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Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
Je-Oh Lim,Se-Jin Lee,Woong_Il Kim,So-Won Pak,In-Sik Shin,Jong-Choon Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Yijin-tang is an oriental traditional herbal prescription used to treat inflammatory diseases. In present study, we investigated the protective effect of Yijin-tang water extract (YTE) in an ovalbumin (OVA)-induced asthma model focusing on its antioxidatant and anti-inflammatory properties. BALB/c mice were intraperitoneally injected with OVA on days 0 and 14; then, they were challenged with OVA on days 21, 22, and 23. YTE (200 and 400 mg/kg) was orally administered from day 18 to 23. Subsequently, YTE significantly decreased the elevation of airway hyperresponsiveness and, recruitment of inflammatory cells, cytokines, and OVA-specific immuno-globulin E in asthmatic mice. Additionally, YTE was associated with a marked reduction in airway inflammation and mucus production in the lung tissue of asthmatic mice. Further, YTE suppressed matrix metalloproteinase-9 expression and ERK phosphorylation in the lung, which was accompanied by a reduction in inducible nitric oxide synthases and an elevation in reduced glutathione and heme oxygenase-1. In conclusion, YTE effectively suppressed allergic responses in the asthmatic mice and the effect was closely related to its antioxidant and anti-inflammatory properties. Our results indicate that YTE may be a potential material in the treatment of allergic asthma.
Brief introduction of Butterfly(Lepidoptera) from Myanmar
Ja Lang LIM,Jinyoung PARK,Ik Je CHOI,Yong Kyun OH,Eui Seok JEONG,Dong Pyeo LYU,U Pho Cho,Khin Mar Myint,Khin Mar Yi,Jong Kyun PARK 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Myanmar is located in the south-east Asia peninsular and it is flanked by five neighboring states: Bangladesh, India, China, Laos and Thailand. It is located 10~22 degree north latitude, to 92~101 degrees east longitude. Myanmar has a tropical climate with three seasons in Myanmar. Hot season (March through April), rainy season (May through October) and the cool season (November through February). The coastal regions can get very hot and humid, especially before the rainy season. Myanmar has a monsoon season from May to October when there are heavy rains and often flooding. The investigation was carried out during the dry season(2013) in Nat Ma Taung National Park and Popa Mountain Park. Popa Mountain Park is located in Kyawpadaung Township, Myinchan district, Mandaly Division. The area is 49.63 square miles. Its coordinates are 29°31'60" N and 27°43'60" E. Nat Ma Taung National Park, Myanmar treasure is in Mindut District of Chin State and its area of 279 square miles. It is the third highest mountain in Myanmar with the height of 10,500 feet. Its coordinates are 21°14'00" N and 93°54'00" E. As the result, butterflies(Lepidoptera) collected in the two regions were about 60 species of 7 familys. Collecting dates, expedition activities, photo of main specimen and information of Myanmar were provided.
Lim, Chae-Oh,Kim, Min-Gab,Kim, Ho-Yeon,Chung, Woo-Sik,Park, Sung-Han,Hwang, In-Hwan,Jo, Moo-Je Plant Molecular Biology & Biotechnology Research C 1994 Plant molecular biology and biotechnology research Vol.1994 No.
Single-run partial sequencing was performed on randomly selected coda clones from a chinese cabbage flower buds cDNA library. Sequences of seven hundreds sixty nine individual cDNA clones have been compared with sequences in protein database, and three hundreds sixty seven clones (47.7%) showed a varying degree of sequence homology to a variety of known proteins involved in various biological processes. Among the cDNAs with no sequence similarity to known to previously registered other plant ESTs. Most of the EST matched clones also showed sequence similarity with deduced polypeptide sequences of the corresponding ESTs at the amino acid level. Most likely these EST matched cDNAs encode polypeptides conserved in plants. These sequences together with no matched sequences (39.2%) may encode currently unknown flower bud-specific of plant-specific proteins. These Brassica sequences add new EST plants and will be useful to understand genome utilization and genome organization in various tissue within a plant and between different plant species. These EST can also serve as a useful gene resource for basic science in plant molecular biology and for application in agriculture.