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Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
악성 혈액질환에서 성공적인 동종골수이식 후 숙주 기질 미세환경의 구축
조상희,이제중,남찬은,최경상,정익주,이일권,김진희,박종태,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1
인체의 골수는 간엽모세포를 함유하고 있으며 이들은 골수미세환경의 주된 세포들로 분화가 가능하여 조혈기능을 지지한다. 본 연구에서는 성별이 다른 동종조혈모세포이식 환경에서 조혈모세포의 완전 생착을 보이고, 이식 후 1년에서 8년이 지난 11예의 재생불량성 빈혈 및 백혈병 환자들을 대상으로 하여 골수에서 MSC를 분리하고 체외 확장을 통해 배양된 MSC에서 X 염색체 탐식자를 이용한 FISH 및 microsatellite polymorphism PCR 기법으로 그 기원을 확인하였다. 그 결과 조혈모세포는 완전히 공여자 기원으로 대치되었음에도 불구하고 MSC는 모두 수여자 기원임을 알 수 있어, 동종조혈모세포이식에서 미세환경의 구축은 수여자의 자가 생산에 의한 골수 간질세포에 의한 것으로 생각된다. Background: Human bone marrow (BM) contains mesenchymal stem cells (MSC) that can differentiate into various cells of mesenchymal origin. It remains a matter of controversy whether donor-derived stromal cells are capable of engraftment following hematopoietic stem cell transplantation (HSCT) or not. Methods: To determine if donor-derived stromal cells are transferred to the recipients of allogeneic HSCT, we investigated the characterization of MSC in 11 patients 1 to 8 years after sex mis-matched allogeneic HSCT in severe aplastic anemia and leukemia. Results: All patients had complete engraftment with donor- derived stem cells as shown by detection of donor type DNA in peripheral blood mononuclear cells. Following culture, MSC showed the expression of SH2 and SH4, but none of the hematopoietic markers of CD14, CD34, or CD45. MSC which can be differentiated to osteogenic lineage showed the genotype of recipient completely using FISH or PCR analysis. Conclusion: This study confirmed that MSC isolated from recipients of allogeneic HSCT in severe aplastic anemia and leukemia are not of donor genotype despite of full hematopoietic engraftment with donor type. Donor cells did not contribute to reconstitute the marrow microenvironment.
김준섭,권오구,박진석,오종수,박정현,박제식,안세한,이용환,서정호,신태섭,최영배,김덕수,이관,박수경 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1
본 연구는 경주지역 1개 고등학교 3학년 여고생을 대상으로 초경 시작 전인 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레 수치와 초경 연령을 파악하여 여성의 초경이 빠를수록 체성장 속도의 변화가 있을 것이라는 가설을 기초로 두 요인간의 관련성을 파악하고자 시행되었다. 경주시 1개 여자고등학교 3학년생 총 317명에 대해 ㅊ경 나이, 초경시 심리 상태, 초경이 시작되었을 때의 상담 여부와 상담하였던 사람, 부모 신장과 초경전후의 식사 규칙성, 다이어트 경험, 수면시간, 스트레스, 음주/흡연 여부, 질병력 등에 대한 설문 조사를 시행하였고, 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레에 대한 정보는 건강기록부에서 확보하였다. 상기 대상자 중 건강기록부가 분실된 39명, 초경나이에 대해 응답하지 않았던 29명 및 결석 등으로 조사를 하지 못하였던 42명을 제외한 조사 대상자는 206명으로 선정하였다. 대상자들의 초경연령 평균값(Mean±SD)은 13.0±1.11이었고, 초등학교 4학년부터 고등학교 2학년까지의 초경 이후 신장 성장률은 감소하였으며, 초경연령이 빠른 군이 초등학교 때는 신장에 있어서 우위를 차지하나 고등학교에 오면서 신장은 비슷한 수준이 되었다. 초경후 1-2년 사이에 체중과 흉위의 증가율은 감소하였고, 초경연령이 빠른 군이 초등학교와 고등학교 사이에 체중과 흉위에서 모두 우위를 차지하였다. 