폐암과 동반되어 나타난 기관기관지병증 골연골형성증 1예

이영진,전현수,박시형,김모세,김현주,이승헌,이영민,이현욱,이현경 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Tracheobronchopathia osteochondroplastica (TPO) is a rare benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. Although some disorders were reported combined with TPO, these seemed to be considered casual. We report a case of TPO that combined with adenocarcinoma of lung. She was 50-year-old non smoking woman presented with chronic cough with right chest pain. Lung mass on right lower lobe was found on chest x-ray, so lung cancer was suspected. Multiple scattered whitish small elevations from trachea to bronchial trees were found on bronchoscopic exam. We mistook these lesions for metastases from lung cancer and biopsies of these lesions were done. Transbronchial biopsy for right lower lobe mass lesion was also done. But biopsies from trachea and bronchus revealed TPO rather than lung cancer. Transbronchial lung biopsy of right lower lobe mass was diagnosed adenocarcinoma of lung. So TPO combined with adenocarcinoma of lung was diagnosed.

프롤린 함량 증가 및 내건성 강화 관련 새로운 RING-Type E3 유비퀴틴 리가아제 애기장대 atrzf1 돌연변이체의 생리적 기능 연구

주현우,민지희,정문수,김철수 전남대학교 농업과학기술연구소 2021 농업생명과학연구동향 Vol.59 No.-

The covalent attachment of ubiquitin to proteins plays a fundamental role in the regulation of cellular function through biological events involving abiotic of biotic stress responses, immune responses, and apoptosis, Here, we characterize the biological function of the Arabidopsis thaliana RING Zinc Finger 1 (AtRZF1) in dehydration response. AtRZF1 was significantly reduced by drought stress. The atrzf1 mutant was less sensitive to osmotic stress than the wild-type during early seedling development, wheareas transgenic pants overexpressing AtRZF1 were hypersensitive, indicating that AtRZF1 megatively regulates drought-mediated control of early seedling developmeng. Moreover, the ectopic expression of the AtRZF1 gene was very significantly influential in drought sensitiv parameters including proline content, water loss, membrance ion leakage and the expression of dehy-dration stress-relat genes. ARZF1 is a functional E3 ubiquitin ligase, and its conserved C3H2C3-type RING domain is likely important for the biological function of AtRZF1 in drought response. Together, these results suggest that the E3 ligase AtRZF1 is an important regulator of water deficit stress during early seedling development.

In situ 고상 에피택시 방법에 의한 CoSi₂/Si(111)구조의 형성

이정주,강민성,김현수,최치규,이운환,이종덕,이영백,김건호,이정용 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.2

초고진공에서 공상에피택시(solid-phase epiyaxy, SPE) 방법으로 CoSi₂를 Si(111)기판 위에 에피택시 성장시켰다. 2MeV⁴He++ ion후방산란 분광기와 사중결정 x-선 회절기 및 고분해 투과전자 현미경을 이용하여 성장된 CoSi₂의 상과 조성, 결정성, 그리고 계면의 미시구조를 조사하였다. 초고진공상태의 실온에서 Si(111)-7X7기판에 Co를 약 20 ~50 ?? 중착한 후 SPE에 의하여 실리사이드를 형성시키는 경우 600℃에서는 B-형의 CoSi₂가, 그리고 700℃에서는 A형의 CoSi₂가 선택적으로 에피택시 성장하였으며, 정합성은 B-CoSi₂[110]//Si[110] and CoSi₂(111)//Si(111)이, 그리고 700℃에서는 A-CoSi₂[110]//Si[110], CoSi₂(002)//Si(002)을 나타내었다. Epitaxial films of CoSi₂were grown on Si(111) substrates by in situ solid-phase epitaxy in a ultrahigh vacuum. The phase, the chemical composition, the crystallinity, and the microstructure of the Silicide/Si interface were investigated by 2-MeV⁴He++ ion-backscattering spectrometry, quadruple crystal X-ray diffractometry, and high-resolution transmission eletron micorscopy. High-quality films of either B-type or A-type CoSi₂ could be grown selectively on Si(111) substrates by depositing ~ 20 ~ 50 ?? of Co on a Si(111)-7X7 substrate followed by in situ annealing at 600℃ or 700℃ for 10 min. The matching face relationships are CoSi₂[110]//Si[110] and CoSi₂(111)//Si(111) by B-type CoSi₂ and CoSi₂[110]//Si[110]//Si[110] and CoSi₂(002)//Si(002) for A-type CoSi₂.

