도달하였으나 6명에서는 12개월 이후에 최고치에 도달하기도 하였다. ALT치는 72명(65%)에서 치료 전 값 이상으로 상승하였으며, 67명(56%)에서 정상치의 5배 이상, 29예(24%)에서 10배 이상 상승하였다. Breakthrough후에 라미부딘 계속투여로 혈청 ALT치가 정상으로 유지된 경우는 22예(18%)에 불과하였으며 98예는 치료전보다 높게 유지되었고 16예에서는 지속적으로 상승하였다. Breakthrough후의 혈청 ALT치 및 AST치가 치료 전보다 의미 있게 상승하였으나 혈청 HBV DNA치는 차이가 없었다. Breakthrough후에 10명에서 HBeAg의 음전이 있었으나 5예에서는 음전 후에 HBV DNA가 재양전되고 혈청 ALT치가 상승되는 HBeAg 음성 만성 간염형태로 나타났다. Breakthrough와 관련된 예측자로 치료 중 정량적 HBeAg의 변화양상만이 유일하게 의미가 있어 감소 후 증가군 82.5%에서,. 지속적 유지군 23.7%에서 Breakthrough가 발생하였으나 지속적 감소군에서는 단지 3.5%만이 발생하였다. 또한 감소 후 증가군에서 정량적 HBeAg치의 감소 후 재상승시점은 약물투여후 평균 9개월로 HBV DNA가 재양전되는 평균시점인 16개월보다 의미 있게 짧았다. Breakthrough후에 투약을 중지한 예는 40예(33%)였다. 이 중 11예에서 중단전보다 혈청 ALT치가 상승되었으며 8개월 내에 전예에서 발생하였다. 중단시 혈청 ALT치가 치료 전 수치보다 높은 경우에서 중단한 26예 중 25명은 중단 후에 혈청 ALT치가 중단 시보다 낮았지만 치료 전 수치보다 낮은 경우에서 중단한 14명 중 10예에서 중단 후에 중단 시보다 더 높아졌다. 결론: 만성 B형 간염환자에서 라미부딘 투여 중에 발생한 HBeAg후의 임상양상은 상당수에서 급성악화를 보였다. Breakthrough를 예측할 수 있는 인자로는 치료 중 정량적 HBeAg치의 변화양상만이 유일한 인자였으며 HBeAg치가 지속적 감소 후에 다시 증가하는 양상을 보인 경우에는 HBV DNA의 재양전보다 더 빨리 Breakthrough을 예측할 수 있었다. Background/Aims: Long-term treatment with lamivudine causes breakthrough, but the clinical course after lamivudine breakthrough is not well known. The aims of this study were to evaluate the clinical course in lamivudine after breakthrough, and to identify predictive factors of breakthrough. Methods: 124 patients with chronic hepatitis B infection, who represented viral breakthrough during lamivudine therapy, were included. The mean duration of lamivudine therapy and additional lamivudine therapy after breakthrough was 30.5 months and 12.5 months, respectively. Results: The cumulative breakthrough rates at 12, 18, 24 and 36 months were 8, 24, 36 and 52%, respectively. After viral breakthrough, only 4 patients maintained normal ALT levels. 120 patients showed ALT elevation. The number of patients with ALT levels greater than 5 times, and greater than 10 times, the upper normal limit were 67(56%) and 29 (24%), respectively. While still on lamivudine therapy after breakthrough, 98 patients presented ALT elevation. Only 22 had normalized ALT levels. Hepatic decompensation developed in 2 patients. HBeAg seroconversion after breakthrough occurred in 10 patients. The changing pattern of quantitative HBeAg levels during lamivudine therapy was the only predictive factor associated with viral breakthrough. The mean time of turning points in decrescendo-crescendo patterns of HBeAg levels during lamivudine therapy was earlier than viral breakthrough (9 months vs. 17 months). Conclusions: These results suggested that deterioration of hepatic function can usually be observed after breakthrough. The serial monitoring of serum quantitative HBeAg levels may allow an early recognition of viral breakthrough.(Korean J Hepatol 2003;9:293-303)

고혈압 환자에서 Leukoaraiosis 정도와 망막증과의 연관성 : 예비연구 Preliminary Results

신동익,한현정,서대희,이광훈 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

Changes in the cerebral white matter (leukoaraiosis;LA) are detected with increasing frequency by computed tomography (CT) and magnetic resonance imaging (MRI) in elderly patients with diabetes mellitus and hypertension. The purpose of this study is to determine whether the severity of retinopathy is correlated with degree of LA in patients with hypertension. Twenty-three consecutive patients with patients with hypertension admitted in the department of neurology were evaluated for degree of LA and severity of retinopathy. 8patients were 15female. The age distribution was between 52 and 85 years(mean 69.1years). The duration of hypertension was between 1 and 30 years(mean8.2 years). The degree of LA was correlated with severity of hypertensive retinopathy(p<0.05), especially in relatively young patient, short periods of disease, and female paitents(p<0.05). We can make a rough estimation of degree of LA with fundus examination without CT or MRI evaluations in hypertensive patients, especially in relatively young and female patients with short durations of disease. However, more broad study should be made for these value and relationship.

불악산(경기도)의 식물상에 관한 연구

안영희,안영철,최광율,박대식,정연택 중앙대학교 유전공학연구소 2001 遺傳工學硏究論集 Vol.13 No.1

Field surveys were carried out 3 times from 2000 5. 17 to 2000. 6. 4. Main results obtained from this study wet·e as follows : 1.The vascular Plants in Mt. Bull-ak were consisted of 221 taxa such as 71 families, 163 genera, 188 species, 30 varieties, 2 forma, 1 hybrid. 2.Family Compositae and Gramineae covers 8.6% and 7.2% of total number of naturalized plants, respectively. 3.Pteridophyte, Gymnosperm, Dicotyledon and Monocotyledon covers 2.5%, 2.7%, 75.9% and 18.1% of total number of naturalized plants, respectively. 4.The life cycle of the plants was annual 11.8%, biennial 11.3%, perennial 76.9%. As it compared with consistency ratio in the flora of Korea, the distribution of biennial appeared highly. 5.The highest peak of blooming month is May (49.3% among total number of naturalized plants). 6.In this area the Korean endemic plants are 5 taxa (2.3% among total number of naturalized plants). 7.Number of naturalized is 20 taxa (9.0% among total number of naturalized plant)