본 연구의 결과는, 흔히 이차 성징의 시작 시점 혹은 사춘기의 시작 시점으로 보고있는 초경 연령이 청소년기의 성장과 밀접한 관련성이 있고, 특히 체중과 흉위의 성장 속도와 밀접한 관련성이 있음을 시사한다. To understand the onset of menarche in relation to changes in physical growth that take place during female adolescence, especially the changes in height and weight velocity. The 207 senior in one women high school of Kyongju were investigated in April 3 to 8, 2001. We collected the information, relation in the age at menarche, height & weight of parents, regularity of eating, and obesity diet, duration of sleeping, sickness & stress near age at menarche, by self-recording. The status of height, weight & chest circumference between the 4th grade of primary school and the junior of high school was collected by individual Health Record. The results were followed; The average age at menarche was 12.95±1.11 years old and the most frequent age of menarche is 13 years. After menarche, the velocity of height, weight and chest circumference were decreased. The most rapid group of menarche hold dominant position in height during elementary school. As time passed, they dont hold dominant position in height. The most rapid group of menarche get an advantage in the weight and the girth of chest after elementary school. The height of subjects is directly proportional to the height of their parents. These results suggest that the starting age at menestuation can be closely associated with physical growth and development.
Park, Jong Il,Han, sang seop,Jeong, Tae Cheon,Roh, Jung Koo,Kim, Hyoung Chin,Kim, Jeong Hwan,Jeon, Yeong Joong,Kim, Dal Hyun,Kim,Je Hak,Park, Kwan Ha 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1
The antigenic potential of CFA-001, cefazolin, a cephalosporin derivative produced by an enzymatic semisynthesis, was determined in Hartley guinea pigs. A battery of tests employed consisted of active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA), and indirect hemagglutination test (IHA). The results were as follows: 1) In ASA, no signs attributable to anaphylaxis was observed in guinea pigs sensitized with CFA-001, whereas OVA-sensitized animals induced severe anaphylactic symptoms; 2) guinea pigs did not produce antibodies against CFA-001 when sensitized with or without Freund's complete adjuvant (FCA) in homologous PCA tests. Meanwhile, antibodies against ovalbumin (OVA) were clearly detected; 3) No CFA-001-specific hemagglutination was observed in the IHA using sera obtained from CFA-001-sensitized guinea pigs. These results suggest that CFA-001 has no antigenicity potential in guinea pigs.
Applications of Hydrochemical Models for the Assessment of Groundwater
( Jong Yeon Hwang ),( Sunhwa Park ),( Moon-su Kim ),( Hun-je Jo ),( Gyeong-mi Lee ),( In Kyu Shin ),( Sang Ho Jeon ),( Da Hee Song ),( Deok-hyun Kim ),( Tae-seung Kim ),( Hyen Mi Chung ),( Hyun-koo Ki 한국환경분석학회 2017 환경분석과 독성보건 Vol.20 No.3
In this study, we focused on the evaluation and comparison of the physico-chemical characteristics and distribution of cations and anions in groundwater sampled from 2015 (485 samples) to 2016 (145 samples) in rural provinces of Korea. The major objectives of this study were as follows: 1) quality assessment of groundwater for special usage, such as agricultural or industrial applications; 2) the determination of groundwater types; and 3) the tracing of ion sources in groundwater. The assessment of the groundwater qualities from 2015 (n=480 samples) to 2016 (n=145 samples)) for agricultural usages were conducted using SAR (Sodium Adsorption Ratio), Na(%), RSC (Residual Sodium Carbonate), PI (Permeability Index), SSP (Soluble Sodium Percent), MH (Magnesium Hazard), KR (Kelly’s