카아네이션 잎마름병 (Alternaria dianthi Stevens & Hall)의 발생에 관하여

文炳周,孫賢秀,金正基 東亞大學校 大學院 1984 大學院論文集 Vol.8 No.2

The study has been carried to examine a new disease of carnation caused by Alternaria isolate, which was found in Gim Hae, Gyoungnam province and the suburbs of Busan City, recently. 1. The pathogen was identified as Alternaria dianthi Stevens & Hall which has not been described in Korea. The common name of the disease was given as IB Ma Reum Byung(carnation blight). 2. Morphological studies of the fungus have shown a wide variation in shape, size and septation of conidia. The size of conidia formed on carnation leaf lesions in field is 22.8-101.2μ(av. 60.4μ)×10.1-27.8μ(av. 18.6μ), which was larger than those on potato dextrose agar in vitro. 3. Of 13 carnation varieties tested, Boston, Linda and Red Alaska were highly susceptible, and Angel, Flamingo Sim, William Sim and Yo Soo were moderately susceptible whereas Brauns Yollw Sim, Colquate, Imp Sisney Little Field, Cardinal Sim, La Reve Salmon Sim and Safari were slightly susceptible to the fungus under the condition of artificial infection.

쌀, 조, 수수 및 콩의 食餌가 흰쥐의 成長 및 血液性狀에 미치는 影響

한백수,주현규,사동민,박병순,박기웅 선문대학교 첨단과학기술연구소 1996 첨단과학기술연구소 논문집 Vol.1 No.1

쌀, 조 수수, 및 콩의 식이가 흰쥐의 성장 및 혈액 성상에 미치는 영향을 조사하기 위하여, 평균체중 180g의 Sprague-Dawley계 rat(♂) 각 5마리씩을 대조군(T_(0)), 쌀(T_(1)), 조(T_(2)), 수수(T_(3)), 콩(T_(4))급이군등 5개군으로 나누어 실온에서 6주간 사육하면서 사료섭취량, 급수량, 증체량과 6주후의 혈액상의 변화틀 조사하였다. 사료 섭취량은 대조군이 각 처리 실험군보다 높았으며 물의 급수량도 동일한 결과이었으며 그 순위는 쌀, 조, 콩, 수수 순으로 감소하였으며, 각 처리군의 증체량은 대조군 보다 낮았으며, 특히 수수는 초기보다 감소하였고, 각 처리군의 사료효율은 대조군보다 낮았으며 특히 수수처리군이 타 처리군보다 낮았다. 연액성상의 변희는 대조군에서는 큰 변화가 없으나 수수군에서 BUN, HOT지 다른군보다 높았으며 쌀의 처리군은 creatinine치가 높았고 조에서는 혈당치가 낮았으며, 콩에서는 LDH는 높았고, HGB, HCT, PI.T, RBC가 낮았고, 특히 콩 수수에서는 혈액상의 변화가 가장 컸으며 다른 실험군과 비교하였을 때 통계적인 유의성이 인정되었다. This study was conducted to investigate the effects of rice, millet, sorghum and soybean diet on the growth rate, daily intake feed ratio and change in hematology of male rats. The experimental male rats of 180g average weight were fed on control (T_(0)), rice (T_(1)), millet (T_(2)), sorghum (T_(3)) and soybean diet (T_(4)) for 6 weeks. The amount of daily feed and water intake supply in each diet group is higher than that of control group to as shown in the following order: rice, millet, soybean, sorghum. The growth ratio of each diet group is lower than that of control group. Especially, sorghum made each diet group reduce the weight even more than the initial weight. Control group is lower than each diet group in regard to the effective ratio of feed. Especially, the sorghum group is lower than other groups. Control group remained same in the change of hematology, however, sorghum group is higher than other groups for BUN, HCT. Rice group is higher in creatinine and millet group is lower in glucose content of serum than any other groups. Soybean group is higher in LDH but lower in HGB, HCT, PLT, RBC than control group. Especially, the soybean and sorghum groups showed a big change in hematology and had the statistic significance in comparison to other groups.

불안정 대퇴골 전자간 골절 치료에서MHS (Intramedullary Hip Screw)와 압박고 나사의 비교

정필현,황정수,강석,김종필,곽주영 대한고관절학회 2004 Hip and Pelvis Vol.16 No.1

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

췌장의 점액성 낭선암 1예

송현주,김도영,정혜경,남승현,문일환,구혜수 梨花女子大學校 醫科大學 醫科學硏究所 2002 EMJ (Ewha medical journal) Vol.25 No.2

Nowadays increasing use of abdominal ultrasound in routine check-up may increase the detection rate asymtomatic cystic lesions of pancreas. Even through the majority of the cystic lesions of pancreas is pseudocyst, about 10-15% of those lesions are caused by pancreatic cystic tumor. In the pancreatic cystic tumor, especially, mucinous cystic tumor should be exicised due to its malignant potential, while the pancreatic pseudocyst or serous cystic tumon can be observed for a period or treated medically. Several clinical, radiological, biochemical and pathologic guidelines have been developed in order to distinguish among them. Among pancreatic cystic tumors, mucinous cystic adenocarcinoma is very rare and accounts for only 1% of all pancreatic neoplasms. Unlike extremely poor prognosis of pancreatic adenocarcinoma, mucinous cystic adenocarcinoma has an indolent course and shows a good prognosis after its curative resection. Recently we experienced a 69-year-old woman who had a mucinous cystic adenocarcinoma of the pancreas. We report this case with a review of literature.

船體의 springing 振動에 관한 硏究

김사수,윤경화,강현주 부산대학교 1994 生産技術硏究所論文集 Vol.47 No.

비교적 완만한 해상에서 선수 벌브를 가진 배가 밸러스트 상태로 항해할 때 수직이절진동으로써 상당한 진동이 발생한다는 사실은 잘 알려지고 있다.[17] 파중에서 슬래밍이나 청파에 의한 whipping진동에 대해서는 이미 많은 연구[16]∼[18]가 행해져 왔지만 완만한 해상에서 springing진동에 관한 연구는 비교적 적은 편이다. 본 논문의 목적은 주로 항해중인 선박에서 중요한 문제가 되는 소위 springing현상에 대해서 이론적 및 실험적으로 고찰할려는 것이다. 본 논문에서는 선체진동의 원인을 주기적인 파에 의한 외력이라 가정하고, 또 운동방정식을 풀기 위해서 선체를 Euler & Bernoulli 보로 그리고 서측은 수직으로 간주했다. 또 외력은 주기파에 기인한 부력변화로 보아 1차 mode 및 2차mode의 상호 비교와 1, 2, 3차 공진시의 각각의 기여도를 조사해보았다. 이때 이 이론해석은 몇몇 동적요소 및 비선형성을 고려하면 광석운반선이나 원유수송선 등에 실제 응용될 수 있다고 생각된다. There is well known fact that the considerable vibration occured by two node vertical ship hull vibration even if the ship sails on the calm water under the ballast conditions. There have been quite a many researches about Whipping Vibration caused by slamming, green water on the wave, but the research about Springing vibration has not frequently researched. So this paper aimed at springing phenomena which came up to main issue as the ship sails .Also, this paper explains the cause of ship vibration as a periodic external force, the ship as a Euler & Bernoulli beam, and ship side as a transverse bulkhead additionally, we take the external force as the buoyance spectrum caused by periodic wave. Firstly, we compared 1st mode and 2nd mode, then we check out the effectiveness fo each 1st, 2nd, 3rd mode under the resonance condition. I think that this analysis of the theory can be applied to any bulk carrier and VLCC, if the dynamic element and nonlinearity are considerable.