Ratio) and PS (Potential soil Salinity). Furthermore, the results of samples in 2015 were classified as SAR [Excellent (100%)], Sodium [(Excellent (34%), Good (55%), Permissible (9%), Doubtful (1.6%), Unsuitable (0.4%)], RSC [(Good (95.7%), Medium (3.5%), Bad (0.8%)], PI [(Excellent (40.6%), Good (59%), Unsuitable (0.4%)], SSP [(Excellent (26.3%), Good (59.8%), Fair (13.1%), Poor (0.8%)], MH [(Acceptable (94.4%), Non-Acceptable (5.6%)], and Kelly’s Ratio [(Permissible (93%), Non-Permissible (7%)], PS [(Excellent to Good (98%), Good to Injurious (1.2%), and Injurious to Unsatisfactory (0.2%)]. In addition, the groundwater sampled in 2016 was classified as SAR [Excellent (100%)], Sodium [Excellent (2.1%), Good (51.1%), Permissible (39.3%), Doubtful (6.2%), Unsuitable (0.7%)], RSC [Good (100%)], PI [Excellent (100%)], SSP [Excellent (0.7%), Good (37.2%), Fair (61.4%), Poor (0.7%)], MH [Acceptable (96.6%), Non- Acceptable (3.4%)], KR [Permissible (69.7%), (Non-Permissible (30.3%)], and PS [Excellent to Good (100%)]. Evaluations based on the Wilcox diagram were classified as “excellent to good” or “good to permissible” and the water quality evaluated using the U.S. Salinity Laboratory’s Diagram was classified as C1S1 (Excellent/ Excellent) and C2S1 (Good/Excellent) for all samples from 2015 to 2016. Moreover, in the application of two factors of the Langelier Saturation Index (LSI) and Corrosive ratio (CR), we obtained similar results for defining the suitability of groundwater for industrial purposes.
Assessment of Inorganic Chemicals in Groundwater in Rural Provinces of Korea
( Jong Yeon Hwang ),( Sunhwa Park ),( Moon-su Kim ),( Hun-je Jo ),( Gyong-mi Lee ),( Sang Ho Jeon ),( Da Hee Song ),( Deok-hyun Kim ),( Tae-seung Kim ),( Hyen Mi Chung ),( Hyun-koo Kim ) 한국환경분석학회 2017 환경분석과 독성보건 Vol.20 No.2
In this study, we focused on the evaluation, comparison of the physiochemical characteristics, and distribution of cations and anions in groundwater sampled in rural areas of Korea. The on-site measurements of pH, EC, DO, and ORP (average, minimum, and maximum) respectively ranged as follows: 5.7~8.7, 49~1,224 μS/cm, 0.5~11.8 mg/L, and -53.0~697 mV. The assessments of water quality for agricultural usages were evaluated using SAR, sodium (%), RSC, PI, SSP, MH, PS, and Kelly`s ratio (KR) and were classified as SAR [Excellent (100%)], Sodium [Excellent (2.1%), Good (51.1%), Permissible (39.3%), Doubtful (6.2%), Unsuitable (0.7%)], RSC [Good (100%)], PI [Excellent (100%)], SSP [Excellent (0.7%), Good (37.2%), Fair (61.4%), Poor (0.7%)], MH [Acceptable (96.6%), Non-Acceptable (3.4%)], KR [Permissible (69.7%), (Non-Permissible (30.3%)], and PS [Excellent to Good (100%)]. In addition, classifications of groundwater based on the Piper diagram showed that the groundwater was grouped into the Ca<sup>2+</sup>-(Cl<sup>-</sup>-NO<sub>3</sub><sup>-</sup>) and Ca<sup>2+</sup>-HCO<sub>3</sub><sup>-</sup> types, which are general features of groundwater in Korea. Moreover, the tracking of dominance types (classified as evaporation, rock, and precipitation) based on the Gibbs diagram showed that the origins of anions and cations in the groundwater are of rock dominance.